THOMAS DAVID GILMORE

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer
    Thomas D Gilmore
    Biology Department, Boston University, Boston, MA, USA
    Cancer Treat Res 115:241-65. 2003
  2. doi request reprint Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth
    Leila Haery
    Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA
    Mol Cancer 13:29. 2014
  3. pmc Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter
    Ryan C Thompson
    Department of Biology, Boston University, Boston, MA 02215, USA
    BMC Mol Biol 14:24. 2013
  4. doi request reprint A report from the second Nematostella vectensis research conference
    Thomas D Gilmore
    Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA
    Dev Genes Evol 223:207-11. 2013
  5. doi request reprint NF-κB: where did it come from and why?
    Thomas D Gilmore
    Department of Biology, Boston University, Boston, MA 02215, USA
    Immunol Rev 246:14-35. 2012
  6. ncbi request reprint Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel
    T D Gilmore
    Department of Biology, Boston University, 5 Cummington Street, Boston, Massachusetts, MA 02215, USA
    Oncogene 20:7098-103. 2001
  7. ncbi request reprint Introduction to NF-kappaB: players, pathways, perspectives
    T D Gilmore
    Biology Department, Boston University, Boston, MA 02215, USA
    Oncogene 25:6680-4. 2006
  8. ncbi request reprint Inhibitors of NF-kappaB signaling: 785 and counting
    T D Gilmore
    Biology Department, Boston University, Boston, MA 02215, USA
    Oncogene 25:6887-99. 2006
  9. ncbi request reprint Multiple myeloma: lusting for NF-kappaB
    Thomas D Gilmore
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Cell 12:95-7. 2007
  10. doi request reprint Inhibition of NF-κB signaling as a strategy in disease therapy
    Thomas D Gilmore
    Biology Department, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Curr Top Microbiol Immunol 349:245-63. 2011

Research Grants

  1. TRANSFORMATION OF CELLS BY THE V-REL ONCOGENE
    Thomas Gilmore; Fiscal Year: 1999
  2. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2007
  3. TRANSFORMATION OF CELLS BY THE V REL ONCOGENE
    Thomas Gilmore; Fiscal Year: 2003
  4. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2009

Collaborators

  • Louis M Staudt
  • Alexander Hoffmann
  • Demetrios Kalaitzidis
  • Mei Chih Liang
  • Michael R Garbati
  • Maria Emily R Gapuzan
  • James C Sullivan
  • Daniel T Starczynowski
  • Francis S Wolenski
  • John A Porco
  • Sujata Bardhan
  • John R Finnerty
  • Leila Haery
  • Ryan C Thompson
  • Emily A Pace
  • Nikki Traylor-Knowles
  • Chaomin Li
  • Joshua R Leeman
  • Joseph G Reynolds
  • Andrew J Andrews
  • Ryan A Henry
  • Julián G Lugo-Picó
  • Iosif Vardinogiannis
  • Haley Goucher
  • Erica Dresselhaus
  • Derek J Stefanik
  • Tristan J Lubinski
  • Gökçen Alço
  • Courtney E French
  • Adam M Reitzel
  • John A Beutler
  • Diana Rosman
  • Oliver Schmah
  • Ashley D Pollock
  • Lawrence Sulak
  • John Ok
  • George A Pitoc
  • Andreas Rosenwald
  • Pavel V Yufit
  • R Eric Davis

