I Goldstein

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Female sexual arousal disorder: new insights
    I Goldstein
    Department of Urology, Boston University School of Medicine, MA, USA
    Int J Impot Res 12:S152-7. 2000
  2. ncbi request reprint Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study
    Irwin Goldstein
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes Care 26:777-83. 2003
  3. ncbi request reprint Vasomax for the treatment of male erectile dysfunction
    I Goldstein
    Boston University School of Medicine, Department of Urology, MA, USA
    World J Urol 19:51-6. 2001
  4. ncbi request reprint Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides
    A Traish
    Department of Urology, Center for Advanced Biomedical Research, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol Res Commun 2:131-7. 1999
  5. ncbi request reprint Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Int J Impot Res 12:S26-36. 2000
  6. ncbi request reprint Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathway
    I W McAuley
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 22:623-8. 2001
  7. ncbi request reprint Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Life Sci 69:2249-56. 2001
  8. ncbi request reprint Effects of castration and androgen replacement on erectile function in a rabbit model
    A M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Endocrinology 140:1861-8. 1999
  9. ncbi request reprint Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder
    J R Berman
    Department of Urology and Biostatistics, Boston Medical Center, Boston, Massachusetts, USA
    J Sex Marital Ther 27:411-20. 2001
  10. ncbi request reprint Clinical evaluation of female sexual function: effects of age and estrogen status on subjective and physiologic sexual responses
    J R Berman
    Boston University Medical Center, MA, USA
    Int J Impot Res 11:S31-8. 1999

Detail Information

Publications95

  1. ncbi request reprint Female sexual arousal disorder: new insights
    I Goldstein
    Department of Urology, Boston University School of Medicine, MA, USA
    Int J Impot Res 12:S152-7. 2000
    ..International Journal of Impotence Research (2000) 12, Suppl 4, S152-S157...
  2. ncbi request reprint Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study
    Irwin Goldstein
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes Care 26:777-83. 2003
    ..This study evaluated the efficacy and safety of vardenafil treatment for erectile dysfunction (ED) in men with diabetes...
  3. ncbi request reprint Vasomax for the treatment of male erectile dysfunction
    I Goldstein
    Boston University School of Medicine, Department of Urology, MA, USA
    World J Urol 19:51-6. 2001
    ..Results of clinical trials with Vasomax support the concept of adrenergic-blockade as a clinically relevant mechanism in the control of penile erection...
  4. ncbi request reprint Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides
    A Traish
    Department of Urology, Center for Advanced Biomedical Research, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol Res Commun 2:131-7. 1999
    ....
  5. ncbi request reprint Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Int J Impot Res 12:S26-36. 2000
    ..These findings suggest that antagonism of alpha-adrenergic signaling enables other independent relaxatory pathways to predominate within penile trabecular smooth muscle...
  6. ncbi request reprint Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathway
    I W McAuley
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 22:623-8. 2001
    ....
  7. ncbi request reprint Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Life Sci 69:2249-56. 2001
    ..The more pronounced increase of cGMP in the presence of NO in intact cells suggests that vardenafil will be effective at lower doses than sildenafil under clinical conditions...
  8. ncbi request reprint Effects of castration and androgen replacement on erectile function in a rabbit model
    A M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Endocrinology 140:1861-8. 1999
    ..The results of this study demonstrate that androgen deprivation alters the functional responses and structure of erectile tissue...
  9. ncbi request reprint Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder
    J R Berman
    Department of Urology and Biostatistics, Boston Medical Center, Boston, Massachusetts, USA
    J Sex Marital Ther 27:411-20. 2001
    ..Double-blind, placebo-controlled studies are currently in progress to further determine efficacy of this medication for treatment of female sexual dysfunction complaints in different populations of women...
  10. ncbi request reprint Clinical evaluation of female sexual function: effects of age and estrogen status on subjective and physiologic sexual responses
    J R Berman
    Boston University Medical Center, MA, USA
    Int J Impot Res 11:S31-8. 1999
    ..We describe methodology for evaluating physiologic and subjective components of the female sexual response in the clinical setting and determine the effects of age and estrogen status on them...
  11. ncbi request reprint Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cells
    A Traish
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 12:S41-47. 2000
    ..These observations further support the concept that erectile function is a balance between contractile and relaxatory processes, which in turn regulate structure and function of the corpora cavernosa...
