D J Hunter

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis
    Leonid Kalichman
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street Suite X200, Boston, MA 02118, USA
    Arthritis Res Ther 9:R26. 2007
  2. pmc A functional difficulty and functional pain instrument for hip and knee osteoarthritis
    Alan M Jette
    Health and Disability Research Institute, Boston University School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Res Ther 11:R107. 2009
  3. pmc Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Arthritis Res Ther 11:R90. 2009
  4. pmc Osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    BMJ 332:639-42. 2006
  5. ncbi request reprint Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Osteoarthritis Cartilage 15:93-7. 2007
  6. ncbi request reprint Genetic contribution to cartilage volume in women: a classical twin study
    David J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Rheumatology (Oxford) 42:1495-500. 2003
  7. ncbi request reprint The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Ann Rheum Dis 67:206-11. 2008
  8. ncbi request reprint Change in joint space width: hyaline articular cartilage loss or alteration in meniscus?
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Arthritis Center, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:2488-95. 2006
  9. ncbi request reprint The association of cartilage volume with knee pain
    D J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
    Osteoarthritis Cartilage 11:725-9. 2003
  10. ncbi request reprint Imaging outcomes and their role in determining outcomes in osteoarthritis and rheumatoid arthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, and the Department of Medicine at Boston Medical Center, Boston, Massachussetts 02118, USA
    Curr Opin Rheumatol 18:157-62. 2006

Research Grants

  1. Patellofemoral Osteoarthritis Epidemiology
    David Hunter; Fiscal Year: 2006

Collaborators

Detail Information

Publications159 found, 100 shown here

  1. pmc The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis
    Leonid Kalichman
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street Suite X200, Boston, MA 02118, USA
    Arthritis Res Ther 9:R26. 2007
    ..Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA...
  2. pmc A functional difficulty and functional pain instrument for hip and knee osteoarthritis
    Alan M Jette
    Health and Disability Research Institute, Boston University School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Res Ther 11:R107. 2009
    ....
  3. pmc Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Arthritis Res Ther 11:R90. 2009
    ....
  4. pmc Osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    BMJ 332:639-42. 2006
  5. ncbi request reprint Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Osteoarthritis Cartilage 15:93-7. 2007
    ..We used data from a longitudinal observation study to determine if urinary pentosidine could serve as a marker to predict cartilage loss...
  6. ncbi request reprint Genetic contribution to cartilage volume in women: a classical twin study
    David J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Rheumatology (Oxford) 42:1495-500. 2003
    ..A classical twin study was performed to assess the relative contribution of genetic and environmental factors to cartilage volume...
  7. ncbi request reprint The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Ann Rheum Dis 67:206-11. 2008
    ..The aim of this work was to assess the reliability of a novel MRI scoring system for evaluating OA of the knee and explore the validity of the bone marrow lesion (BML) scoring component of this new tool...
  8. ncbi request reprint Change in joint space width: hyaline articular cartilage loss or alteration in meniscus?
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Arthritis Center, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:2488-95. 2006
    ..To explore the relative contribution of hyaline cartilage morphologic features and the meniscus to the radiographic joint space...
  9. ncbi request reprint The association of cartilage volume with knee pain
    D J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
    Osteoarthritis Cartilage 11:725-9. 2003
    ..The aim of this study was to examine the association between knee symptoms and MRI cartilage volume...
  10. ncbi request reprint Imaging outcomes and their role in determining outcomes in osteoarthritis and rheumatoid arthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, and the Department of Medicine at Boston Medical Center, Boston, Massachussetts 02118, USA
    Curr Opin Rheumatol 18:157-62. 2006
    ..This review describes the advances in knowledge of outcomes that have occurred recently as a result of imaging research in both osteoarthritis and rheumatoid arthritis...
  11. ncbi request reprint A genome scan for joint-specific hand osteoarthritis susceptibility: The Framingham Study
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:2489-96. 2004
    ..We undertook this study to test our hypothesis that phenotypes of hand OA may show stronger linkage than has been shown for overall hand OA...
  12. ncbi request reprint Chopstick arthropathy: the Beijing Osteoarthritis Study
    David J Hunter
    Boston University Arthritis Center, BU School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 50:1495-500. 2004
    ..We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent hand OA...
  13. ncbi request reprint Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Arthritis Center, the Department of Medicine at Boston Medical Center, Boston, Massachusetts 02118, USA
    J Rheumatol 33:1341-5. 2006
    ..To assess several putative risk factors, including thiazide and loop diuretics use, thought to trigger recurrent gout attacks...
