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| Michael HolickSummaryAffiliation: Boston University Country: USA Publications
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Publications
Vitamin d, sunlight and cancer connectionMichael F Holick
Boston University School of Medicine, 85 East Newton Street, M 1013, Boston MA 02118, USA
Anticancer Agents Med Chem 13:70-82. 2013..This can be accomplished by children taking 600-1000 and adults 1500-2000 international units (IU) vitamin D daily from diet and supplements along with sensible sun exposure when the sun is capable of producing vitamin D in the skin...
Vitamin D - effects on skeletal and extraskeletal health and the need for supplementationMatthias Wacker
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M 1013, Boston, MA 02118, USA
Nutrients 5:111-48. 2013....- Potential role of OPG/RANKL system and FokI genotypes in pathogenesis and clinical manifestations in multiple sclerosisK Mirzaei
Tehran University of Medical Sciences, Tehran, Iran
Minerva Med 103:313-21. 2012..The aim of this study is to measure plasma levels of OPG and RANKL as well as to analyze VDR FokI polymorphism (rs2228570) in MS patients and healthy individuals to detect any potential correlation... - Vitamin D: extraskeletal healthMichael F Holick
Department of Medicine, Boston University School of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Rheum Dis Clin North Am 38:141-60. 2012.... 
The D-lightful vitamin D for child healthMichael F Holick
Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
JPEN J Parenter Enteral Nutr 36:9S-19S. 2012..The Endocrine Society's Clinical Guidelines recommended that to prevent and treat vitamin D deficiency, children 0-1 year and 1-18 years need 400-1000 and 600-1000 IU/d, respectively...- The role of vitamin D for bone health and fracture preventionMichael F Holick
Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
Curr Osteoporos Rep 4:96-102. 2006.... - Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?Michael F Holick
Department of Medicine, Section of Endocrinology, Nutrition and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, 715 Albany Street, M 1 013, Boston, MA 02118, USA
Adv Exp Med Biol 624:1-15. 2008..There needs to be a renewed appreciation of the beneficial effect of moderate sunlight for providing all humans with their vitamin D requirement for health... - Vitamin D status: measurement, interpretation, and clinical applicationMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
Ann Epidemiol 19:73-8. 2009..The goal should be to maintain both children and adults at a level >30 ng/mL to take full advantage of all the health benefits that vitamin D provides... - Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin DMichael F Holick
Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 93:677-81. 2008..Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status... - Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular diseaseMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
Am J Clin Nutr 80:1678S-88S. 2004.... - Stay tuned to PXR: an orphan actor that may not be D-structive only to boneMichael F Holick
Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Invest 115:32-4. 2005..This cross-talk behavior has important health ramifications and can be mitigated through the identification and treatment of PXR-induced vitamin D deficiency... - Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapyMichael F Holick
Boston University School of Medicine, 715 Albany Street, M1013, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 90:3215-24. 2005..To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis... - High prevalence of vitamin D inadequacy and implications for healthMichael F Holick
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
Mayo Clin Proc 81:353-73. 2006..The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health... - Vitamin D for health and in chronic kidney diseaseMichael F Holick
Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Semin Dial 18:266-75. 2005..Vigilance for maintaining a 25-hydroxyvitamin D level of at least 20 ng/ml and preferably 30-50 ng/ml has important benefits for both healthy children and adults, as well as children and adults suffering from chronic kidney disease... - Vitamin D deficiencyMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
N Engl J Med 357:266-81. 2007 - Vitamin D: its role in cancer prevention and treatmentMichael F Holick
Boston University Medical Center, 715 Albany Street, M 1013, Boston, MA 02118, USA
Prog Biophys Mol Biol 92:49-59. 2006..Therefore, measurement of 25-hydroxyvitamin D is important not only to monitor vitamin D status for bone health, but also for cancer prevention... - The influence of vitamin D on bone health across the life cycleMichael F Holick
Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Vitamin D Laboratory, Boston, MA 02118, USA
J Nutr 135:2726S-7S. 2005 - The vitamin D epidemic and its health consequencesMichael F Holick
Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Vitamin D Laboratory, Boston, MA 02118, USA