  12. ncbi request reprint Role of alpha adrenergic receptors in erectile function
    A Traish
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 12:S48-63. 2000
    ....
  13. ncbi request reprint Pathophysiology of prolonged penile erection associated with trazodone use
    I Saenz de Tejada
    Department of Urology, Boston University Medical Center, Massachusetts
    J Urol 145:60-4. 1991
    ..We conclude that trazodone can enhance penile erection in man and propose a mechanism related to the alpha-adrenoceptor blocking properties of trazodone by interference with the sympathetic control of penile detumescence...
  14. ncbi request reprint Novel approaches to female sexual dysfunction
    L A Berman
    Division of Urology, Boston University Medical Center, 720 Harrison Ave, Suite 606, Boston, MA 02110, USA
    Expert Opin Investig Drugs 10:85-95. 2001
    ....
  15. ncbi request reprint Female neurogenic sexual dysfunction secondary to clitoral neuropathy
    D S Sax
    Department of Urology, Boston University Medical School, 720 Harrison Ave, Boston, MA 02118, USA
    J Sex Marital Ther 27:599-602. 2001
    ..We herein present several cases of female sexual dysfunction related in part to organic neurologic pathophysiology. These cases emphasize the role of the central and peripheral nervous systems in female sexual function...
  16. ncbi request reprint Cyclic AMP modulates TGF-beta 1-induced fibrillar collagen synthesis in cultured human corpus cavernosum smooth muscle cells
    R B Moreland
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 10:159-63. 1998
    ..Since PGE1 induces cyclic AMP (cAMP) synthesis in HCC SMC, the aim of this research is to investigate the role of cAMP in the regulation of connective tissue biosynthesis in human corporal smooth muscle cells in culture...
  17. ncbi request reprint Female sexual dysfunction: anatomy, physiology, evaluation and treatment options
    J R Berman
    Department of Urology, Boston University Medical Center, Massachusetts, USA
    Curr Opin Urol 9:563-8. 1999
    ..This review addresses the etiologies and incidence of female sexual complaints, as well as new findings in the evaluation and treatment of female sexual dysfunction...
  18. ncbi request reprint Experimental models for the investigation of female sexual function and dysfunction
    K Min
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 13:151-6. 2001
    ..Data from experimental models have provided a preliminary understanding of the mechanisms of the female sexual arousal response...
  19. ncbi request reprint Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum
    I Saenz de Tejada
    Department of Urology, Boston University Medical Center, Massachusetts 02118
    Am J Physiol 261:H1078-85. 1991
    ....
  20. ncbi request reprint O2-dependent prostanoid synthesis activates functional PGE receptors on corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Heart Circ Physiol 281:H552-8. 2001
    ..These data support a role of differential O2 tension in the penis in the smooth muscle synthesis of PGE2, which in turn increases cAMP synthesis via EP2 receptors...
  21. ncbi request reprint Pharmacotherapy or psychotherapy?: effective treatment for FSD related to unresolved childhood sexual abuse
    L A Berman
    Department of Urology, UCLA Medical Center, 924 Westwood Ave 520, Los Angeles, CA 90024, USA
    J Sex Marital Ther 27:421-5. 2001
    ..Trends were calculated comparing women with and without unresolved CSA history. A minority of women with CSA responded positively to sildenafil...
  22. ncbi request reprint Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility
    N N Kim
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Int J Impot Res 16:43-50. 2004
    ..These observations suggest that steroid hormones may be important regulators of vaginal tissue structure and contractility...
  23. ncbi request reprint Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vagina
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Int J Impot Res 15:397-404. 2003
    ..We suggest that changes in vaginal blood flow and compliance may depend on the endocrine status and the levels of circulating androgens and estrogens...
  24. ncbi request reprint Lower extremity above-knee prosthesis-associated erectile dysfunction
    R Munarriz
    Boston University School of Medicine, Department of Urology, Massachusetts, USA
    Int J Impot Res 15:290-2. 2003
    ..Further research is needed in above-knee prosthesis design to prevent erectile dysfunction...
  25. ncbi request reprint Female sexual dysfunction
    J R Berman
    Center for Female Sexual Medicine, Department of Urology, University of California Los Angeles Medical Center, Los Angeles, California, USA
    Urol Clin North Am 28:405-16. 2001
    ....
