John C Fiala

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Mechanisms of amyloid plaque pathogenesis
    John C Fiala
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    Acta Neuropathol 114:551-71. 2007
  2. ncbi request reprint Mitochondrial degeneration in dystrophic neurites of senile plaques may lead to extracellular deposition of fine filaments
    John C Fiala
    Department of Health Sciences, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    Brain Struct Funct 212:195-207. 2007
  3. ncbi request reprint Reconstruct: a free editor for serial section microscopy
    J C Fiala
    Department of Biology, Boston University, Boston, MA, USA
    J Microsc 218:52-61. 2005
  4. ncbi request reprint Dendritic spine pathology: cause or consequence of neurological disorders?
    John C Fiala
    Department of Biology, Boston University, 5 Cummington Street, MA 02215, USA
    Brain Res Brain Res Rev 39:29-54. 2002
  5. ncbi request reprint Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices
    Linnaea E Ostroff
    Biology Department, Program in Neuroscience, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Neuron 35:535-45. 2002
  6. ncbi request reprint Timing of neuronal and glial ultrastructure disruption during brain slice preparation and recovery in vitro
    John C Fiala
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 465:90-103. 2003
  7. ncbi request reprint Dendritic spines do not split during hippocampal LTP or maturation
    John C Fiala
    Biology Department, Program in Neuroscience, Boston University, 5 Cummington St, Boston, Massachusetts 02215, USA
    Nat Neurosci 5:297-8. 2002
  8. pmc Extending unbiased stereology of brain ultrastructure to three-dimensional volumes
    J C Fiala
    Boston University, Boston, MA 02215, USA
    J Am Med Inform Assoc 8:1-16. 2001
  9. ncbi request reprint Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane
    James R Cooney
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 22:2215-24. 2002
  10. ncbi request reprint Cylindrical diameters method for calibrating section thickness in serial electron microscopy
    J C Fiala
    Department of Biology and Program in Neuroscience, 5 Cummington St, Boston University, Boston MA 02215, USA
    J Microsc 202:468-72. 2001

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Mechanisms of amyloid plaque pathogenesis
    John C Fiala
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    Acta Neuropathol 114:551-71. 2007
    ..The theory of amyloid plaque pathogenesis has thus come full circle, back to the intuitions of the very first researchers in the field...
  2. ncbi request reprint Mitochondrial degeneration in dystrophic neurites of senile plaques may lead to extracellular deposition of fine filaments
    John C Fiala
    Department of Health Sciences, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    Brain Struct Funct 212:195-207. 2007
    ..This progression of degeneration suggests that extracellular filaments originate inside degenerating mitochondria of neuritic diverticula, which may be a common process in diverse diseases...
  3. ncbi request reprint Reconstruct: a free editor for serial section microscopy
    J C Fiala
    Department of Biology, Boston University, Boston, MA, USA
    J Microsc 218:52-61. 2005
    ..As a flexible editor, Reconstruct can reduce the time and resources expended for serial section studies and allows a larger tissue volume to be analysed more quickly...
  4. ncbi request reprint Dendritic spine pathology: cause or consequence of neurological disorders?
    John C Fiala
    Department of Biology, Boston University, 5 Cummington Street, MA 02215, USA
    Brain Res Brain Res Rev 39:29-54. 2002
    ..More detailed studies are needed to determine the cause of spine pathology in most disorders and relationship between spine pathology and cognitive deficits...
  5. ncbi request reprint Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices
    Linnaea E Ostroff
    Biology Department, Program in Neuroscience, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Neuron 35:535-45. 2002
    ..Furthermore, coincident polyribosomes and synapse enlargement might indicate spines that are expressing long-term potentiation induced by tetanic stimulation...
  6. ncbi request reprint Timing of neuronal and glial ultrastructure disruption during brain slice preparation and recovery in vitro
    John C Fiala
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 465:90-103. 2003
    ..Submersing these slices in normal oxygenated media at 34 degrees C led to glycogen depletion, as well as increased coated vesicles and microtubule disassembly within 1 minute...
  7. ncbi request reprint Dendritic spines do not split during hippocampal LTP or maturation
    John C Fiala
    Biology Department, Program in Neuroscience, Boston University, 5 Cummington St, Boston, Massachusetts 02215, USA
    Nat Neurosci 5:297-8. 2002
  8. pmc Extending unbiased stereology of brain ultrastructure to three-dimensional volumes
    J C Fiala
    Boston University, Boston, MA 02215, USA
    J Am Med Inform Assoc 8:1-16. 2001
    ..This paper introduces a new reconstruction system and new methods for analyzing in three dimensions the location and ultrastructure of neuronal components, such as synapses, which are distributed non-randomly throughout the brain...
  9. ncbi request reprint Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane
    James R Cooney
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 22:2215-24. 2002
    ..Small vesicles did not colocalize in spines with endosomes or SER. Three-dimensional reconstructions revealed that up to 20 spines shared a recycling pool of plasmalemmal proteins rather than maintaining independent stores at each spine...
  10. ncbi request reprint Cylindrical diameters method for calibrating section thickness in serial electron microscopy
    J C Fiala
    Department of Biology and Program in Neuroscience, 5 Cummington St, Boston University, Boston MA 02215, USA
    J Microsc 202:468-72. 2001
    ..The cylindrical diameters method gives the same answer as that obtained by the minimal folds METHOD: It is preferable because it can be done in a series that has no folds that can distort and obscure the objects that are being measured...
  11. pmc Structural changes at dendritic spine synapses during long-term potentiation
    Kristen M Harris
    Synapses and Cell Signaling Program, Medical College of Georgia, Institute of Molecular Medicine and Genetics, 1120 15th Street, CB 2803, Augusta, GA 30912 2630, USA
    Philos Trans R Soc Lond B Biol Sci 358:745-8. 2003
    ..Thus, both enhanced connectivity and enlarged synapses result during LTP, with synapse enlargement being the greater effect...