  14. ncbi request reprint The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis
    D J Hunter
    Boston Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 54:795-801. 2006
    ..To explore the role of meniscal tears and meniscal malposition as risk factors for subsequent cartilage loss in subjects with symptomatic osteoarthritis (OA)...
  15. ncbi request reprint Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Arthritis Center, Boston University, MA 02118, USA
    J Rheumatol 32:2192-9. 2005
    ..One of the mechanical influences on cartilage loss is limb alignment. We explored the structural factors associated with malalignment in subjects with symptomatic OA...
  16. ncbi request reprint Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, Massachusetts, USA
    Arthritis Rheum 54:1529-35. 2006
    ..These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA)...
  17. ncbi request reprint Responsiveness, effect size, and smallest detectable difference of Magnetic Resonance Imaging in knee osteoarthritis
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Osteoarthritis Cartilage 14:A112-5. 2006
    ....
  18. ncbi request reprint Trapeziometacarpal subluxation predisposes to incident trapeziometacarpal osteoarthritis (OA): the Framingham Study
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Brigham and Women s Hospital, Boston, MA 02118, USA
    Osteoarthritis Cartilage 13:953-7. 2005
    ..However, as yet there have been no longitudinal evaluations to determine if this hypothesis is true. We examined the relation of radial subluxation to the risk of radiographic OA at trapeziometacarpal joint...
  19. pmc Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    Arthritis Res Ther 9:R108. 2007
    ..With the exception of COMP, if changes in cartilage turnover in patients with symptomatic knee OA are associated with cartilage loss, they do not appear to affect systemic biomarker levels...
  20. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  21. ncbi request reprint Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study
    David J Hunter
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:1212-8. 2007
    ....
  22. ncbi request reprint A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Cancer 87:204-10. 2000
    ..4. The lack of an established effect on CYP19 function associated with the 10 allele means that these findings should be interpreted with caution...
  23. ncbi request reprint Dietary fat and protein in relation to risk of non-Hodgkin's lymphoma among women
    S Zhang
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:1751-8. 1999
    ..In this study, we examined the intake of specific types of dietary fat and protein in relation to the risk of non-Hodgkin's lymphoma...
  24. ncbi request reprint Dietary carotenoids and vitamins A, C, and E and risk of breast cancer
    S Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:547-56. 1999
    ..Furthermore, studies of vitamins A, C, and E in relation to breast cancer risk are inconclusive. We have conducted a large, prospective study to evaluate long-term intakes of these nutrients and breast cancer risk...
  25. pmc Patella malalignment, pain and patellofemoral progression: the Health ABC Study
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
    Osteoarthritis Cartilage 15:1120-7. 2007
    ..Risk factors for pain and structural progression in PF OA are poorly understood. Our objective was to determine the association between patella malalignment and its relation to pain severity, and PF OA disease progression...
  26. ncbi request reprint A prospective study of folate intake and the risk of breast cancer
    S Zhang
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 281:1632-7. 1999
    ..Folate is involved in DNA synthesis and methylation and may reduce breast cancer risk, particularly among women with greater alcohol consumption...
  27. ncbi request reprint The association of bone attrition with knee pain and other MRI features of osteoarthritis
    G Hernández-Molina
    Clinical Epidemiology Reseach and Training Unit and the Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:43-7. 2008
    ....
  28. pmc Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis
    W F Harvey
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Ann Rheum Dis 67:1524-8. 2008
    ..We measured various knee alignment indices among Chinese and Caucasians and assessed whether these indices were different between the two racial groups...
  29. doi request reprint The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period
    M D Crema
    Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:336-43. 2010
    ..To investigate the association of different types of magnetic resonance imaging (MRI)-detected medial meniscal pathology with subregional cartilage loss in the medial tibiofemoral compartment...
  30. pmc Oral contraceptive use and risk of melanoma in premenopausal women
    D Feskanich
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 81:918-23. 1999
    ..Further research is needed to determine whether low-dose oestrogen pills in particular are associated with an increase in risk and to describe possible interactions between OC use and sun exposure or other risk factors for melanoma...
  31. pmc Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study
    G H Lo
    Tufts New England Medical Center, Boston, MA 02111, USA
    Osteoarthritis Cartilage 16:261-7. 2008
    ..We hypothesized that knees with higher M:L BMD, consistent with increased medial subchondral BMD, would be associated with medial meniscal damage, and lower ratios with lateral meniscal damage...
