DAVID TOBIN FELSON

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Comparing the functional impact of knee replacements in two cohorts
    Jingbo Niu
    From the Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X200, Boston, MA 02118, USA
    BMC Musculoskelet Disord 15:145. 2014
  2. doi request reprint Progression of osteoarthritis as a state of inertia
    David Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann Rheum Dis 72:924-9. 2013
  3. pmc Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
    D T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Osteoarthritis Cartilage 21:789-95. 2013
  4. pmc Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative
    David T Felson
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA
    Arthritis Rheum 65:355-62. 2013
  5. pmc Osteoarthritis as a disease of mechanics
    D T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, X200, 650 Albany Street, Boston, MA 02118, USA
    Osteoarthritis Cartilage 21:10-5. 2013
  6. pmc Defining remission in rheumatoid arthritis
    David Felson
    Clinical Epidemiology Research and Training Unit, Boston University, 715 Albany Street, A203, Boston, MA 02118, USA
    Ann Rheum Dis 71:i86-8. 2012
  7. pmc Relation of hand enthesophytes with knee enthesopathy: is osteoarthritis related to a systemic enthesopathy?
    Nadia Gibson
    Departments of Clinical Epidemiology, Rheumatology and Radiology, Boston University Medical Center, Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    J Rheumatol 39:359-64. 2012
  8. pmc Can health care databases be used to identify incident cases of osteonecrosis?
    Steven C Vlad
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Arthritis Res Ther 11:R89. 2009
  9. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
  10. pmc Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    Arthritis Res Ther 9:R108. 2007

Research Grants

  1. MULTICENTER OSTEOARTHRITIS STUDY (MOST)
    David Felson; Fiscal Year: 2007
  2. RHEUMATOLOGY TRAINING GRANT
    David Felson; Fiscal Year: 2007
  3. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2006
  4. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2000
  5. Strutural Correlates of Knee Pain
    David Felson; Fiscal Year: 2006
  6. (BOAMRI) Biomarkers in Osteoarthritis MRI Studies
    David Felson; Fiscal Year: 2006
  7. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2005
  8. CLINICAL RESEARCH TRAINING PROGRAM
    David Felson; Fiscal Year: 2004
  9. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2004
  10. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2009

Detail Information

Publications83

  1. pmc Comparing the functional impact of knee replacements in two cohorts
    Jingbo Niu
    From the Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X200, Boston, MA 02118, USA
    BMC Musculoskelet Disord 15:145. 2014
    ..To examine if different rates of total knee replacement (TKR) in two similar cohorts with symptomatic knee osteoarthritis (OA) were associated with different functional impact of disease...
  2. doi request reprint Progression of osteoarthritis as a state of inertia
    David Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann Rheum Dis 72:924-9. 2013
    ....
  3. pmc Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
    D T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Osteoarthritis Cartilage 21:789-95. 2013
    ..To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment...
  4. pmc Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative
    David T Felson
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA
    Arthritis Rheum 65:355-62. 2013
    ..To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression...
  5. pmc Osteoarthritis as a disease of mechanics
    D T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, X200, 650 Albany Street, Boston, MA 02118, USA
    Osteoarthritis Cartilage 21:10-5. 2013
    ..I shall lastly contend that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven...
  6. pmc Defining remission in rheumatoid arthritis
    David Felson
    Clinical Epidemiology Research and Training Unit, Boston University, 715 Albany Street, A203, Boston, MA 02118, USA
    Ann Rheum Dis 71:i86-8. 2012
    ..Given the inconsistency of remission definitions in rheumatoid arthritis (RA) trials, the goal of this American College of Rheumatology/European League Against Rheumatism committee was to define remission...
  7. pmc Relation of hand enthesophytes with knee enthesopathy: is osteoarthritis related to a systemic enthesopathy?
    Nadia Gibson
    Departments of Clinical Epidemiology, Rheumatology and Radiology, Boston University Medical Center, Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    J Rheumatol 39:359-64. 2012
    ..We previously reported that central bone marrow lesions (BML) on magnetic resonance imaging (MRI) scans are associated with OA. In this study, we evaluated whether hand and knee enthesopathy were related...
  8. pmc Can health care databases be used to identify incident cases of osteonecrosis?
