David T Felson

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Comparing the prevalence of rheumatic diseases in China with the rest of the world
    David T Felson
    Arthritis Res Ther 10:106. 2008
  2. ncbi request reprint Clinical practice. Osteoarthritis of the knee
    David T Felson
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 354:841-8. 2006
  3. ncbi request reprint Knee buckling: prevalence, risk factors, and associated limitations in function
    David T Felson
    Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women s Hospital, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Intern Med 147:534-40. 2007
  4. pmc Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, FGH Building, 820 Harrison Avenue, Boston, MA 02118, USA
    BMJ 345:e5339. 2012
  5. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
  6. pmc Clinically important improvement in function is common in people with or at high risk of knee OA: the MOST study
    Daniel K White
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street X 200, Boston, MA 02118, USA
    J Rheumatol 37:1244-51. 2010
  7. pmc The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study
    Daniel K White
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:938-43. 2010
  8. pmc Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study
    Frank W Roemer
    Department of Radiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann Rheum Dis 72:942-8. 2013
  9. ncbi request reprint Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 57:6-12. 2007
  10. pmc Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study
    Martin Englund
    Boston University School of Medicine, Boston, Massachusetts, and Lund University Hospital, Lund, Sweden
    Arthritis Rheum 60:831-9. 2009

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. pmc Comparing the prevalence of rheumatic diseases in China with the rest of the world
    David T Felson
    Arthritis Res Ther 10:106. 2008
    ..With increasing obesity, gout is becoming endemic in China. Finally, symptomatic knee osteoarthritis is extremely common in China and constitutes a major public health problem there...
  2. ncbi request reprint Clinical practice. Osteoarthritis of the knee
    David T Felson
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 354:841-8. 2006
  3. ncbi request reprint Knee buckling: prevalence, risk factors, and associated limitations in function
    David T Felson
    Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women s Hospital, and Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Intern Med 147:534-40. 2007
    ..Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence in the community is unknown...
  4. pmc Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, FGH Building, 820 Harrison Avenue, Boston, MA 02118, USA
    BMJ 345:e5339. 2012
    ..To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity...
  5. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  6. pmc Clinically important improvement in function is common in people with or at high risk of knee OA: the MOST study
    Daniel K White
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street X 200, Boston, MA 02118, USA
    J Rheumatol 37:1244-51. 2010
    ..To calculate the frequency of clinically important improvement in function over 30 months and identify risk factors in people who have or are at risk of knee osteoarthritis (OA)...
  7. pmc The independent effect of pain in one versus two knees on the presence of low physical function in a multicenter knee osteoarthritis study
    Daniel K White
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:938-43. 2010
    ..We examined the relationship between unilateral versus bilateral pain with low physical functioning at baseline and 30 months while accounting for knee pain severity...
  8. pmc Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study
    Frank W Roemer
    Department of Radiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann Rheum Dis 72:942-8. 2013
    ..To assess risk of cartilage loss in the tibiofemoral joint in relation to baseline damage severity, and to analyse the association of nearby pathologic findings on the risk of subsequent cartilage loss...
  9. ncbi request reprint Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 57:6-12. 2007
    ..To evaluate the long-term effect of recreational exercise on the development of knee osteoarthritis (OA) in a community-based cohort of older adults, many of whom were overweight or obese...
  10. pmc Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study
    Martin Englund
    Boston University School of Medicine, Boston, Massachusetts, and Lund University Hospital, Lund, Sweden
    Arthritis Rheum 60:831-9. 2009
    ..Furthermore, meniscal damage is common. The aim of this study was to evaluate the association between meniscal damage in knees without surgery and the development of radiographic tibiofemoral OA...
  11. pmc Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging--the MOST study
    Michel D Crema
    Quantitative Imaging Center, Department of Radiology, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Radiology 256:855-62. 2010
    ....
  12. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  13. pmc Incidental meniscal findings on knee MRI in middle-aged and elderly persons
    Martin Englund
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 359:1108-15. 2008
    ..However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographic evidence of osteoarthritis...