  26. ncbi request reprint Hemodynamic evaluation of the female sexual arousal response in an animal model
    K Min
    Department of Urology, Boston University School of Medicine, 700 Albany Street, W607, Boston, MA 02118, USA
    J Sex Marital Ther 27:557-65. 2001
    ....
  27. ncbi request reprint Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options
    J R Berman
    Women s Sexual Health Clinic, Department of Urology, Boston University School of Medicine, MA, USA
    Eur Urol 38:20-9. 2000
    ..Therapy aimed at restoring hormone levels as well as genital blood flow will be discussed...
  28. ncbi request reprint The 'effectiveness' scale--therapeutic outcome of pharmacologic therapies for ED: an international consensus panel report
    C Carson
    Department of Urology, University of North Carolina, Chapel Hill, North Carolina, USA
    Int J Impot Res 16:207-13. 2004
    ..The concept of 'treatment effectiveness' is proposed as a new 'umbrella concept' or distal outcome to be evaluated...
  29. ncbi request reprint Functional prostaglandin E (EP) receptors in human penile corpus cavernosum
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Int J Impot Res 15:362-8. 2003
    ..Thus, we suggest that the ultimate response in erectile tissue to various prostanoids is the integration of responses elicited by individual EP receptor subtypes to a given ligand...
  30. ncbi request reprint A double-blind, placebo-controlled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction
    I Goldstein
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Urology 57:301-5. 2001
    ..No significant changes in vital signs were noted. CONCLUSIONS: Topiglan applied to the glans penis increased penile rigidity and expectations regarding vaginal penetration in patients with erectile dysfunction...
  31. ncbi request reprint Improving the accuracy of vascular testing in impotent men: correcting hemodynamic alterations using a vasoactive medication re-dosing schedule
    J P Mulhall
    Loyola University Medical Center, Stritch School of Medicine, Boston, Massachusetts, USA
    J Urol 166:923-6. 2001
    ..In this way a false diagnosis of venous leakage may be avoided in a significant number of cases...
  32. ncbi request reprint Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism
    R Berger
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 13:S39-43. 2001
    ..Critical areas to be addressed include the multiple pathophysiologies of priapism as well as multi-institutional trials to objectively assess safety and efficacy in the various treatment modalities...
  33. pmc Possible role of Na(+)-K(+)-ATPase in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide
    S Gupta
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Br J Pharmacol 116:2201-6. 1995
    ..They also suggest that stimulation of Na+-K+-ATPase activity plays an important role in NO-induced relaxation of HCC smooth muscle..
  34. ncbi request reprint Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Int J Impot Res 14:446-52. 2002
    ..These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function...
  35. pmc Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Eur Urol 52:54-70. 2007
    ....
  36. ncbi request reprint Women's sexual function improves when partners are administered vardenafil for erectile dysfunction: a prospective, randomized, double-blind, placebo-controlled trial
    Irwin Goldstein
    J Sex Med 2:819-32. 2005
    ..There are limited data concerning the sexual function of women whose male partners receive pharmacological treatment for erectile dysfunction (ED)...
  37. ncbi request reprint Practical aspects in the management of vaginal atrophy and sexual dysfunction in perimenopausal and postmenopausal women
    Irwin Goldstein
    J Sex Med 2:154-65. 2005
    ..Vaginal atrophy is an important contributor to postmenopausal sexual dysfunction...
  38. ncbi request reprint Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
    John B Kostis
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Am J Cardiol 96:313-21. 2005
    ..Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended...
  39. ncbi request reprint The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: results of a randomized controlled trial with vardenafil
    Raymond Rosen
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    J Sex Med 4:1009-21. 2007
    ..The ED Treatment Satisfaction Scale (TSS) is a brief, comprehensive self-report measure of patient and partner satisfaction...