    Steven C Vlad
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Arthritis Res Ther 11:R89. 2009
    ..Identifying additional risk factors is difficult as the number of cases at any single center is small. We investigated whether data available in large health care databases can be used to identify incident ON cases...
  9. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  10. pmc Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    Arthritis Res Ther 9:R108. 2007
    ..With the exception of COMP, if changes in cartilage turnover in patients with symptomatic knee OA are associated with cartilage loss, they do not appear to affect systemic biomarker levels...
  11. pmc The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis
    Leonid Kalichman
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street Suite X200, Boston, MA 02118, USA
    Arthritis Res Ther 9:R26. 2007
    ..Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA...
  12. pmc Leg-length inequality is not associated with greater trochanteric pain syndrome
    Neil A Segal
    Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 0728 JPP, Iowa City, IA 52242 1088, USA
    Arthritis Res Ther 10:R62. 2008
    ..Although leg-length inequality has been suggested as a potential risk factor for GTPS, this widely held assumption has not been tested...
  13. pmc A functional difficulty and functional pain instrument for hip and knee osteoarthritis
    Alan M Jette
    Health and Disability Research Institute, Boston University School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Res Ther 11:R107. 2009
    ....
  14. ncbi request reprint Glucosamine and chondroitin sulfate in knee osteoarthritis: where now?
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Rheumatol 2:356-7. 2006
  15. ncbi request reprint The effect of body weight on progression of knee osteoarthritis is dependent on alignment
    David T Felson
    Boston University Clinical Epidemiology Research and Training, Boston, Massachusetts, USA
    Arthritis Rheum 50:3904-9. 2004
    ..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...
  16. ncbi request reprint Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:129-36. 2007
    ..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...
  17. ncbi request reprint Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 57:6-12. 2007
    ..To evaluate the long-term effect of recreational exercise on the development of knee osteoarthritis (OA) in a community-based cohort of older adults, many of whom were overweight or obese...
  18. ncbi request reprint Aromatase inhibitors and the syndrome of arthralgias with estrogen deprivation
    David T Felson
    Boston University Clinical Epidemiology Research and Training Unit, Boston, Massachusetts, USA
    Arthritis Rheum 52:2594-8. 2005
  19. ncbi request reprint Rationale and strategies for reevaluating the ACR20
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Rheumatol 34:1184-7. 2007
    ..To assess whether the American College of Rheumatology response criteria ACR20 should be replaced by another definition of response with enhanced discriminant validity...
  20. ncbi request reprint Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:2986-92. 2007
    ..This study was undertaken to determine whether enlarging BMLs are associated with new knee pain...
  21. pmc Trials in rheumatoid arthritis: choosing the right outcome measure when minimal disease is achievable
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Ann Rheum Dis 67:580-3. 2008
  22. pmc A new approach yields high rates of radiographic progression in knee osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    J Rheumatol 35:2047-54. 2008
    ..We propose a new approach using multiple views and compartments that is likely to be more sensitive to change and reveals progression throughout the knee...
  23. doi request reprint Imaging abnormalities that correlate with joint pain
    David T Felson
    University of Manchester, Manchester, UK
    Br J Sports Med 45:289-91. 2011
    ..This article summarises evidence on structural pathology in the joint that causes joint pain. Evidence, mostly from studies using MRI scans in persons with and without joint pain has suggested that pain often originates in bone or synovium...
  24. ncbi request reprint Epidemiologic studies for osteoarthritis: new versus conventional study design approaches
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, Room A207, Boston, MA 02118, USA
    Rheum Dis Clin North Am 30:783-97, vii. 2004
    ..This article discusses epidemiologic study designs for osteoarthritis and why traditional designs are outmoded. It reviews the design of new studies, the Osteoarthritis Initiative and Multicenter Ostroarthritis Study...
  25. ncbi request reprint Osteophytes and progression of knee osteoarthritis
    D T Felson
    715 Albany Street, A207, Boston University School of Medicine, Boston, MA 02118, USA
    Rheumatology (Oxford) 44:100-4. 2005
    ..Meagre longitudinal data suggest, however, that they are associated with an increased risk of structural progression. Our objective was to evaluate the effect of osteophyte size on radiographic progression in osteoarthritis (OA)...
