V L Gabai

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    Vladimir L Gabai
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:929-40. 2012
  2. doi HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling
    V L Gabai
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:1952-62. 2010
  3. ncbi Mechanisms of tumor cell necrosis
    Sergey Y Proskuryakov
    Dept Biochemistry, Boston University Medical School, 715 Albany St, Boston, MA 02118, USA
    Curr Pharm Des 16:56-68. 2010
  4. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
  5. doi Hsp70 in cancer: back to the future
    M Y Sherman
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 34:4153-61. 2015
  6. ncbi Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
    A B Meriin
    Boston Biomedical Research Institute, Boston, Massachusetts 02114, USA
    J Biol Chem 273:6373-9. 1998
  7. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010

Collaborators

  • Michael Y Sherman
  • L Meng
  • Sergey Y Proskuryakov
  • J A Yaglom
  • C Hunt
  • A B Meriin
  • J Yaglom
  • V I Shifrin

Detail Information

Publications7

  1. pmc Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    Vladimir L Gabai
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:929-40. 2012
    ..Therefore, in addition to OIS, Hsf1 regulates the HuR-HIF-1 pathway, thus affecting both cancer initiation and progression...
  2. doi HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling
    V L Gabai
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:1952-62. 2010
    ..The resulting strong induction of p21 precipitated senescence following exposure to DNA-damaging agents, thus accounting for higher sensitivity of cells to genotoxic stresses...
  3. ncbi Mechanisms of tumor cell necrosis
    Sergey Y Proskuryakov
    Dept Biochemistry, Boston University Medical School, 715 Albany St, Boston, MA 02118, USA
    Curr Pharm Des 16:56-68. 2010
    ..On the other hand, excessive spontaneous necrosis during tumor development may lead to more aggressive tumors due to stimulatory role of necrosis-induced inflammation on their growth...
  4. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
    ..Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways...
  5. doi Hsp70 in cancer: back to the future
    M Y Sherman
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 34:4153-61. 2015
    ..A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts. ..
  6. ncbi Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
    A B Meriin
    Boston Biomedical Research Institute, Boston, Massachusetts 02114, USA
    J Biol Chem 273:6373-9. 1998
    ..A balance between these two effects might define the fate of cells exposed to the inhibitors...
  7. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010
    ..Therefore, HSF1 is critical for proliferation of HER2-expressing cells, most likely because it maintains the levels of HSPs, which in turn control regulators of senescence p21 and survivin...