E E Hatch

..Bisphenol A (BPA) and polyfluoroalkyl chemicals (PFCs) are suspected endocrine disrupting compounds known to be ubiquitous in people's bodies. Population disparities in exposure to these chemicals have not been fully characterized...

..Many epidemiologic studies have evaluated the association between caffeine and fertility, with inconsistent results. Some studies suggest that various caffeine-containing beverages may affect fertility differently...

..Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s70s, has been shown to cause reproductive problems in the daughters. Studies of prenatally-exposed males have yielded conflicting results...

..16; 95% CI=0.97, 1.39). This study provides evidence that prenatal DES exposure was associated with fetal growth and gestational length, which may mediate associations between DES and health outcomes in later life...

..As this field of research advances, there are challenging methodological questions that must be considered by both epidemiologists and toxicologists...

..Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity...

..Age at menopause has been related, albeit inconsistently, to several exposures, but, to the authors' knowledge, this is the first study to suggest that a prenatal exposure may influence reproductive lifespan...

..The findings suggest that hormonal exposures early in life may be associated with risk of glioma, but the evidence is inconsistent and does not point clearly to a specific causal or protective hypothesis...

..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...

..This study was conducted to investigate the association between prenatal DES exposure and cancer risk in men via prospective follow-up...

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..If such a risk does exist, the matter would be of considerable public health importance, given the rapid increase worldwide in the use of these devices...

..In these data, high birth weight was associated with breast cancer risk in younger and in more educated women, but was not associated overall...

..The possibility that active cigarette smoking modifies this effect is also suggested...

..2, 4.6), respectively. The present findings indicate that diethylstilbestrol-exposed women have a higher risk of infertility than do unexposed women and that the increased risk of infertility is primarily due to uterine or tubal problems...

..Recent studies have shown that both female and male obesity may delay time-to-pregnancy (TTP). Little is known about central adiposity or weight gain and fecundability in women...

..Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation...

..The successful conduct of this pilot study suggests that the internet may be a useful tool to recruit and follow subjects in prospective cohort studies...

..Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio...

..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...

..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...

..The findings support the hypothesis that prenatal hormone levels influence breast cancer risk...

..We evaluated the relation of in-utero DES exposure to the risk of adult breast cancer...

..To investigate the association between prenatal diethylstilbestrol (DES) exposure and risk of benign gynecologic tumors...

..Overall, results indicate that extremely low frequency electromagnetic fields from commonly used household appliances are unlikely to increase the risk of brain tumors...

..We conducted a prospective study on a large birth cohort in Sweden...

..Associations between tumor laterality and symptoms may influence the probability or timing of diagnosis, possibly differentially by marital status...

..At the start of this study, cigarette smoking history was obtained directly from the mother...

..To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters...

..There is less opportunity for such influences to operate for the rapidly progressing, high-grade gliomas than for more slowly growing tumours...

..This study explored the risk of childhood acute lymphoblastic leukemia (ALL) associated with participation by household members in hobbies or other home projects involving organic solvents...

..The adverse effects of prenatal exposure on the genitourinary tract in men and the reproductive tract in women are well established, but the possible effects on psychosexual characteristics remain largely unknown...

..Evaluate known breast cancer risk factors in relation to breast density...

..We report menstrual and reproductive characteristics in a unique cohort comprising daughters of women exposed prenatally to DES...

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..Specifically, these studies show an elevated incidence of reproductive tumors in the female offspring of prenatally-exposed mice...

..To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women...

..The study is limited by its cross-sectional nature. Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity. ..

..If successful, we envision this study to be the first of more elaborate studies that employ the internet to enroll cohort members into long-term follow-up studies. ..

..Identifying modifiable risk factors for infertility and miscarriage is an important public health goal, especially because the effectiveness of treatments for these conditions is relatively poor. ..