  40. ncbi request reprint Patient education series. Erectile dysfunction
    Jean H Lewis
    Erectile Dysfunction Clinic, Veterans Affairs Medical Center, Minneapolis, MN, USA
    Nursing 35:64. 2005
  41. ncbi request reprint Erectile dysfunction in primary care
    Jean H Lewis
    Erectile Dysfunction Clinic, Veterans Affairs Medical Center Minneapolis, MN, USA
    Nurse Pract 29:42-6, 48-50, 55; quiz 55-7. 2004
  42. ncbi request reprint Bicycle riding, perineal trauma, and erectile dysfunction: data and solutions
    Irwin Goldstein
    San Diego Sexual Medicine, Alvarado Hospital, 6655 Alvarado Road, San Diego, CA 92120, USA
    Curr Urol Rep 8:491-7. 2007
    ....
  43. doi request reprint Growing up and seeking guidance
    Irwin Goldstein
    J Sex Med 5:1515-7. 2008
  44. ncbi request reprint Modulation of rat vaginal blood flow and estrogen receptor by estradiol
    Soo Woong Kim
    Department of Urology, Seoul National University College of Medicine, Seoul, Korea
    J Urol 172:1538-43. 2004
    ..The effects of subphysiological and physiological levels of estradiol on vaginal blood flow and estrogen receptor were investigated...
  45. ncbi request reprint The role of sex steroid hormones in female sexual function and dysfunction
    Irwin Goldstein
    Institute for Sexual Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Obstet Gynecol 47:471-84. 2004
  46. ncbi request reprint Bicycle riding and erectile dysfunction: an increase in interest (and concern)
    Vincent Huang
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Boston, MA 02118, USA
    J Sex Med 2:596-604. 2005
    ..In the previous 18 years, there have been 14 such studies...
  47. ncbi request reprint Only the nose knows: penile hemodynamic study of the perineum-saddle interface in men with erectile dysfunction utilizing bicycle saddles and seats with and without nose extensions
    Ricardo Munarriz
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Suite 600, Boston, MA 02118, USA
    J Sex Med 2:612-9. 2005
    ..To investigate the differential impact of straddles (A(ns) and B(ns)) and noseless two-cheek seats (A(ntcs) and B(ntcs)) on penile hemodynamics and perineal compressive forces in subjects who cycle in a stationary bicycle...
  48. ncbi request reprint Efficacy and safety of tadalafil in men with erectile dysfunction with a high prevalence of comorbid conditions: results from MOMENTUS: multiple observations in men with erectile dysfunction in National Tadalafil Study in the US
    Irwin Goldstein
    Milton, MA 02186, USA
    J Sex Med 4:166-75. 2007
    ..Limited efficacy and safety data exist from open-label clinical trials of phosphodiesterase 5 inhibitors in men with erectile dysfunction (ED) and multiple comorbid (MCM) conditions, historically a difficult group to treat...
  49. ncbi request reprint Validation of the erection hardness score
    John P Mulhall
    Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Sex Med 4:1626-34. 2007
    ..Erection hardness is a fundamental component of erectile function, and is a very specific and easily monitored outcome. The Erection Hardness Score (EHS) is a single-item, patient-reported outcome (PRO) for scoring erection hardness...
  50. ncbi request reprint Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomized, double-blind, pooled crossover study
    Eusebio Rubio-Aurioles
    Asociacion Mexicana para la Salud Sexual AC, Tlalpan, Mexico
    J Sex Med 3:1037-49. 2006
    ....
  51. ncbi request reprint Management of ischemic priapism with high-dose intracavernosal phenylephrine: from bench to bedside
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 3:918-22. 2006
    ..We determined the effect of acidosis on ligand dissociation from adrenergic receptors and assessed the efficacy of high-dose phenylephrine in treating patients with acute ischemic priapism...
  52. ncbi request reprint Differential regulation of the expression of estrogen, progesterone, and androgen receptors by sex steroid hormones in the vagina: immunohistochemical studies
    Monica A Pessina
    Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 3:804-14. 2006
    ..The goal of this study was to assess changes in steroid hormone receptor expression and distribution in response to sex steroid hormone deprivation and administration...
  53. pmc Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers
    Noel N Kim
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, USA
    BMC Physiol 6:4. 2006
    ..We further related these changes with estrogen receptor alpha (ERalpha) and androgen receptor (AR) expression...
  54. ncbi request reprint Erectile dysfunction: monitoring response to treatment in clinical practice--recommendations of an international study panel
    John Mulhall
    Department of Urology, Weill Medical College of Cornell University, Department of Urology, Memorial Sloan Kettering Cancer Center New York, NY, USA
    J Sex Med 4:448-64. 2007
    ..Clinical practice guidelines for management of erectile dysfunction (ED) provide limited direction in defining appropriate treatment goals with phosphodiesterase type 5 (PDE5) inhibitor therapy...
