Jane Freedman

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint CD40 ligand influences platelet release of reactive oxygen intermediates
    Subrata Chakrabarti
    The Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 25:2428-34. 2005
  2. pmc Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study
    Jane E Freedman
    Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 700 Albany St, W 507, Boston, MA 02118, USA
    Circulation 122:119-29. 2010
  3. pmc The role of the blood transcriptome in innate inflammation and stroke
    Jane E Freedman
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1207:41-5. 2010
  4. doi request reprint Oxidative stress and platelets
    Jane E Freedman
    Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 28:s11-6. 2008
  5. ncbi request reprint Molecular regulation of platelet-dependent thrombosis
    Jane E Freedman
    Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, MA 02118, USA
    Circulation 112:2725-34. 2005
  6. ncbi request reprint Nitric oxide and its relationship to thrombotic disorders
    J E Freedman
    The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Haemost 1:1183-8. 2003
  7. ncbi request reprint The effect of dipyridamole on vascular cell-derived reactive oxygen species
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Pharmacol Exp Ther 315:494-500. 2005
  8. doi request reprint Neutrophil CD40 enhances platelet-mediated inflammation
    Pantila Vanichakarn
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Thromb Res 122:346-58. 2008
  9. ncbi request reprint Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates
    Olga Vitseva
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cardiovasc Pharmacol 46:445-51. 2005
  10. pmc Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release
    Sybille Rex
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, 02118 MA, USA
    Thromb Haemost 102:97-110. 2009