  14. ncbi request reprint Chopstick arthropathy: the Beijing Osteoarthritis Study
    David J Hunter
    Boston University Arthritis Center, BU School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 50:1495-500. 2004
    ..We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent hand OA...
  15. pmc Do radiographic disease and pain account for why people with or at high risk of knee osteoarthritis do not meet physical activity guidelines?
    Daniel K White
    Boston University, Clinical Epidemiology Research and Training Unit, and Massachusetts General Hospital Institute of Health Professions, Boston, Massachusetts 02118, USA
    Arthritis Rheum 65:139-47. 2013
    ..The purpose of this study was to determine the proportions of people with and those without knee OA and knee pain who meet recommended physical activity levels through walking...
  16. pmc Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
    Frank W Roemer
    Department of Radiology, Boston University Medical Center, FGH Building, 3rd Floor, 820 Harrison Avenue, Boston, MA 02118, USA
    Ann Rheum Dis 70:1804-9. 2011
    ....
  17. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
    ..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
  18. ncbi request reprint Association of squatting with increased prevalence of radiographic tibiofemoral knee osteoarthritis: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:1187-92. 2004
    ....
  19. ncbi request reprint Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Arthritis Center, Boston University, MA 02118, USA
    J Rheumatol 32:2192-9. 2005
    ..One of the mechanical influences on cartilage loss is limb alignment. We explored the structural factors associated with malalignment in subjects with symptomatic OA...
  20. pmc Medial posterior meniscal root tears are associated with development or worsening of medial tibiofemoral cartilage damage: the multicenter osteoarthritis study
    Ali Guermazi
    Quantitative Imaging Center, Department of Radiology, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 820 Harrison Ave, Boston, MA 02118, USA
    Radiology 268:814-21. 2013
    ..To assess the association of meniscal root tear with the development or worsening of tibiofemoral cartilage damage...
  21. doi request reprint Breaking the Law of Valgus: the surprising and unexplained prevalence of medial patellofemoral cartilage damage
    K Douglas Gross
    Correspinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann Rheum Dis 71:1827-32. 2012
    ..To compare the prevalence of medial and lateral patellofemoral (PF) cartilage damage in three large osteoarthritis (OA) studies and determine the relationship of this damage to varus, neutral and valgus knee alignment...
  22. ncbi request reprint Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:129-36. 2007
    ..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...
  23. pmc A new approach yields high rates of radiographic progression in knee osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    J Rheumatol 35:2047-54. 2008
    ..We propose a new approach using multiple views and compartments that is likely to be more sensitive to change and reveals progression throughout the knee...
  24. pmc Central bone marrow lesions in symptomatic knee osteoarthritis and their relationship to anterior cruciate ligament tears and cartilage loss
    Gabriela Hernández-Molina
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 58:130-6. 2008
    ....
  25. pmc Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis
    Catherine L Hill
    Boston University School of Medicine, A203, 80 E Concord Street, Boston, MA 02118, USA
    Ann Rheum Dis 66:1599-603. 2007
    ..To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis...
  26. ncbi request reprint Are foot disorders associated with functional limitation and disability among community-dwelling older adults?
    Julie J Keysor
    Department of Rehabilitation Science, Programs in Physical Therapy, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    J Aging Health 17:734-52. 2005
    ..001), and disability (p = .009). Foot pain was associated with self-report function (p = .01) and disability (p = .007). Foot pain and ankle weakness seem to be related to important health outcomes among older adults...
  27. ncbi request reprint Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:3508-12. 2006
    ..Data on its prevalence are scarce in other ethnic populations. This study was undertaken to compare the prevalence of chondrocalcinosis in Chinese subjects with that in white subjects...
  28. doi request reprint Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study
    Ali Guermazi
    Quantitative Imaging Center QIC, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
    Ann Rheum Dis 70:805-11. 2011
    ..To introduce a comprehensive and reliable scoring system for the assessment of whole-knee joint synovitis based on contrast-enhanced (CE) MRI...
