James A Hamilton

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
    J A Hamilton
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Diabetes 48:2255-69. 1999
  2. ncbi request reprint Fatty acid transport: the diffusion mechanism in model and biological membranes
    J A Hamilton
    Department of Biophysics, Boston Medical Center, MA 02118, USA
    J Mol Neurosci 16:99-108; discussion 151-7. 2001
  3. ncbi request reprint Fluorescence assays for measuring fatty acid binding and transport through membranes
    Kellen Brunaldi
    Department of Physiology and Biophysics, Boston University School of Medicine, MA, USA
    Methods Mol Biol 400:237-55. 2007
  4. pmc Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity
    Jeffrey R Simard
    Department of Biophysics and Physiology, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 51:914-22. 2010
  5. pmc Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir
    Wen Guo
    Section of Endocrinology, Boston University School of Medicine, 670 Albany Street, Second Floor, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:2028-32. 2009
  6. pmc Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy
    Biju K Pillai
    Department of Biophysics and Physiology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 284:33296-304. 2009
  7. pmc Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited
    Jun Cai
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Biophys J 102:2585-94. 2012
  8. ncbi request reprint Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism
    Frits Kamp
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 52:2526-31. 2003
  9. doi request reprint In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Cardiovasc Imaging 3:323-32. 2010
  10. pmc Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes
    Jeffrey R Simard
    Departments of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biophys J 94:4493-503. 2008

Collaborators

Detail Information

Publications59

  1. ncbi request reprint How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
    J A Hamilton
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Diabetes 48:2255-69. 1999
    ..Thus, unlike the glucose transporters, these proteins would not be single-function proteins. Definitive proof of their function as FFA transporters awaits their reconstitution into simple model systems...
  2. ncbi request reprint Fatty acid transport: the diffusion mechanism in model and biological membranes
    J A Hamilton
    Department of Biophysics, Boston Medical Center, MA 02118, USA
    J Mol Neurosci 16:99-108; discussion 151-7. 2001
    ....
  3. ncbi request reprint Fluorescence assays for measuring fatty acid binding and transport through membranes
    Kellen Brunaldi
    Department of Physiology and Biophysics, Boston University School of Medicine, MA, USA
    Methods Mol Biol 400:237-55. 2007
    ..Also, experiments designed to investigate such artifacts, and improve the reliability and interpretation of the data are described...
  4. pmc Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity
    Jeffrey R Simard
    Department of Biophysics and Physiology, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 51:914-22. 2010
    ....
  5. pmc Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir
    Wen Guo
    Section of Endocrinology, Boston University School of Medicine, 670 Albany Street, Second Floor, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:2028-32. 2009
    ..The purpose of this study was to test the hypothesis that inhibition of adipose lipolysis will retard atherogenic lesion development induced by the antiviral protease inhibitors...
  6. pmc Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy
    Biju K Pillai
    Department of Biophysics and Physiology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 284:33296-304. 2009
    ..Because VLCFA diffuse through the lipid bilayer, proteins may not be required for their transport across the peroxisomal membrane...
  7. pmc Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited
    Jun Cai
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Biophys J 102:2585-94. 2012
    ..Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics...
  8. ncbi request reprint Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism
    Frits Kamp
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 52:2526-31. 2003
    ..Thus, we now provide a molecular mechanism by which sulfonylureas can penetrate the plasma membrane and reach intracellular sites regulating exocytosis...
  9. doi request reprint In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Cardiovasc Imaging 3:323-32. 2010
    ..We used a rabbit model of controlled atherothrombosis to test whether in vivo MRI can noninvasively distinguish between plaques that disrupt after pharmacological triggering (vulnerable) and those that do not (stable)...
  10. pmc Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes
    Jeffrey R Simard
    Departments of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biophys J 94:4493-503. 2008
    ..These studies provide a framework and basis for evaluation of the potential roles of proteins in binding and transport of FA in biological membranes...
  11. pmc Mice deficient in phosphofructokinase-M have greatly decreased fat stores
    Lisa Getty-Kaushik
    Obesity Research Center, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:434-40. 2010
    ..This may be related to the ability of this isoform to generate glycolytic oscillations, because such oscillations may enhance the production of the triacylglycerol precursor alpha-glycerophosphate...
  12. pmc Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen
    Chie Hayashi
    Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 189:3681-8. 2012
    ..We demonstrate an atheroprotective role for TLR4 in response to infection with the oral pathogen P. gingivalis. Our results point to a role for pathogen-specific TLR signaling in chronic inflammation and atherosclerosis...
