Robert C Green

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Risk of dementia among white and African American relatives of patients with Alzheimer disease
    Robert C Green
    Genetics Program and Alzheimer s Disease Center, Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    JAMA 287:329-36. 2002
  2. pmc Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
    Robert C Green
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, L 320, Boston, MA 02118, USA
    JAMA 302:2557-64. 2009
  3. ncbi request reprint Primary prevention trials in Alzheimer disease
    Robert C Green
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 67:S2-5. 2006
  4. ncbi request reprint Depression as a risk factor for Alzheimer disease: the MIRAGE Study
    Robert C Green
    Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 60:753-9. 2003
  5. pmc Disclosure of APOE genotype for risk of Alzheimer's disease
    Robert C Green
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 361:245-54. 2009
  6. ncbi request reprint Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial
    J Scott Roberts
    Departments of Neurology and Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street B 7800, Boston, MA 02118, USA
    Genet Med 6:197-203. 2004
  7. pmc Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
  8. pmc Predicting cognitive decline and conversion to Alzheimer's disease in older adults using the NAB List Learning test
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Int Neuropsychol Soc 16:651-60. 2010
  9. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
  10. pmc Effect of Alzheimer disease genetic risk disclosure on dietary supplement use
    Jacqueline A Vernarelli
    Department of Neurology, Boston University School of Public Health, Boston, MA, USA
    Am J Clin Nutr 91:1402-7. 2010

Detail Information

Publications67

  1. ncbi request reprint Risk of dementia among white and African American relatives of patients with Alzheimer disease
    Robert C Green
    Genetics Program and Alzheimer s Disease Center, Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    JAMA 287:329-36. 2002
    ..Family studies of probands with AD offer an opportunity to evaluate lifetime risk of dementia among relatives of these probands...
  2. pmc Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
    Robert C Green
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, L 320, Boston, MA 02118, USA
    JAMA 302:2557-64. 2009
    ..Tarenflurbil, a selective Abeta(42)-lowering agent, demonstrated encouraging results on cognitive and functional outcomes among mildly affected patients in an earlier phase 2 trial...
  3. ncbi request reprint Primary prevention trials in Alzheimer disease
    Robert C Green
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 67:S2-5. 2006
    ..Primary prevention trials for AD present many design challenges. In most situations, secondary prevention trials provide the most feasible first step toward primary prevention...
  4. ncbi request reprint Depression as a risk factor for Alzheimer disease: the MIRAGE Study
    Robert C Green
    Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 60:753-9. 2003
    ..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
  5. pmc Disclosure of APOE genotype for risk of Alzheimer's disease
    Robert C Green
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 361:245-54. 2009
    ..We examined the effect of genotype disclosure in a prospective, randomized, controlled trial...
  6. ncbi request reprint Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial
    J Scott Roberts
    Departments of Neurology and Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street B 7800, Boston, MA 02118, USA
    Genet Med 6:197-203. 2004
    ..This study's main purposes were to estimate interest in such testing and to examine demographic predictors of study participation...
  7. pmc Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
    ..Results for the other MRI traits were unremarkable. This study highlights the potential value of neuroimaging endophenotypes as a tool for finding genes influencing AD pathogenesis...
  8. pmc Predicting cognitive decline and conversion to Alzheimer's disease in older adults using the NAB List Learning test
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Int Neuropsychol Soc 16:651-60. 2010
    ..The predictive validity of the NAB List Learning algorithm makes it a clinically useful tool for the assessment of older adults...
  9. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
    ..Our results suggest that low serum paraoxonase activity is a risk factor for AD. Furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic...
  10. pmc Effect of Alzheimer disease genetic risk disclosure on dietary supplement use
    Jacqueline A Vernarelli
    Department of Neurology, Boston University School of Public Health, Boston, MA, USA
    Am J Clin Nutr 91:1402-7. 2010
    ..Little is known about whether APOE genotype disclosure would actually prompt changes in nutrition behaviors among at-risk individuals...