  29. ncbi request reprint Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study
    David J Hunter
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:1212-8. 2007
    ....
  30. ncbi request reprint Knee height, knee pain, and knee osteoarthritis: the Beijing Osteoarthritis Study
    David J Hunter
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 52:1418-23. 2005
    ..Although this would suggest that having long legs would be related to the occurrence of knee OA and pain, this issue has not been studied. Our aim was to explore the association between knee height, knee pain, and knee OA...
  31. pmc Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis
    Li Xu
    Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Semin Arthritis Rheum 42:105-18. 2012
    ..Histologic basis, natural history, and clinical significance are also briefly discussed...
  32. ncbi request reprint The lateral view radiograph for assessment of the tibiofemoral joint space in knee osteoarthritis: its reliability, sensitivity to change, and longitudinal validity
    Michael P LaValley
    Boston University School of Medicine, A203, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 52:3542-7. 2005
    ..To evaluate the reliability, validity, and sensitivity to change of tibiofemoral (TF) narrowing on lateral radiographic views...
  33. ncbi request reprint Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study
    Yuqing Zhang
    Boston University Arthritis Center, Massachusetts 02118, USA
    Arthritis Rheum 48:1034-40. 2003
    ..The goals of this study were to estimate the prevalence of hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States...
  34. pmc Relation of hand enthesophytes with knee enthesopathy: is osteoarthritis related to a systemic enthesopathy?
    Nadia Gibson
    Departments of Clinical Epidemiology, Rheumatology and Radiology, Boston University Medical Center, Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    J Rheumatol 39:359-64. 2012
    ..We previously reported that central bone marrow lesions (BML) on magnetic resonance imaging (MRI) scans are associated with OA. In this study, we evaluated whether hand and knee enthesopathy were related...
  35. pmc Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative
    David T Felson
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA
    Arthritis Rheum 65:355-62. 2013
    ..To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression...
  36. pmc Morphologic differences between the hips of Chinese women and white women: could they account for the ethnic difference in the prevalence of hip osteoarthritis?
    Marcel Dudda
    Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:2992-9. 2011
    ..This study was undertaken to examine whether particular abnormalities predisposing to hip OA occur more frequently in whites and whether these differences in hip shape account for differences in the prevalence of OA...
  37. pmc Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: the Multicenter Osteoarthritis study
    Michel D Crema
    Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA
    Radiology 264:494-503. 2012
    ..To assess the associations of meniscal tears, knee mal-alignment, cartilage damage, knee effusion, and body mass index with meniscal extrusion...
  38. pmc Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data
    Uyen Sa D T Nguyen
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Ann Intern Med 155:725-32. 2011
    ..A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population...
  39. pmc Reasons for functional decline despite reductions in knee pain: the Multicenter Osteoarthritis Study
    Daniel K White
    Department of Physical Therapy and Athletic Training, College of Health and Rehabilitation Sciences, Sargent College, Boston University, 685 Commonwealth Avenue, Boston, MA 02115, USA
    Phys Ther 91:1849-56. 2011
    ..However, this assumption is not universally true, and a paradoxical decline in function is not uncommon following reduction in knee pain...
  40. ncbi request reprint A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis
    Kristin Baker
    Veterans Affairs Boston Health Care System, Boston University Medical School, Massachusetts 02118, USA
    Arthritis Rheum 56:1198-203. 2007
    ..The aim of this study was to test the efficacy of this simple, low-cost intervention for pain in patients with medial knee OA...
  41. ncbi request reprint The effect of body weight on progression of knee osteoarthritis is dependent on alignment
    David T Felson
    Boston University Clinical Epidemiology Research and Training, Boston, Massachusetts, USA
    Arthritis Rheum 50:3904-9. 2004
    ..This study evaluated whether the effect of body weight on progression of knee osteoarthritis (OA) differs depending on the degree of limb malalignment...
  42. ncbi request reprint Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, Massachusetts, USA
    Arthritis Rheum 54:1529-35. 2006
    ..These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA)...