  26. ncbi request reprint An update on the pathogenesis and epidemiology of osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA
    Radiol Clin North Am 42:1-9, v. 2004
    ..The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion...
  27. ncbi request reprint Assessing the efficacy and safety of rheumatic disease treatments: obstacles and proposed solutions
    David T Felson
    Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 48:1781-7. 2003
  28. ncbi request reprint Obesity and vocational and avocational overload of the joint as risk factors for osteoarthritis
    David T Felson
    Arthritis Center, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
    J Rheumatol Suppl 70:2-5. 2004
  29. pmc A surplus of positive trials: weighing biases and reconsidering equipoise
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Res Ther 6:117-9. 2004
    ..Neither is it clear how investigators and sponsors, who are invested in the success of a proposed therapy, would (or whether they should) develop such a formula...
  30. pmc A computer-adaptive disability instrument for lower extremity osteoarthritis research demonstrated promising breadth, precision, and reliability
    Alan M Jette
    Health and Disability Research Institute, Boston University School of Public Health, Boston, MA 02118, USA
    J Clin Epidemiol 62:807-15. 2009
    ..To develop and evaluate a prototype measure (OA-DISABILITY-CAT) for osteoarthritis research using item response theory (IRT) and computer-adaptive test (CAT) methodologies...
  31. pmc Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
    Tuhina Neogi
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    BMJ 339:b2844. 2009
    ..To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts...
  32. pmc Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study
    Tuhina Neogi
    Boston University School of Medicine, 650 Albany Street, Clinical Epidemiology Unit, Suite X 200, Boston, MA 02118, USA
    Ann Rheum Dis 69:841-4. 2010
    ..This study evaluated the effects of malalignment, which can cause focal excessive load, and systemic bone density on the presence and incidence of SBA...
  33. ncbi request reprint Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study
    Kristin R Baker
    Clinical Epidemiology and Research Training Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arthritis Rheum 50:1815-21. 2004
    ....
  34. ncbi request reprint What WOMAC pain score should make a patient eligible for a trial in knee osteoarthritis?
    Joyce Goggins
    Boston University Clinical Epidemiology Research and Training Unit and the Arthritis Center, Boston University Medical Center, Boston, MA 02118, USA
    J Rheumatol 32:540-2. 2005
    ..To evaluate different Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain thresholds as eligibility criteria for a knee osteoarthritis (OA) trial and their effect on number of subjects recruited...
  35. ncbi request reprint Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study
    Clinton T Baldwin
    Boston University Arthritis Center, Department of Medicine and Neurology, Boston University School of Medicine, MA 02118, USA
    J Rheumatol 29:161-5. 2002
    ..both on chromosome 12q, are associated with the occurrence of osteoarthritis (OA). We examined linkage and association between the VDR/COL2A1 locus and hand/knee OA in the Framingham Osteoarthritis Study (FOS)...
  36. ncbi request reprint Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:245-52. 2002
    ..Several nutrients are known to affect bone mineral density (BMD). However, these nutrients occur together in foods and dietary patterns, and the overall effects of dietary choices are not well understood...
  37. ncbi request reprint Bone mineral density and the risk of Alzheimer disease
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
    Arch Neurol 62:107-11. 2005
    ..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
  38. doi request reprint Exercise therapy and orthotic devices in rheumatoid arthritis: evidence-based review
    Vicki Oldfield
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Curr Opin Rheumatol 20:353-9. 2008
  39. pmc Central bone marrow lesions in symptomatic knee osteoarthritis and their relationship to anterior cruciate ligament tears and cartilage loss
    Gabriela Hernández-Molina
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 58:130-6. 2008
    ....
  40. ncbi request reprint Periarticular lesions detected on magnetic resonance imaging: prevalence in knees with and without symptoms
    Catherine L Hill
    Boston Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:2836-44. 2003
    ..To evaluate, using magnetic resonance imaging (MRI), the prevalence of periarticular lesions in older persons with or without knee pain, and to assess the association of these lesions with knee pain...
  41. ncbi request reprint [High prevalence of knee, but not hip or hand osteoarthritis in Beijing elders: comparison with data of Caucasian in United States]
    Ling Xu
    Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 83:1206-9. 2003
    ..To investigate the prevalence of knee, hip and hand osteoarthritis (OA) in the elderly of Beijing and to compare the prevalence of OA between the Beijing elders and the US Caucasians...