  55. ncbi request reprint Physiology of female sexual function: animal models
    Annamaria Giraldi
    Rigshospitalet, Copenhagen, Denmark
    J Sex Med 1:237-53. 2004
    ..Data concerning the physiology of desire, arousal, and orgasm in women are limited because of ethical constraints. Aim. To gain knowledge of physiology of female sexual function through animal models...
  56. ncbi request reprint Testosterone increases blood flow and expression of androgen and estrogen receptors in the rat vagina
    Abdulmaged M Traish
    Departments of Biochemistry, and Urology, Boston University School of Medicine, Boston, MA, USA
    J Sex Med 4:609-19. 2007
    ..The mechanisms by which testosterone modulates female genital sexual arousal responses are poorly understood...
  57. ncbi request reprint A three-dimensional theoretical model of the relationship between cavernosal expandability and percent cavernosal smooth muscle
    Haibiao Luo
    Department of Aerospace and Mechanical Engineering, College of Engineering, Boston University, Boston, MA, USA
    J Sex Med 4:644-5; discussion 651-55. 2007
    ....
  58. ncbi request reprint Improving the sexual quality of life of couples affected by erectile dysfunction: a double-blind, randomized, placebo-controlled trial of vardenafil
    William A Fisher
    Department of Psychology, Social Science Centre 6430, University of Western Ontario, London, Ontario, Canada N6A 5C2
    J Sex Med 2:699-708. 2005
    ....
  59. ncbi request reprint Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction
    Noel N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 23:76-83. 2002
    ..The disparity between the laboratory and clinical studies suggests that there may be differences between species with regard to the role of endothelin in erectile function...
  60. ncbi request reprint Biology of female sexual function
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Suite 606, Boston, MA 02118, USA
    Urol Clin North Am 29:685-93. 2002
    ....
  61. ncbi request reprint Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model
    Kweonsik Min
    Department of Biochemistry, Boston University School of Medicine, Mass, USA
    Am J Obstet Gynecol 187:1370-6. 2002
    ..Our purpose was to investigate the effects of ovariectomy and estradiol and testosterone treatment on sildenafil- induced changes in genital hemodynamics and vaginal lubrication...
  62. ncbi request reprint Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina
    Noel N Kim
    Department of Urology, School of Medicine, Boston University, 700 Albany St W607, Boston, MA 02118, USA
    Life Sci 71:2909-20. 2002
    ..Thus, vaginal tissue expresses functional alpha-1 and alpha-2 AR, which modulate vaginal smooth muscle contractility and genital engorgement...
  63. ncbi request reprint Biochemical and physiological mechanisms of female genital sexual arousal
    Abdulmaged M Traish
    Arch Sex Behav 31:393-400. 2002
    ..A comprehensive and integral understanding of female sexual function requires detailed investigation of the vascular, neurological (central and peripheral), and structural components of this complex physiological process...
  64. ncbi request reprint Role of androgens in female genital sexual arousal: receptor expression, structure, and function
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Massachusetts, Boston 02118, USA
    Fertil Steril 77:S11-8. 2002
    ..In this article, we review the mechanisms of androgen action and discuss new data on the effects of androgens in vaginal and clitoral tissues...
  65. ncbi request reprint Efficacy of vardenafil and sildenafil in facilitating penile erection in an animal model
    Seong Choi
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 23:332-7. 2002
    ..On the basis of the biochemical data and physiological responses from this study, further clinical evaluation of vardenafil as treatment for erectile dysfunction is warranted...
  66. ncbi request reprint Oral sildenafil in the treatment of erectile dysfunction. 1998
    Irwin Goldstein
    J Urol 167:1197-203; discussion 1204. 2002
  67. ncbi request reprint Androgens in female genital sexual arousal function: a biochemical perspective
    Abdulmaged M Traish
    Departments of Biochemistry and Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Sex Marital Ther 28:233-44. 2002
    ..Androgens modulate the growth and function of female genital sexual organs included the labia, vagina, and clitoris. This article discusses the potential role for androgens in facilitating female genital sexual arousal...