  11. ncbi request reprint Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study
    L Adrienne Cupples
    Departments of Biostatistics and Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Med 6:192-6. 2004
    ..The protocol presents risk information as cumulative incidence curves. This article describes how these curves were estimated...
  12. ncbi request reprint Genetic risk assessment for adult children of people with Alzheimer's disease: the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study
    J Scott Roberts
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    J Geriatr Psychiatry Neurol 18:250-5. 2005
    ....
  13. pmc Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease
    Michael R Cassidy
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Alzheimers Dement 4:406-13. 2008
    ..The purpose of this study was to compare the psychological impact of using these two different types of genetic information to disclose genetic risk for AD to family members of affected patients...
  14. pmc Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    Karen T Cuenco
    Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 65:1640-8. 2008
    ....
  15. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  16. pmc Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease
    Laura H Eggermont
    Alzheimer s Disease Clinical and Research Program, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Arch Phys Med Rehabil 91:584-8. 2010
    ..To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD)...
  17. pmc Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study
    Serena Chao
    Department of Medicine Geriatrics Section Boston University School of Medicine, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 22:94-7. 2008
    ..Despite lack of preventive measures for AD, knowledge of APOE genotype, numerical lifetime risk, or both, influences health behavior...
  18. pmc Clock drawing test ratings by dementia specialists: interrater reliability and diagnostic accuracy
    Anil K Nair
    Alzheimer s Disease Center, Boston University School of Medicine, Boston, USA
    J Neuropsychiatry Clin Neurosci 22:85-92. 2010
    ..Based on rating systems, clock drawing test scoring by dementia clinicians had excellent interrater reliability and sensitivity for differentiating the mild Alzheimer's disease subjects from comparison subjects...
  19. pmc Geriatric performance on an abbreviated version of the Boston naming test
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Appl Neuropsychol 14:215-23. 2007
    ..001). Geriatric normative data therefore suggest that sex, race, and education are all associated with naming performance, and these variables should be taken into consideration when interpreting geriatric BNT-30 performance...
  20. pmc Magnetic resonance imaging traits in siblings discordant for Alzheimer disease
    Karen T Cuenco
    Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    J Neuroimaging 18:268-75. 2008
    ..We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their association with AD in families from the Multi-Institutional Research in Alzheimer Genetic Epidemiology (MIRAGE) Study...
  21. pmc Diagnostic utility of the NAB List Learning test in Alzheimer's disease and amnestic mild cognitive impairment
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Int Neuropsychol Soc 15:121-9. 2009
    ..58 to .92 and univariate specificity values ranged from .52 to .97. Multivariate ordinal regression produced a model that classified individuals with 80% accuracy and good predictive power. (JINS, 2009, 15, 121-129.)...
  22. ncbi request reprint Association between apolipoprotein E genotype and Alzheimer disease in African American subjects
    Neill R Graff-Radford
    Genetics Program L 320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 59:594-600. 2002
    ..The association between Alzheimer disease (AD) and genotypes at the apolipoprotein E (APOE) locus has been confirmed in numerous populations worldwide, but appears to be inconsistent in African American subjects...
  23. ncbi request reprint Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 21:85-91. 2007
    ..In the Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study of AD-discordant siblings, MRI traits are heritable and are potential endophenotypes for genetic association studies...
  24. pmc Willingness to pay for genetic testing for Alzheimer's disease: a measure of personal utility
    Ilona M Kopits
    Boston University School of Medicine, Boston, Massachusetts, USA
    Genet Test Mol Biomarkers 15:871-5. 2011
    ..The increased availability of genetic tests for common, complex diseases, such as Alzheimer's disease (AD), raises questions about what people are willing to pay for these services...
  25. pmc A comprehensive genetic association study of Alzheimer disease in African Americans
    Mark W Logue
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 68:1569-79. 2011
    ..To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites...
  26. pmc Test-retest stability on the WRAT-3 reading subtest in geriatric cognitive evaluations
    Lee Ashendorf
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
    J Clin Exp Neuropsychol 31:605-10. 2009
    ..Results indicated that WRAT-3 Reading scores are appropriate for use with older adults, though the use of categorical descriptors to describe premorbid ability based on these scores is not supported...
