Michael Holick

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. pmc Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial
    Arash Hossein-Nezhad
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e58725. 2013
  3. ncbi request reprint Vitamin D and neurocognitive function
    Mathias Schlögl
    University Center for Medicine of Aging Basel, University of Basel, Basel, Switzerland
    Clin Interv Aging 9:559-68. 2014
  4. pmc Evidence-based D-bate on health benefits of vitamin D revisited
    Michael F Holick
    Department of Medicine Section of Endocrinology, Nutrition and Diabetes Vitamin D, Skin and Bone Research Laboratory Boston University Medical Center Boston, MA USA
    Dermatoendocrinol 4:183-90. 2012
  5. pmc Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation
    Rachael M Biancuzzo
    Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 98:973-9. 2013
  6. ncbi request reprint Vitamin D, sunlight and cancer connection
    Michael F Holick
    Boston University School of Medicine, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Anticancer Agents Med Chem 13:70-82. 2013
  7. pmc Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation
    Matthias Wacker
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Nutrients 5:111-48. 2013
  8. ncbi request reprint Potential role of OPG/RANKL system and FokI genotypes in pathogenesis and clinical manifestations in multiple sclerosis
    K Mirzaei
    Tehran University of Medical Sciences, Tehran, Iran
    Minerva Med 103:313-21. 2012
  9. ncbi request reprint Vitamin D: extraskeletal health
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Rheum Dis Clin North Am 38:141-60. 2012
  10. doi request reprint The D-lightful vitamin D for child health
    Michael F Holick
    Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 36:9S-19S. 2012

Research Grants

  1. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1993
  2. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2005
  3. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2004
  4. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2003
  5. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2002
  6. PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2000
  7. PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 1999
  8. PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1992
  9. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1991
  10. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1990

Detail Information

Publications94

  1. ncbi request reprint Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. pmc Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial
    Arash Hossein-Nezhad
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e58725. 2013
    ..The objective of this study was to determine the effect of vitamin D status and subsequent vitamin D supplementation on broad gene expression in healthy adults. (Trial registration: ClinicalTrials.gov NCT01696409)...
  3. ncbi request reprint Vitamin D and neurocognitive function
    Mathias Schlögl
    University Center for Medicine of Aging Basel, University of Basel, Basel, Switzerland
    Clin Interv Aging 9:559-68. 2014
    ..There is a need for well-designed randomized trials to assess the benefits of vitamin D and lifestyle interventions in persons with mild cognitive impairment and dementia. ..
  4. pmc Evidence-based D-bate on health benefits of vitamin D revisited
    Michael F Holick
    Department of Medicine Section of Endocrinology, Nutrition and Diabetes Vitamin D, Skin and Bone Research Laboratory Boston University Medical Center Boston, MA USA
    Dermatoendocrinol 4:183-90. 2012
    ..To prevent vitamin D deficiency The Guidelines recommended vitamin D intake should be: children < 1 y 400-1,000 IU/d, children 1-18 y 600-1,000 IU/d and adults 1,500-2,000 IU/d...
  5. pmc Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation
    Rachael M Biancuzzo
    Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 98:973-9. 2013
    ..Therefore, ingestion of 1000 IU vitamin D2 or vitamin D3 for 11 weeks was effective in raising total serum concentrations of 25(OH)D as well as sustaining serum concentrations of total 1,25(OH)2D...
  6. ncbi request reprint Vitamin D, sunlight and cancer connection
    Michael F Holick
    Boston University School of Medicine, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Anticancer Agents Med Chem 13:70-82. 2013
    ..This can be accomplished by children taking 600-1000 and adults 1500-2000 international units (IU) vitamin D daily from diet and supplements along with sensible sun exposure when the sun is capable of producing vitamin D in the skin...
  7. pmc Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation
    Matthias Wacker
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Nutrients 5:111-48. 2013
    ....
  8. ncbi request reprint Potential role of OPG/RANKL system and FokI genotypes in pathogenesis and clinical manifestations in multiple sclerosis
    K Mirzaei
    Tehran University of Medical Sciences, Tehran, Iran
    Minerva Med 103:313-21. 2012
    ..The aim of this study is to measure plasma levels of OPG and RANKL as well as to analyze VDR FokI polymorphism (rs2228570) in MS patients and healthy individuals to detect any potential correlation...
