V L Gabai

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    Vladimir L Gabai
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:929-40. 2012
  2. doi HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling
    V L Gabai
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:1952-62. 2010
  3. ncbi Mechanisms of tumor cell necrosis
    Sergey Y Proskuryakov
    Dept Biochemistry, Boston University Medical School, 715 Albany St, Boston, MA 02118, USA
    Curr Pharm Des 16:56-68. 2010
  4. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
  5. ncbi Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
    A B Meriin
    Boston Biomedical Research Institute, Boston, Massachusetts 02114, USA
    J Biol Chem 273:6373-9. 1998
  6. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010

Collaborators

  • Michael Y Sherman
  • L Meng
  • Sergey Y Proskuryakov
  • C Hunt
  • J A Yaglom
  • A B Meriin
  • V I Shifrin
  • J Yaglom

Detail Information

Publications6

  1. pmc Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    Vladimir L Gabai
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:929-40. 2012
    ..Therefore, in addition to OIS, Hsf1 regulates the HuR-HIF-1 pathway, thus affecting both cancer initiation and progression...
  2. doi HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling
    V L Gabai
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:1952-62. 2010
    ..The resulting strong induction of p21 precipitated senescence following exposure to DNA-damaging agents, thus accounting for higher sensitivity of cells to genotoxic stresses...
  3. ncbi Mechanisms of tumor cell necrosis
    Sergey Y Proskuryakov
    Dept Biochemistry, Boston University Medical School, 715 Albany St, Boston, MA 02118, USA
    Curr Pharm Des 16:56-68. 2010
    ..On the other hand, excessive spontaneous necrosis during tumor development may lead to more aggressive tumors due to stimulatory role of necrosis-induced inflammation on their growth...
  4. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
    ..Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways...
  5. ncbi Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
    A B Meriin
    Boston Biomedical Research Institute, Boston, Massachusetts 02114, USA
    J Biol Chem 273:6373-9. 1998
    ..A balance between these two effects might define the fate of cells exposed to the inhibitors...
  6. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010
    ..Therefore, HSF1 is critical for proliferation of HER2-expressing cells, most likely because it maintains the levels of HSPs, which in turn control regulators of senescence p21 and survivin...