Research Topics
Genomes and Genes
Species | Daniel GottliebSummaryAffiliation: Boston University Country: USA Publications
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Detail Information
Publications
Framingham Heart Study genome-wide association: results for pulmonary function measuresJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 8:S8. 2007..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
Does snoring predict sleepiness independently of apnea and hypopnea frequency?D J Gottlieb
Department of Medicine, Boston University School of Medicine and VA Boston Healthcare System, Boston, Massachusetts, USA
Am J Respir Crit Care Med 162:1512-7. 2000..We conclude that both snoring and RDI are independently associated with excess sleepiness in community-dwelling, middle-aged and older adults...- Symptoms of sleep-disordered breathing in 5-year-old children are associated with sleepiness and problem behaviorsDaniel J Gottlieb
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
Pediatrics 112:870-7. 2003..The goal of this study was to assess the prevalence of SDB symptoms in 5-year-old children and their relation to sleepiness and problem behaviors... - Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old childrenDaniel J Gottlieb
Department of Medicine, Slone Epidemiology Center, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
J Pediatr 145:458-64. 2004..To assess the relation of sleep-disordered breathing (SDB) symptoms in children to neurocognitive function... - Association of sleep time with diabetes mellitus and impaired glucose toleranceDaniel J Gottlieb
The Pulmonary Center, Boston University School of Medicine, VA Boston Healthcare System, 715 Albany St, Mail Stop R 304, Boston, MA 02118, USA
Arch Intern Med 165:863-7. 2005.... - APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health StudyD J Gottlieb
The Pulmonary Center, Boston University School of Medicine and VA Boston Healthcare System, MA 02118 2394, USA
Neurology 63:664-8. 2004..The objective of this study was to further examine the association of the APOE epsilon4 allele with OSAH in a community-dwelling cohort, exploring age dependency of the association... - Association of usual sleep duration with hypertension: the Sleep Heart Health StudyDaniel J Gottlieb
The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
Sleep 29:1009-14. 2006..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort... - Heritability of longitudinal change in lung function. The Framingham studyD J Gottlieb
Research Service, VA Boston Healthcare System, and Department of Medicine and Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Respir Crit Care Med 164:1655-9. 2001.... 
Prevalent hypertension and stroke in the Sleep Heart Health Study: association with an ECG-derived spectrographic marker of cardiopulmonary couplingRobert Joseph Thomas
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Sleep 32:897-904. 2009..This study assesses, at a population level, the associations of this spectrographic biomarker with prevalent cardiovascular disease using the Sleep Heart Health Study (SHHS)-I dataset...- Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?Vishesh K Kapur
Department of Medicine, University of Washington, Seattle, WA, USA
Sleep 31:1127-32. 2008..We explore whether self-reported sleepiness modifies the relationship between sleep disordered breathing and prevalent hypertension... - Sleepiness in patients with moderate to severe sleep-disordered breathingVishesh K Kapur
Department of Medicine, University of Washington Sleep Disorders Center, Box 359803, 325 Ninth Avenue, Seattle, WA 98104, USA
Sleep 28:472-7. 2005..We investigated the prevalence of sleepiness as well as factors associated with sleepiness in individuals with moderate to severe sleep-disordered breathing (apnea-hypopnea index > or = 15)... - Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sampleAnjali A Patwardhan
Boston University School of Medicine, Boston, MA, USA
Sleep 29:1301-6. 2006..CONCLUSION: Lack of association of natriuretic peptides with OSAH indices suggests that undiagnosed OSAH may not be associated with major alterations in left ventricular function, as reflected in morning natriuretic peptide levels... - Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary functionJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Respir Crit Care Med 175:554-60. 2007..Previously reported linkage to FEV(1) (LOD score = 5.0) on 6q27 in the Framingham Heart Study (FHS) led us to explore a candidate gene, SMOC2, at 168.6 Mb... - Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health StudyJohn W Winkelman
Harvard Medical School, Boston, MA, USA
Sleep 32:772-8. 2009..The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS... - Genetic loci influencing lung function: a genome-wide scan in the Framingham StudyOscar Joost
Boston University School of Medicine, Boston, Massachusetts, USA
Am J Respir Crit Care Med 165:795-9. 2002..FEV1 was most influenced by the locus on chromosome 6 (logarithm of the odds favoring genetic linkage [LOD] = 2.4), whereas chromosome 21 contained markers with the strongest linkage to FVC (LOD = 2.6)... - Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health StudyHassan A Chami
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Circulation 117:2599-607. 2008..We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults... - Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health studyDaniel J Gottlieb
VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
Circulation 122:352-60. 2010..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women... - Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health studySusan Redline
Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
Am J Respir Crit Care Med 182:269-77. 2010.... - A genome-wide association study of pulmonary function measures in the Framingham Heart StudyJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
PLoS Genet 5:e1000429. 2009..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation... - Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathingHassan A Chami
Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
Vasc Med 14:351-60. 2009..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation... 