  32. pmc Premorbid knee osteoarthritis is not characterised by diffuse thinness: the Framingham Osteoarthritis Study
    D J Hunter
    Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:1545-9. 2008
    ....
  33. ncbi request reprint Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies
    S A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 285:769-76. 2001
    ..CONCLUSION: These results suggest that fruit and vegetable consumption during adulthood is not significantly associated with reduced breast cancer risk...
  34. pmc Prevalence of bone attrition on knee radiographs and MRI in a community-based cohort
    S Reichenbach
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, United States
    Osteoarthritis Cartilage 16:1005-10. 2008
    ....
  35. ncbi request reprint Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis
    K M Fairfield
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer 92:2318-26. 2001
    ..Antioxidant vitamins may decrease risk of cancer by limiting oxidative DNA damage leading to cancer initiation. Few prospective studies have assessed relations between antioxidant vitamins and ovarian carcinoma...
  36. pmc Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania
    S Mehta
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 64:808-17. 2010
    ..There is limited published research examining lipid-soluble vitamins in human immunodeficiency virus (HIV)-infected pregnant women, particularly in resource-limited settings...
  37. ncbi request reprint A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 58:3307-11. 1998
    ..02). These prospective data, which need to be confirmed in other studies, suggest that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk...
  38. ncbi request reprint N-acetyl transferase 2 genotypes, meat intake and breast cancer risk
    D M Gertig
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cancer 80:13-7. 1999
    ..We observed no evidence of differential susceptibility to these exposures by NAT2 genotype...
  39. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  40. ncbi request reprint Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study
    F Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Int J Cancer 91:568-74. 2001
    ..83 for PCB 153 (95% CI: 0.47-1.48), and 0.98 for PCB 180 (95% CI: 0.55-1.75). Sub-group analyses were also performed. Overall, our results do not support the hypothesis that exposure to DDT and PCBs increases the risk of breast cancer...
  41. pmc Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Ann Rheum Dis 68:349-56. 2009
    ..Our objective was to assess the rate of natural disease progression of cartilage morphometry measures from baseline to 1 year in knees with osteoarthritis (OA) from a subset of participants from the Osteoarthritis Initiative (OAI)...
  42. ncbi request reprint Physical activity and breast cancer risk in a cohort of young women
    B Rockhill
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 90:1155-60. 1998
    ..Increased physical activity has been hypothesized to be a means of breast cancer prevention. We examined the associations between physical activity at two different times in life and breast cancer risk...
  43. ncbi request reprint MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 58:1381-7. 2002
    ..Also, the association between never smoking and PD risk may be present only in people with the MAOB G allele...
  44. pmc Does cartilage volume or thickness distinguish knees with and without mild radiographic osteoarthritis? The Framingham Study
    S Reichenbach
    Clinical Epidemiology Unit, Boston University Medical Center, Boston, Massachusetts, USA
    Ann Rheum Dis 69:143-9. 2010
    ..To examine whether the quantity of cartilage or semiquantitative scores actually differ in knees with mild radiographic osteoarthritis compared with knees without osteoarthritis...
  45. pmc Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Ave, Building 2, 3rd Floor, Boston, MA 02115, USA
    J Neurol 258:1676-82. 2011
    ..91, 95% CI: 0.80, 1.04). This preliminary finding suggests the possibility that the putative beneficial effect of vitamin D on MS risk maybe attenuated in individuals carrying the HLA-DR15 MS risk allele...
  46. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  47. ncbi request reprint The ratio of medial to lateral tibial plateau bone mineral density and compartment-specific tibiofemoral osteoarthritis
    G H Lo
    Tufts New England Medical Center, Boston, MA 0211, USA
    Osteoarthritis Cartilage 14:984-90. 2006
    ..Bone is thought to play an important role in osteoarthritis (OA) pathophysiology. Our aim was to look at specific features of OA and their relation to the ratio of medial:lateral tibial plateau bone mineral density (M:L BMD Ratio)...
  48. ncbi request reprint High signal in knee osteophytes is not associated with knee pain
    M Sengupta
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, MA 02118, USA
    Osteoarthritis Cartilage 14:413-7. 2006
    ..We undertook this study to determine if the presence of high-signal osteophytes on magnetic resonance imaging (MRI) was associated with pain presence, location or severity...
  49. ncbi request reprint Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies
    K B Michels
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 153:275-83. 2001
    ..11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer...
  50. ncbi request reprint Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:477-85. 2000
    ..Higher intake of vegetables, particularly cruciferous vegetables, may reduce the risk of non-Hodgkin's lymphoma among women...