  27. pmc A new scale measuring psychologic impact of genetic susceptibility testing for Alzheimer disease
    Winston W Chung
    Boston University School of Medicine, 715 Albany Street, R 7800, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 23:50-6. 2009
    ....
  28. ncbi request reprint Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer's disease
    David H Tsai
    Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    J Neuropsychiatry Clin Neurosci 18:384-8. 2006
    ..Clinicians counseling family members of Alzheimer's disease patients who express subjective memory complaint should first evaluate cognition. If cognition is intact, depression should be considered...
  29. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  30. pmc The Framingham Brain Donation Program: neuropathology along the cognitive continuum
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Curr Alzheimer Res 9:673-86. 2012
    ..We observed that an aggregate ischemic injury score was significantly higher in persons with a CDR score of 0.5 than in normal controls...
  31. pmc Perceptions of familial risk in those seeking a genetic risk assessment for Alzheimer's disease
    Susan Hiraki
    Dept of Neurology, Boston University School of Medicine, Boston, MA, USA
    J Genet Couns 18:130-6. 2009
    ..001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease...
  32. ncbi request reprint Polymorphisms in the PON gene cluster are associated with Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 15:77-85. 2006
    ..The most significantly associated haplotype comprised SNPs in the region spanning the -161[C/T] SNP (P=0.00009). Our results demonstrate association between AD and variants in the PON gene cluster in Caucasians and African Americans...
  33. pmc Clock drawing performance in cognitively normal elderly
    Emily J Hubbard
    Alzheimer s Disease Clinical and Research Program, Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Arch Clin Neuropsychol 23:295-327. 2008
    ..Our results may serve as useful comparisons for clinicians wishing to know whether their patients perform in the general range of cognitively normal elderly...
  34. pmc The beliefs, motivations, and expectations of parents who have enrolled their children in a genetic biorepository
    Erin D Harris
    Department of Medicine, Division of Genetics and Program in Genomics, Children s Hospital Boston, Boston, Massachusetts, USA
    Genet Med 14:330-7. 2012
    ..The aim of this study was to understand the views of the parents who enrolled their children in a genomic repository in which IRRs will be returned...
  35. ncbi request reprint Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease
    J Scott Roberts
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Alzheimer Dis Assoc Disord 17:86-93. 2003
    ..3, p < 0.01). Findings suggest that genetic susceptibility testing is of interest to individuals at risk for AD for a variety of reasons, even in the relative absence of available treatments...
  36. ncbi request reprint Genetic susceptibility for Alzheimer's disease: why did adult offspring seek testing?
    Ann C Hurley
    Brigham and Women s Hospital, Center for Excellence in Nursing Practice, and School of Nursing, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts, USA
    Am J Alzheimers Dis Other Demen 20:374-81. 2005
    ....
  37. pmc ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 15:565-74. 2013
    ....
  38. pmc Design of a randomized trial of diabetes genetic risk testing to motivate behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for Diabetes Prevention
    Richard W Grant
    Division of General Medicine, Massachusetts General Hospital, Boston, MA, USA
    Clin Trials 8:609-15. 2011
    ..The efficacy of diabetes genetic risk testing to motivate behavior change for diabetes prevention is currently unknown...
  39. pmc Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    Agustin G Yip
    Department of Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston MA 02118 2526, USA
    BMC Geriatr 5:2. 2005
    ..We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-epsilon4 carrier status and ethnicity...
  40. ncbi request reprint Differences between African Americans and whites in their perceptions of Alzheimer disease
    J Scott Roberts
    Department of Neurology, Boston University School of Medicine, Massachusetts, USA
    Alzheimer Dis Assoc Disord 17:19-26. 2003
    ..Health psychologic research suggests that such differences in illness perceptions could shape response to disease burden, assessment and diagnosis, and available health care options...