Detail Information

Publications43

  1. ncbi request reprint CD40 ligand influences platelet release of reactive oxygen intermediates
    Subrata Chakrabarti
    The Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 25:2428-34. 2005
    ..In this study, we examined the effect of sCD40L on platelet function and reactive oxygen and nitrogen species (RONS) generation...
  2. pmc Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study
    Jane E Freedman
    Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 700 Albany St, W 507, Boston, MA 02118, USA
    Circulation 122:119-29. 2010
    ..Quantitative differences in the abundance of transcripts has been demonstrated in malignancies, but gene expression from a large community-based cohort examining risk of cardiovascular disease has never been reported...
  3. pmc The role of the blood transcriptome in innate inflammation and stroke
    Jane E Freedman
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1207:41-5. 2010
    ..By defining these changes, new insight into cerebrovascular disease and its therapeutics is being achieved...
  4. doi request reprint Oxidative stress and platelets
    Jane E Freedman
    Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 28:s11-6. 2008
    ....
  5. ncbi request reprint Molecular regulation of platelet-dependent thrombosis
    Jane E Freedman
    Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, MA 02118, USA
    Circulation 112:2725-34. 2005
    ..However, this process is complex and influenced by a myriad of cellular and plasma-derived mediators that regulate the balance between occlusive and nonocclusive thrombosis...
  6. ncbi request reprint Nitric oxide and its relationship to thrombotic disorders
    J E Freedman
    The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Haemost 1:1183-8. 2003
    ..Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired NO release or decrease in NO bioavailability...
  7. ncbi request reprint The effect of dipyridamole on vascular cell-derived reactive oxygen species
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Pharmacol Exp Ther 315:494-500. 2005
    ..These data suggest that the redox-dependent properties of dipyridamole have a direct effect on vascular cells...
  8. doi request reprint Neutrophil CD40 enhances platelet-mediated inflammation
    Pantila Vanichakarn
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Thromb Res 122:346-58. 2008
    ..While CD40 was recently reported to be present on neutrophils, the detailed mechanism of its interaction with platelets via CD40-CD40L has not been examined...
  9. ncbi request reprint Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates
    Olga Vitseva
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cardiovasc Pharmacol 46:445-51. 2005
    ..These findings suggest potentially beneficial platelet-dependent antithrombotic and anti-inflammatory properties of purple grape-derived flavonoids...
  10. pmc Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release
    Sybille Rex
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, 02118 MA, USA
    Thromb Haemost 102:97-110. 2009
    ..In summary, stimulation of platelets by either thrombotic or immune receptors leads to markedly different signalling responses and granular protein release consistent with differential contribution to coagulation and thrombosis...
  11. ncbi request reprint Aspirin resistance: current concepts
    Peter J Mason
    Section of Cardiology, Boston University Medical Center, Boston, Massachusetts, USA
    Rev Cardiovasc Med 5:156-63. 2004
    ..The biological mechanisms, population prevalence, laboratory methods for detection, and clinical relevance of aspirin resistance are discussed in this review...
  12. ncbi request reprint Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02481, USA
    Thromb Res 113:225-33. 2004
    ..Blocking the GPIIb/IIIa receptor prevents platelet aggregation but not activation and the subsequent effect on other platelet pathways is largely unknown...
  13. ncbi request reprint Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Cardiovasc Pharmacol 50:449-57. 2007
    ....
  14. pmc Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase
    Price Blair
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston, MA 02118 2526, USA
    Circ Res 104:346-54. 2009
    ..This work substantiates the role of platelets in the immune and inflammatory response and suggests a mechanism by which bacteria could directly activate platelets...
  15. doi request reprint Dipyridamole, cerebrovascular disease, and the vasculature
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA
    Vascul Pharmacol 48:143-9. 2008
    ....
  16. doi request reprint CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease
    Muhammad Rizvi
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Mol Med 14:530-8. 2008
    ..Understanding the roles and regulation of CD40-CD40L-mediated oxidative signaling in immune and non-immune cells could facilitate the development of therapeutics targeting diverse inflammatory diseases...
  17. doi request reprint Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Immunol Lett 122:170-84. 2009
    ..In summary, we show that hypoxia can alter CD40-CD40L mediated endothelial-monocyte interaction, playing a significant role in vascular inflammation and cellular adhesion processes...
  18. pmc M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Thrombolysis 28:394-400. 2009
    ..In an animal model of vascular plaque, M118 is a potent inhibitor of arterial thrombosis and, despite lower in vivo anti-Xa and anti-IIa activity levels, M118 was superior to UFH in the prevention of arterial thrombosis...
  19. pmc The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes
    Lea M Beaulieu
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 700 Albany St, W507, Boston, MA 02118, USA
    Thromb Res 125:205-9. 2010
    ..Through TLRs, platelets go beyond hemostatic regulation and play a pivotal role in inflammation and infection...
  20. doi request reprint The role of CD40L and VEGF in the modulation of angiogenesis and inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Vascul Pharmacol 53:130-7. 2010
    ..Together, these studies reveal a new pathway by which VEGF-CD40L interactions can regulate the angiogenic and inflammatory process depending on the specific environment...
  21. doi request reprint Review: Nutriceuticals as antithrombotic agents
    Subrata Chakrabarti
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Ther 28:227-35. 2010
    ..In addition, therapeutic opportunities in the area of nutragenomics and nutraceuticals in vascular and nonvascular diseases are also discussed...
  22. ncbi request reprint CD40-40L signaling in vascular inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:18307-17. 2007
