Genomes and Genes
M J Fenton
Affiliation: Boston University
- Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosisM J Fenton
Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
Infect Immun 65:5149-56. 1997..These studies are the first to demonstrate an autoregulatory role for IFN-gamma produced by alveolar macrophages infected in vitro with M. tuberculosis...
- LPS-binding proteins and receptorsM J Fenton
The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
J Leukoc Biol 64:25-32. 1998..These knockout mice have revealed several unexpected features of LPS action in vivo. Together, these animal models may provide a means to develop and evaluate novel therapeutic approaches to the control of endotoxin shock...
- Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responsesT K Means
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 166:4074-82. 2001..Together, these data suggest that Mtb-induced TNF-alpha production is largely dependent on TLR signaling. In contrast, Mtb-induced NO production may be either TLR independent or mediated by TLR proteins in a MyD88-independent manner...
- Different Toll-like receptor agonists induce distinct macrophage responsesB W Jones
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
J Leukoc Biol 69:1036-44. 2001..Thus, different TLR proteins are still capable of activating distinct cellular responses, in spite of their shared capacities to activate NF-kappaB, AP-1, and MAP kinases...
- PU.1 and multiple IFN regulatory factor proteins synergize to mediate transcriptional activation of the human IL-1 beta geneS Marecki
Pulmonary Center and Department of Pathology, Boston University School of Medicine, Boston MA 02118, USA
J Immunol 166:6829-38. 2001..1, IRF-4 (or ICSBP), IRF1, and IRF2. Together, our observations suggest that these factors may function together as an enhanceosome...
- Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharideE Lien
The Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
J Clin Invest 105:497-504. 2000..These data suggest that TLR4 is the central lipid A-recognition protein in the LPS receptor complex...
- Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophagesB W Jones
Pulmonary Centre, Boston University School of Medicine, MA 02118 2394, USA
Ann Rheum Dis 60:iii6-12. 2001..It was recently shown that stimulation of RAW264.7 murine macrophages by LPS, LAM, STF, and PIM rapidly activated NF-kappaB, AP1, and MAP kinases...
- Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthmaG R Strohmeier
The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 166:2063-70. 2001..Thus, LBP appears to participate in the development of Ag-induced airway reactivity and peroxynitrite production, but does not seem to be required for the development of pulmonary inflammation...
- Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the processX Yang
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cell Biochem 82:163-70. 2001..Taken together, these results point to c-Jun as a key intermediary in the activation of the expression of this gene by mediators. However, participation of motifs outside of the promoter are necessary to obtain this inducible expression...
- IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibitionD G Alleva
Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118, USA
J Immunol 159:2941-51. 1997..This study demonstrates a novel dose-dependent and autocrine activity of IL-15 in Mphi regulation...
- Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophagesS Marecki
Pulmonary Center, Department of Pathology, Boston University School of Medicine, MA 02118, USA
J Immunol 163:2713-22. 1999..Synergistic activation of the IL-1beta promoter by these IRF proteins and PU.1 was found to require PU.1 serine 148. Together, these data demonstrate that IRF4 and ICSBP are dichotomous regulators of transcription in macrophages...
- Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intactM M Wurfel
The Rockefeller University, New York 10021, USA
J Exp Med 186:2051-6. 1997..These data suggest the presence of an LBP-independent mechanism for responding to LPS. These LBP knockout mice may provide a tool for discovering the nature of the presumed second mechanism for transferring LPS to responsive cells...
- Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4A E Medvedev
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 167:2257-67. 2001..Thus, tolerance to LPS and mycobacterial components cannot be attributed solely to a decrease in TLR/MD-2 expression levels, suggesting inhibition of expression or function of other signaling intermediates...
- Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4R P Donnelly
Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892
J Immunol 145:569-75. 1990..Together these findings demonstrate that the relative levels of IFN-gamma and IL-4 may profoundly influence the state of monocyte activation by differentially regulating the expression of IL-1...