Detail Information

Publications32

  1. ncbi request reprint The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer
    Thomas D Gilmore
    Biology Department, Boston University, Boston, MA, USA
    Cancer Treat Res 115:241-65. 2003
  2. doi request reprint Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth
    Leila Haery
    Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA
    Mol Cancer 13:29. 2014
    ..We previously demonstrated that the human DLBCL cell line RC-K8 expresses a C-terminally truncated, HAT-defective p300 protein (p300ΔC-1087), whose expression is essential for cell proliferation...
  3. pmc Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter
    Ryan C Thompson
    Department of Biology, Boston University, Boston, MA 02215, USA
    BMC Mol Biol 14:24. 2013
    ..Nevertheless, direct regulation of the human MIR155HG promoter by NF-κB has not been convincingly demonstrated previously...
  4. doi request reprint A report from the second Nematostella vectensis research conference
    Thomas D Gilmore
    Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA
    Dev Genes Evol 223:207-11. 2013
    ..In addition, research was presented on the use of Nematostella in developmental, regeneration, signal transduction, host-symbiont, and gene-environment interaction studies...
  5. doi request reprint NF-κB: where did it come from and why?
    Thomas D Gilmore
    Department of Biology, Boston University, Boston, MA 02215, USA
    Immunol Rev 246:14-35. 2012
    ....
  6. ncbi request reprint Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel
    T D Gilmore
    Department of Biology, Boston University, 5 Cummington Street, Boston, Massachusetts, MA 02215, USA
    Oncogene 20:7098-103. 2001
    ..These results are the first demonstration of a lymphoid cell malignant transforming ability for mammalian Rel/NF-kappaB transcription factors, and implicate c-Rel as a molecular target for cancer therapeutics...
  7. ncbi request reprint Introduction to NF-kappaB: players, pathways, perspectives
    T D Gilmore
    Biology Department, Boston University, Boston, MA 02215, USA
    Oncogene 25:6680-4. 2006
    ..The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-kappaB...
  8. ncbi request reprint Inhibitors of NF-kappaB signaling: 785 and counting
    T D Gilmore
    Biology Department, Boston University, Boston, MA 02215, USA
    Oncogene 25:6887-99. 2006
    ..Moreover, the therapeutic and preventative effects of many natural products may, at least in part, be due to their ability to inhibit NF-kappaB...
  9. ncbi request reprint Multiple myeloma: lusting for NF-kappaB
    Thomas D Gilmore
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Cell 12:95-7. 2007
    ..These results reveal the molecular basis for constitutive NF-kappaB activity in many MMs and further validate the NF-kappaB signaling pathway as an appropriate target for MM therapy...
  10. doi request reprint Inhibition of NF-κB signaling as a strategy in disease therapy
    Thomas D Gilmore
    Biology Department, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Curr Top Microbiol Immunol 349:245-63. 2011
    ..Finally, the rationale and strategies for inhibiting specific NF-κB subunit activity for disease therapy are discussed...
  11. ncbi request reprint The c-Rel transcription factor and B-cell proliferation: a deal with the devil
    Thomas D Gilmore
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 23:2275-86. 2004
    ..In any event, REL may provide an appropriate therapeutic target for certain human lymphoid cell malignancies...
  12. ncbi request reprint Stable expression of the avian retroviral oncoprotein v-Rel in avian, mouse, and dog cell lines
    Thomas D Gilmore
    Biology Department, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Virology 316:9-16. 2003
    ..The findings reported here are an essential first step in the development of mammalian systems to study Rel-mediated oncogenesis...
  13. ncbi request reprint Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer
    Thomas Gilmore
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Cancer Lett 181:1-9. 2002
    ..In many cases, inhibition of Rel/NF-kappa B activity reverses all or part of the malignant state. Thus, the Rel/NF-kappa B pathway has received much attention as a focal point for clinical intervention...
  14. ncbi request reprint Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype
    Maria Emily R Gapuzan
    Biology Department, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 21:2484-92. 2002
    ..Taken together, these results suggest that RelA has tumor suppressing activity under some circumstances and that RelA complexes are involved in the control of a variety of cellular properties associated with oncogenesis...
  15. pmc Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8
    Michael R Garbati
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Lett 291:237-45. 2010
    ..However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma...
  16. ncbi request reprint Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells
    Daniel T Starczynowski
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 22:6928-36. 2003
    ....
  17. ncbi request reprint Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells
    Demetrios Kalaitzidis
    Department of Biology, Boston University, 5 Cummington Street, MA 02215, USA
    Oncogene 23:7580-7. 2004
    ....
  18. ncbi request reprint Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability
    Daniel T Starczynowski
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 24:7355-68. 2005
    ..Lastly, these results suggest that similar mutations in the REL transactivation domain contribute to the development of certain human B-cell lymphomas...