  41. pmc The adult galactosemic phenotype
    Susan E Waisbren
    Children s Hospital Boston, Boston, MA, USA
    J Inherit Metab Dis 35:279-86. 2012
    ..Data on how individuals with galactosemia fare as adults will improve our ability to predict disease progression...
  42. pmc Exploring concordance and discordance for return of incidental findings from clinical sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 14:405-10. 2012
    ..The aim of this study was to explore specific conditions and types of genetic variants that specialists in genetics recommend should be returned as incidental findings in clinical sequencing...
  43. pmc Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility
    Christopher A Cassa
    Children s Hospital Informatics Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Genome Res 22:421-8. 2012
    ..Additionally, if the growth rate from the previous 4 yr continues, we estimate that the total number of disease-associated variants will grow 37% over the next 4 yr...
  44. pmc Navigating a research partnership between academia and industry to assess the impact of personalized genetic testing
    Lisa Soleymani Lehmann
    Department of Medicine and Center for Bioethics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Genet Med 14:268-73. 2012
    ....
  45. pmc Cognitive correlates of HVOT performance differ between individuals with mild cognitive impairment and normal controls
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Robinson Complex, Suite 7800, 715 Albany Street, Boston, MA 02118 2526, USA
    Arch Clin Neuropsychol 21:405-12. 2006
    ....
  46. pmc Genome-wide association study of the rate of cognitive decline in Alzheimer's disease
    Richard Sherva
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA Electronic address
    Alzheimers Dement 10:45-52. 2014
    ..We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition...
  47. pmc Management of incidental findings in clinical genomic sequencing
    Joel B Krier
    Harvard Medical School Genetics Training Program, Boston, MA, USA
    Curr Protoc Hum Genet . 2013
    ..The unit focuses on the clinical aspects of handling incidental findings, with an emphasis on the key role of clinical context in defining incidental findings and determining their clinical relevance and utility...
  48. pmc Genetic susceptibility testing for chronic disease and intention for behavior change in healthy young adults
    Jason L Vassy
    Section of General Internal Medicine, VA Boston Healthcare System, 150 Huntington Avenue, Bldg 9, STE 425, Boston, MA, 02130, USA
    J Community Genet 4:263-71. 2013
    ..To be effective, genetic risk testing in young adults may need to be coupled with other strategies to enable behavior change...
  49. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  50. pmc Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy
    Daniel M Jordan
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 88:183-92. 2011
    ....
  51. ncbi request reprint Epidemiology of apathy in older adults: the Cache County Study
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Geriatr Psychiatry 15:365-75. 2007
    ..The objectives of this study are to describe the distribution of apathy in community-based older adults and to investigate its relationships with cognition and day-to-day functioning...
  52. ncbi request reprint Genetic susceptibility testing versus family history-based risk assessment: Impact on perceived risk of Alzheimer disease
    Susan LaRusse
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    Genet Med 7:48-53. 2005
    ....
  53. pmc Genetic testing for Alzheimer's disease and its impact on insurance purchasing behavior
    Cathleen D Zick
    University of Utah, Salt Lake City, USA
    Health Aff (Millwood) 24:483-90. 2005
    ..If genetic testing for Alzheimer's risk assessment becomes common, it could trigger adverse selection in long-term care insurance...
  54. ncbi request reprint Differences between African Americans and Whites in their attitudes toward genetic testing for Alzheimer's disease
    Yvonne G Hipps
    Department of Pharmacology, Morehouse School of Medicine, Altanta, Georgia, USA
    Genet Test 7:39-44. 2003
    ..Future research in real-life testing situations with more representative samples will be necessary to confirm these racial and cultural differences in perceptions of genetic testing...
  55. ncbi request reprint Predictive genetic testing for Alzheimer's disease: impact upon risk perception
    Theresa M Marteau
    Psychology and Genetics Research Group, Institute of Psychiatry, King s College London, London, UK
    Risk Anal 25:397-404. 2005
    ..e., perceiving risks as equal to or lower than population risks of AD), although this possibility should be assessed in other testing contexts...