  43. pmc Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: the MOST study
    Joshua J Stefanik
    Boston University School of Medicine, Boston, MA 02118, USA
    J Orthop Res 30:1-8. 2012
    ..0001). Lateral trochlear inclination may be the best method for assessment of trochlear morphology as it was strongly association with structural damage in the PFJ...
  44. pmc The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study
    Frank W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA
    Semin Arthritis Rheum 42:573-81. 2013
    ..The aim was to assess the cross-sectional associations of posterior horn meniscal damage with perimeniscal synovitis, and with synovitis posterior to the posterior cruciate ligament (PCL) using contrast enhanced (CE) MRI...
  45. pmc Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative
    Tuhina Neogi
    Boston University School of Medicine, Boston, MA 02118, USA
    Arthritis Rheum 65:2048-58. 2013
    ..To examine whether magnetic resonance imaging (MRI)-based 3-dimensional (3-D) bone shape predicts the onset of radiographic knee osteoarthritis (OA)...
  46. pmc Walking to meet physical activity guidelines in knee osteoarthritis: is 10,000 steps enough?
    Daniel K White
    Dept of Physical Therapy and Athletic Training, College of Health and Rehabilitation Sciences, Boston University, Boston, MA 02115, USA
    Arch Phys Med Rehabil 94:711-7. 2013
    ..To study if step goals (eg, walking 10,000 steps a day) approximate meeting the 2008 Physical Activity Guidelines for Americans...
  47. pmc Vitamin K deficiency is associated with incident knee osteoarthritis
    Devyani Misra
    Boston University School of Medicine, Mass, USA
    Am J Med 126:243-8. 2013
    ..We therefore examined the relation of vitamin K to new-onset radiographic knee osteoarthritis and early osteoarthritis changes on magnetic resonance imaging (MRI)...
  48. pmc Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study
    Frank W Roemer
    Department of Radiology, Boston University Medical Center, 820 Harrison Ave, FGH Building, Third Floor, Boston, MA 02118, USA
    Radiology 252:772-80. 2009
    ..To assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-month period...
  49. pmc Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis
    Joshua J Stefanik
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Care Res (Hoboken) 63:1391-7. 2011
    ..To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta...
  50. pmc Are features of the neighborhood environment associated with disability in older adults?
    Daniel K White
    Clinical Epidemiology Research and Training Unit, Boston University Medical Center, Boston, Massachusetts, USA
    Disabil Rehabil 32:639-45. 2010
    ..To explore the association of features of a person's neighborhood environment with disability in daily activities...
  51. pmc Association of flat feet with knee pain and cartilage damage in older adults
    K Douglas Gross
    Massachusetts General Hospital Institute of Health Professions and Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Care Res (Hoboken) 63:937-44. 2011
    ..To assess the cross-sectional relation of planus foot morphology to ipsilateral knee pain and compartment-specific knee cartilage damage in older adults...
  52. pmc Relative responsiveness of physician/assessor-derived and patient-derived core set measures in rheumatoid arthritis trials
    Tuhina Neogi
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Rheumatol 35:757-62. 2008
    ....
  53. pmc The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 61:1070-6. 2009
    ....
  54. pmc Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study
    Tuhina Neogi
    Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X 200, Boston, MA 02118, USA
    J Rheumatol 36:378-84. 2009
    ....
  55. ncbi request reprint The online case-crossover study is a novel approach to study triggers for recurrent disease flares
    Yuqing Zhang
    Boston University Clinical Epidemiology Research and Training Unit, the Department of Medicine at Boston Medical Center, A203, Boston University School of Medicine, Boston, MA 02118, USA
    J Clin Epidemiol 60:50-5. 2007
    ..To evaluate the feasibility of conducting an online case-crossover study of triggers for recurrent disease flares...
  56. pmc Sex differences in musculoskeletal pain in older adults
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 103, Boston, MA 02215, USA
    Pain 116:332-8. 2005
    ..Men and women differ in the factors associated with musculoskeletal pain in older ages. Further research is needed to understand sex differences in musculoskeletal pain the older population...