  9. ncbi request reprint Vitamin D: extraskeletal health
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Rheum Dis Clin North Am 38:141-60. 2012
    ....
  10. doi request reprint The D-lightful vitamin D for child health
    Michael F Holick
    Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 36:9S-19S. 2012
    ..The Endocrine Society's Clinical Guidelines recommended that to prevent and treat vitamin D deficiency, children 0-1 year and 1-18 years need 400-1000 and 600-1000 IU/d, respectively...
  11. ncbi request reprint Vitamin D: its role in cancer prevention and treatment
    Michael F Holick
    Boston University Medical Center, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Prog Biophys Mol Biol 92:49-59. 2006
    ..Therefore, measurement of 25-hydroxyvitamin D is important not only to monitor vitamin D status for bone health, but also for cancer prevention...
  12. pmc Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:677-81. 2008
    ..Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status...
  13. ncbi request reprint High prevalence of vitamin D inadequacy and implications for health
    Michael F Holick
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Mayo Clin Proc 81:353-73. 2006
    ..The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health...
  14. pmc Vitamin D status: measurement, interpretation, and clinical application
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Ann Epidemiol 19:73-8. 2009
    ..The goal should be to maintain both children and adults at a level >30 ng/mL to take full advantage of all the health benefits that vitamin D provides...
  15. ncbi request reprint Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
    Michael F Holick
    Boston University School of Medicine, 715 Albany Street, M1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 90:3215-24. 2005
    ..To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis...
  16. doi request reprint Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, 715 Albany Street, M 1 013, Boston, MA 02118, USA
    Adv Exp Med Biol 624:1-15. 2008
    ..There needs to be a renewed appreciation of the beneficial effect of moderate sunlight for providing all humans with their vitamin D requirement for health...
  17. ncbi request reprint Vitamin D for health and in chronic kidney disease
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Semin Dial 18:266-75. 2005
    ..Vigilance for maintaining a 25-hydroxyvitamin D level of at least 20 ng/ml and preferably 30-50 ng/ml has important benefits for both healthy children and adults, as well as children and adults suffering from chronic kidney disease...
  18. pmc Resurrection of vitamin D deficiency and rickets
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 116:2062-72. 2006
    ..This review summarizes the role of vitamin D in the prevention of rickets and its importance in the overall health and welfare of infants and children...
  19. ncbi request reprint The influence of vitamin D on bone health across the life cycle
    Michael F Holick
    Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Vitamin D Laboratory, Boston, MA 02118, USA
    J Nutr 135:2726S-7S. 2005
  20. ncbi request reprint The vitamin D epidemic and its health consequences
    Michael F Holick
    Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Vitamin D Laboratory, Boston, MA 02118, USA
    J Nutr 135:2739S-48S. 2005
    ..Vigilance of one's vitamin D status by the yearly measurement of 25-hydroxyvitamin D should be part of an annual physical examination...
  21. ncbi request reprint The role of vitamin D for bone health and fracture prevention
    Michael F Holick
    Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Curr Osteoporos Rep 4:96-102. 2006
    ....
  22. ncbi request reprint Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers
    Michael F Holick
    Vitamin D, Skin and Bone Research Laboratory, and the Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    South Med J 98:1024-7. 2005
    ..Vitamin D deficiency increases the risk of many common cancers, multiple sclerosis, rheumatoid arthritis, hypertension, cardiovascular heart disease, and type I diabetes...
  23. ncbi request reprint PTH (1-34): a novel anabolic drug for the treatment of osteoporosis
    Michael F Holick
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    South Med J 98:1114-7. 2005
    ..In addition, the relative risk of having moderate vertebral fracture was reduced by 90%. Thus, PTH (1-34) offers an exciting new approach for the treatment of severe osteoporosis...
  24. pmc Stay tuned to PXR: an orphan actor that may not be D-structive only to bone
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 115:32-4. 2005
    ..This cross-talk behavior has important health ramifications and can be mitigated through the identification and treatment of PXR-induced vitamin D deficiency...
  25. ncbi request reprint Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    Am J Clin Nutr 80:1678S-88S. 2004
    ....
