Suryaram Gummuluru

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003291. 2013
  2. pmc Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Virol 77:12865-74. 2003
  3. pmc HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 109:7475-80. 2012
  4. pmc Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 76:10692-701. 2002
  5. pmc Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization
    Gillian M Schiralli Lester
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, United States
    Virology 436:235-43. 2013
  6. pmc Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
    Adv Exp Med Biol 762:131-53. 2013
  7. pmc PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection
    Timothy M Hanley
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000981. 2010
  8. ncbi Advances in HIV molecular biology
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    AIDS 16:S17-23. 2002
  9. ncbi Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells
    Xinwei Yu
    Department of Chemistry and The Photonics Center, Boston University, Boston, Massachusetts 02215, USA
    Nat Commun 5:4136. 2014
  10. pmc Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection
    Steven C Hatch
    Department of Microbiology, Boston University School of Medicine, 72 E Concord St, R509, Boston, MA 02118, USA
    J Virol 83:3496-506. 2009

Research Grants

  1. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2010
  2. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2005
  3. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2006
  4. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2007
  5. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2009

Collaborators

  • Juswinder Singh
  • Leonidas Stamatatos
  • Vineet N Kewalramani
  • Wendy Blay Puryear
  • Xinwei Yu
  • Hisashi Akiyama
  • Bj√∂rn M Reinhard
  • Gillian M Schiralli Lester
  • Nora P Ramirez
  • Timothy M Hanley
  • Steven C Hatch
  • Rebecca D Wiley
  • Fangda Xu
  • Amin Feizpour
  • Linxi Wu
  • Nora Guadalupe P Ramirez
  • Suzanne D Geer
  • Erica Evans
  • Andrew J Henderson
  • Gregory A Viglianti
  • Jacob Archer

Detail Information

Publications11

  1. pmc Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003291. 2013
    ..Together, these findings describe a novel mechanism of pathogen parasitization of host encoded cellular recognition machinery (GM3--CD169 interaction) for DC-dependent HIV dissemination...
  2. pmc Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Virol 77:12865-74. 2003
    ..We propose that pathways to HIV-1 attachment and uptake in DC exhibit functional redundancy; that is, they are made up of multiple independent activities that can, at least in part, compensate for one another...
  3. pmc HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 109:7475-80. 2012
    ....
  4. pmc Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 76:10692-701. 2002
    ..These results suggest that dendritic cell-mediated transmission of HIV-1 enables virus replication under conditions of rapid cell turnover in vivo...
  5. pmc Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization
    Gillian M Schiralli Lester
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, United States
    Virology 436:235-43. 2013
    ..These data provide insight as to how ITK influences HIV-1 replication and suggest that targeting host factors that regulate HIV-1 egress provides an innovative strategy for controlling HIV infection...
  6. pmc Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection
    Wendy Blay Puryear
    Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
    Adv Exp Med Biol 762:131-53. 2013
    ....
  7. pmc PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection
    Timothy M Hanley
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000981. 2010
    ..The ability of NR ligands to repress DC mediated trans-infection, inflammation, and DC migration underscores their potential therapeutic value in inhibiting HIV-1 mucosal transmission...
  8. ncbi Advances in HIV molecular biology
    Suryaram Gummuluru
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    AIDS 16:S17-23. 2002
  9. ncbi Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells
    Xinwei Yu
    Department of Chemistry and The Photonics Center, Boston University, Boston, Massachusetts 02215, USA
    Nat Commun 5:4136. 2014
    ..They also indicate that plasmonic AVNs offer improved features over liposome-based systems and represent a versatile tool for probing specific virus-cell interactions. ..
  10. pmc Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection
    Steven C Hatch
    Department of Microbiology, Boston University School of Medicine, 72 E Concord St, R509, Boston, MA 02118, USA
    J Virol 83:3496-506. 2009
    ....
  11. pmc Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
    Rebecca D Wiley
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 103:738-43. 2006
    ....

Research Grants6

  1. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2010
    ....
  2. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2005
    ..We believe that the studies described in these aims would delineate the role of dendritic cells, and especially DC-SIGN, in the initiation and propagation of HIV-1 infection in vivo. ..
  3. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2006
    ..We believe that the studies described in these aims would delineate the role of dendritic cells, and especially DC-SIGN, in the initiation and propagation of HIV-1 infection in vivo. ..
  4. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2007
    ..We believe that the studies described in these aims would delineate the role of dendritic cells, and especially DC-SIGN, in the initiation and propagation of HIV-1 infection in vivo. ..
  5. Mechanism of cell-associated HIV-1 transmission
    Suryaram Gummuluru; Fiscal Year: 2009
    ..We believe that the studies described in these aims would delineate the role of dendritic cells, and especially DC-SIGN, in the initiation and propagation of HIV-1 infection in vivo. ..