The Sleep Heart Health Study: a progress reportDaniel J Gottlieb
VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
Curr Opin Pulm Med 14:537-42. 2008..The results of longitudinal analysis are not yet available, but numerous analyses of cross-sectional data have been published. This review provides an overview of study results so far...- Association between glycemic state and lung function: the Framingham Heart StudyRobert E Walter
The Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Am J Respir Crit Care Med 167:911-6. 2003..The adverse effect of diabetes and glycemic level on pulmonary function was stronger among ever smokers than never smokers, suggesting an interaction between the level of fasting glycemia and tobacco smoking... - A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart StudyJemma B Wilk
Boston University School of Medicine, B 601, 715 Albany Street, Boston, MA 02118, USA
Am J Respir Crit Care Med 167:1528-33. 2003..0. FEV1 and FVC were suggestively linked to regions on chromosome 18 with multipoint LOD scores of 2.4 for FEV1 and 1.5 for FVC at 31 cM (D18S843) and a LOD of 2.9 for FVC at 79 cM (D18S858)... - Genome-wide association of sleep and circadian phenotypesDaniel J Gottlieb
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S9. 2007..More than 700 participants were genotyped using the Affymetrix 100K SNP GeneChip, providing a unique opportunity to assess genetic linkage and association of these traits... - Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart StudyJemma B Wilk
Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
Hum Mol Genet 12:2745-51. 2003..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)... - Polysomnography performed in the unattended home versus the attended laboratory setting--Sleep Heart Health Study methodologyConrad Iber
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Sleep 27:536-40. 2004..To compare polysomnographic recordings obtained in the home and laboratory setting... - Sleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathingHassan A Chami
The Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, R 304, Boston, MA 02118, USA
Am J Respir Crit Care Med 181:997-1002. 2010..The impact of REM-predominant sleep-disordered breathing (SDB) on sleepiness, quality of life (QOL), and sleep maintenance is uncertain... - A pilot trial of a telecommunications system in sleep apnea managementDeborah A DeMolles
VA Medical Center, Boston, MA 02130, USA
Med Care 42:764-9. 2004..The purpose of this study was to investigate the effectiveness of totally automated telephone technology in improving adherence to prescribed CPAP therapy... - Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health StudyJohn W Winkelman
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
Neurology 70:35-42. 2008..We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects... - Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health StudySinziana Seicean
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Diabetes Care 31:1001-6. 2008..To characterize the association between sleep-disordered breathing (SDB) and impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined IFG and IGT, and occult diabetes in individuals of different body habitus... - The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architectureSusan Redline
Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA
Arch Intern Med 164:406-18. 2004..Individual assessment of the effect of SDB on sleep quality needs to account for other host characteristics. Men, but not women, show evidence of poorer sleep with aging, suggesting important sex differences in sleep physiology... - Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based methodRobert Joseph Thomas
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
Sleep 30:1756-69. 2007..The objective of this study was to assess the utility of an electrocardiogram (ECG)-based cardiopulmonary coupling technique to distinguish obstructive from central or complex sleep apnea... - The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007.... - Correlates of long sleep durationSanjay R Patel
Division of Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Sleep 29:881-9. 2006..Future causal research on the effects of long sleep should include a detailed assessment of psychiatric disease and socioeconomic status... - Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health StudyTerry Young
Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
Arch Intern Med 162:893-900. 2002..Breathing pauses and obesity may be particularly insensitive for identifying SDB in older people. A better understanding of predictive factors for SDB, particularly in older adults, is needed... - Epidemiology of obstructive sleep apnea: a population health perspectiveTerry Young
Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Am J Respir Crit Care Med 165:1217-39. 2002..Primary care providers will be central to clinical approaches for addressing the burden and the development of cost-effective case-finding strategies and feasible treatment for mild obstructive sleep apnea warrants high priority... - Association between reduced sleep and weight gain in womenSanjay R Patel
Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Epidemiol 164:947-54. 2006..These data suggest that short sleep duration is associated with a modest increase in future weight gain and incident obesity. Further research is needed to understand the mechanisms by which sleep duration may affect weight... - Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health StudyNaresh M Punjabi
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
Am J Epidemiol 160:521-30. 2004..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus... - Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health StudyReena Mehra
Department of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Respir Crit Care Med 173:910-6. 2006..Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development... - The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of careElliott S Fisher
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Ann Intern Med 138:273-87. 2003..The health implications of regional differences in Medicare spending are unknown... - Detection of prostate cancer via biopsy in the Medicare-SEER population during the PSA eraH Gilbert Welch
VA Outcomes Group 111B, Department of Veterans Affairs Medical Center, White River Junction, VT 05009, USA
J Natl Cancer Inst 99:1395-400. 2007..We sought national estimates on the proportion of men found to have prostate cancer after a needle biopsy of the prostate and the risk of subsequent biopsies among those not found to have prostate cancer... - The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with careElliott S Fisher
Center for Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Ann Intern Med 138:288-98. 2003..The health implications of regional differences in Medicare spending are unknown... - Variations in the longitudinal efficiency of academic medical centersElliott S Fisher
Dartmouth Medical School in Hanover, New Hampshire, USA
Health Aff (Millwood) . 2004.... - The future risks of childhood sleep-disordered breathingDaniel J Gottlieb
Sleep 28:796-7. 2005 - Can sleep apnea be treated without modifying anatomy?Daniel J Gottlieb
N Engl J Med 353:2604-6. 2005 - Comorbidity risk-adjustment strategies are comparable among persons with hip fractureDavid C Radley
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
J Clin Epidemiol 61:580-7. 2008.... - Regional variations in health care intensity and physician perceptions of quality of careBrenda E Sirovich
Veterans Affairs Medical Center Outcomes Group, White River Junction, Vermont 05009, USA
Ann Intern Med 144:641-9. 2006.... - Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep MedicineNancy A Collop
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Clin Sleep Med 3:737-47. 2007..Negative or technically inadequate PM tests in patients with a high pretest probability of moderate to severe OSA should prompt in-laboratory polysomnography... - Analysis of observational studies in the presence of treatment selection bias: effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methodsTherese A Stukel
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
JAMA 297:278-85. 2007..Comparisons of outcomes between patients treated and untreated in observational studies may be biased due to differences in patient prognosis between groups, often because of unobserved treatment selection biases... - The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and proceduresClete A Kushida
Stanford Universit y, Stanfbrd, CA, USA
J Clin Sleep Med 2:288-300. 2006..To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea... - Cardiac pacing--a novel therapy for sleep apnea?Daniel J Gottlieb
N Engl J Med 346:444-5. 2002