M J Fenton

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis
    M J Fenton
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
    Infect Immun 65:5149-56. 1997
  2. ncbi LPS-binding proteins and receptors
    M J Fenton
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Leukoc Biol 64:25-32. 1998
  3. ncbi Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses
    T K Means
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4074-82. 2001
  4. ncbi Different Toll-like receptor agonists induce distinct macrophage responses
    B W Jones
    The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 69:1036-44. 2001
  5. ncbi PU.1 and multiple IFN regulatory factor proteins synergize to mediate transcriptional activation of the human IL-1 beta gene
    S Marecki
    Pulmonary Center and Department of Pathology, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 166:6829-38. 2001
  6. pmc Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    E Lien
    The Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 105:497-504. 2000
  7. pmc Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages
    B W Jones
    Pulmonary Centre, Boston University School of Medicine, MA 02118 2394, USA
    Ann Rheum Dis 60:iii6-12. 2001
  8. ncbi Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma
    G R Strohmeier
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:2063-70. 2001
  9. ncbi Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process
    X Yang
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 82:163-70. 2001
  10. ncbi IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition
    D G Alleva
    Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118, USA
    J Immunol 159:2941-51. 1997

Collaborators

Detail Information

Publications14

  1. pmc Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis
    M J Fenton
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
    Infect Immun 65:5149-56. 1997
    ..These studies are the first to demonstrate an autoregulatory role for IFN-gamma produced by alveolar macrophages infected in vitro with M. tuberculosis...
  2. ncbi LPS-binding proteins and receptors
    M J Fenton
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Leukoc Biol 64:25-32. 1998
    ..These knockout mice have revealed several unexpected features of LPS action in vivo. Together, these animal models may provide a means to develop and evaluate novel therapeutic approaches to the control of endotoxin shock...
  3. ncbi Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses
    T K Means
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4074-82. 2001
    ..Together, these data suggest that Mtb-induced TNF-alpha production is largely dependent on TLR signaling. In contrast, Mtb-induced NO production may be either TLR independent or mediated by TLR proteins in a MyD88-independent manner...
  4. ncbi Different Toll-like receptor agonists induce distinct macrophage responses
    B W Jones
    The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 69:1036-44. 2001
    ..Thus, different TLR proteins are still capable of activating distinct cellular responses, in spite of their shared capacities to activate NF-kappaB, AP-1, and MAP kinases...
  5. ncbi PU.1 and multiple IFN regulatory factor proteins synergize to mediate transcriptional activation of the human IL-1 beta gene
    S Marecki
    Pulmonary Center and Department of Pathology, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 166:6829-38. 2001
    ..1, IRF-4 (or ICSBP), IRF1, and IRF2. Together, our observations suggest that these factors may function together as an enhanceosome...
  6. pmc Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    E Lien
    The Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 105:497-504. 2000
    ..These data suggest that TLR4 is the central lipid A-recognition protein in the LPS receptor complex...
  7. pmc Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages
    B W Jones
    Pulmonary Centre, Boston University School of Medicine, MA 02118 2394, USA
    Ann Rheum Dis 60:iii6-12. 2001
    ..It was recently shown that stimulation of RAW264.7 murine macrophages by LPS, LAM, STF, and PIM rapidly activated NF-kappaB, AP1, and MAP kinases...
  8. ncbi Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma
    G R Strohmeier
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:2063-70. 2001
    ..Thus, LBP appears to participate in the development of Ag-induced airway reactivity and peroxynitrite production, but does not seem to be required for the development of pulmonary inflammation...
  9. ncbi Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process
    X Yang
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 82:163-70. 2001
    ..Taken together, these results point to c-Jun as a key intermediary in the activation of the expression of this gene by mediators. However, participation of motifs outside of the promoter are necessary to obtain this inducible expression...
  10. ncbi IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition
    D G Alleva
    Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118, USA
    J Immunol 159:2941-51. 1997
    ..This study demonstrates a novel dose-dependent and autocrine activity of IL-15 in Mphi regulation...
  11. ncbi Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages
    S Marecki
    Pulmonary Center, Department of Pathology, Boston University School of Medicine, MA 02118, USA
    J Immunol 163:2713-22. 1999
    ..Synergistic activation of the IL-1beta promoter by these IRF proteins and PU.1 was found to require PU.1 serine 148. Together, these data demonstrate that IRF4 and ICSBP are dichotomous regulators of transcription in macrophages...
  12. pmc Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact
    M M Wurfel
    The Rockefeller University, New York 10021, USA
    J Exp Med 186:2051-6. 1997
    ..These data suggest the presence of an LBP-independent mechanism for responding to LPS. These LBP knockout mice may provide a tool for discovering the nature of the presumed second mechanism for transferring LPS to responsive cells...
  13. ncbi Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4
    A E Medvedev
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 167:2257-67. 2001
    ..Thus, tolerance to LPS and mycobacterial components cannot be attributed solely to a decrease in TLR/MD-2 expression levels, suggesting inhibition of expression or function of other signaling intermediates...
  14. ncbi Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4
    R P Donnelly
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892
    J Immunol 145:569-75. 1990
    ..Together these findings demonstrate that the relative levels of IFN-gamma and IL-4 may profoundly influence the state of monocyte activation by differentially regulating the expression of IL-1...