  26. pmc Vitamin D: a d-lightful solution for health
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    J Investig Med 59:872-80. 2011
    ..Therefore, sensible sun exposure along with vitamin D supplementation of at least 2000 IU/d for adults and 1000 IU/d for children is essential to maximize their health...
  27. ncbi request reprint Evolution and function of vitamin D
    Michael F Holick
    Vitamin D Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Recent Results Cancer Res 164:3-28. 2003
    ..The use of agonists and antagonists for PTHrP has important clinical applications for the prevention and treatment of skin diseases and disorders of hair growth...
  28. ncbi request reprint Vitamin D: evolutionary, physiological and health perspectives
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Curr Drug Targets 12:4-18. 2011
    ..It is estimated that 1 billion people worldwide are vitamin D deficient or insufficient. Correcting and preventing this deficiency could have an enormous impact on reducing health costs worldwide...
  29. doi request reprint Vitamin D: extraskeletal health
    Michael F Holick
    Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Boston University School of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Endocrinol Metab Clin North Am 39:381-400, table of contents. 2010
    ..To increase the blood level to the minimum 30 ng/mL requires the ingestion of at least 1000 IU of vitamin D per day for adults. In general, there is no downside to increasing either a child's or adult's vitamin D intake...
  30. ncbi request reprint Vitamin D: A millenium perspective
    Michael F Holick
    Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:296-307. 2003
    ..There needs to be a better appreciation of the importance of vitamin D for overall health and well being...
  31. pmc The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Mol Aspects Med 29:361-8. 2008
    ....
  32. doi request reprint Vitamin D: a D-Lightful health perspective
    Michael F Holick
    The Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    Nutr Rev 66:S182-94. 2008
    ..Healthcare professionals need to be aware of the vitamin D deficiency pandemic. Guidelines for sensible sun exposure and supplemental vitamin D of 800-1000 IU/day are needed...
  33. ncbi request reprint Diabetes and the vitamin d connection
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Curr Diab Rep 8:393-8. 2008
    ..Children and adults need at least 1000 IU of vitamin D per day to prevent deficiency when there is inadequate sun exposure...
  34. doi request reprint Vitamin D and sunlight: strategies for cancer prevention and other health benefits
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1548-54. 2008
    ....
  35. ncbi request reprint Vitamin D deficiency: a worldwide problem with health consequences
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Am J Clin Nutr 87:1080S-6S. 2008
    ..Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations...
  36. ncbi request reprint Topical PTH (1-34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trial
    M F Holick
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University Medical Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Br J Dermatol 149:370-6. 2003
    ..There continues to be a need to develop new pharmacological approaches for treating the common skin disease psoriasis. Human skin produces parathyroid hormone related peptide. This peptide is a potent inhibitor of epidermal cell growth...
  37. ncbi request reprint Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
    ..The recommended adequate intakes for vitamin D are inadequate, and, in the absence of exposure to sunlight, a minimum of 1000 IU vitamin D/d is required to maintain a healthy concentration of 25(OH)D in the blood...
  38. ncbi request reprint Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density
    Vin Tangpricha
    Vitamin D, Skin and Bone Research Laboratory and the Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 80:1645-9. 2004
    ..Subjects who use a tanning bed that emits ultraviolet B radiation (290-315 nm) are likely to have higher 25-hydroxyvitamin D [25(OH)D] concentrations than do subjects who do not regularly use a tanning bed...
  39. ncbi request reprint Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health
    Vin Tangpricha
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Am J Clin Nutr 77:1478-83. 2003
    ..Additional foods need to be fortified with vitamin D...
  40. pmc Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
    Rachael M Biancuzzo
    Department of Medicine, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 91:1621-6. 2010
    ..Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements...
  41. ncbi request reprint Optimal vitamin D status for the prevention and treatment of osteoporosis
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    Drugs Aging 24:1017-29. 2007
    ..Patients being treated for osteoporosis should be adequately supplemented with calcium and vitamin D to maximise the benefit of treatment...
  42. ncbi request reprint Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D
    John N Flanagan
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 26:2567-72. 2006
    ..Here, the questions of whether prostate cells express vitamin D-25-hydroxylase (25-OHase) and can convert vitamin D3 to 1alpha,25(OH)2D3 were investigated...
