Genomes and Genes
Affiliation: Boston University
- A genome-wide association study of serum uric acid in African AmericansBashira A Charles
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
BMC Med Genomics 4:17. 2011....
- Development of admixture mapping panels for African Americans from commercial high-density SNP arraysGuanjie Chen
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
BMC Genomics 11:417. 2010..The increased availability of dense marker data on commercial chips has made it feasible to develop panels wherein the markers need not be predetermined...
- The fat tail of obesity as told by the genomeAlan Herbert
Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Curr Opin Clin Nutr Metab Care 11:366-70. 2008..Many genes affect pathways that predispose to and protect against obesity. We ask how many different variants affect human obesity and how common are they?..
- A common genetic variant is associated with adult and childhood obesityAlan Herbert
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
Science 312:279-83. 2006..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
- The role of binding domains for dsRNA and Z-DNA in the in vivo editing of minimal substrates by ADAR1A Herbert
Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 98:12132-7. 2001..An unexpected finding was that the DRBMs are not necessary for the editing of the shorter 15-bp substrates. However, mutation of the Z-DNA-binding domains of ADAR1 decreased the efficiency with which such a substrate was edited...
- The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart StudyA Herbert
Department of Genetics and Genomics, Boston University School of Medicine, Boston, MA, USA
Diabetologia 48:1492-5. 2005..We evaluated the -174 IL-6 gene polymorphism as a risk factor for type 2 diabetes mellitus in a family-based analysis...
- Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editingAlan Herbert
Department of Neurology, E633, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Mol Cell 10:1235-46. 2002..Point mutations within each domain are identified that reduce nuclear translation; those in the DRBM region are also known to diminish RNA binding. This report adds to the growing functionality ascribed to the nucleus...
- The four Rs of RNA-directed evolutionAlan Herbert
Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Genet 36:19-25. 2004..Together, the actions of reading, 'riting, 'rithmetic and replication constitute the four Rs of RNA-directed evolution...
- BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham StudyAlan Herbert
Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Obesity (Silver Spring) 14:1454-61. 2006..Because white fat is a major source of IL-6 in resting individuals, we tested the hypothesis that BMI modifies the association among the IL-6 genotype, insulin resistance (IR) (measured using the homeostasis model), and risk of diabetes...
- Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary functionJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Respir Crit Care Med 175:554-60. 2007..Previously reported linkage to FEV(1) (LOD score = 5.0) on 6q27 in the Framingham Heart Study (FHS) led us to explore a candidate gene, SMOC2, at 168.6 Mb...
- Genomic screening and replication using the same data set in family-based association testingKristel Van Steen
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nat Genet 37:683-91. 2005..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
- Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart StudySamer Karamohamed
Framingham Heart Study Genetics Laboratory, Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Diabetes 52:1562-7. 2003..002) and type 2 diabetes (P < 0.001, odds ratio 1.96, 95% CI 1.28-3.00). The evidence presented supports the possibility that IDE is a susceptibility gene for diabetes in populations of European descent...
- Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)Luc Djousse
Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
Am J Cardiol 96:227-32. 2005..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
- Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart StudyJemma B Wilk
Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
Hum Mol Genet 12:2745-51. 2003..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)...
- PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sampleJames B Meigs
General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Obesity (Silver Spring) 14:753-8. 2006..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
- Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring StudyLuc Djousse
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am Heart J 153:636-9. 2007..Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease...
- The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and womenJames B Meigs
General Medicine Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:1137-43. 2005..These data support the hypothesis that the INS VNTR is a genetic risk factor for type 2 diabetes, with the TT genotype accounting for about 6.6% of cases in the FHS population...
- Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis StudySerge L Ferrari
Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
J Bone Miner Res 19:552-9. 2004..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups...
- Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in menDouglas P Kiel
Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
Bone 40:587-96. 2007..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...
- A genetic variant in the ACC gene that decreases Body Mass IndexAlan G Herbert; Fiscal Year: 2010..We will then perform directed resequencing of non-coding regions and of exons to identify functional variant(s). ..
- A genetic variant in the ACC gene that decreases Body Mass IndexAlan Herbert; Fiscal Year: 2009..We will then perform directed resequencing of non-coding regions and of exons to identify functional variant(s). ..