  42. pmc Relative responsiveness of physician/assessor-derived and patient-derived core set measures in rheumatoid arthritis trials
    Tuhina Neogi
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Rheumatol 35:757-62. 2008
    ....
  43. pmc Exploring the determinants of racial and ethnic disparities in total knee arthroplasty: health insurance, income, and assets
    Amresh D Hanchate
    Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 01532, USA
    Med Care 46:481-8. 2008
    ..To estimate national total knee arthroplasty (TKA) rates by economic factors, and the extent to which differences in insurance coverage, income, and assets contribute to racial and ethnic disparities in TKA use...
  44. pmc Protective effects of NSAIDs on the development of Alzheimer disease
    Steven C Vlad
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany St, Suite X200, Boston, MA 02118, USA
    Neurology 70:1672-7. 2008
    ..Prior studies have also been relatively short and small. We examined the effects on AD risk of NSAID use for >5 years and of NSAIDs that suppress formation of A beta (1-42) amyloid in a large health care database...
  45. ncbi request reprint Knee buckling: prevalence, risk factors, and associated limitations in function
    David T Felson
    Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women s Hospital, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Intern Med 147:534-40. 2007
    ..Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence in the community is unknown...
  46. ncbi request reprint Statistical presentation and analysis of ordered categorical outcome data in rheumatology journals
    Michael P LaValley
    Boston University School of Public Health, Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 47:255-9. 2002
    ..To assess the appropriateness of presentation of summary measures and analysis of ordered categorical (ordinal) data in three rheumatology journals in 1999, and to consider differences between basic and clinical science articles...
  47. ncbi request reprint High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects
    David T Felson
    Boston Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 46:1217-22. 2002
    ..Our objective was to evaluate whether Chinese subjects might have more medial disease than do Caucasians, given a report of varus alignment in the knee joints of Chinese elderly...
  48. ncbi request reprint Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States
    Shoji Yoshida
    Department of Orthopedic Surgery, Nagasaki University School of Medicine, Japan
    J Rheumatol 29:1454-8. 2002
    ..We compared the prevalence of radiographic knee and hand OA between women in Hizen-Oshima, Japan, and in Framingham, Massachusetts, USA...
  49. ncbi request reprint Relative costs and effectiveness of specialist and general internist ambulatory care for patients with 2 chronic musculoskeletal conditions
    Jennifer J Anderson
    Center for Health Quality Outcomes and Economic Research, Bedford Veterans Affairs Hospital BVAH, Boston, Massachusetts, USA
    J Rheumatol 29:1488-95. 2002
    ....
  50. ncbi request reprint Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis
    D Casey Kerrigan
    University of Virginia, Department of Physical Medicine and Rehabilitation, Charlottesville 22903 2981, USA
    Arch Phys Med Rehabil 83:889-93. 2002
    ....
  51. ncbi request reprint Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 156:1021-7. 2002
    ....
  52. pmc Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study
    Elizabeth J Samelson
    Boston University Arthritis Center, Boston, Mass, USA
    Am J Public Health 92:858-62. 2002
    ..This study examined the effect of birth cohort on incidence rates of hip fracture among women and men in the Framingham Study...
  53. ncbi request reprint Bone mass and the risk of prostate cancer: the Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston, University School of Medicine, Massachusetts 02118, USA
    Am J Med 113:734-9. 2002
    ..To examine the relation of bone mass-a potential biologic marker for cumulative exposure to androgens, insulin-like growth factors, and calcium intake-to subsequent development of prostate cancer...
  54. pmc Incidental meniscal findings on knee MRI in middle-aged and elderly persons
    Martin Englund
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 359:1108-15. 2008
    ..However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographic evidence of osteoarthritis...
  55. ncbi request reprint Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University Arthritis Center, Massachusetts 02118, USA
    Arthritis Rheum 48:1034-40. 2003
    ..The goals of this study were to estimate the prevalence of hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States...
  56. ncbi request reprint Varus foot alignment and hip conditions in older adults
    K Douglas Gross
    Boston University School of Medicine, and Boston University Sargent College of Health and Rehabilitation Sciences, Boston, Massachusetts2118, USA
    Arthritis Rheum 56:2993-8. 2007
    ..Mechanical strain on the hip can result from varus malalignment of the foot. This study was undertaken to explore the cross-sectional relationship between varus foot alignment and hip conditions in a population of older adults...