  13. pmc Identification of atherosclerotic lipid deposits by diffusion-weighted imaging
    Ye Qiao
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:1440-6. 2007
    ..Our goal was to achieve accurate detection of mobile lipids by a single magnetic resonance imaging sequence...
  14. ncbi request reprint Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of unbound fatty acids
    Jeffrey R Simard
    Department of Physiology, Boston University School of Medicine, MA, USA
    Methods Mol Biol 400:27-43. 2007
    ..The results with in vitro systems suggest that there will be caveats with the application of ADIFAB to measure FA concentrations in vivo, where the precise environment of the probe is not known or cannot be tightly controlled...
  15. ncbi request reprint Fatty acid transport and metabolism in HepG2 cells
    Wen Guo
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Gastrointest Liver Physiol 290:G528-34. 2006
    ..Our results show that natural fatty acids rapidly bind to, and diffuse through, the plasma membrane without hindrance by metabolic inhibitors or by an inhibitor of putative membrane-bound fatty acid transporters...
  16. ncbi request reprint Oleate-induced formation of fat cells with impaired insulin sensitivity
    Weisheng Xie
    Obesity Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Lipids 41:267-71. 2006
    ....
  17. ncbi request reprint Rapid flip-flop of oleic acid across the plasma membrane of adipocytes
    Frits Kamp
    Obesity Research Center, Boston Medical Center, Massachusetts 02118, USA
    J Biol Chem 278:7988-95. 2003
    ..Any postulated transport mechanism for facilitating translocation of fatty acid across the plasma membrane of adipocytes, including a protein transporter, would have to compete with the highly effective flip-flop mechanism...
  18. doi request reprint Correspondence of fatty acid and drug binding sites on human serum albumin: a two-dimensional nuclear magnetic resonance study
    Eileen S Krenzel
    Department of Pharmacology of the Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 52:1559-67. 2013
    ..With this strategy, 2D NMR spectral analysis permits site-specific characterization of the binding of drugs and FA and provides a sensitive probe of the mutual effects of FA and ligand binding...
  19. ncbi request reprint Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins
    James A Hamilton
    Department of Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Opin Lipidol 14:263-71. 2003
    ..Lack of definitive knowledge has given rise to speculation about the mechanism(s) of membrane 'transport' proteins for fatty acids and cholesterol...
  20. pmc Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice
    Powen Tu
    Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 58:1739-48. 2009
    ..In this study, we determined whether Mstn disruption could prevent the development of insulin resistance, proatherogenic dyslipidemia, and atherogenesis...
  21. pmc The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome
    Frederick L Ruberg
    Department of Medicine, Section of Cardiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1116-21. 2010
    ..Site-specific functional abnormalities were observed for pericardial but not periaortic lipid. These findings underscore the utility of MRI to assess individual differences in ectopic lipid that are not predictable from BMI...
  22. doi request reprint Regions of low endothelial shear stress colocalize with positive vascular remodeling and atherosclerotic plaque disruption: an in vivo magnetic resonance imaging study
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Cardiovasc Imaging 6:302-10. 2013
    ..We used in vivo MRI to investigate the role of the magnitude of ESS on vascular remodeling, plaque burden, and disruption using a rabbit model of controlled atherothrombosis...
  23. pmc Magnetization transfer magnetic resonance of human atherosclerotic plaques ex vivo detects areas of high protein density
    Ye Qiao
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118 2526, USA
    J Cardiovasc Magn Reson 13:73. 2011
    ..We sought to assess the feasibility of magnetization transfer (MT) magnetic resonance (MR) for identifying fibrin and collagen in carotid atherosclerotic plaques ex vivo...
  24. ncbi request reprint Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis
    Jeffrey R Simard
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street Boston, MA 02118, USA
    J Mol Biol 361:336-51. 2006
    ..Our results also yield direct insights into the interactions between FA and other ligands...
  25. pmc Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes
    Vandana Gupta
    Department of Medicine, Boston University, School of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Mol Cell Endocrinol 296:32-40. 2008
    ..DHT stimulated forskolin-stimulated lipolysis in subcutaneous and mesenteric preadipocytes and inhibited incorporation of fatty acid into triglyceride in adipocytes differentiated from preadipocytes from all fat depots...
  26. ncbi request reprint Role of caveolin-1 and cholesterol in transmembrane fatty acid movement
    Tova Meshulam
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 45:2882-93. 2006
    ..We conclude that transport of FA across the plasma membrane is modulated by caveolin-1 and cholesterol and is not dependent on the putative FA transport proteins CD36 and FATP...
  27. ncbi request reprint Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins?
    James A Hamilton
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Cell Biochem 239:17-23. 2002
    ..We also present new results using dual fluorescence approaches showing that fatty acids diffuse very rapidly across the plasma membrane of the adipocyte...