J Nutr 135:2739S-48S. 2005..Vigilance of one's vitamin D status by the yearly measurement of 25-hydroxyvitamin D should be part of an annual physical examination... - Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancersMichael F Holick
Vitamin D, Skin and Bone Research Laboratory, and the Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
South Med J 98:1024-7. 2005..Vitamin D deficiency increases the risk of many common cancers, multiple sclerosis, rheumatoid arthritis, hypertension, cardiovascular heart disease, and type I diabetes... - PTH (1-34): a novel anabolic drug for the treatment of osteoporosisMichael F Holick
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
South Med J 98:1114-7. 2005..In addition, the relative risk of having moderate vertebral fracture was reduced by 90%. Thus, PTH (1-34) offers an exciting new approach for the treatment of severe osteoporosis... - Resurrection of vitamin D deficiency and ricketsMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Clin Invest 116:2062-72. 2006..This review summarizes the role of vitamin D in the prevention of rickets and its importance in the overall health and welfare of infants and children... - Vitamin D deficiency: a worldwide problem with health consequencesMichael F Holick
Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
Am J Clin Nutr 87:1080S-6S. 2008..Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations... - Vitamin D: extraskeletal healthMichael F Holick
Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Boston University School of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Endocrinol Metab Clin North Am 39:381-400, table of contents. 2010..To increase the blood level to the minimum 30 ng/mL requires the ingestion of at least 1000 IU of vitamin D per day for adults. In general, there is no downside to increasing either a child's or adult's vitamin D intake... - Vitamin D and sunlight: strategies for cancer prevention and other health benefitsMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
Clin J Am Soc Nephrol 3:1548-54. 2008.... - Vitamin D: evolutionary, physiological and health perspectivesMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
Curr Drug Targets 12:4-18. 2011..It is estimated that 1 billion people worldwide are vitamin D deficient or insufficient. Correcting and preventing this deficiency could have an enormous impact on reducing health costs worldwide... - Vitamin D: a d-lightful solution for healthMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
J Investig Med 59:872-80. 2011..Therefore, sensible sun exposure along with vitamin D supplementation of at least 2000 IU/d for adults and 1000 IU/d for children is essential to maximize their health... - Evolution and function of vitamin DMichael F Holick
Vitamin D Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Recent Results Cancer Res 164:3-28. 2003..The use of agonists and antagonists for PTHrP has important clinical applications for the prevention and treatment of skin diseases and disorders of hair growth... - Topical PTH (1-34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trialM F Holick
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University Medical Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Br J Dermatol 149:370-6. 2003..There continues to be a need to develop new pharmacological approaches for treating the common skin disease psoriasis. Human skin produces parathyroid hormone related peptide. This peptide is a potent inhibitor of epidermal cell growth... - Vitamin D: a D-Lightful health perspectiveMichael F Holick
The Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
Nutr Rev 66:S182-94. 2008..Healthcare professionals need to be aware of the vitamin D deficiency pandemic. Guidelines for sensible sun exposure and supplemental vitamin D of 800-1000 IU/day are needed... - Vitamin D: A millenium perspectiveMichael F Holick
Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Cell Biochem 88:296-307. 2003..There needs to be a better appreciation of the importance of vitamin D for overall health and well being... - The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of actionMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
Mol Aspects Med 29:361-8. 2008.... - Diabetes and the vitamin d connectionMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
Curr Diab Rep 8:393-8. 2008..Children and adults need at least 1000 IU of vitamin D per day to prevent deficiency when there is inadequate sun exposure... - Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral densityVin Tangpricha
Vitamin D, Skin and Bone Research Laboratory and the Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Am J Clin Nutr 80:1645-9. 2004..CONCLUSION: The regular use of a tanning bed that emits vitamin D-producing ultraviolet radiation is associated with higher 25(OH)D concentrations and thus may have a benefit for the skeleton... - Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosisMichael F Holick
Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118-2394, USA
Am J Clin Nutr 79:362-71. 2004..The recommended adequate intakes for vitamin D are inadequate, and, in the absence of exposure to sunlight, a minimum of 1000 IU vitamin D/d is required to maintain a healthy concentration of 25(OH)D in the blood... - Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional healthVin Tangpricha
Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, MA 02118, USA
Am J Clin Nutr 77:1478-83. 2003..CONCLUSIONS: The fat content of milk does not affect vitamin D bioavailability. Vitamin D fortification at 1000 IU/240 mL orange juice for 12 wk safely increased 25(OH)D(3) concentrations in adults... - Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adultsRachael M Biancuzzo
Department of Medicine, Boston University School of Medicine, MA, USA
Am J Clin Nutr 91:1621-6. 2010..Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements... - Optimal vitamin D status for the prevention and treatment of osteoporosisMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
Drugs Aging 24:1017-29. 2007..Patients being treated for osteoporosis should be adequately supplemented with calcium and vitamin D to maximise the benefit of treatment... - Sickle cell bone disease: response to vitamin D and calciumAdeboye H Adewoye
The Center of Excellence in Sickle Cell Disease and the Vitamin D, Skin and Bone Research Laboratories, Boston University School of Medicine, Boston, MA 02118, USA
Am J Hematol 83:271-4. 2008..Treatment of adult SCD with vitamin D and calcium can restore 25(OH)D levels to normal and improve BMD, but, markers of bone resorption remained unchanged. Screening for vitamin D deficiency and BMD in SCD patients seems warranted... - Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin DJohn N Flanagan
Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
Anticancer Res 26:2567-72. 2006..CONCLUSION: The autocrine synthesis of 1alpha,25(OH)2D3 from vitamin D3 suggests that maintaining adequate levels of serum vitamin D could be a safe and effective chemo-preventive measure to decrease the risk of prostate cancer... - The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin DMichael V Young
Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
Carcinogenesis 25:967-71. 2004..These findings support the hypothesis that vitamin D or 25(OH)D may be useful as chemopreventive agents for prostate cancer because their administration should cause an increased synthesis of 1 alpha,25(OH)(2)D within prostate cells... - Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c miceVin Tangpricha
Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Nutr 135:2350-4. 2005..We conclude that vitamin D deficiency enhances the growth of colon cancer in mice. The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D... - Vitamin D insufficiency among free-living healthy young adultsVin Tangpricha
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Med 112:659-62. 2002 - A thyroid hormone deiodinase inhibitor can decrease cutaneous cell proliferation in vitroJoshua D Safer
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Thyroid 19:181-5. 2009..Although IOP is known to inhibit T(4) to T(3) conversion, the inhibition of cutaneous cell proliferation by IOP might conceivably result from other properties of IOP... - Factors that influence the cutaneous synthesis and dietary sources of vitamin DTai C Chen
Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Arch Biochem Biophys 460:213-7. 2007.... - Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancerJohn N Flanagan
Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Anticancer Res 29:3547-53. 2009..Thus, these data suggest that MART-10 may be a potential candidate as a therapeutic agent for prostate cancer, especially for patients who fail in conventional therapies... - Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of menMarian T Hannan
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
J Clin Endocrinol Metab 93:40-6. 2008..Although racial and ethnic differences in vitamin D status and bone mineral density (BMD) are recognized, less is known about how differences in vitamin D status impact BMD, especially among men... - A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in miceJoshua D Safer
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, MA 02118, USA
Endocrinology 148:1167-70. 2007..Our study is the first to report the hair-stimulating effect of a PTH/PTHrP receptor antagonist topically applied to skin in vivo. Thus, we introduce a novel paradigm to develop topical PTH analogs for treating disorders of hair growth... - A role for thyroid hormone in wound healing through keratin gene expressionJoshua D Safer
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1022, Boston, Massachusetts 02118, USA
Endocrinology 145:2357-61. 2004..Thus, for hypothyroid patients undergoing surgery that cannot be delayed until euthyroidism is achieved, our data support T(3) treatment for the perioperative period... - Vitamin D and prostate cancer prevention and treatmentTai C Chen
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Trends Endocrinol Metab 14:423-30. 2003.... - Topical thyroid hormone accelerates wound healing in miceJoshua D Safer
Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, Massachusetts 02118, USA
Endocrinology 146:4425-30. 2005..The data support our previous hypothesis that T3 is necessary for optimal wound healing. Now, we further suggest that topical thyroid hormone may be an inexpensive agent to hasten healing of certain wounds... - Evaluation of vitamin D analogs as therapeutic agents for prostate cancerTai C Chen
Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Recent Results Cancer Res 164:273-88. 2003..These compounds may be good candidates for human clinical trials in prostate cancer... - Vitamin D and bone health in postmenopausal womenAlan O Malabanan
Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
J Womens Health (Larchmt) 12:151-6. 2003..There are insufficient available data supporting a benefit from vitamin D supplementation alone, without calcium, to prevent osteoporotic fracture in postmenopausal women... - Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase and its implication in prostate cancerTai C Chen
Vitamin D, Skin and Bone Research Laboratory, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
J Cell Biochem 88:315-22. 2003..Thus, the results suggest that the defect in enzyme activity may result from the decreased promoter activity in prostate cancer cells... - Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administrationJoshua D Safer
Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Thyroid 13:159-65. 2003..Insight into the interplay among the competing factors will be important in understanding thyroid hormone regulation of skin physiology... - Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cellsNarasimha Swamy
Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
Clin Cancer Res 10:8018-27. 2004..Collectively, these results strongly suggested that 25-OH-D(3)-3-BE has a strong potential as a therapeutic agent for androgen-sensitive and androgen-refractory prostate cancer... - Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trialMichael F Holick
Boston University School of Medicine, Boston, MA, USA
J Bone Miner Metab 28:342-50. 2010..01). Treatment with hop rho iso-alpha acids, berberine sulfate trihydrate, vitamin D(3) and vitamin K(1) produced a more favorable bone biomarker profile that supports a healthy bone metabolism... - Vitamin D and skin physiology: a D-lightful storyMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
J Bone Miner Res 22:V28-33. 2007.... - Relation of body fat indexes to vitamin D status and deficiency among obese adolescentsCarine M Lenders
Boston Medical Center, Boston University School of Medicine, MA, USA
Am J Clin Nutr 90:459-67. 2009..Data on the relation between vitamin D status and body fat indexes in adolescence are lacking... - Vitamin D deficiency and osteoporosis in rehabilitation inpatientsLeonid M Shinchuk
Department of Physical Medicine and Rehabilitation, Boston University Medical Center, Boston, MA, USA
Arch Phys Med Rehabil 87:904-8. 2006..The study emphasizes the need for vigilance for vitamin D status and BMD testing in patients admitted to rehabilitation facilities... - Vitamin d and rehabilitation: improving functional outcomesLeonid M Shinchuk
Spaulding Rehabilitation Hospital, Boston, MA, USA
Nutr Clin Pract 22:297-304. 2007..There is a need for better education of health professionals and the general public regarding the optimization of vitamin D status in the care of rehabilitation patients... - 25-Hydroxyvitamin D-1alpha-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transferLyman W Whitlatch
Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Boston University School of Medicine, Boston, MA 02118, USA
J Steroid Biochem Mol Biol 81:135-40. 2002.... - A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose studyKerry E Broe
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
J Am Geriatr Soc 55:234-9. 2007..To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents... - Regulation of the 25-hydroxyvitamin D-1alpha-hydroxylase gene and its splice variantJohn N Flanagan
Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Recent Results Cancer Res 164:157-67. 2003.... - Refractory hypocalcemia following near-total thyroidectomy in a patient with a prior Roux-en-Y gastric bypassSara M Pietras
Boston University School of Medicine, Boston Medical Center, Boston, MA 02118 2393, USA
Obes Surg 19:524-6. 2009..Providers should be aware that malabsorption of calcium and vitamin D after RYGB may complicate patient management after thyroidectomy... - Association between vitamin D deficiency and primary cesarean sectionAnne Merewood
Department of Pediatrics, Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, and Division of General Pediatrics, Boston Medical Center, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 94:940-5. 2009..The current U.S. cesarean birth rate is at an all-time high of 30.2%. We analyzed the relationship between maternal serum 25-hydroxyvitamin D [25(OH)D] status, and prevalence of primary cesarean section... - AMPK regulation of the growth of cultured human keratinocytesAsish K Saha
Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Biochem Biophys Res Commun 349:519-24. 2006..They also suggest that AMPK activators, such as AICAR and troglitazone, inhibit keratinocyte growth and that the inhibition of cell growth by 1,25-dihydroxyvitamin D3 is AMPK-independent... - Vitamin D autocrine system and prostate cancerLilin Wang
Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Recent Results Cancer Res 164:223-37. 2003..Thus, our results suggest that differential phosphorylation of CREB through PKA and MAPK pathways may be involved in the regulation of 1alpha-OHase promoter activity... - Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cellsLilin Wang
Department of Medicine, Endocrine Division, Boston University Medical Center, Boston, MA 02118, USA
J Steroid Biochem Mol Biol 89:127-30. 2004..Because EGF has no effect on 1alpha-OHase promoter activity in LNCaP cells, we propose that the ability of EGF to stimulate 1alpha,25(OH)(2)D synthesis may be abolished or diminished in cancer cells... - Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitorLilin Wang
Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Anticancer Res 28:2009-13. 2008.... - Analysis of the vitamin D system in cutaneous malignanciesJorn Kamradt
Department of Dermatology, University of Saarland, Kirrberger Str, 66421 Homburg Saar, Germany
Recent Results Cancer Res 164:259-69. 2003.... - Do panther chameleons bask to regulate endogenous vitamin D3 production?Gary W Ferguson
Department of Biology, Texas Christian University, Fort Worth, TX 76129, USA
Physiol Biochem Zool 76:52-9. 2003..Vitamin D(3) photoregulation seems to be an important additional component of the function of basking... - Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferolRobert P Heaney
Creighton University, Omaha, NE 68131, USA
Am J Clin Nutr 77:204-10. 2003..The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin... - Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3Gary G Schwartz
Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Carcinogenesis 25:1015-26. 2004.... - Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissueMichael Friedrich
Department of Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
Anticancer Res 26:2615-20. 2006..The aim of this study was to analyze whether normal breast tissue or breast cancer cells expressed 1alpha-OHase and to evaluate whether breast tissue possessed the capacity to produce 1alpha,25(OH)2D3 from 25(OH)D3... - The role of vitamin D in cancer preventionCedric F Garland
Department of Family and Preventive Medicine, 0631C, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0631, USA
Am J Public Health 96:252-61. 2006..The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects... - Review of treatment modalities for postmenopausal osteoporosisRonald C Hamdy
East Tennessee State University, Johnson City, TN 37614, USA
South Med J 98:1000-14; quiz 1015-7, 1048. 2005..Drugs on the horizon include strontium ranelate, which has been shown to reduce vertebral and nonvertebral fracture risk, and zoledronic acid, an injectable bisphosphonate that increased bone density with once-yearly administration... - The urgent need to recommend an intake of vitamin D that is effectiveReinhold Vieth
Am J Clin Nutr 85:649-50. 2007 - Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United StatesWilliam B Grant
Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
Photochem Photobiol 81:1276-86. 2005..Further research is required to confirm these estimates... - Vitamin D deficiency in CKD: why should we care?Michael F Holick
Am J Kidney Dis 45:1119-21. 2005 - Adolescent girls in Maine are at risk for vitamin D insufficiencySusan S Sullivan
Department of Food Science and Human Nutrition, University of Maine, Orono 04469, USA
J Am Diet Assoc 105:971-4. 2005..Mean parathyroid hormone levels increased 4 pg/mL (15%) from September to March. Vitamin D intakes need to be increased in winter at northern latitudes... - Estimates of optimal vitamin D statusBess Dawson-Hughes
Osteoporos Int 16:713-6. 2005..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture... - Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American childrenKumaravel Rajakumar
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Obesity (Silver Spring) 16:90-5. 2008..Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults... - Vitamin D intake in the United StatesCarolyn Moore
The Beverage Institute for Health and Wellness, Coca Cola North America, Houston, TX 77056, USA
J Am Diet Assoc 104:980-3. 2004..Dairy products were the primary sources of both vitamin D and calcium. Additional food fortification as well as dietary and supplement guidance are needed for the general population... - Analysis of the vitamin D system in cutaneous squamous cell carcinomasJörg Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
J Cutan Pathol 31:224-31. 2004.... - Synthesis of vitamin D in skin after burnsGordon L Klein
Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555 0352, USA
Lancet 363:291-2. 2004..Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury... - Deficiency of sunlight and vitamin DMichael F Holick
BMJ 336:1318-9. 2008 - Too little vitamin D in premenopausal women: why should we care?Michael F Holick
Am J Clin Nutr 76:3-4. 2002
Research Grants
- THE PHOTOBIOLOGY OF VITAMIN D3Michael Holick; Fiscal Year: 1993....
- THE PHOTOBIOLOGY OF VITAMIN DMichael Holick; Fiscal Year: 2005..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
- PHOTOBIOLOGY OF VITAMIN DMichael Holick; Fiscal Year: 2000....
- PTH (7-34) for Chemotherapy alopecia in Breast CancerMichael Holick; Fiscal Year: 2006....