K L Hartshorn


Affiliation: Boston University
Country: USA


  1. Hartshorn K, White M, Smith K, Sorensen G, Kuroki Y, Holmskov U, et al. Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity. Scand J Immunol. 2010;72:22-30 pubmed publisher
    ..Of interest, we show conservation of some monoclonal antibody-binding epitopes between bovine collectin NCRD and hSP-D, suggesting shared structural motifs. ..
  2. Hoeksema M, Tripathi S, White M, Qi L, TAUBENBERGER J, van Eijk M, et al. Arginine-rich histones have strong antiviral activity for influenza A viruses. Innate Immun. 2015;21:736-45 pubmed publisher
    ..Despite strong antiviral activity against the seasonal IAV strains, H4 was inactive against pandemic H1N1. These findings indicate a possible role for histones in the innate immune response against IAV. ..
  3. Hartshorn K. New look at an old problem: bacterial superinfection after influenza. Am J Pathol. 2010;176:536-9 pubmed publisher
  4. Hsieh I, Hartshorn K. The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy. Pharmaceuticals (Basel). 2016;9: pubmed publisher
    ..Major emphasis will be placed on novel synthetic AMPs derived from modification of natural proteins, and on potential methods of increasing expression of endogenous AMPs, since these approaches may lead to novel antiviral therapeutics. ..
  5. Chua M, Ortega C, Sheikh A, Lee M, Abdul Rassoul H, Hartshorn K, et al. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017;10: pubmed publisher
  6. de Luna X, Hartshorn K. Influenza Casts a Lung Shadow. Am J Pathol. 2017;187:697-699 pubmed publisher
    ..This commentary highlights the article by Pociask et al that provides new insights into the lingering effects of influenza infection. ..
  7. Chang W, White M, Moyo P, McClear S, Thiel S, Hartshorn K, et al. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010;11:64 pubmed publisher
    ..MBL plays a key role in clearing IAV and maintaining lung homeostasis. In addition, our findings also suggest that MBL deficiency maybe a risk factor in IAV infection and MBL may be a useful adjunctive therapy for IAV infection. ..
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    Hartshorn K, Sastry K, Chang D, White M, Crouch E. Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. Am J Physiol Lung Cell Mol Physiol. 2000;278:L90-8 pubmed
  9. Hartshorn K, Ligtenberg A, White M, van Eijk M, Hartshorn M, Pemberton L, et al. Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochem J. 2006;393:545-53 pubmed
    ..These findings may relate to inter-individual variations in innate defence against highly pathogenic IAV and to effects of aspiration of oral contents on SP-D-mediated lung functions. ..

More Information


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    Hartshorn K, White M, Tecle T, Holmskov U, Crouch E. Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D. J Immunol. 2006;176:6962-72 pubmed
    ..These results are relevant to the early phase of host defense against IAV, and suggest a complex interplay between SP-D and HNPs at sites of active inflammation. ..
  2. Hartshorn K, Webby R, White M, Tecle T, Pan C, Boucher S, et al. Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D. Respir Res. 2008;9:65 pubmed publisher
    ..Inhibition by SP-D correlates with presence of several glycan attachment sites on the HA. Pandemic and avian strains appear to lack susceptibility to SP-D and this could be a contributory factor to their virulence. ..
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    Hartshorn K, White M, Mogues T, Ligtenberg T, Crouch E, Holmskov U. Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1066-76 pubmed
    ..Furthermore, removal of gp-340 from BAL fluid and saliva significantly reduced anti-IAV activity. Hence, gp-340 contributes to defense against IAV and may be particularly relevant to defense against SP-D-resistant viral strains. ..