  51. ncbi request reprint Rotating night shifts and risk of breast cancer in women participating in the nurses' health study
    E S Schernhammer
    E S Schernhammer, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1563-8. 2001
    ..There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer...
  52. pmc Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?
    D J Hunter
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:175-83. 2010
    ..We examined if by selecting regions of interest with denuded cartilage, the remaining cartilage within this region of interest was susceptible to greater rates of cartilage loss...
  53. ncbi request reprint Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness
    M Englund
    Clinical Epidemiology Branch and Training Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 56:4048-54. 2007
    ..To evaluate the effect of meniscal damage on the development of frequent knee pain, aching, or stiffness in middle-aged and older adults...
  54. ncbi request reprint Vitamin supplement use and the risk of non-Hodgkin's lymphoma among women and men
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:1056-63. 2001
    ..Because an elevated risk among multivitamin users was not observed consistently in the two cohorts and the pooled data were not significant, the elevated risk among women may be the result of chance...
  55. ncbi request reprint A prospective study of recreational physical activity and breast cancer risk
    B Rockhill
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 159:2290-6. 1999
    ..We thus examined this issue in a large cohort of women, using several different measures of adult physical activity...
  56. pmc Systematic review of the concurrent and predictive validity of MRI biomarkers in OA
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Osteoarthritis Cartilage 19:557-88. 2011
    ..To summarize literature on the concurrent and predictive validity of MRI-based measures of osteoarthritis (OA) structural change...
  57. ncbi request reprint Prospective study of talc use and ovarian cancer
    D M Gertig
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 92:249-52. 2000
    ..In this study, we conducted a prospective analysis of perineal talc use and the risk of ovarian cancer...
  58. ncbi request reprint A prospective study of oral contraceptives and NIDDM among U.S. women
    L Chasan-Taber
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 20:330-5. 1997
    ..To examine prospectively the association between modern oral contraceptives with low doses of estrogen and progestin and subsequent incidence of NIDDM...
  59. pmc Polymorphic repeat in AIB1 does not alter breast cancer risk
    C A Haiman
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 191 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 2:378-85. 2000
    ..These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population...
  60. ncbi request reprint Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention
    B Rockhill
    B Rockhill, C Byrne, Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 93:358-66. 2001
    ..to aid decision making regarding potential prevention options for breast cancer, including chemoprevention with tamoxifen...
  61. pmc The relation of plasma homocysteine to radiographic knee osteoarthritis
    M Fayfman
    Boston University School of Medicine, Boston, USA
    Osteoarthritis Cartilage 17:766-71. 2009
    ..In the present study we considered the possible relationship between plasma homocysteine levels and the development and progression of knee osteoarthritis (OA)...
  62. ncbi request reprint Prospective study of recreational physical activity and ovarian cancer
    E R Bertone
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 93:942-8. 2001
    ..The only prospective study to date reported a positive association between frequent vigorous exercise and ovarian cancer risk. We further evaluated this relationship in the Nurses' Health Study cohort...
  63. pmc The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 17:748-53. 2009
    ..To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA)...
  64. ncbi request reprint Determinants of low birth weight among HIV-infected pregnant women in Tanzania
    M L Dreyfuss
    Departments of Nutrition, Biostatistics, and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 74:814-26. 2001
    ..Low birth weight (LBW) increases the risk of infant death, but little is known about its causes among HIV-infected populations in sub-Saharan Africa...
  65. doi request reprint Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 17:1170-6. 2009
    ..To ascertain the contribution of articular cartilage morphometry and meniscal position on MRI to joint space width (JSW) measured in the Lyon schuss radiograph of the knee...
  66. pmc Physical activity and risk of breast cancer in premenopausal women
    G A Colditz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Br J Cancer 89:847-51. 2003
    ..The potential interactions between physical activity, adiposity, and current use of OCs require further study...
  67. doi request reprint The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis
    V Stein
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:192-9. 2010
    ..The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume...
  68. ncbi request reprint Prospective study of oral contraceptives and hypertension among women in the United States
    L Chasan-Taber
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:483-9. 1996
    ..However, neither the responsible hormone in the oral contraceptive nor particular subgroups of women who might be susceptible to the hypertensive effect of oral contraceptives have been identified...
  69. pmc Facet orientation and tropism: associations with spondylolysis
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    J Spinal Disord Tech 23:101-5. 2010
    ..Cross-sectional study...
