Research Topics
| C HorsburghSummaryAffiliation: Boston University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Revisiting rates of reactivation tuberculosis: a population-based approachC Robert Horsburgh
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Am J Respir Crit Care Med 182:420-5. 2010..10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since...
Randomized clinical trials to identify optimal antibiotic treatment durationC Robert Horsburgh
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA
Trials 14:88. 2013..We propose a new method to identify the optimal treatment duration of an antibiotic treatment regimen...- Compassionate use of and expanded access to new drugs for drug-resistant tuberculosisC R Horsburgh
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Int J Tuberc Lung Dis 17:146-52. 2013..Following these steps can ensure that patients will be able to benefit from access to these drugs, while minimizing the risk of emergence of resistance to the drug... - Evaluation of exposure-specific risks from two independent samples: a simulation studyWilliam M Reichmann
Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
BMC Med Res Methodol 11:1. 2011..The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs)... - Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum cultureMuhammad Bakari
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
BMC Infect Dis 8:32. 2008..We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a large cohort of HIV-infected patients... - Latent TB infection treatment acceptance and completion in the United States and CanadaC Robert Horsburgh
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Chest 137:401-9. 2010..Treatment of latent TB infection (LTBI) is essential for preventing TB in North America, but acceptance and completion of this treatment have not been systematically assessed... 
A large, simple trial of a tuberculosis vaccineC R Horsburgh
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Clin Infect Dis 30:S213-6. 2000..Readiness for tuberculosis vaccine efficacy trials will require epidemiological field studies to identify potential trial sites and investment in local diagnostic, surveillance, and data management capabilities...- Priorities for the treatment of latent tuberculosis infection in the United StatesC Robert Horsburgh
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
N Engl J Med 350:2060-7. 2004..Currently, the rate of completion of treatment is low... - Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000C R Horsburgh
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Clin Infect Dis 33:1938-43. 2001..001). Prolonged survival was associated with receiving therapy that included clarithromycin and receiving combination antiretroviral therapy that included a protease inhibitor... - Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfectionCamilla S Graham
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA
J Infect Dis 195:847-56. 2007..We wanted to determine whether IDU or alcohol affected immune responses in HCV-infected and human immunodeficiency virus (HIV)/HCV coinfected subjects... - The GirlStars program: challenges to recruitment and retention in a physical activity and health education program for adolescent girls living in public housingLee Strunin
Boston University School of Public Health, Boston, MA 02118, USA
Prev Chronic Dis 7:A42. 2010..After-school programs can reduce high-risk behaviors and strengthen schools, families, and communities... - Environmental risk factors for infection with Mycobacterium avium complexCarrie Reed
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Am J Epidemiol 164:32-40. 2006..Results indicate that soil is a reservoir for M. avium complex associated with human infection and that persons whose occupations involve prolonged soil exposure are at increased risk of M. avium complex infection... - Recent drug use, homelessness and increased short-term mortality in HIV-infected persons with alcohol problemsAlexander Y Walley
Clinical Addiction Research and Education CARE Unit, USA
AIDS 22:415-20. 2008..To assess the impact of recent heavy alcohol use, heroin/cocaine use, and homelessness on short-term mortality in HIV-infected persons... - Using resident health advocates to improve public health screening and follow-up among public housing residents, Boston, 2007-2008Jo Anna Rorie
Department of Community Health Sciences, Boston University School of Public Health, 801 Massachusetts Ave 442, Boston, MA 02118 2526, USA
Prev Chronic Dis 8:A15. 2011.... - Predictors of treatment for hepatitis C virus (HCV) infection in drug usersCarrie Reed
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Subst Abus 29:5-15. 2008..01, for trend). Focused strategies to overcome these potentially modifiable factors may be indicated to increase HCV treatment in affected populations... - The associations of binge alcohol use with HIV/STI risk and diagnosis among heterosexual African American menAnita Raj
Social Behavioral Sciences Department, Boston University School of Public Health, Boston, MA 02118, USA
Drug Alcohol Depend 101:101-6. 2009.... - Predicting non-completion of treatment for latent tuberculous infection: a prospective surveyFred K Shieh
Pulmonary Center, Boston University School of Medicine, 80 East Concord Street, R-304, Boston, MA 02118, USA
Am J Respir Crit Care Med 174:717-21. 2006..Targeting TB high-risk individuals, minimizing inconveniences, further education, and use of diagnostic tests with improved specificity for TB may address these concerns... - Use of a population-based survey to describe the health of Boston public housing residentsEleni C Digenis-Bury
Boston Public Health Commission, Boston, MA, USA
Am J Public Health 98:85-91. 2008..We compared the health of public housing residents with other Boston residents through a random-digit-dial survey... - Risk of progression to active tuberculosis among foreign-born persons with latent tuberculosisShalini Patel
Department of Medicine, Section of Infectious Diseases, School of Medicine, Boston University, Boston, USA
Chest 131:1811-6. 2007..This could be explained by undetected TB disease at entry, increased prevalence of latent TB infection (LTBI), increased progression from LTBI to TB, or a combination of these factors... - Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infectionDavid Nunes
Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Gastroenterol 105:1346-53. 2010..Noninvasive markers of liver fibrosis correlate with the stage of liver fibrosis, but have not been widely applied to predict liver-related mortality... - Predictors of failure to complete treatment for latent tuberculosis infectionArmen E Parsyan
Department of Epidemiology, Boston University, School of Public Health, 715 Albany Street, T3E, Boston, MA 02118 2526, USA
J Infect 54:262-6. 2007..This retrospective cohort study assessed predictors of completion of LTBI treatment among patients seen at an urban United States TB clinic in 1998... - When to start antiretroviral therapy in resource-limited settingsRochelle P Walensky
Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 151:157-66. 2009..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years... - Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfectionCatherine A Fleming
Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Clin Infect Dis 38:572-8. 2004..These findings underscore the importance of a multidisciplinary approach to the treatment of these patient populations... - HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver diseaseDavid Nunes
Section of Gastroenterology, Boston Medical Center, Boston University, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 40:538-44. 2005..The aim of the current study was to compare the diagnostic performance and characteristics of a number of noninvasive markers of hepatic fibrosis in populations of hepatitis C virus (HCV)-infected patients with and without HIV infection... - Endothelial function in HIV-infected personsAnthony Solages
Division of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Clin Infect Dis 42:1325-32. 2006..CONCLUSIONS: HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users... - Integration of a participatory research strategy into a rural health surveyDale Stratford
Centers for Disease Control and Prevention, Atlanta, GA, USA
J Gen Intern Med 18:586-8. 2003..These activities led to establishment of a community-based organization that received funding for HIV counseling and testing and HIV prevention case management... - Hospital water as a source of Mycobacterium avium complex isolates in respiratory specimensMitchell A Blass
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
J Infect Dis 189:98-104. 2004..We conclude that acquisition of MAC from institutional water systems leads to substantial MAC disease but that most patients with MAC recovered from respiratory specimens have only transient colonization by MAC... - Detection of latent tuberculosis among HIV-infected patients after initiation of highly active antiretroviral therapyTamara L Fisk
Division of Infectious Diseases, Department of Medicine, Emory University and Grady Memorial Hospital, Atlanta, GA, USA
AIDS 17:1102-4. 2003..Skin testing is reliable for the identification or exclusion of LTBI once the CD4 cell count recovers to >= 100 cells/mm3... - Baseline mycobacterial immune responses in HIV-infected adults primed with bacille Calmette-Guérin during childhood and entering a tuberculosis booster vaccine trialMecky Matee
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
J Infect Dis 195:118-23. 2007..Most new tuberculosis vaccines will be administered as a booster to subjects primed with bacille Calmette-Guérin (BCG) during childhood... - Reinfection with Mycobacterium tuberculosisC Fordham von Reyn
Am J Respir Crit Care Med 173:133-4; author reply 134-5. 2006 - History of incarceration and gang involvement are associated with recent sexually transmitted disease/HIV diagnosis in African American menAnita Raj
J Acquir Immune Defic Syndr 47:131-4. 2008 - Factors associated with loss to follow-up in a large tuberculosis treatment trial (TBTC Study 22)Donna Sepulveda Conwell
Infectious Diseases Section 151B, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
Contemp Clin Trials 28:288-94. 2007..We evaluated factors associated with loss to follow-up after completion of treatment phase in a large tuberculosis treatment trial (TBTC/USPHS Study 22) in the U.S. and Canada... - Lack of weight gain and relapse risk in a large tuberculosis treatment trialAwal Khan
TBTC Data and Coordinating Center, Clinical and Health System Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Respir Crit Care Med 174:344-8. 2006..Readily identified markers of tuberculosis relapse risk are needed, particularly in resource-limited settings. The association between weight gain or loss during antituberculosis therapy and relapse has not been well studied... - The scope and impact of treatment of latent tuberculosis infection in the United States and CanadaTimothy R Sterling
Division of Infectious Diseases and Center for Health Services Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Respir Crit Care Med 173:927-31. 2006..Identifying the types of clinics that administer such treatment and patients who receive it could guide resource utilization and improve treatment initiation and completion... - High rates of clinical and subclinical tuberculosis among HIV-infected ambulatory subjects in TanzaniaLillian Mtei
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
Clin Infect Dis 40:1500-7. 2005.... - Human immunodeficiency virus infection in a rural community in the United StatesTedd V Ellerbrock
Division of HIV AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Epidemiol 160:582-8. 2004..Interventions targeting HIV-endemic neighborhoods will be needed to further reduce HIV prevalence in this area...
Research Grants
- Partners in Health and Housing Prevention Research Cent*C Horsburgh; Fiscal Year: 2007..Abstract not provided ..
- NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASEC Horsburgh; Fiscal Year: 2006..These investigations will define the role of HIV infection in progression of HCV disease and guide HCV treatment and prevention strategies for IDU. ..
- BU Clinical HIV/AIDS Research Training ProgramC Horsburgh; Fiscal Year: 2007..This will prepare trainees for success in future independent clinical research careers. ..
- NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASEC Horsburgh; Fiscal Year: 2003..These studies are expected to improve our understanding of the natural history and pathogenesis of HCV in immunosuppressed hosts. ..