  43. ncbi request reprint Sickle cell bone disease: response to vitamin D and calcium
    Adeboye H Adewoye
    The Center of Excellence in Sickle Cell Disease and the Vitamin D, Skin and Bone Research Laboratories, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Hematol 83:271-4. 2008
    ..Treatment of adult SCD with vitamin D and calcium can restore 25(OH)D levels to normal and improve BMD, but, markers of bone resorption remained unchanged. Screening for vitamin D deficiency and BMD in SCD patients seems warranted...
  44. ncbi request reprint Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice
    Vin Tangpricha
    Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 135:2350-4. 2005
    ..We conclude that vitamin D deficiency enhances the growth of colon cancer in mice. The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D...
  45. ncbi request reprint The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D
    Michael V Young
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Carcinogenesis 25:967-71. 2004
    ..These findings support the hypothesis that vitamin D or 25(OH)D may be useful as chemopreventive agents for prostate cancer because their administration should cause an increased synthesis of 1 alpha,25(OH)(2)D within prostate cells...
  46. ncbi request reprint Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase and its implication in prostate cancer
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    J Cell Biochem 88:315-22. 2003
    ..Thus, the results suggest that the defect in enzyme activity may result from the decreased promoter activity in prostate cancer cells...
  47. ncbi request reprint Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer
    John N Flanagan
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Anticancer Res 29:3547-53. 2009
    ..Thus, these data suggest that MART-10 may be a potential candidate as a therapeutic agent for prostate cancer, especially for patients who fail in conventional therapies...
  48. ncbi request reprint Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells
    Narasimha Swamy
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Clin Cancer Res 10:8018-27. 2004
    ..Collectively, these results strongly suggested that 25-OH-D(3)-3-BE has a strong potential as a therapeutic agent for androgen-sensitive and androgen-refractory prostate cancer...
  49. ncbi request reprint Vitamin D and bone health in postmenopausal women
    Alan O Malabanan
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 12:151-6. 2003
    ..There are insufficient available data supporting a benefit from vitamin D supplementation alone, without calcium, to prevent osteoporotic fracture in postmenopausal women...
  50. doi request reprint A thyroid hormone deiodinase inhibitor can decrease cutaneous cell proliferation in vitro
    Joshua D Safer
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 19:181-5. 2009
    ..Although IOP is known to inhibit T(4) to T(3) conversion, the inhibition of cutaneous cell proliferation by IOP might conceivably result from other properties of IOP...
  51. ncbi request reprint A role for thyroid hormone in wound healing through keratin gene expression
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1022, Boston, Massachusetts 02118, USA
    Endocrinology 145:2357-61. 2004
    ..Thus, for hypothyroid patients undergoing surgery that cannot be delayed until euthyroidism is achieved, our data support T(3) treatment for the perioperative period...
  52. pmc Vitamin D insufficiency among free-living healthy young adults
    Vin Tangpricha
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Med 112:659-62. 2002
  53. ncbi request reprint Vitamin D and prostate cancer prevention and treatment
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Endocrinol Metab 14:423-30. 2003
    ....
  54. ncbi request reprint Evaluation of vitamin D analogs as therapeutic agents for prostate cancer
    Tai C Chen
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:273-88. 2003
    ..These compounds may be good candidates for human clinical trials in prostate cancer...
  55. ncbi request reprint Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration
    Joshua D Safer
    Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 13:159-65. 2003
    ..Insight into the interplay among the competing factors will be important in understanding thyroid hormone regulation of skin physiology...
  56. ncbi request reprint Topical thyroid hormone accelerates wound healing in mice
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, Massachusetts 02118, USA
    Endocrinology 146:4425-30. 2005
    ..The data support our previous hypothesis that T3 is necessary for optimal wound healing. Now, we further suggest that topical thyroid hormone may be an inexpensive agent to hasten healing of certain wounds...
  57. ncbi request reprint A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in mice
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, MA 02118, USA
    Endocrinology 148:1167-70. 2007
    ..Our study is the first to report the hair-stimulating effect of a PTH/PTHrP receptor antagonist topically applied to skin in vivo. Thus, we introduce a novel paradigm to develop topical PTH analogs for treating disorders of hair growth...
  58. pmc Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Clin Endocrinol Metab 93:40-6. 2008
    ..Although racial and ethnic differences in vitamin D status and bone mineral density (BMD) are recognized, less is known about how differences in vitamin D status impact BMD, especially among men...
