A M Healy
Affiliation: Boston University
- Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin depositionA M Healy
The Pulmonary Center, Boston University School of Medicine the Department of Pathology, Harvard Medical School, Boston, MA, USA
Blood 92:4188-97. 1998..Our findings show that TM chimerism results in spontaneous, intravascular fibrin deposition that is dependent on age and the magnitude of the TM deficiency...
- VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lungA M Healy
The Pulmonary Center, Boston University School of Medicine, Boston Massachusetts 02118, USA
Dev Dyn 219:341-52. 2000..The restricted temporal and spatial expression of VEGF suggests that matrix-associated VEGF links airway branching with blood vessel formation by stimulating neovascularization at the leading edge of branching airways...
- Gas 6 promotes Axl-mediated survival in pulmonary endothelial cellsA M Healy
Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Am J Physiol Lung Cell Mol Physiol 280:L1273-81. 2001..Collectively, the data demonstrate antiapoptotic activities for Gas 6 in HPAEC and suggest that Gas 6 signaling may be relevant to endothelial cell survival in the quiescent environment of the vessel wall...
- A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic stateH Weiler-Guettler
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Invest 101:1983-91. 1998..The thrombomodulin-deficient animals provide a murine model to examine known or identify unknown genetic and environmental factors that lead to the development of thrombosis...
- Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular systemA M Healy
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Proc Natl Acad Sci U S A 92:850-4. 1995....
- Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenaseA M Healy
Division of Pulmonary Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0642, USA
J Biol Chem 274:29812-8. 1999..As nuclear import of 5-lipoxygenase may regulate leukotriene production, natural or induced mutations in this bipartite nuclear localization sequence may also be important in affecting leukotriene synthesis...