C Horsburgh

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Revisiting rates of reactivation tuberculosis: a population-based approach
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Am J Respir Crit Care Med 182:420-5. 2010
  2. pmc Randomized clinical trials to identify optimal antibiotic treatment duration
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Trials 14:88. 2013
  3. doi request reprint Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis
    C R Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Int J Tuberc Lung Dis 17:146-52. 2013
  4. pmc Evaluation of exposure-specific risks from two independent samples: a simulation study
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    BMC Med Res Methodol 11:1. 2011
  5. pmc Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum culture
    Muhammad Bakari
    Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    BMC Infect Dis 8:32. 2008
  6. doi request reprint Latent TB infection treatment acceptance and completion in the United States and Canada
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Chest 137:401-9. 2010
  7. ncbi request reprint A large, simple trial of a tuberculosis vaccine
    C R Horsburgh
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Clin Infect Dis 30:S213-6. 2000
  8. ncbi request reprint Priorities for the treatment of latent tuberculosis infection in the United States
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    N Engl J Med 350:2060-7. 2004
  9. ncbi request reprint Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000
    C R Horsburgh
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Clin Infect Dis 33:1938-43. 2001
  10. ncbi request reprint Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA
    J Infect Dis 195:847-56. 2007

Detail Information

Publications36

  1. pmc Revisiting rates of reactivation tuberculosis: a population-based approach
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Am J Respir Crit Care Med 182:420-5. 2010
    ..10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since...
  2. pmc Randomized clinical trials to identify optimal antibiotic treatment duration
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Trials 14:88. 2013
    ..We propose a new method to identify the optimal treatment duration of an antibiotic treatment regimen...
  3. doi request reprint Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis
    C R Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Int J Tuberc Lung Dis 17:146-52. 2013
    ..Following these steps can ensure that patients will be able to benefit from access to these drugs, while minimizing the risk of emergence of resistance to the drug...
  4. pmc Evaluation of exposure-specific risks from two independent samples: a simulation study
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    BMC Med Res Methodol 11:1. 2011
    ..The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs)...
  5. pmc Basis for treatment of tuberculosis among HIV-infected patients in Tanzania: the role of chest x-ray and sputum culture
    Muhammad Bakari
    Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    BMC Infect Dis 8:32. 2008
    ..We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a large cohort of HIV-infected patients...
  6. doi request reprint Latent TB infection treatment acceptance and completion in the United States and Canada
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Chest 137:401-9. 2010
    ..Treatment of latent TB infection (LTBI) is essential for preventing TB in North America, but acceptance and completion of this treatment have not been systematically assessed...
  7. ncbi request reprint A large, simple trial of a tuberculosis vaccine
    C R Horsburgh
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Clin Infect Dis 30:S213-6. 2000
    ..Readiness for tuberculosis vaccine efficacy trials will require epidemiological field studies to identify potential trial sites and investment in local diagnostic, surveillance, and data management capabilities...
  8. ncbi request reprint Priorities for the treatment of latent tuberculosis infection in the United States
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    N Engl J Med 350:2060-7. 2004
    ..Currently, the rate of completion of treatment is low...
  9. ncbi request reprint Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000
    C R Horsburgh
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Clin Infect Dis 33:1938-43. 2001
    ..001). Prolonged survival was associated with receiving therapy that included clarithromycin and receiving combination antiretroviral therapy that included a protease inhibitor...
  10. ncbi request reprint Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA
    J Infect Dis 195:847-56. 2007
    ..We wanted to determine whether IDU or alcohol affected immune responses in HCV-infected and human immunodeficiency virus (HIV)/HCV coinfected subjects...
  11. pmc The GirlStars program: challenges to recruitment and retention in a physical activity and health education program for adolescent girls living in public housing
    Lee Strunin
    Boston University School of Public Health, Boston, MA 02118, USA
    Prev Chronic Dis 7:A42. 2010