  57. ncbi request reprint Comparison of rheumatoid arthritis clinical trial outcome measures: a simulation study
    Jennifer J Anderson
    Boston University, Boston, Massachusetts 02118, USA
    Arthritis Rheum 48:3031-8. 2003
    ..In order to generalize beyond results from a single trial, we performed simulation studies...
  58. pmc Greater trochanteric pain syndrome: epidemiology and associated factors
    Neil A Segal
    Department of Orthopaedics and Rehabilitation, University of Iowa and VA Medical Center, Iowa City, IA, USA
    Arch Phys Med Rehabil 88:988-92. 2007
    ....
  59. ncbi request reprint Low vitamin K status is associated with osteoarthritis in the hand and knee
    Tuhina Neogi
    Boston University School of Medicine, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:1255-61. 2006
    ..Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a vitamin K-dependent process. We undertook this study to determine whether vitamin K deficiency is associated with radiographic features of OA...
  60. pmc Osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    BMJ 332:639-42. 2006
  61. ncbi request reprint Clinical practice. Osteoarthritis of the knee
    David T Felson
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 354:841-8. 2006
  62. ncbi request reprint Are foot disorders associated with functional limitation and disability among community-dwelling older adults?
    Julie J Keysor
    Department of Rehabilitation Science, Programs in Physical Therapy, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    J Aging Health 17:734-52. 2005
    ..001), and disability (p = .009). Foot pain was associated with self-report function (p = .01) and disability (p = .007). Foot pain and ankle weakness seem to be related to important health outcomes among older adults...
  63. ncbi request reprint Current status of outcome measures in vasculitis: focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7
    Peter A Merkel
    Boston University School of Medicine, Boston, MA 02118, USA
    J Rheumatol 32:2488-95. 2005
    ....
  64. ncbi request reprint Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Arthritis Center, Boston University, MA 02118, USA
    J Rheumatol 32:2192-9. 2005
    ..One of the mechanical influences on cartilage loss is limb alignment. We explored the structural factors associated with malalignment in subjects with symptomatic OA...
  65. ncbi request reprint The lateral view radiograph for assessment of the tibiofemoral joint space in knee osteoarthritis: its reliability, sensitivity to change, and longitudinal validity
    Michael P LaValley
    Boston University School of Medicine, A203, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 52:3542-7. 2005
    ..To evaluate the reliability, validity, and sensitivity to change of tibiofemoral (TF) narrowing on lateral radiographic views...
  66. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  67. ncbi request reprint Chopstick arthropathy: the Beijing Osteoarthritis Study
    David J Hunter
    Boston University Arthritis Center, BU School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 50:1495-500. 2004
    ..We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent hand OA...
  68. pmc Sex differences in musculoskeletal pain in older adults
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 103, Boston, MA 02215, USA
    Pain 116:332-8. 2005
    ..Men and women differ in the factors associated with musculoskeletal pain in older ages. Further research is needed to understand sex differences in musculoskeletal pain the older population...
  69. ncbi request reprint Relation of obesity and of vocational and avocational risk factors to osteoarthritis
    David T Felson
    Arthritis Center, Boston University School of Medecine, Boston, MA, USA
    J Rheumatol 32:1133-5. 2005
  70. ncbi request reprint Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, Massachusetts, USA
    Arthritis Rheum 54:1529-35. 2006
    ..These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA)...
  71. ncbi request reprint The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee
    Timothy Bhattacharyya
    Arthritis Center, Department of Orthopaedics, Boston University Medical Center, Massachusetts, USA
    J Bone Joint Surg Am 85:4-9. 2003
    ..This study was designed to investigate the relationship between meniscal tears and osteoarthritis and between such tears and pain in patients with osteoarthritis...
  72. ncbi request reprint Glucosamine for pain in osteoarthritis: why do trial results differ?
    Steven C Vlad
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:2267-77. 2007
    ..Investigators in trials of glucosamine report a range of estimates for efficacy, making conclusions difficult. We undertook this study to identify factors that explain heterogeneity in trials of glucosamine...
