K L Hartshorn
Affiliation: Boston University
Hartshorn K, White M, Smith K, Sorensen G, Kuroki Y, Holmskov U, et al
. Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity. Scand J Immunol. 2010;72:22-30 pubmed publisher
..Of interest, we show conservation of some monoclonal antibody-binding epitopes between bovine collectin NCRD and hSP-D, suggesting shared structural motifs. ..
Hoeksema M, Tripathi S, White M, Qi L, TAUBENBERGER J, van Eijk M, et al
. Arginine-rich histones have strong antiviral activity for influenza A viruses. Innate Immun. 2015;21:736-45 pubmed publisher
..Despite strong antiviral activity against the seasonal IAV strains, H4 was inactive against pandemic H1N1. These findings indicate a possible role for histones in the innate immune response against IAV. ..
Hartshorn K. New look at an old problem: bacterial superinfection after influenza. Am J Pathol. 2010;176:536-9 pubmed publisher
Hsieh I, Hartshorn K. The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy. Pharmaceuticals (Basel). 2016;9: pubmed publisher
..Major emphasis will be placed on novel synthetic AMPs derived from modification of natural proteins, and on potential methods of increasing expression of endogenous AMPs, since these approaches may lead to novel antiviral therapeutics. ..
Chua M, Ortega C, Sheikh A, Lee M, Abdul Rassoul H, Hartshorn K, et al
. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017;10: pubmed publisher
de Luna X, Hartshorn K. Influenza Casts a Lung Shadow. Am J Pathol. 2017;187:697-699 pubmed publisher
..This commentary highlights the article by Pociask etÂ al that provides new insights into the lingering effects of influenza infection. ..
Chang W, White M, Moyo P, McClear S, Thiel S, Hartshorn K, et al
. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010;11:64 pubmed publisher
..MBL plays a key role in clearing IAV and maintaining lung homeostasis. In addition, our findings also suggest that MBL deficiency maybe a risk factor in IAV infection and MBL may be a useful adjunctive therapy for IAV infection. ..
Hartshorn K, Sastry K, Chang D, White M, Crouch E. Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. Am J Physiol Lung Cell Mol Physiol. 2000;278:L90-8 pubmed
Hartshorn K, Ligtenberg A, White M, van Eijk M, Hartshorn M, Pemberton L, et al
. Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochem J. 2006;393:545-53 pubmed
..These findings may relate to inter-individual variations in innate defence against highly pathogenic IAV and to effects of aspiration of oral contents on SP-D-mediated lung functions. ..