Noyan Gokce

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients
    Noyan Gokce
    Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:266-8. 2005
  2. ncbi request reprint L-arginine and hypertension
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 134:2807S-2811S; discussion 2818S-2819S. 2004
  3. pmc Long-term successful weight loss improves vascular endothelial function in severely obese individuals
    Sherman J Bigornia
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:754-9. 2010
  4. pmc Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity
    Melissa G Farb
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:232-7. 2011
  5. pmc Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
    Naomi M Hamburg
    Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:2650-6. 2007
  6. pmc Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
    X Julia Xu
    Diabetes and Metabolism Unit, Section of Endocrinology, Boston University School of Medicine, Boston, MA 02118, USA
    J Lipid Res 53:792-801. 2012
  7. pmc The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors
    William B Chung
    Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:606-12. 2009
  8. pmc Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease
    Craig J McMackin
    Evans Department of Medicine and Whitaker Cardovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Clin Hypertens (Greenwich) 9:249-55. 2007
  9. ncbi request reprint Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:310-5. 2003
  10. pmc Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects
    Caroline M Apovian
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 28:1654-9. 2008

Research Grants

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients
    Noyan Gokce
    Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:266-8. 2005
    ..These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction...
  2. ncbi request reprint L-arginine and hypertension
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 134:2807S-2811S; discussion 2818S-2819S. 2004
    ..In view of the rising prevalence of hypertension, randomized human clinical studies investigating the potential therapeutic role of L-arginine may be warranted...
  3. pmc Long-term successful weight loss improves vascular endothelial function in severely obese individuals
    Sherman J Bigornia
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:754-9. 2010
    ..The results also demonstrate that metabolic changes in association with weight loss are stronger determinants of vascular phenotype than degree of weight reduction...
  4. pmc Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity
    Melissa G Farb
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:232-7. 2011
    ..The purpose of this study was to determine whether obese individuals with reduced adipose tissue inflammation exhibit a more favorable cardiovascular risk profile...
  5. pmc Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
    Naomi M Hamburg
    Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:2650-6. 2007
    ..Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance...
  6. pmc Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
    X Julia Xu
    Diabetes and Metabolism Unit, Section of Endocrinology, Boston University School of Medicine, Boston, MA 02118, USA
    J Lipid Res 53:792-801. 2012
    ..However, most changes in gene expression appear to be depot-specific...
  7. pmc The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors
    William B Chung
    Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:606-12. 2009
    ..Recent studies have shown that the brachial artery and other peripheral arteries are enlarged in patients with risk factors and cardiovascular disease, and we tested the hypothesis that this finding represents maladaptive remodeling...
  8. pmc Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease
    Craig J McMackin
    Evans Department of Medicine and Whitaker Cardovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Clin Hypertens (Greenwich) 9:249-55. 2007
    ..Further studies are needed to confirm these findings and determine the clinical utility of alpha-lipoic acid/acetyl-L-carnitine as antihypertensive therapy...
  9. ncbi request reprint Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:310-5. 2003
    ....
  10. pmc Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects
    Caroline M Apovian
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 28:1654-9. 2008
    ..Our goal was to characterize the state of inflammation in human fat in relation to vascular function and metabolic parameters in obese individuals...
  11. pmc B lymphocytes in human subcutaneous adipose crown-like structures
    Marie E McDonnell
    Department of Medicine and Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine, Boston, MA, USA
    Obesity (Silver Spring) 20:1372-8. 2012
    ..These results indicate that in human OIR, B cells are an integral component of organized inflammation in subcutaneous fat, and defining their role will lead to a better understanding of OIR pathogenesis and potentially impact treatment...
  12. ncbi request reprint Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 41:1769-75. 2003
    ..The goal of this study was to prospectively examine the long-term predictive value of brachial-artery endothelial dysfunction for future cardiovascular events...
  13. ncbi request reprint Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease
    Joseph A Vita
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Am J Cardiol 91:857-60. 2003
  14. pmc Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    Noriyuki Ouchi
    Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Science 329:454-7. 2010
    ..Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue...
  15. pmc Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery
    Alex L Huang
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2113-9. 2007
    ..The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied...
  16. pmc Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects
    Megan R Ruth
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University, 88 E Newton St, Suite D4400, Boston, MA 02118
    Metabolism 62:1779-87. 2013
    ..We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity...
  17. pmc Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus
    Corey E Tabit
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circulation 127:86-95. 2013
    ..We sought to establish whether similar mechanisms operate in the endothelium in human diabetes mellitus...
  18. pmc Arteriolar function in visceral adipose tissue is impaired in human obesity
    Melissa G Farb
    Boston Medical Center, 88 East Newton St, D 8, Cardiology, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 32:467-73. 2012