  59. pmc Factors that influence the cutaneous synthesis and dietary sources of vitamin D
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Biochem Biophys 460:213-7. 2007
    ....
  60. ncbi request reprint Vitamin D deficiency and osteoporosis in rehabilitation inpatients
    Leonid M Shinchuk
    Department of Physical Medicine and Rehabilitation, Boston University Medical Center, Boston, MA, USA
    Arch Phys Med Rehabil 87:904-8. 2006
    ..To determine vitamin D status and bone mineral density (BMD) in patients admitted to a subacute rehabilitation facility...
  61. ncbi request reprint A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study
    Kerry E Broe
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 55:234-9. 2007
    ..To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents...
  62. pmc Relation of body fat indexes to vitamin D status and deficiency among obese adolescents
    Carine M Lenders
    Boston Medical Center, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 90:459-67. 2009
    ..Data on the relation between vitamin D status and body fat indexes in adolescence are lacking...
  63. doi request reprint Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial
    Michael F Holick
    Boston University School of Medicine, Boston, MA, USA
    J Bone Miner Metab 28:342-50. 2010
    ..01). Treatment with hop rho iso-alpha acids, berberine sulfate trihydrate, vitamin D(3) and vitamin K(1) produced a more favorable bone biomarker profile that supports a healthy bone metabolism...
  64. ncbi request reprint Vitamin d and rehabilitation: improving functional outcomes
    Leonid M Shinchuk
    Spaulding Rehabilitation Hospital, Boston, MA, USA
    Nutr Clin Pract 22:297-304. 2007
    ..There is a need for better education of health professionals and the general public regarding the optimization of vitamin D status in the care of rehabilitation patients...
  65. ncbi request reprint Vitamin D and skin physiology: a D-lightful story
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 22:V28-33. 2007
    ....
  66. ncbi request reprint 25-Hydroxyvitamin D-1alpha-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer
    Lyman W Whitlatch
    Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Boston University School of Medicine, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 81:135-40. 2002
    ....
  67. pmc Association between vitamin D deficiency and primary cesarean section
    Anne Merewood
    Department of Pediatrics, Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, and Division of General Pediatrics, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:940-5. 2009
    ..The current U.S. cesarean birth rate is at an all-time high of 30.2%. We analyzed the relationship between maternal serum 25-hydroxyvitamin D [25(OH)D] status, and prevalence of primary cesarean section...
  68. ncbi request reprint Vitamin D autocrine system and prostate cancer
    Lilin Wang
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:223-37. 2003
    ..Thus, our results suggest that differential phosphorylation of CREB through PKA and MAPK pathways may be involved in the regulation of 1alpha-OHase promoter activity...
  69. ncbi request reprint Regulation of the 25-hydroxyvitamin D-1alpha-hydroxylase gene and its splice variant
    John N Flanagan
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:157-67. 2003
    ....
  70. ncbi request reprint AMPK regulation of the growth of cultured human keratinocytes
    Asish K Saha
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Biochem Biophys Res Commun 349:519-24. 2006
    ..They also suggest that AMPK activators, such as AICAR and troglitazone, inhibit keratinocyte growth and that the inhibition of cell growth by 1,25-dihydroxyvitamin D3 is AMPK-independent...
  71. ncbi request reprint Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cells
    Lilin Wang
    Department of Medicine, Endocrine Division, Boston University Medical Center, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 89:127-30. 2004
    ..Because EGF has no effect on 1alpha-OHase promoter activity in LNCaP cells, we propose that the ability of EGF to stimulate 1alpha,25(OH)(2)D synthesis may be abolished or diminished in cancer cells...
  72. doi request reprint Refractory hypocalcemia following near-total thyroidectomy in a patient with a prior Roux-en-Y gastric bypass
    Sara M Pietras
    Boston University School of Medicine, Boston Medical Center, Boston, MA 02118 2393, USA
    Obes Surg 19:524-6. 2009
    ..Providers should be aware that malabsorption of calcium and vitamin D after RYGB may complicate patient management after thyroidectomy...
  73. ncbi request reprint Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor
    Lilin Wang
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 28:2009-13. 2008
    ....