    ..After-school programs can reduce high-risk behaviors and strengthen schools, families, and communities...
  12. ncbi request reprint Environmental risk factors for infection with Mycobacterium avium complex
    Carrie Reed
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Am J Epidemiol 164:32-40. 2006
    ..Results indicate that soil is a reservoir for M. avium complex associated with human infection and that persons whose occupations involve prolonged soil exposure are at increased risk of M. avium complex infection...
  13. pmc Recent drug use, homelessness and increased short-term mortality in HIV-infected persons with alcohol problems
    Alexander Y Walley
    Clinical Addiction Research and Education CARE Unit, USA
    AIDS 22:415-20. 2008
    ..To assess the impact of recent heavy alcohol use, heroin/cocaine use, and homelessness on short-term mortality in HIV-infected persons...
  14. pmc Using resident health advocates to improve public health screening and follow-up among public housing residents, Boston, 2007-2008
    Jo Anna Rorie
    Department of Community Health Sciences, Boston University School of Public Health, 801 Massachusetts Ave 442, Boston, MA 02118 2526, USA
    Prev Chronic Dis 8:A15. 2011
    ....
  15. doi request reprint Predictors of treatment for hepatitis C virus (HCV) infection in drug users
    Carrie Reed
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Subst Abus 29:5-15. 2008
    ..01, for trend). Focused strategies to overcome these potentially modifiable factors may be indicated to increase HCV treatment in affected populations...
  16. doi request reprint The associations of binge alcohol use with HIV/STI risk and diagnosis among heterosexual African American men
    Anita Raj
    Social Behavioral Sciences Department, Boston University School of Public Health, Boston, MA 02118, USA
    Drug Alcohol Depend 101:101-6. 2009
    ....
  17. ncbi request reprint Predicting non-completion of treatment for latent tuberculous infection: a prospective survey
    Fred K Shieh
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street, R 304, Boston, MA 02118, USA
    Am J Respir Crit Care Med 174:717-21. 2006
    ..Little is known about patients' reasons for not completing treatment. We hypothesized that certain health beliefs, lifestyle, and clinic- and regimen-related barriers to provision of care could predict non-completion of LTBI treatment...
  18. pmc Use of a population-based survey to describe the health of Boston public housing residents
    Eleni C Digenis-Bury
    Boston Public Health Commission, Boston, MA, USA
    Am J Public Health 98:85-91. 2008
    ..We compared the health of public housing residents with other Boston residents through a random-digit-dial survey...
  19. ncbi request reprint Risk of progression to active tuberculosis among foreign-born persons with latent tuberculosis
    Shalini Patel
    Department of Medicine, Section of Infectious Diseases, School of Medicine, Boston University, Boston, USA
    Chest 131:1811-6. 2007
    ..This could be explained by undetected TB disease at entry, increased prevalence of latent TB infection (LTBI), increased progression from LTBI to TB, or a combination of these factors...
  20. doi request reprint Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection
    David Nunes
    Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 105:1346-53. 2010
    ..Noninvasive markers of liver fibrosis correlate with the stage of liver fibrosis, but have not been widely applied to predict liver-related mortality...
  21. ncbi request reprint Predictors of failure to complete treatment for latent tuberculosis infection
    Armen E Parsyan
    Department of Epidemiology, Boston University, School of Public Health, 715 Albany Street, T3E, Boston, MA 02118 2526, USA
    J Infect 54:262-6. 2007
    ..This retrospective cohort study assessed predictors of completion of LTBI treatment among patients seen at an urban United States TB clinic in 1998...
  22. pmc When to start antiretroviral therapy in resource-limited settings
    Rochelle P Walensky
    Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
    Ann Intern Med 151:157-66. 2009
    ..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years...
  23. ncbi request reprint Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection
    Catherine A Fleming
    Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Infect Dis 38:572-8. 2004
    ..These findings underscore the importance of a multidisciplinary approach to the treatment of these patient populations...
  24. ncbi request reprint HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease
    David Nunes
    Section of Gastroenterology, Boston Medical Center, Boston University, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 40:538-44. 2005
    ..The aim of the current study was to compare the diagnostic performance and characteristics of a number of noninvasive markers of hepatic fibrosis in populations of hepatitis C virus (HCV)-infected patients with and without HIV infection...
  25. pmc Endothelial function in HIV-infected persons
    Anthony Solages
    Division of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Clin Infect Dis 42:1325-32. 2006