  56. pmc Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience
    Kurt D Christensen
    Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 0471, USA
    Genet Med 10:207-14. 2008
    ..To describe how investigators in a multisite randomized clinical trial addressed scientific and ethical issues involved in creating risk models based on genetic testing for African American participants...
  57. pmc Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
    Katherine A Treiber
    Department of Psychology, Utah State University, Logan, U S A
    Int Psychogeriatr 20:538-53. 2008
    ..To examine, in an exploratory analysis, the association between vascular conditions and the occurrence of neuropsychiatric symptoms (NPS) in a population-based sample of incident Alzheimer's disease (AD)...
  58. pmc Trail Making Test errors in normal aging, mild cognitive impairment, and dementia
    Lee Ashendorf
    Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States
    Arch Clin Neuropsychol 23:129-37. 2008
    ..The findings show that TMT B time and errors are independently meaningful scores, and both therefore have clinical utility in assessing individuals referred for dementia evaluations...
  59. ncbi request reprint Recall of disclosed apolipoprotein E genotype and lifetime risk estimate for Alzheimer's disease: the REVEAL Study
    Susan LaRusse Eckert
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    Genet Med 8:746-51. 2006
    ..To determine whether individuals recall their apolipoprotein E genotype and numeric lifetime risk estimates after undergoing a risk assessment for Alzheimer's disease...
  60. ncbi request reprint Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
    Abimbola Akomolafe
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Arch Neurol 63:1551-5. 2006
    ..Diabetes mellitus (DM) could increase the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between DM and the development of AD remains uncertain...
  61. pmc Education effects on cognitive function in a healthy aged Arab population
    Rivka Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Int Psychogeriatr 19:593-603. 2007
    ..We investigated the influence of gender, education and occupation in a cognitively normal community sample which was assessed using an Arabic translation of the MMSE and the BCST...
  62. ncbi request reprint Genetic susceptibility testing for Alzheimer disease: motivation to obtain information and control as precursors to coping with increased risk
    Holly C Gooding
    Division of Community Health and Human Development, University of California School of Public Health, Berkeley, CA, USA
    Patient Educ Couns 64:259-67. 2006
    ..This study investigated appraisals, including motivation, and coping preferences for undergoing Apolipoprotein E (APOE) susceptibility testing for Alzheimer disease (AD)...
  63. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006
    ....
  64. ncbi request reprint Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 13:656-64. 2005
    ..Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND)...
  65. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  66. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...
  67. pmc GINA, genism, and civil rights
    George J Annas
    Bioethics 22:ii-iv. 2008

Research Grants15

  1. Risk Evaluation and Education for Alzheimer's Disease (REVEAL IV)
    Robert C Green; Fiscal Year: 2010
    ....
  2. Risk Evaluation and Education for Alzheimer's Disease
    Robert Green; Fiscal Year: 2009
    ..This study will have an impact on public health by informing policy makers and clinicians about safe and effective ways to integrate genetic discoveries into the practice of medicine. ..
  3. Risk Evaluation and Education for Alzheimer's Disease
    Robert Green; Fiscal Year: 2007
    ..This study will have an impact on public health by informing policy makers and clinicians about safe and effective ways to integrate genetic discoveries into the practice of medicine. ..
  4. Characterizing and Communicating Genetic Risk for Alzheimer's Disease
    Robert Green; Fiscal Year: 2007
    ..This award will also help refine the candidate's own research skills in the area of genetic epidemiology and lay the groundwork for expanding the MIRAGE Study and the REVEAL Study in new directions. ..
  5. Risk Evaluation and Education for Alzheimer's Disease
    Robert Green; Fiscal Year: 2005
    ..abstract_text> ..
  6. GENETIC RISK ASSESSMENT FOR ALZHEIMER'S DISEASE
    Robert Green; Fiscal Year: 2003
    ....
  7. Impact of Direct to Consumer Genetic Testing
    Scott Roberts; Fiscal Year: 2010
    ..This study will produce results that can be translated into recommendations to guide practice and policy in this rapidly emerging area. ..