  57. pmc A functional difficulty and functional pain instrument for hip and knee osteoarthritis
    Alan M Jette
    Health and Disability Research Institute, Boston University School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Res Ther 11:R107. 2009
    ....
  58. pmc American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 63:573-86. 2011
    ..This work was undertaken to develop such a definition...
  59. doi request reprint Imaging of synovitis in osteoarthritis: current status and outlook
    Daichi Hayashi
    Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Semin Arthritis Rheum 41:116-30. 2011
    ..Computed tomography and nuclear medicine including positron emission tomography are also briefly discussed...
  60. pmc Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis
    Gabriela Hernández-Molina
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 59:1221-8. 2008
    ..To provide more targeted recommendations for the hip, we gathered evidence for the efficacy of exercise for hip OA from randomized controlled trials...
  61. pmc The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis
    Leonid Kalichman
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street Suite X200, Boston, MA 02118, USA
    Arthritis Res Ther 9:R26. 2007
    ..Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA...
  62. pmc The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report
    Tuhina Neogi
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 62:2582-91. 2010
    ..The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set...
  63. ncbi request reprint Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Bone Miner Res 21:1207-14. 2006
    ..Incidence was 24% in women and 10% in men. Few factors in middle-aged persons, except prevalent (moderate) fracture and alcohol consumption (in men), predicted long-term incidence of vertebral fracture...
  64. ncbi request reprint Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:2986-92. 2007
    ..This study was undertaken to determine whether enlarging BMLs are associated with new knee pain...
  65. ncbi request reprint Varus foot alignment and hip conditions in older adults
    K Douglas Gross
    Boston University School of Medicine, and Boston University Sargent College of Health and Rehabilitation Sciences, Boston, Massachusetts2118, USA
    Arthritis Rheum 56:2993-8. 2007
    ..Mechanical strain on the hip can result from varus malalignment of the foot. This study was undertaken to explore the cross-sectional relationship between varus foot alignment and hip conditions in a population of older adults...
  66. pmc The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand
    Barton L Wise
    Framingham Heart Study, National Heart, Lung and Blood Institute, National Institutes of Health, Boston, Massachusetts, USA
    J Rheumatol 36:2772-9. 2009
    ..We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2)...
  67. ncbi request reprint Foot musculoskeletal disorders, pain, and foot-related functional limitation in older persons
    Fadi Badlissi
    School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 53:1029-33. 2005
    ..To examine whether common musculoskeletal disorders of feet are associated with pain and foot-related functional limitation...
  68. ncbi request reprint Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study
    Shreyasee Amin
    Boston University Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Am J Med 119:426-33. 2006
    ..We examined whether low estradiol increases the risk for future hip fracture among men and explored whether testosterone levels influence this risk...
  69. pmc Osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    BMJ 332:639-42. 2006
  70. pmc Protective effects of NSAIDs on the development of Alzheimer disease
    Steven C Vlad
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany St, Suite X200, Boston, MA 02118, USA
    Neurology 70:1672-7. 2008
    ..Prior studies have also been relatively short and small. We examined the effects on AD risk of NSAID use for >5 years and of NSAIDs that suppress formation of A beta (1-42) amyloid in a large health care database...
  71. pmc Exploring the determinants of racial and ethnic disparities in total knee arthroplasty: health insurance, income, and assets
    Amresh D Hanchate
    Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 01532, USA
    Med Care 46:481-8. 2008
    ..To estimate national total knee arthroplasty (TKA) rates by economic factors, and the extent to which differences in insurance coverage, income, and assets contribute to racial and ethnic disparities in TKA use...
  72. ncbi request reprint Relation of obesity and of vocational and avocational risk factors to osteoarthritis
    David T Felson
    Arthritis Center, Boston University School of Medecine, Boston, MA, USA
    J Rheumatol 32:1133-5. 2005
  73. ncbi request reprint Periarticular lesions detected on magnetic resonance imaging: prevalence in knees with and without symptoms
    Catherine L Hill
    Boston Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:2836-44. 2003
    ..To evaluate, using magnetic resonance imaging (MRI), the prevalence of periarticular lesions in older persons with or without knee pain, and to assess the association of these lesions with knee pain...