  28. ncbi request reprint Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats
    Jianrong Han
    Obesity Research Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Obes Res 11:734-44. 2003
    ..To test the hypothesis that adipose tissue could be one of the primary targets through which medium-chain fatty acids (MCFAs) exert their metabolic influence...
  29. doi request reprint Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase
    Jeffrey R Simard
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 47:9081-9. 2008
    ....
  30. ncbi request reprint New insights into the roles of proteins and lipids in membrane transport of fatty acids
    James A Hamilton
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Prostaglandins Leukot Essent Fatty Acids 77:355-61. 2007
    ..Finally, some proteins have undefined mechanisms. The established mechanisms are consistent with biophysical properties of LCFA in membranes, including fast free diffusion by "flip-flop" in the phospholipid bilayer...
  31. ncbi request reprint A model for fatty acid transport into the brain
    James A Hamilton
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany St, Boston, MA 02118 2526, USA
    J Mol Neurosci 33:12-7. 2007
    ..Acyl-CoA synthetases trap FA by forming acyl-CoA, which cannot diffuse out of the cell. Selection of FA is controlled largely by enzymes in the pathways of intracellular metabolism, beginning with the acyl-CoA synthetase...
  32. pmc Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice
    Chie Hayashi
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, United States
    Atherosclerosis 215:52-9. 2011
    ..gingivalis infection accelerates inflammation and atherosclerosis in the innominate artery of mice, an artery which has been reported to exhibit many features of human atherosclerotic disease, including plaque rupture...
  33. ncbi request reprint Interactions between fatty acids and alpha-synuclein
    Christian Lücke
    Department of Physiology and Biophysics, Boston University School of Medicine, MA 02118, USA
    J Lipid Res 47:1714-24. 2006
    ..Binding to negatively charged membranes, however, appears to be an intrinsic property of alphaS that is most likely related to its physiological role(s) in the cell...
  34. ncbi request reprint Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism
    Fengli Zhang
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Biochemistry 42:7339-47. 2003
    ..Structural details of this portal region will be discussed in view of the influence residue 54 exerts on the functional properties of human I-FABP...
  35. ncbi request reprint Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes
    Wen Guo
    Obesity Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Lipids 40:815-21. 2005
    ..We suggest that EPA increased the activity of CPT-1 and beta-oxidation in adipocytes by altering the structure or dynamics of the mitochondrial membranes...
  36. ncbi request reprint Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS
    Frederick L Ruberg
    Whitaker Cardiovascular Institute, Evans Department of Medicine and Section of Cardiology, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 47:310-7. 2006
    ..This procedure may permit the noninvasive detection and quantification of CE in atherosclerotic plaque in vivo...
  37. doi request reprint NMR reveals molecular interactions and dynamics of fatty acid binding to albumin
    James A Hamilton
    Boston University School of Medicine, Dept of Physiology and Biophysics, 700 Albany St, Boston, MA 02118, USA Electronic address
    Biochim Biophys Acta 1830:5418-26. 2013
    ..The molecular details of fatty acid (FA) interactions with albumin are fundamental to understanding transport in the plasma and cellular utilization of these key nutrients and building blocks of membranes...
  38. pmc Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
    Yasuhiro Izumiya
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cell Metab 7:159-72. 2008
    ..Our findings indicate that an increase in fast/glycolytic muscle mass can result in the regression of obesity and metabolic improvement through its ability to alter fatty acid oxidation in remote tissues...
  39. ncbi request reprint Fatty acid interactions with proteins: what X-ray crystal and NMR solution structures tell us
    James A Hamilton
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA
    Prog Lipid Res 43:177-99. 2004
    ..This review discusses the structural features of these proteins and their binding pocket(s) and compares the specific modes of their interactions with fatty acids...
  40. pmc Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration
    Ye Qiao
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany St, W302, Boston, MA, USA
    Circulation 118:e147-8. 2008
  41. pmc A robust rabbit model of human atherosclerosis and atherothrombosis
    Alkystis Phinikaridou
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 50:787-97. 2009
    ..Our findings reveal novel insights into plaque vulnerability and could guide the design of noninvasive imaging approaches for detecting and treating high-risk plaques...
  42. pmc Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein
    Julius L Decano
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 119:1501-9. 2009
    ..Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications...
  43. ncbi request reprint Interactions of acyl carnitines with model membranes: a (13)C-NMR study
    Jet K Ho
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Lipid Res 43:1429-39. 2002
    ..We hypothesize that the effects of high levels of long-chain AC (as found in ischemia or in certain diseases) on cell membranes result from molecular effects on membrane functions rather than from gross disruption of the lipid bilayer...