  68. ncbi request reprint The prevalence of phimosis of the clitoris in women presenting to the sexual dysfunction clinic: lack of correlation to disorders of desire, arousal and orgasm
    Ricardo Munarriz
    Center for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Sex Marital Ther 28:181-5. 2002
    ..Other than its link to sexual pain, the clinical significance of this finding, in particular the relation to diminished sensitivity and impaired orgasmic capability, is unclear at this time...
  69. ncbi request reprint Characteristics of female patients with sexual dysfunction who also had a history of blunt perineal trauma
    Ricardo Munarriz
    Center for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Sex Marital Ther 28:175-9. 2002
    ..A neurogenic form of sexual dysfunction has been implicated, with primary complaints of orgasm disorder and abnormalities noted on genital sensory testing. Further research in this area is needed...
  70. ncbi request reprint Laser oximetry: A novel noninvasive method to determine changes in penile hemodynamics in an anesthetized rabbit model
    Seong Choi
    Department of Urology, Kosin University School of Medicine, Pusan, South Korea
    J Androl 23:278-83. 2002
    ..Its sensitivity in detecting small changes in oxyhemoglobin concentration and its noninvasive nature make it advantageous over invasive methods such as ICP monitoring and laser Doppler flowmetry...
  71. ncbi request reprint Penile revascularization for treatment of erectile dysfunction secondary to blunt perineal trauma
    Ricardo M Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 61:222-3. 2003
  72. ncbi request reprint Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits
    Kweonsik Min
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Fertil Steril 79:393-8. 2003
    ..To determine the expression of P2Y(2) receptors in vaginal and cervical tissues and the effects of P2Y(2) receptor agonists INS45973 and INS365 on vaginal moisture...
  73. ncbi request reprint A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model
    Ricardo Munarriz
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, 720 Harrison Ave, Suite 600, Boston, Massachusetts 02118, USA
    J Urol 170:S40-4; discussion S44-5. 2003
    ..We review contemporary scientific data concerning the physiology and pharmacology of peripheral female genital arousal responses in the animal (rabbit and rat) model...
  74. ncbi request reprint Erectile dysfunction
    Jean H Lewis
    ED Clinic, Veterans Affairs Medical Center, Minneapolis, MN, USA
    Am J Nurs 103:48-57; quiz 57-8. 2003
  75. ncbi request reprint Cocaine and ephedrine-induced priapism: case reports and investigation of potential adrenergic mechanisms
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:187-92. 2003
    ..However, the effects of cocaine and ephedrine on adrenergic regulation of cavernosal tissue and the potential role of sympathetic dysregulation in the development of priapism have not been studied...
  76. ncbi request reprint Binding characteristics of [3H]delta(5)-androstene-3beta,17beta-diol to a nuclear protein in the rabbit vagina
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, 700 Albany Street, Room W607, Boston, MA 02118, USA
    Steroids 69:71-8. 2004
    ..These data suggest that rabbit vaginal tissue expresses a novel binding protein which specifically binds delta(5)-androstene-3beta,17beta-diol and is distinct from the androgen and estrogen receptors...
  77. ncbi request reprint A prospective duplex Doppler ultrasonographic study in women with sexual arousal disorder to objectively assess genital engorgement induced by EROS therapy
    Ricardo Munarriz
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Sex Marital Ther 29:85-94. 2003
    ..This study shows that EROS therapy is associated with significant increases in clitoral and corpus spongiosum diameter as well as with clitoral and corpus spongiosum peak systolic and end-diastolic velocity values...
  78. ncbi request reprint Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model
    Kweonsik Min
    Department of Urology, Inje University School of Medicine, Pusan, South Korea
    J Sex Marital Ther 29:77-84. 2003
    ..Estrogen replacement normalized lubrication values and tissue wet weight to control levels. In conclusion, vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement...
  79. ncbi request reprint Effects of medical or surgical castration on erectile function in an animal model
    Abdulmaged M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 24:381-7. 2003
    ..We conclude that androgen deprivation produces structural alterations in the corpus cavernosum leading to corporal veno-occlusive dysfunction...