  74. pmc Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study
    David J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    Arthritis Res Ther 9:R108. 2007
    ..With the exception of COMP, if changes in cartilage turnover in patients with symptomatic knee OA are associated with cartilage loss, they do not appear to affect systemic biomarker levels...
  75. pmc No association between markers of inflammation and osteoarthritis of the hands and knees
    Steven C Vlad
    Clinical Epidemiology Research and Training Unit and the Division of Rheumatology, Boston University School of Medicine, Boston, MA 02118, USA
    J Rheumatol 38:1665-70. 2011
    ..This could be reflected in the presence of elevated soluble inflammatory markers. We conducted analyses to assess the association of inflammatory markers with radiographic OA of the hands and knees in a large community-based cohort...
  76. ncbi request reprint Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis
    Heike A Bischoff-Ferrari
    Clinical Epidemiology Unit, Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 53:821-6. 2005
    ..To describe the association between serum 25-hydroxyvitamin D (25[OH]D) level and bone mineral density (BMD) in persons with primary knee osteoarthritis (OA)...
  77. ncbi request reprint Rationale and strategies for reevaluating the ACR20
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Rheumatol 34:1184-7. 2007
    ..To assess whether the American College of Rheumatology response criteria ACR20 should be replaced by another definition of response with enhanced discriminant validity...
  78. pmc Can health care databases be used to identify incident cases of osteonecrosis?
    Steven C Vlad
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Arthritis Res Ther 11:R89. 2009
    ..Identifying additional risk factors is difficult as the number of cases at any single center is small. We investigated whether data available in large health care databases can be used to identify incident ON cases...
  79. ncbi request reprint Glucosamine for pain in osteoarthritis: why do trial results differ?
    Steven C Vlad
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:2267-77. 2007
    ..Investigators in trials of glucosamine report a range of estimates for efficacy, making conclusions difficult. We undertook this study to identify factors that explain heterogeneity in trials of glucosamine...
  80. ncbi request reprint Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 156:1021-7. 2002
    ....
  81. ncbi request reprint Effect of medical conditions on improvement in self-reported and observed functional performance of elders
    Ram R Miller
    Geriatrics Section, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:217-23. 2004
    ..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...
  82. pmc Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study
    Elizabeth J Samelson
    Boston University Arthritis Center, Boston, Mass, USA
    Am J Public Health 92:858-62. 2002
    ..This study examined the effect of birth cohort on incidence rates of hip fracture among women and men in the Framingham Study...
  83. ncbi request reprint High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects
    David T Felson
    Boston Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 46:1217-22. 2002
    ..Our objective was to evaluate whether Chinese subjects might have more medial disease than do Caucasians, given a report of varus alignment in the knee joints of Chinese elderly...
  84. pmc A surplus of positive trials: weighing biases and reconsidering equipoise
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Res Ther 6:117-9. 2004
    ..Neither is it clear how investigators and sponsors, who are invested in the success of a proposed therapy, would (or whether they should) develop such a formula...
  85. ncbi request reprint Epidemiologic studies for osteoarthritis: new versus conventional study design approaches
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, Room A207, Boston, MA 02118, USA
    Rheum Dis Clin North Am 30:783-97, vii. 2004
    ..This article discusses epidemiologic study designs for osteoarthritis and why traditional designs are outmoded. It reviews the design of new studies, the Osteoarthritis Initiative and Multicenter Ostroarthritis Study...
  86. ncbi request reprint Assessing the efficacy and safety of rheumatic disease treatments: obstacles and proposed solutions
    David T Felson
    Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 48:1781-7. 2003
  87. ncbi request reprint Statistical presentation and analysis of ordered categorical outcome data in rheumatology journals
    Michael P LaValley
    Boston University School of Public Health, Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 47:255-9. 2002
    ..To assess the appropriateness of presentation of summary measures and analysis of ordered categorical (ordinal) data in three rheumatology journals in 1999, and to consider differences between basic and clinical science articles...