  70. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  71. doi request reprint Role of alignment and biomechanics in osteoarthritis and implications for imaging
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Radiol Clin North Am 47:553-66. 2009
    ..There are several ways that mechanical forces across the joint can be measured, including many that rely heavily on imaging methods. These are described and methods to advance the field are proposed...
  72. pmc Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 34:199-205. 2009
    ..Cross-sectional study...
  73. pmc The symptoms of osteoarthritis and the genesis of pain
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Rheum Dis Clin North Am 34:623-43. 2008
    ..Much has been learned during recent years, but much of this puzzle remains unexplored or inadequately understood...
  74. pmc Facet orientation and tropism: associations with facet joint osteoarthritis and degeneratives
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Spine (Phila Pa 1976) 34:E579-85. 2009
    ..Cross-sectional study...
  75. pmc Computed tomography-evaluated features of spinal degeneration: prevalence, intercorrelation, and association with self-reported low back pain
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Spine J 10:200-8. 2010
    ..Although the role of radiographic abnormalities in the etiology of nonspecific low back pain (LBP) is unclear, the frequent identification of these features on radiologic studies continues to influence medical decision making...
  76. ncbi request reprint Advanced imaging in osteoarthritis
    David J Hunter
    Division of Research, New England Baptist Hospital, Boston, Massachusetts 02120, USA
    Bull NYU Hosp Jt Dis 66:251-60. 2008
    ..Additionally, MRI has the potential for assessing the effect of risk factors for epidemiologic investigation and the effectiveness of therapeutic interventions in OA clinical trials...
  77. doi request reprint The management of osteoarthritis: an overview and call to appropriate conservative treatment
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Rheum Dis Clin North Am 34:689-712. 2008
    ..It provides the clinician with an overview of the available treatments in line with the guidelines of the Osteoarthritis Research Society International and the European League Against Rheumatism...
  78. doi request reprint Alignment and osteoarthritis of the knee
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    J Bone Joint Surg Am 91:85-9. 2009
    ..It is also apparent that malalignment changes with disease progression and is itself possibly influenced by structural changes within the joint...
  79. ncbi request reprint Association of squatting with increased prevalence of radiographic tibiofemoral knee osteoarthritis: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:1187-92. 2004
    ....
  80. pmc Facet joint osteoarthritis and low back pain in the community-based population
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Spine (Phila Pa 1976) 33:2560-5. 2008
    ..Cross-sectional study...
  81. pmc Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis
    Catherine L Hill
    Boston University School of Medicine, A203, 80 E Concord Street, Boston, MA 02118, USA
    Ann Rheum Dis 66:1599-603. 2007
    ..To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis...
  82. doi request reprint Association between age, sex, BMI and CT-evaluated spinal degeneration features
    Leonid Kalichman
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    J Back Musculoskelet Rehabil 22:189-95. 2009
    ..The aim of our study was to evaluate the association between age, sex and body mass index (BMI) and lumbar spine degeneration features evaluated on computed tomography (CT) in a community-based sample...
  83. doi request reprint Hip Osteoarthritis MRI Scoring System (HOAMS): reliability and associations with radiographic and clinical findings
    F W Roemer
    Quantitative Imaging Center, Department of Radiology, Boston University Medical Center, 820 Harrison Avenue, Boston, MA 02118, USA
    Osteoarthritis Cartilage 19:946-62. 2011
    ..To develop a semiquantitative MRI-based scoring system (HOAMS) of hip osteoarthritis (OA) and test its reliability and validity...
  84. doi request reprint MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis
    F W Roemer
    Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Osteoarthritis Cartilage 17:1115-31. 2009
    ..To discuss terminology, radiological differential diagnoses and significance of magnetic resonance imaging (MRI)-detected subchondral bone marrow lesions (BMLs) of the knee joint...
  85. ncbi request reprint Osteophytes and progression of knee osteoarthritis
    D T Felson
    715 Albany Street, A207, Boston University School of Medicine, Boston, MA 02118, USA
    Rheumatology (Oxford) 44:100-4. 2005
    ..Meagre longitudinal data suggest, however, that they are associated with an increased risk of structural progression. Our objective was to evaluate the effect of osteophyte size on radiographic progression in osteoarthritis (OA)...
  86. ncbi request reprint Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis: results of two prospective longitudinal magnetic resonance imaging studies
    T Neogi
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 54:1822-8. 2006
    ..To evaluate the relationship between chondrocalcinosis and the progression of knee osteoarthritis (OA) using longitudinal magnetic resonance imaging (MRI) assessments...
