O Gursky

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc High- and low-temperature unfolding of human high-density apolipoprotein A-2
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Protein Sci 5:1874-82. 1996
  2. ncbi request reprint Thermodynamic analysis of human plasma apolipoprotein C-1: high-temperature unfolding and low-temperature oligomer dissociation
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Biochemistry 37:1283-91. 1998
  3. pmc Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118 2526, USA
    Protein Sci 8:2055-64. 1999
  4. ncbi request reprint Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation
    O Gursky
    Department of Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2526, USA
    Biochim Biophys Acta 1476:93-102. 2000
  5. ncbi request reprint Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study
    O Gursky
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 40:12178-85. 2001
  6. ncbi request reprint Probing the lipid-free structure and stability of apolipoprotein A-I by mutation
    I N Gorshkova
    Section of Molecular Genetics at Whitaker Cardiovascular Institute and Department of Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 39:15910-9. 2000

Collaborators

Detail Information

Publications6

  1. pmc High- and low-temperature unfolding of human high-density apolipoprotein A-2
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Protein Sci 5:1874-82. 1996
    ..52 kcal/mol.K inferred from the far-UV CD analysis of apoA-2 unfolding, and absence of tertiary packing interactions involving Tyr groups suggested by near-UV CD, are consistent with a molten globular-like state of lipid-free apoA-2...
  2. ncbi request reprint Thermodynamic analysis of human plasma apolipoprotein C-1: high-temperature unfolding and low-temperature oligomer dissociation
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118, USA
    Biochemistry 37:1283-91. 1998
    ....
  3. pmc Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide
    O Gursky
    Department of Biophysics, Boston University School of Medicine, Massachusetts 02118 2526, USA
    Protein Sci 8:2055-64. 1999
    ..Comparison with the maximal alpha-helical content of 73% observed in lipid-bound apoC-1 suggests that the TMAO-stabilized secondary structure resembles the functional lipid-bound apolipoprotein conformation...
  4. ncbi request reprint Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation
    O Gursky
    Department of Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2526, USA
    Biochim Biophys Acta 1476:93-102. 2000
    ..Our results demonstrate the importance of temperature and thermal history for the conformation of Abeta...
  5. ncbi request reprint Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study
    O Gursky
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 40:12178-85. 2001
    ..Correlation of far- and near-UV CD of the mutant peptides suggests that the hydrophobic cluster containing W41 is essential for the helical stability and may form a helix nucleation site in apoC-1...
  6. ncbi request reprint Probing the lipid-free structure and stability of apolipoprotein A-I by mutation
    I N Gorshkova
    Section of Molecular Genetics at Whitaker Cardiovascular Institute and Department of Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 39:15910-9. 2000
    ..The effect of the substitution (G185P, G186P) on the exposure of tryptophans located in the N-terminal half suggests an apoA-I tertiary conformation with the C-terminus located close to the N-terminus...