  73. pmc Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis
    Catherine L Hill
    Boston University School of Medicine, A203, 80 E Concord Street, Boston, MA 02118, USA
    Ann Rheum Dis 66:1599-603. 2007
    ..To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis...
  74. pmc Minimal clinically important improvement and patient acceptable symptom state for subjective outcome measures in rheumatic disorders
    Florence Tubach
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Hopital Bichat, Paris, France
    J Rheumatol 34:1188-93. 2007
    ..The purpose of this SIG at OMERACT 8 was to inform participants of the MCII and PASS concepts and to agree on MCII and PASS values for pain, patient global assessment, and functional impairment...
  75. ncbi request reprint Effect of medical conditions on improvement in self-reported and observed functional performance of elders
    Ram R Miller
    Geriatrics Section, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:217-23. 2004
    ..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...
  76. ncbi request reprint Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss
    Michael C Nevitt
    University of California, San Francisco, CA 94107, USA
    Arthritis Rheum 56:1512-20. 2007
    ..We evaluated the ability of the nonfluoroscopically guided fixed-flexion radiography protocol to detect knee joint space loss over 3 years...
  77. ncbi request reprint Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study
    David J Hunter
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:1212-8. 2007
    ....
  78. ncbi request reprint A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis
    Kristin Baker
    Veterans Affairs Boston Health Care System, Boston University Medical School, Massachusetts 02118, USA
    Arthritis Rheum 56:1198-203. 2007
    ..The aim of this study was to test the efficacy of this simple, low-cost intervention for pain in patients with medial knee OA...
  79. ncbi request reprint Smoking, alcohol consumption, and Raynaud's phenomenon in middle age
    Lisa G Suter
    VA Connecticut Healthcare System, West Haven, Conn, USA
    Am J Med 120:264-71. 2007
    ..Our objective was to determine whether smoking and alcohol are independently associated with Raynaud's in a large, community-based cohort...
  80. ncbi request reprint Association of squatting with increased prevalence of radiographic tibiofemoral knee osteoarthritis: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:1187-92. 2004
    ....
  81. ncbi request reprint The online case-crossover study is a novel approach to study triggers for recurrent disease flares
    Yuqing Zhang
    Boston University Clinical Epidemiology Research and Training Unit, the Department of Medicine at Boston Medical Center, A203, Boston University School of Medicine, Boston, MA 02118, USA
    J Clin Epidemiol 60:50-5. 2007
    ..To evaluate the feasibility of conducting an online case-crossover study of triggers for recurrent disease flares...
  82. ncbi request reprint Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:3508-12. 2006
    ..Data on its prevalence are scarce in other ethnic populations. This study was undertaken to compare the prevalence of chondrocalcinosis in Chinese subjects with that in white subjects...
  83. ncbi request reprint Foot musculoskeletal disorders, pain, and foot-related functional limitation in older persons
    Fadi Badlissi
    School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 53:1029-33. 2005
    ..To examine whether common musculoskeletal disorders of feet are associated with pain and foot-related functional limitation...

Research Grants22

  1. MULTICENTER OSTEOARTHRITIS STUDY (MOST)
    David Felson; Fiscal Year: 2007
    ..abstract_text> ..
  2. RHEUMATOLOGY TRAINING GRANT
    David Felson; Fiscal Year: 2007
    ..The faculty provide a strong and experienced approach and will devote their talents to the training grant. ..
  3. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2006
    ....
  4. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2000
    ....
  5. Strutural Correlates of Knee Pain
    David Felson; Fiscal Year: 2006
    ....
  6. (BOAMRI) Biomarkers in Osteoarthritis MRI Studies
    David Felson; Fiscal Year: 2006
    ..Use of validated biomarkers will greatly accelerate therapeutic development for this pressing public health concern. ..
  7. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2005
    ....
  8. CLINICAL RESEARCH TRAINING PROGRAM
    David Felson; Fiscal Year: 2004
    ..Fourth, we will integrate residents in training into the CREST program to develop an interest in clinical research at an early stage of training. ..
  9. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2004
    ....
  10. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2009
    ....
  11. Structural Correlates of Knee Pain
    David Felson; Fiscal Year: 2007
    ....
  12. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    ....
  13. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2003
    ....
  14. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2007
    ....
  15. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2002
    ....