  19. ncbi request reprint Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras
    Maria Emily R Gapuzan
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 24:6574-83. 2005
    ..These results suggest that RelA is a potential protein target for human tumors driven by oncogenic Ras mutations, but caution that inhibition of RelA may promote tumorigenesis in some circumstances...
  20. pmc Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation
    Michael R Garbati
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Gene Expr 14:195-205. 2008
    ..Taken together, these results do not support a role for IKK-mediated phosphorylation as means for regulating the activity of REL in vivo...
  21. ncbi request reprint The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway
    Demetrios Kalaitzidis
    Department of Biology, Boston University, 5 Cummington Street, Boston, Massachusetts, MA 02215, USA
    Oncogene 21:8759-68. 2002
    ..Nevertheless, the RC-K8 cell line is the first tumor cell line identified with mutations in genes encoding multiple proteins in the Rel/NF-kappaB signal transduction pathway...
  22. ncbi request reprint Rel homology domain-containing transcription factors in the cnidarian Nematostella vectensis
    James C Sullivan
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Dev Genes Evol 217:63-72. 2007
    ....
  23. ncbi request reprint Mutations within a conserved protein kinase A recognition sequence confer temperature-sensitive and partially defective activities onto mouse c-Rel
    Maria Emily R Gapuzan
    Biology Department, Boston University, 5 Cummington Street, Boston, MA 02215 2406, USA
    Biochem Biophys Res Commun 307:92-9. 2003
    ..Conditional and partially defective mutants such as those described herein may be useful for identifying physiological responses and genes regulated by specific Rel/NF-kappaB family members...
  24. ncbi request reprint Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase
    Mei Chih Liang
    Department of Biology, Boston University, Boston, Massachusetts, USA
    Mol Pharmacol 64:123-31. 2003
    ....
  25. ncbi request reprint The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line
    Mei Chih Liang
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Cancer Lett 241:69-78. 2006
    ..These results suggest that JD and EqM can induce apoptosis in IkappaBalpha-deficient lymphoma cells through a mechanism involving direct inhibition of transcription factor REL...
  26. pmc Characterization of the core elements of the NF-κB signaling pathway of the sea anemone Nematostella vectensis
    Francis S Wolenski
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Mol Cell Biol 31:1076-87. 2011
    ..These results indicate that NF-κB pathway proteins in Nematostella are similar to their vertebrate homologs, and these results also provide a framework for understanding the evolutionary origins of NF-κB signaling...
  27. pmc Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities
    James C Sullivan
    Department of Biology, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7311. 2009
    ..NF-kappaB proteins contain a highly conserved DNA-binding/dimerization domain called the Rel homology domain...
  28. ncbi request reprint Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity
    Mei Chih Liang
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Biochem Pharmacol 71:634-45. 2006
    ..Taken together, these results suggest that EqM inhibits growth and induces cell death in tumor cells through a mechanism that involves inhibition of NF-kappaB activity at multiple steps in the signaling pathway...
  29. pmc Alternative splicing in the NF-kappaB signaling pathway
    Joshua R Leeman
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Gene 423:97-107. 2008
    ..Moreover, some NF-kappaB alternative splicing events appear to be specific for certain diseases, and could serve as therapeutic targets or biomarkers...
  30. ncbi request reprint Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB
    Chaomin Li
    Department of Chemistry and Center for Streamlined Synthesis, Boston University, Massachusetts 02215, USA
    Org Lett 4:3267-70. 2002
    ..In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-kappaB...
  31. ncbi request reprint Transcription factor cross-talk: the estrogen receptor and NF-kappaB
    Demetrios Kalaitzidis
    Boston University, Department of Biology, 5 Cummington Street, Boston, MA 02215, USA
    Trends Endocrinol Metab 16:46-52. 2005
    ..Such cross-talk between these important regulators of the endocrine and immune systems might be exploited for the treatment of cancer and inflammatory and autoimmune diseases...
  32. ncbi request reprint Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8
    Demetrios Kalaitzidis
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Genes Chromosomes Cancer 34:129-35. 2002
    ..Furthermore, like c-Rel, c-Rel-Nrg is a cytoplasmic protein when overexpressed in fibroblasts in culture and can bind to a kappaB DNA site in vitro...

Research Grants12

  1. TRANSFORMATION OF CELLS BY THE V-REL ONCOGENE
    Thomas Gilmore; Fiscal Year: 1999
    ..Together, these experiments will serve as models for understanding the molecular mechanisms underlying the development of a subset of human lymphoid malignancies. ..
  2. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2007
    ....
  3. TRANSFORMATION OF CELLS BY THE V REL ONCOGENE
    Thomas Gilmore; Fiscal Year: 2003
    ..A long-term goal of this project will be to develop mammalian model systems for studying Rel-mediated oncogenesis, in order to more closely mimic human cancers that involve alterations in Rel transcription factor function. ..
  4. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2009
    ....