    ..Increased CD40L and MCP1 may contribute to the adherence of CD40-positive cells, such as platelets and monocytes, to the vessel wall modulating atherothrombosis...
  23. ncbi request reprint The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates
    Olga Vitseva
    Boston University School of Medicine, 715 Albany St, W507, Boston, MA 02118, USA
    J Pharmacol Exp Ther 312:1144-50. 2005
    ..This results in modest changes in platelet function and seems to be consistent with previous oncological studies demonstrating tamoxifen-dependent increase in reactive oxygen species generation...
  24. ncbi request reprint Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease
    Peter J Mason
    Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 96:1365-9. 2005
    ..In conclusion, our data demonstrate the complex nature of CD40L and highlight the distinct processes of expression, shedding, and clearance of this ligand in patient populations...
  25. ncbi request reprint Compensatory mechanisms influence hemostasis in setting of eNOS deficiency
    Mark D Iafrati
    Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 288:H1627-32. 2005
    ..Such compensatory mechanisms may partially explain the lack of spontaneous thrombosis, minimally elevated baseline blood pressure, and normal life span that are seen in animals deficient in a pivotal regulator of vascular patency...
  26. doi request reprint Facts and controversies of aspirin and clopidogrel therapy
    David P Faxon
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am Heart J 157:412-22. 2009
    ..Overall, despite the existing controversies, antiplatelet therapy with aspirin and/or clopidogrel remains a proven and essential therapeutic tool for safe and effective management of atherothrombotic risk in specific clinical settings...
  27. ncbi request reprint Aspirin resistance in atherosclerosis
    Price Blair
    Boston University School of Medicine, 700 Albany Street, W507, Boston, MA 02118, USA
    Curr Atheroscler Rep 10:149-57. 2008
    ..Due to the multifactorial nature of cardiovascular disease, it is likely that a single therapy like aspirin cannot fully treat and prevent all thrombotic complications in the setting of atherosclerosis...
  28. ncbi request reprint The many antithrombotic actions of nitric oxide
    Constantine Tziros
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Drug Targets 7:1243-51. 2006
    ..Recently, through the development of new NO donors and by targeting specific signaling pathways, there has been an attempt to enhance the antithrombotic actions of NO as a means to manipulate arterial thrombosis...
  29. pmc Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Am Heart J 156:1003-1009.e1. 2008
    ..Circulating soluble CD40L (sCD40L) concentration predicts cardiovascular risk in selected patient samples. The purpose of this study was to determine the predictors of sCD40L in a large, community-based sample...
  30. ncbi request reprint Aspirin resistance and atherothrombotic disease
    Peter J Mason
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 46:986-93. 2005
    ..Currently, however, there are many unanswered questions regarding the biological mechanism, diagnosis, population prevalence, clinical relevance, and optimal therapeutic intervention for aspirin resistance...
  31. pmc Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases
    Elaine Lin
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Ther 27:117-23. 2009
    ..This article reviews the current experimental and clinical evidence for the role of TLRs in the cardiovascular system, and examines the mechanisms by which TLR antagonists could potentially be used in targeted therapy...
  32. ncbi request reprint CD40-CD40L and platelet function: beyond hemostasis
    Jane E Freedman
    Circ Res 92:944-6. 2003
  33. ncbi request reprint Regulation of endogenous reactive oxygen species in platelets can reverse aggregation
    Patricia Clutton
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
    Arterioscler Thromb Vasc Biol 24:187-92. 2004
    ..In addition, NO is a known potent inhibitor of platelet function. In this study, the role of PI3-kinase in the regulation of endogenous platelet NO and the relevance to platelet function was determined...
  34. ncbi request reprint Platelet-monocyte aggregates: bridging thrombosis and inflammation
    Jane E Freedman
    Circulation 105:2130-2. 2002
  35. ncbi request reprint Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol
    Jose E Tanus-Santos
    Division of Clinical Pharmacology, Georgetown University Medical School, Washington, DC, USA
    Pharmacogenetics 12:407-13. 2002
    ....
  36. ncbi request reprint CD40 ligand--assessing risk instead of damage?
    Jane E Freedman
    N Engl J Med 348:1163-5. 2003
  37. ncbi request reprint Heritability, platelet function, and aspirin: a link established but cause unknown
    Jane E Freedman
    Circulation 115:2468-70. 2007
  38. ncbi request reprint High-fat diets and cardiovascular disease: are nutritional supplements useful?
    Jane E Freedman
    J Am Coll Cardiol 41:1750-2. 2003
  39. doi request reprint Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development
    Neal S Kleiman
    Methodist DeBakey Heart Center, Houston, Texas, USA
    Platelets 19:239-51. 2008
    ....
  40. ncbi request reprint Nitrated lipids: defining their bioactivity
    Jane E Freedman
    Circ Res 91:371-2. 2002
  41. ncbi request reprint The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease
    Anne R Albers
    Arterioscler Thromb Vasc Biol 24:e179-80. 2004
  42. ncbi request reprint The aspirin resistance controversy: clinical entity or platelet heterogeneity?
    Jane E Freedman
    Circulation 113:2865-7. 2006
  43. ncbi request reprint Medication errors in acute cardiac care: An American Heart Association scientific statement from the Council on Clinical Cardiology Subcommittee on Acute Cardiac Care, Council on Cardiopulmonary and Critical Care, Council on Cardiovascular Nursing, and Co
    Jane E Freedman
    Circulation 106:2623-9. 2002

Research Grants14

  1. Gene Expression and Thrombosis in a Community Based Cohort Study
    Jane Freedman; Fiscal Year: 2007
    ..Do changes in gene expression in platelets and leukocytes predict subclinical and clinical CVD? ..
  2. eNOS Polymorphisms, Aging and Platelet Function
    Jane Freedman; Fiscal Year: 2005
    ..We have continued to examine the imoortance of this mutation to the vascular response. ..
  3. PLATELET-DERIVED NITRIC OXIDE AND HEMOSTASIS
    Jane Freedman; Fiscal Year: 2003
    ....
  4. Gene Expression and Thrombosis in a Community Based Cohort Study
    Jane E Freedman; Fiscal Year: 2010
    ..Do changes in gene expression in platelets and leukocytes predict subclinical and clinical CVD? ..