  80. ncbi request reprint An in vivo rat model to investigate female vaginal arousal response
    Soo Woong Kim
    Department of Urology, Seoul National University College of Medicine, Seoul, Korea
    J Urol 171:1357-61. 2004
    ..We established a rat model to investigate the female vaginal arousal response and the role of the nitric oxide (NO) pathway on vaginal blood flow in vivo...
  81. ncbi request reprint Androgen replacement therapy with dehydroepiandrosterone for androgen insufficiency and female sexual dysfunction: androgen and questionnaire results
    Ricardo Munarriz
    Boston University School of Medicine, Boston, Massachusetts, USA
    J Sex Marital Ther 28:165-73. 2002
    ..However, further research is needed, including prospective, multi-institution, placebo-controlled double-blind studies...
  82. ncbi request reprint A clinical paradigm for the combined management of androgen insufficiency and erectile dysfunction
    Irwin Goldstein
    Sexual Medicine, Alvarado Hospital, 5555 Reservoir Drive, Suite 203, San Diego, CA 92120, USA
    Endocrinol Metab Clin North Am 36:435-52. 2007
    ..This article focuses on a rational, evidence based clinical management paradigm that combines diagnosis and treatment of men who have androgen insufficiency and erectile dysfunction...
  83. ncbi request reprint Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:760-4. 2003
    ..Data are limited concerning reperfusion injury of ischemic erectile tissue associated with reactive oxygen species (ROS) and the potential role of ROS scavengers in the clinical therapy of ischemic priapism...
  84. doi request reprint Sexual dysfunction: looking beyond the obvious
    Irwin Goldstein
    J Sex Med 5:1-3. 2008
  85. ncbi request reprint Current management strategies of the postmenopausal patient with sexual health problems
    Irwin Goldstein
    The Journal of Sexual Medicine, Milton, MA, USA
    J Sex Med 4:235-53. 2007
    ..Sexual health concerns of menopausal women include decreases in sexual interest, arousal, lubrication, and orgasm, and increases in sexual pain, all of which may be associated with distress...
  86. ncbi request reprint Genital duplex Doppler ultrasonography before and after sexual stimulation in women with sexual dysfunction: gray scale, volumetric, and hemodynamic findings
    Sandra Garcia
    Institute of Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, MA 02118, USA
    Fertil Steril 83:995-9. 2005
    ..To report gray scale, volumetric, and duplex ultrasound data before and after sexual stimulation in a large population of women with sexual dysfunction...
  87. ncbi request reprint That's one small step for medicine, one giant leap for sexual medicine
    Irwin Goldstein
    J Sex Med 4:255-6. 2007
  88. ncbi request reprint Sexual experience of female partners of men with erectile dysfunction: the female experience of men's attitudes to life events and sexuality (FEMALES) study
    William A Fisher
    Department of Psychology, Social Science Centre 6430, University of Western Ontario, London, Ontario, Canada N6A 5C2
    J Sex Med 2:675-84. 2005
    ..Much research has explored the experience of erectile dysfunction (ED) among men with ED, but far less attention has been paid to the perceptions and sexual experiences of the female partners of men with ED...
  89. ncbi request reprint Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrity
    Monica A Pessina
    Department of Anatomy and Neurobiology, Institute for Sexual Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Endocrinology 147:61-9. 2006
    ..Present observations also suggest that combined replacement regimens may be required for an optimal physiological response...
  90. ncbi request reprint The Journal of Sexual Medicine in 2007: the electronic age
    Irwin Goldstein
    J Sex Med 4:1-3. 2007
  91. ncbi request reprint Addressing both genders in sexual medicine diagnosis and treatment
    Irwin Goldstein
    J Sex Med 3:949-51. 2006
  92. ncbi request reprint The power of the written word
    Irwin Goldstein
    J Sex Med 3:379-81. 2006
  93. ncbi request reprint Dose-response relationship between testosterone and erectile function: evidence for the existence of a critical threshold
    Abdullah Armagan
    Department of Urology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
    J Androl 27:517-26. 2006
    ..However, different androgen-dependent tissues may exhibit varying sensitivities to circulating testosterone with regard to growth and function...
  94. ncbi request reprint Sexual medicine treatment: lifestyle or life quality? The import of language
    Irwin Goldstein
    J Sex Med 3:191-3. 2006
  95. ncbi request reprint Female sexuality and sexual dysfunction
    Irwin Goldstein
    Arch Sex Behav 31:391. 2002