  44. ncbi request reprint Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders
    James A Hamilton
    Boston University School of Medicine, Boston, MA, USA
    J Mol Neurosci 33:2-11. 2007
    ..In this article, we will provide an overview of the topics discussed in these sessions...
  45. ncbi request reprint Interactions of very long-chain saturated fatty acids with serum albumin
    Ji Kyung Choi
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Lipid Res 43:1000-10. 2002
    ..Our studies suggest that albumin has adequate binding capacity for the low plasma levels of VLCFA with 20 to 26 carbons, but the protein may not be able to bind longer chain VLCFA...
  46. ncbi request reprint Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?
    James A Hamilton
    Nat Struct Mol Biol 14:95-7. 2007
  47. pmc Targeted binding of PLA microparticles with lipid-PEG-tethered ligands
    Wynter J Duncanson
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Biomaterials 28:4991-9. 2007
    ..This novel technique used to fabricate these liganded particles combined with the lipid bilayer binding studies provides a platform for systematic optimization of particle binding...
  48. pmc A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems
    Wen Guo
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118 USA
    Biophys J 83:1465-78. 2002
    ..In the environment of a typical biomembrane, the higher proportion of saturated fatty acyl chains in SM compared to other phospholipids may be the most significant factor influencing interactions with Chol...
  49. ncbi request reprint How fatty acids of different chain length enter and leave cells by free diffusion
    Frits Kamp
    Laboratory of Alzheimer s and Parkinson s Disease Research, Institute of Metabolic Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, D 80336 Munich, Germany
    Prostaglandins Leukot Essent Fatty Acids 75:149-59. 2006
    ..Since polyunsaturated FA have basically the same physico-chemical properties as LCFA, they have similar membrane permeabilities. The implications for theories involving proteins to facilitate uptake of FA are discussed...
  50. ncbi request reprint Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation
    Tianguang Lei
    Obesity Research Center, Boston University School of Medicine, Boston, Massachusetts USA
    Obes Res 12:599-611. 2004
    ..To test the hypothesis that incorporation of medium-chain fatty acids (FAs) into adipocyte triglycerides alters intracellular lipolysis...
  51. ncbi request reprint Free fatty acids modulate intermembrane trafficking of cholesterol by increasing lipid mobilities: novel 13C NMR analyses of free cholesterol partitioning
    Rebecca A Johnson
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH 1512, New York, New York 10032, USA
    Biochemistry 42:1637-45. 2003
    ..3-fold. These results demonstrate free fatty acid-facilitated cholesterol movement within and between membranes, which may contribute to their multiple biological effects...
  52. ncbi request reprint Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research
    Robert Katz
    Omega 3 Research Institute, Inc, 16700 Sioux Lane, Gaithersburg, MD 20878, USA
    J Mol Neurosci 33:146-50. 2007
    ..12) The relationship between LC-PUFA, stroke, and AD should be clarified, and neurogenetic metabolic diseases that could benefit from supplementation with omega3 LC-PUFA such as DHA should be identified...
  53. ncbi request reprint The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
    Ronit Sharon
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02215, USA
    Neuron 37:583-95. 2003
    ..We conclude that alpha S interacts with PUFAs in vivo to promote the formation of highly soluble oligomers that precede the insoluble alpha S aggregates associated with neurodegeneration...
  54. ncbi request reprint NMR assignment and structural characterization of the fatty acid binding protein from the flight muscle of Locusta migratoria
    Christian Lücke
    J Biomol NMR 25:355-6. 2003
  55. ncbi request reprint Roundtable discussion of session 4: fatty acids and lipids in brain disorders
    Paul A Watkins
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    J Mol Neurosci 33:120-4. 2007
  56. ncbi request reprint Fatty-acid-binding protein from the flight muscle of Locusta migratoria: evolutionary variations in fatty acid binding
    Christian Lücke
    Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
    Biochemistry 45:6296-305. 2006
    ....
  57. ncbi request reprint Roundtable discussion of session 3: eicosanoids in brain function
    Paul A Watkins
    Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    J Mol Neurosci 33:100-4. 2007
  58. pmc Retinaldehyde represses adipogenesis and diet-induced obesity
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:695-702. 2007
    ..In ob/ob mice, administrating Rald or a Raldh inhibitor reduced fat and increased insulin sensitivity. These results identify Rald as a distinct transcriptional regulator of the metabolic responses to a high-fat diet...
  59. ncbi request reprint Roundtable discussion of session 1: mechanisms of lipid uptake and transport in the brain
    Paul A Watkins
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    J Mol Neurosci 33:45-50. 2007