  87. doi request reprint Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3-6 months' observation using advanced image analysis of 3T MRI?
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:677-83. 2010
    ..The primary outcome was the cartilage thickness in the central medial femur...
  88. ncbi request reprint Lumbar facet joint osteoarthritis: a review
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University, Boston, Massachusetts 02118, USA
    Semin Arthritis Rheum 37:69-80. 2007
    ..We reviewed the anatomy, biomechanics, and possible sources of pain of the FJ, natural history, and risk factors of lumbar FJ osteoarthritis and briefly reviewed the relevant imaging methods...
  89. pmc Diagnosis and conservative management of degenerative lumbar spondylolisthesis
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University, 650 Albany Street X Building, Suite 200, Boston, MA 02118, USA
    Eur Spine J 17:327-35. 2008
    ..An up-to-date knowledge on diagnosis and prevention of lumbar DS can assist in determination of future research goals. Additional studies are required to establish treatment protocols for the conservative treatment of DS...
  90. doi request reprint Plain radiography and magnetic resonance imaging diagnostics in osteoarthritis: validated staging and scoring
    Ali Guermazi
    Section of Musculoskeletal Imaging, Department of Radiology, Boston Medical Center, FGH Building, 820 Harrison Avenue, Boston, MA 02118, USA
    J Bone Joint Surg Am 91:54-62. 2009
    ....
  91. doi request reprint The role of analgesics and intra-articular injections in disease management
    William F Harvey
    Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA 02111, USA
    Med Clin North Am 93:201-11, xii. 2009
    ..Specific attention is paid to current trends and controversies related to pharmacologic management, including the use of oral, topical, and injectable agents...
  92. pmc Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: analysis of longitudinal data from the Osteoarthritis Initiative
    Jeffrey Duryea
    Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 62:932-7. 2010
    ..The objective of our study was to compare the responsiveness of radiographic joint space width (JSW) with MRI-derived measures of cartilage morphometry for OA progression in participants from the Osteoarthritis Initiative (OAI)...
  93. ncbi request reprint Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study
    Tuhina Neogi
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Rheumatol 33:104-9. 2006
    ..To evaluate the patterns and determinants of medication use during recurrent gout attacks...
  94. pmc Incidental meniscal findings on knee MRI in middle-aged and elderly persons
    Martin Englund
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 359:1108-15. 2008
    ..However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographic evidence of osteoarthritis...
  95. doi request reprint How close are we to having structure-modifying drugs available?
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Rheum Dis Clin North Am 34:789-802. 2008
    ..The authors hope that at the end of this narrative review the reader will appreciate the complexities of this rapidly evolving field and of the development of disease-modifying drugs for osteoarthritis drugs...
  96. doi request reprint The genetics of intervertebral disc degeneration. Associated genes
    Leonid Kalichman
    Boston University Clinical Epidemiology Research and Training Unit, University School of Medicine, 650 Albany St, Boston, MA 02118, USA
    Joint Bone Spine 75:388-96. 2008
    ..To review current knowledge on genes associated with intervertebral disk degeneration...
  97. doi request reprint The role of analgesics and intra-articular injections in disease management
    William F Harvey
    Division of Rheumatology, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Rheum Dis Clin North Am 34:777-88. 2008
    ..Specific attention is paid to current trends and controversies related to pharmacologic management, including the use of oral, topical, and injectable agents...
  98. ncbi request reprint A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis
    Kristin Baker
    Veterans Affairs Boston Health Care System, Boston University Medical School, Massachusetts 02118, USA
    Arthritis Rheum 56:1198-203. 2007
    ..The aim of this study was to test the efficacy of this simple, low-cost intervention for pain in patients with medial knee OA...
  99. ncbi request reprint Knee buckling: prevalence, risk factors, and associated limitations in function
    David T Felson
    Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women s Hospital, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Intern Med 147:534-40. 2007
    ..Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence in the community is unknown...
  100. ncbi request reprint The effect of body weight on progression of knee osteoarthritis is dependent on alignment
    David T Felson
    Boston University Clinical Epidemiology Research and Training, Boston, Massachusetts, USA
    Arthritis Rheum 50:3904-9. 2004
    ..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...
  101. ncbi request reprint Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:129-36. 2007
    ..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...

Research Grants2

  1. Patellofemoral Osteoarthritis Epidemiology
    David Hunter; Fiscal Year: 2006
    ..In this project we will evaluate PF cartilage loss and development of this same PF cartilage loss associated with symptoms. ..