  88. ncbi request reprint An update on the pathogenesis and epidemiology of osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA
    Radiol Clin North Am 42:1-9, v. 2004
    ..The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion...
  89. ncbi request reprint Bone mass and the risk of prostate cancer: the Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston, University School of Medicine, Massachusetts 02118, USA
    Am J Med 113:734-9. 2002
    ..To examine the relation of bone mass-a potential biologic marker for cumulative exposure to androgens, insulin-like growth factors, and calcium intake-to subsequent development of prostate cancer...
  90. ncbi request reprint Relative costs and effectiveness of specialist and general internist ambulatory care for patients with 2 chronic musculoskeletal conditions
    Jennifer J Anderson
    Center for Health Quality Outcomes and Economic Research, Bedford Veterans Affairs Hospital BVAH, Boston, Massachusetts, USA
    J Rheumatol 29:1488-95. 2002
    ....
  91. ncbi request reprint Current status of outcome measures in vasculitis: focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7
    Peter A Merkel
    Boston University School of Medicine, Boston, MA 02118, USA
    J Rheumatol 32:2488-95. 2005
    ....
  92. ncbi request reprint Glucosamine and chondroitin sulfate in knee osteoarthritis: where now?
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Rheumatol 2:356-7. 2006
  93. doi request reprint Imaging abnormalities that correlate with joint pain
    David T Felson
    University of Manchester, Manchester, UK
    Br J Sports Med 45:289-91. 2011
    ..This article summarises evidence on structural pathology in the joint that causes joint pain. Evidence, mostly from studies using MRI scans in persons with and without joint pain has suggested that pain often originates in bone or synovium...
  94. ncbi request reprint Comparison of rheumatoid arthritis clinical trial outcome measures: a simulation study
    Jennifer J Anderson
    Boston University, Boston, Massachusetts 02118, USA
    Arthritis Rheum 48:3031-8. 2003
    ..In order to generalize beyond results from a single trial, we performed simulation studies...
  95. ncbi request reprint Low vitamin K status is associated with osteoarthritis in the hand and knee
    Tuhina Neogi
    Boston University School of Medicine, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:1255-61. 2006
    ..Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a vitamin K-dependent process. We undertook this study to determine whether vitamin K deficiency is associated with radiographic features of OA...
  96. pmc Effect of rheumatoid factor on mortality and coronary heart disease
    Gunnar Tomasson
    Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Ann Rheum Dis 69:1649-54. 2010
    ..The objective of this study was to determine the effect of RF on mortality and coronary heart disease (CHD) in the general population...
  97. pmc Arthroscopy as a treatment for knee osteoarthritis
    David T Felson
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA, USA
    Best Pract Res Clin Rheumatol 24:47-50. 2010
    ..While initial uncontrolled case series suggested that arthroscopy alleviated pain in patients with osteoarthritis, large randomised trials have suggested that arthroscopy has a limited role as a treatment of osteoarthritis...
  98. pmc Trials in rheumatoid arthritis: choosing the right outcome measure when minimal disease is achievable
    David T Felson
    Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Ann Rheum Dis 67:580-3. 2008
  99. ncbi request reprint Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss
    Michael C Nevitt
    University of California, San Francisco, CA 94107, USA
    Arthritis Rheum 56:1512-20. 2007
    ..We evaluated the ability of the nonfluoroscopically guided fixed-flexion radiography protocol to detect knee joint space loss over 3 years...
  100. ncbi request reprint Aromatase inhibitors and the syndrome of arthralgias with estrogen deprivation
    David T Felson
    Boston University Clinical Epidemiology Research and Training Unit, Boston, Massachusetts, USA
    Arthritis Rheum 52:2594-8. 2005
  101. ncbi request reprint Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis
    D Casey Kerrigan
    University of Virginia, Department of Physical Medicine and Rehabilitation, Charlottesville 22903 2981, USA
    Arch Phys Med Rehabil 83:889-93. 2002
    ....