    ..The purpose of this study was to characterize the relationship between adipose tissue phenotype and depot-specific microvascular function in fat...
  19. pmc Relation of cumulative weight burden to vascular endothelial dysfunction in obesity
    Joshua M Arkin
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:98-101. 2008
    ..In conclusion, these results suggest that cardiovascular risks intensify with higher degrees of obesity and underscore the importance of therapeutic weight loss interventions...
  20. pmc Peripheral artery disease is associated with severe impairment of vascular function
    Soroosh Kiani
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Vasc Med 18:72-8. 2013
    ..008, p = 0.93). Our findings indicate that patients with PAD have greater impairment of vasodilator function and are consistent with the possibility that endothelial dysfunction may contribute to adverse cardiovascular prognosis in PAD...
  21. pmc The A2b adenosine receptor modulates glucose homeostasis and obesity
    Hillary Johnston-Cox
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40584. 2012
    ..We used a diet-induced obesity murine knockout model to investigate the role of this receptor in mediating metabolic homeostasis, and correlated our findings in obese patient samples...
  22. pmc Serum myeloperoxidase levels independently predict endothelial dysfunction in humans
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:1134-9. 2004
    ..We therefore hypothesized that circulating levels of myeloperoxidase would predict risk of endothelial dysfunction in human subjects...
  23. ncbi request reprint Acute effects of vasoactive drug treatment on brachial artery reactivity
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 40:761-5. 2002
    ..The goal of this study was to investigate whether concomitant therapy with vasoactive medications alters the results of noninvasive assessment of endothelial function...
  24. pmc Maladaptive enlargement of the brachial artery in severe obesity is reversed with weight loss
    Naomi M Hamburg
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Vasc Med 15:215-22. 2010
    ..Our findings demonstrate the presence of maladaptive arterial remodeling in advanced obesity that was ameliorated by significant weight loss...
  25. pmc Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    Marie Soleil Gauthier
    Diabetes and Metabolism Unit, Section of Endocrinology, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 404:382-7. 2011
    ..Whether adipose tissue AMPK dysregulation is a causal factor for the development of the inflammation and insulin resistance remains to be determined...
  26. ncbi request reprint Endothelial dysfunction in obesity: etiological role in atherosclerosis
    Melissa R Meyers
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Endocrinol Diabetes Obes 14:365-9. 2007
    ..To review studies of vascular endothelial dysfunction in obesity, discuss potential mechanisms of disease, and address the therapeutic effects of weight loss interventions on arterial health...
  27. ncbi request reprint Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Free Radic Biol Med 38:499-506. 2005
    ..Chronic dietary flavonoid status appears to relate to endothelial function, possibly suggesting that other flavonoids or polyphenolic components of tea favorably influence vascular health and risk for cardiovascular disease...
  28. pmc Insulin status and vascular responses to weight loss in obesity
    Sherman J Bigornia
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts
    J Am Coll Cardiol 62:2297-305. 2013
    ..The aim of this study was to determine whether the effects of weight loss on arterial function are differentially modified by insulin status...
  29. pmc Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:6153-60. 2010
    ....
  30. ncbi request reprint Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:124-7. 2002
    ..These findings suggest that exercise improves endothelial function in peripheral conduit arteries of patients with CAD and that the beneficial effect may be more marked in the vascular beds of the exercised limbs...
  31. ncbi request reprint Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function
    Jeffrey T Kuvin
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 91:732-5. 2003
  32. ncbi request reprint Effects of black race on forearm resistance vessel function
    David F Kahn
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 40:195-201. 2002
    ..Further studies will be required to elucidate the mechanisms and determine whether these insights will lead to more appropriately tailored management of hypertension and its complications...
  33. ncbi request reprint Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 105:1567-72. 2002
    ..However, the predictive value of brachial artery endothelial dysfunction for future cardiovascular events is unknown...
  34. ncbi request reprint The clinical implications of endothelial dysfunction
    Michael E Widlansky
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 42:1149-60. 2003
    ..This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction...
  35. pmc Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue
    Olga I Vitseva
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:932-7. 2008
    ..The aim of this study was to examine differential TLR expression and function in human adipose tissue...
  36. ncbi request reprint New scanning electron microscopic method for determination of adipocyte size in humans and mice
    Wen Guo
    Department of Medicine, Boston University School of Medicine, 650 Albany Streeet, Room 805, Boston, MA 02118, USA
    Obesity (Silver Spring) 15:1657-65. 2007
    ..To evaluate a new scanning electronic microscopic (EM) method for assessing fat cell sizes and compare fat cell size distribution in human adipose tissue from different fat depots before and after weight loss...
  37. ncbi request reprint Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
    Salomon Amar
    Department of Periodontology, Boston University School of Dental Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 23:1245-9. 2003
    ..Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown...

Research Grants10

  1. Obesity, Adipocytokines, and Endothelial Dysfunction
    Noyan Gokce; Fiscal Year: 2007
    ..In addition, the investigators bring a unique combination of expertise that will greatly enhance the project's ability to address these important clinical questions. ..
  2. Inflammation and Vascular Dysfunction in Obesity
    Noyan Gokce; Fiscal Year: 2007
    ....
  3. ENDOTHELIAL DYSFUNCTION AND PERIOPERATIVE EVENTS
    Noyan Gokce; Fiscal Year: 2004
    ..Identifying high-risk subjects with impaired vascular function may lead to potential improvement in management of these patients. ..
  4. Inflammation and Vascular Dysfunction in Obesity
    Noyan Gokce; Fiscal Year: 2010
    ....