    ..Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease...
  26. pmc Integration of a participatory research strategy into a rural health survey
    Dale Stratford
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Gen Intern Med 18:586-8. 2003
    ..These activities led to establishment of a community-based organization that received funding for HIV counseling and testing and HIV prevention case management...
  27. ncbi request reprint Hospital water as a source of Mycobacterium avium complex isolates in respiratory specimens
    Melissa J Tobin-D'Angelo
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Infect Dis 189:98-104. 2004
    ..We conclude that acquisition of MAC from institutional water systems leads to substantial MAC disease but that most patients with MAC recovered from respiratory specimens have only transient colonization by MAC...
  28. ncbi request reprint Detection of latent tuberculosis among HIV-infected patients after initiation of highly active antiretroviral therapy
    Tamara L Fisk
    Division of Infectious Diseases, Department of Medicine, Emory University and Grady Memorial Hospital, Atlanta, GA, USA
    AIDS 17:1102-4. 2003
    ..Skin testing is reliable for the identification or exclusion of LTBI once the CD4 cell count recovers to >= 100 cells/mm3...
  29. pmc Baseline mycobacterial immune responses in HIV-infected adults primed with bacille Calmette-Guérin during childhood and entering a tuberculosis booster vaccine trial
    Mecky Matee
    Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    J Infect Dis 195:118-23. 2007
    ..Most new tuberculosis vaccines will be administered as a booster to subjects primed with bacille Calmette-Guérin (BCG) during childhood...
  30. ncbi request reprint Reinfection with Mycobacterium tuberculosis
    C Fordham von Reyn
    Am J Respir Crit Care Med 173:133-4; author reply 134-5. 2006
  31. ncbi request reprint History of incarceration and gang involvement are associated with recent sexually transmitted disease/HIV diagnosis in African American men
    Anita Raj
    J Acquir Immune Defic Syndr 47:131-4. 2008
  32. ncbi request reprint Factors associated with loss to follow-up in a large tuberculosis treatment trial (TBTC Study 22)
    Donna Sepulveda Conwell
    Infectious Diseases Section 151B, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Contemp Clin Trials 28:288-94. 2007
    ..We evaluated factors associated with loss to follow-up after completion of treatment phase in a large tuberculosis treatment trial (TBTC/USPHS Study 22) in the U.S. and Canada...
  33. ncbi request reprint Lack of weight gain and relapse risk in a large tuberculosis treatment trial
    Awal Khan
    TBTC Data and Coordinating Center, Clinical and Health System Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Respir Crit Care Med 174:344-8. 2006
    ..Readily identified markers of tuberculosis relapse risk are needed, particularly in resource-limited settings. The association between weight gain or loss during antituberculosis therapy and relapse has not been well studied...
  34. ncbi request reprint The scope and impact of treatment of latent tuberculosis infection in the United States and Canada
    Timothy R Sterling
    Division of Infectious Diseases and Center for Health Services Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Respir Crit Care Med 173:927-31. 2006
    ..Identifying the types of clinics that administer such treatment and patients who receive it could guide resource utilization and improve treatment initiation and completion...
  35. ncbi request reprint High rates of clinical and subclinical tuberculosis among HIV-infected ambulatory subjects in Tanzania
    Lillian Mtei
    Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Clin Infect Dis 40:1500-7. 2005
    ..We sought to determine the prevalence of active tuberculosis among ambulatory HIV-infected persons in Tanzania with CD4 cell counts of > or =200 cells/mm3 and a bacille Calmette-Guerin vaccination scar...
  36. ncbi request reprint Human immunodeficiency virus infection in a rural community in the United States
    Tedd V Ellerbrock
    Division of HIV AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Epidemiol 160:582-8. 2004
    ..Interventions targeting HIV-endemic neighborhoods will be needed to further reduce HIV prevalence in this area...

Research Grants10

  1. Partners in Health and Housing Prevention Research Cent*
    C Horsburgh; Fiscal Year: 2007
    ..Abstract not provided ..
  2. NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASE
    C Horsburgh; Fiscal Year: 2006
    ..These investigations will define the role of HIV infection in progression of HCV disease and guide HCV treatment and prevention strategies for IDU. ..
  3. BU Clinical HIV/AIDS Research Training Program
    C Horsburgh; Fiscal Year: 2007
    ..This will prepare trainees for success in future independent clinical research careers. ..
  4. NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASE
    C Horsburgh; Fiscal Year: 2003
    ..These studies are expected to improve our understanding of the natural history and pathogenesis of HCV in immunosuppressed hosts. ..