Marc Jan Gubbels

Summary

Affiliation: Boston College
Country: USA

Publications

  1. pmc A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis
    Alexander Lorestani
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States of America
    PLoS ONE 5:e12302. 2010
  2. pmc Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains
    Ninghan Yang
    Biology Department, Massachusetts Institute of Technology, 77 Massachusetts Ave, building 68 270, Cambridge, MA 02139, USA
    BMC Genomics 14:467. 2013
  3. pmc Evolution of apicomplexan secretory organelles
    Marc Jan Gubbels
    Department of Biology, Boston College, 140 Commonwealth Avenue, Higgins Hall 355, Chestnut Hill, MA 02467, USA
    Int J Parasitol 42:1071-81. 2012
  4. doi The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?
    Marc Jan Gubbels
    Department of Biology, Boston College, 355 Higgins Hall, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Int J Parasitol 38:1343-58. 2008
  5. pmc A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis
    Andrew Farrell
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Science 335:218-21. 2012
  6. pmc Cactin is essential for G1 progression in Toxoplasma gondii
    Tomasz Szatanek
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Mol Microbiol 84:566-77. 2012
  7. pmc Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1
    Alexander Lorestani
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Cytoskeleton (Hoboken) 69:1069-85. 2012
  8. pmc A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii
    Brooke R Anderson-White
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Microbiol 13:18-31. 2011
  9. doi Cytoskeleton assembly in Toxoplasma gondii cell division
    Brooke Anderson-White
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Int Rev Cell Mol Biol 298:1-31. 2012
  10. pmc The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant
    Chun Ti Chen
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Cell Sci 126:3344-55. 2013

Research Grants

  1. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2010
  2. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2009

Collaborators

Detail Information

Publications11

  1. pmc A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis
    Alexander Lorestani
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States of America
    PLoS ONE 5:e12302. 2010
    ..In conclusion, MORN1 is required for basal complex assembly and loss of MORN1 results in defects in apicoplast division and daughter segregation...
  2. pmc Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains
    Ninghan Yang
    Biology Department, Massachusetts Institute of Technology, 77 Massachusetts Ave, building 68 270, Cambridge, MA 02139, USA
    BMC Genomics 14:467. 2013
    ..Moreover, as differences in host cell modulation could affect Toxoplasma replication in the host, we determined differentially modulated host processes among the type I strains through host transcriptional profiling...
  3. pmc Evolution of apicomplexan secretory organelles
    Marc Jan Gubbels
    Department of Biology, Boston College, 140 Commonwealth Avenue, Higgins Hall 355, Chestnut Hill, MA 02467, USA
    Int J Parasitol 42:1071-81. 2012
    ..Briefly, the relationship of this secretion machinery within the Apicomplexa will be discussed, compared with free-living and predatory alveolates, and how these might have evolved from a common ancestor...
  4. doi The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?
    Marc Jan Gubbels
    Department of Biology, Boston College, 355 Higgins Hall, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Int J Parasitol 38:1343-58. 2008
    ....
  5. pmc A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis
    Andrew Farrell
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Science 335:218-21. 2012
    ..However, the major effect was on invasion, suggesting that microneme secretion is dispensable for Plasmodium egress...
  6. pmc Cactin is essential for G1 progression in Toxoplasma gondii
    Tomasz Szatanek
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Mol Microbiol 84:566-77. 2012
    ..Taken together, these results suggest that TgCactin acts as a pivotal protein potentially regulating gene expression at several transition points in parasite development...
  7. pmc Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1
    Alexander Lorestani
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Cytoskeleton (Hoboken) 69:1069-85. 2012
    ..Furthermore, we show that G-actin binding protein TgCAP is localized at the apical cap region in intracellular parasites, but quickly redistributes to a cytoplasmic localization pattern upon egress. © 2012 Wiley Periodicals, Inc...
  8. pmc A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii
    Brooke R Anderson-White
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Microbiol 13:18-31. 2011
    ..Furthermore we identified IMC15 as an early marker of budding and, lastly, the dynamic patterns observed throughout cytokinesis provide a timeline for daughter parasite development and division...
  9. doi Cytoskeleton assembly in Toxoplasma gondii cell division
    Brooke Anderson-White
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Int Rev Cell Mol Biol 298:1-31. 2012
    ..Here, we review newly emerging insights in the prominent role that assembly of the cortical cytoskeletal scaffold plays in the process of daughter parasite formation...
  10. pmc The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant
    Chun Ti Chen
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Cell Sci 126:3344-55. 2013
    ..Moreover, these results conclusively show for the first time that Toxoplasma bud assembly is facilitated by the centrosome because defective centrosome splitting results in single daughter cell budding. ..
  11. pmc An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene
    Lauren Jammallo
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Mol Biochem Parasitol 175:133-43. 2011
    ..Furthermore, these rearrangements provide an explanation for inconsistent locus rescue results observed by molecular biological approaches. Taken together, we have added an approach to identify and study essential genes in Toxoplasma...

Research Grants2

  1. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2010
    ....
  2. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2009
    ....