David T Felson

..With increasing obesity, gout is becoming endemic in China. Finally, symptomatic knee osteoarthritis is extremely common in China and constitutes a major public health problem there...

..Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence in the community is unknown...

..To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity...

..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...

..To calculate the frequency of clinically important improvement in function over 30 months and identify risk factors in people who have or are at risk of knee osteoarthritis (OA)...

..We examined the relationship between unilateral versus bilateral pain with low physical functioning at baseline and 30 months while accounting for knee pain severity...

..However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographic evidence of osteoarthritis...

..We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent hand OA...

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..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...

..To evaluate the long-term effect of recreational exercise on the development of knee osteoarthritis (OA) in a community-based cohort of older adults, many of whom were overweight or obese...

..Furthermore, meniscal damage is common. The aim of this study was to evaluate the association between meniscal damage in knees without surgery and the development of radiographic tibiofemoral OA...

..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...

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..The purpose of this study was to determine the proportions of people with and those without knee OA and knee pain who meet recommended physical activity levels through walking...

..One of the mechanical influences on cartilage loss is limb alignment. We explored the structural factors associated with malalignment in subjects with symptomatic OA...

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..To compare the prevalence of medial and lateral patellofemoral (PF) cartilage damage in three large osteoarthritis (OA) studies and determine the relationship of this damage to varus, neutral and valgus knee alignment...

..We propose a new approach using multiple views and compartments that is likely to be more sensitive to change and reveals progression throughout the knee...

..It may also play an important role in knee symptoms. This study highlights the importance of mechanical forces in the determination of OA and knee symptoms...

..001), and disability (p = .009). Foot pain was associated with self-report function (p = .01) and disability (p = .007). Foot pain and ankle weakness seem to be related to important health outcomes among older adults...

..To introduce a comprehensive and reliable scoring system for the assessment of whole-knee joint synovitis based on contrast-enhanced (CE) MRI...

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..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...

..Given the current lack of understanding of the etiology of chondrocalcinosis, further epidemiologic studies of the impact of genetic and environmental factors on occurrence of chondrocalcinosis are indicated...

..To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis...

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..Histologic basis, natural history, and clinical significance are also briefly discussed...

..We previously reported that central bone marrow lesions (BML) on magnetic resonance imaging (MRI) scans are associated with OA. In this study, we evaluated whether hand and knee enthesopathy were related...

..008). CONCLUSION: In the assessment of TF joint space loss, lateral view radiographs are reliable, valid, and more sensitive to change than fluoroscopically positioned PA radiographs...

..The goals of this study were to estimate the prevalence of hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States...

..This study was undertaken to examine whether particular abnormalities predisposing to hip OA occur more frequently in whites and whether these differences in hip shape account for differences in the prevalence of OA...

..To assess the associations of meniscal tears, knee mal-alignment, cartilage damage, knee effusion, and body mass index with meniscal extrusion...

..A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population...

..However, this assumption is not universally true, and a paradoxical decline in function is not uncommon following reduction in knee pain...

..The aim of this study was to test the efficacy of this simple, low-cost intervention for pain in patients with medial knee OA...

..0001). Lateral trochlear inclination may be the best method for assessment of trochlear morphology as it was strongly association with structural damage in the PFJ...

..These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA)...

..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...

..To explore the association of features of a person's neighborhood environment with disability in daily activities...

..To assess the cross-sectional relation of planus foot morphology to ipsilateral knee pain and compartment-specific knee cartilage damage in older adults...

..To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta...

..To assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-month period...

..To evaluate the feasibility of conducting an online case-crossover study of triggers for recurrent disease flares...

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..Men and women differ in the factors associated with musculoskeletal pain in older ages. Further research is needed to understand sex differences in musculoskeletal pain the older population...

..This work was undertaken to develop such a definition...

..Computed tomography and nuclear medicine including positron emission tomography are also briefly discussed...

..To provide more targeted recommendations for the hip, we gathered evidence for the efficacy of exercise for hip OA from randomized controlled trials...

..The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set...

..Incidence was 24% in women and 10% in men. Few factors in middle-aged persons, except prevalent (moderate) fracture and alcohol consumption (in men), predicted long-term incidence of vertebral fracture...

..Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA...

..This study was undertaken to determine whether enlarging BMLs are associated with new knee pain...