  74. pmc The role of vitamin D in cancer prevention
    Cedric F Garland
    Department of Family and Preventive Medicine, 0631C, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0631, USA
    Am J Public Health 96:252-61. 2006
    ..The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects...
  75. ncbi request reprint Analysis of the vitamin D system in cutaneous malignancies
    Jorn Kamradt
    Department of Dermatology, University of Saarland, Kirrberger Str, 66421 Homburg Saar, Germany
    Recent Results Cancer Res 164:259-69. 2003
    ....
  76. ncbi request reprint Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue
    Michael Friedrich
    Department of Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Anticancer Res 26:2615-20. 2006
    ..The aim of this study was to analyze whether normal breast tissue or breast cancer cells expressed 1alpha-OHase and to evaluate whether breast tissue possessed the capacity to produce 1alpha,25(OH)2D3 from 25(OH)D3...
  77. ncbi request reprint Review of treatment modalities for postmenopausal osteoporosis
    Ronald C Hamdy
    East Tennessee State University, Johnson City, TN 37614, USA
    South Med J 98:1000-14; quiz 1015-7, 1048. 2005
    ..Drugs on the horizon include strontium ranelate, which has been shown to reduce vertebral and nonvertebral fracture risk, and zoledronic acid, an injectable bisphosphonate that increased bone density with once-yearly administration...
  78. ncbi request reprint Do panther chameleons bask to regulate endogenous vitamin D3 production?
    Gary W Ferguson
    Department of Biology, Texas Christian University, Fort Worth, TX 76129, USA
    Physiol Biochem Zool 76:52-9. 2003
    ..Vitamin D(3) photoregulation seems to be an important additional component of the function of basking...
  79. ncbi request reprint Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 77:204-10. 2003
    ..The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin...
  80. ncbi request reprint Vitamin D intake in the United States
    Carolyn Moore
    The Beverage Institute for Health and Wellness, Coca Cola North America, Houston, TX 77056, USA
    J Am Diet Assoc 104:980-3. 2004
    ..Dairy products were the primary sources of both vitamin D and calcium. Additional food fortification as well as dietary and supplement guidance are needed for the general population...
  81. ncbi request reprint Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 25:1015-26. 2004
    ....
  82. ncbi request reprint Vitamin D deficiency in CKD: why should we care?
    Michael F Holick
    Am J Kidney Dis 45:1119-21. 2005
  83. doi request reprint Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:90-5. 2008
    ..Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults...
  84. ncbi request reprint Adolescent girls in Maine are at risk for vitamin D insufficiency
    Susan S Sullivan
    Department of Food Science and Human Nutrition, University of Maine, Orono 04469, USA
    J Am Diet Assoc 105:971-4. 2005
    ..Mean parathyroid hormone levels increased 4 pg/mL (15%) from September to March. Vitamin D intakes need to be increased in winter at northern latitudes...
  85. ncbi request reprint Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Photochem Photobiol 81:1276-86. 2005
    ..Further research is required to confirm these estimates...
  86. pmc Deficiency of sunlight and vitamin D
    Michael F Holick
    BMJ 336:1318-9. 2008
  87. ncbi request reprint The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  88. ncbi request reprint Analysis of the vitamin D system in cutaneous squamous cell carcinomas
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    J Cutan Pathol 31:224-31. 2004
    ....
  89. ncbi request reprint Estimates of optimal vitamin D status
    Bess Dawson-Hughes
    Osteoporos Int 16:713-6. 2005
    ..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture...
  90. ncbi request reprint Synthesis of vitamin D in skin after burns
    Gordon L Klein
    Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555 0352, USA
    Lancet 363:291-2. 2004
    ..Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury...
  91. ncbi request reprint Too little vitamin D in premenopausal women: why should we care?
    Michael F Holick
    Am J Clin Nutr 76:3-4. 2002

Research Grants19

  1. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1993
    ....
  2. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2005
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  3. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2004
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  4. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2003
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  5. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2002
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  6. PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2000
    ....
  7. PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 1999
    ....
  8. PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1992
    ....
  9. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1991
    ....
  10. THE PHOTOBIOLOGY OF VITAMIN D3
    Michael Holick; Fiscal Year: 1990
    ....
  11. PTH (7-34) for Chemotherapy alopecia in Breast Cancer
    Michael Holick; Fiscal Year: 2006
    ....