..Mechanical strain on the hip can result from varus malalignment of the foot. This study was undertaken to explore the cross-sectional relationship between varus foot alignment and hip conditions in a population of older adults...

..To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression...

..We therefore examined the relation of vitamin K to new-onset radiographic knee osteoarthritis and early osteoarthritis changes on magnetic resonance imaging (MRI)...

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..To evaluate, using magnetic resonance imaging (MRI), the prevalence of periarticular lesions in older persons with or without knee pain, and to assess the association of these lesions with knee pain...

..We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2)...

..Prior studies have also been relatively short and small. We examined the effects on AD risk of NSAID use for >5 years and of NSAIDs that suppress formation of A beta (1-42) amyloid in a large health care database...

..To estimate national total knee arthroplasty (TKA) rates by economic factors, and the extent to which differences in insurance coverage, income, and assets contribute to racial and ethnic disparities in TKA use...

..With the exception of COMP, if changes in cartilage turnover in patients with symptomatic knee OA are associated with cartilage loss, they do not appear to affect systemic biomarker levels...

..To examine whether common musculoskeletal disorders of feet are associated with pain and foot-related functional limitation...

..We examined whether low estradiol increases the risk for future hip fracture among men and explored whether testosterone levels influence this risk...

..This could be reflected in the presence of elevated soluble inflammatory markers. We conducted analyses to assess the association of inflammatory markers with radiographic OA of the hands and knees in a large community-based cohort...

..To describe the association between serum 25-hydroxyvitamin D (25[OH]D) level and bone mineral density (BMD) in persons with primary knee osteoarthritis (OA)...

..Identifying additional risk factors is difficult as the number of cases at any single center is small. We investigated whether data available in large health care databases can be used to identify incident ON cases...

..To assess whether the American College of Rheumatology response criteria ACR20 should be replaced by another definition of response with enhanced discriminant validity...

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..Investigators in trials of glucosamine report a range of estimates for efficacy, making conclusions difficult. We undertook this study to identify factors that explain heterogeneity in trials of glucosamine...

..This study examined the effect of birth cohort on incidence rates of hip fracture among women and men in the Framingham Study...

..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...

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..This article summarises evidence on structural pathology in the joint that causes joint pain. Evidence, mostly from studies using MRI scans in persons with and without joint pain has suggested that pain often originates in bone or synovium...

..To assess the appropriateness of presentation of summary measures and analysis of ordered categorical (ordinal) data in three rheumatology journals in 1999, and to consider differences between basic and clinical science articles...

..The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion...

..While initial uncontrolled case series suggested that arthroscopy alleviated pain in patients with osteoarthritis, large randomised trials have suggested that arthroscopy has a limited role as a treatment of osteoarthritis...

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..To examine the relation of bone mass-a potential biologic marker for cumulative exposure to androgens, insulin-like growth factors, and calcium intake-to subsequent development of prostate cancer...

..Neither is it clear how investigators and sponsors, who are invested in the success of a proposed therapy, would (or whether they should) develop such a formula...

..The objective of this study was to determine the effect of RF on mortality and coronary heart disease (CHD) in the general population...

..Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a vitamin K-dependent process. We undertook this study to determine whether vitamin K deficiency is associated with radiographic features of OA...

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..The studies also show how patient population and treatment characteristics affect the power of specific outcome measures in RA clinical trials, and provide quantification of those effects...

..This article discusses epidemiologic study designs for osteoarthritis and why traditional designs are outmoded. It reviews the design of new studies, the Osteoarthritis Initiative and Multicenter Ostroarthritis Study...

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..62, 95% CI 0.42-0.90), especially base of thumb OA (OR 0.15, 95% CI 0.11-0.22). CONCLUSION: These findings suggest site-specific differences in the prevalence of OA that may be attributed to genetic and/or environmental factors...

..Meniscal tears in OA knees, although common, have not been linked with pain. Improved, reliable quantification of the structural features and the rapid advances in MRI technology can only improve structure-pain understanding...

..The purpose of this SIG at OMERACT 8 was to inform participants of the MCII and PASS concepts and to agree on MCII and PASS values for pain, patient global assessment, and functional impairment...

..We evaluated the ability of the nonfluoroscopically guided fixed-flexion radiography protocol to detect knee joint space loss over 3 years...

..See p. 2 for complete description of levels of evidence...