Lindsay Farrer

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
  2. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
  3. pmc Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study
    Richard Sherva
    Department of Medicine, Genetics Program, Boston University School of Medicine, Boston 02118, USA
    BMC Med Genet 11:51. 2010
  4. pmc Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    Agustin G Yip
    Department of Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston MA 02118 2526, USA
    BMC Geriatr 5:2. 2005
  5. pmc Empirically derived phenotypic subgroups - qualitative and quantitative trait analyses
    Marsha A Wilcox
    Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Genet 4:S15. 2003
  6. pmc Multifactor-dimensionality reduction versus family-based association tests in detecting susceptibility loci in discordant sib-pair studies
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, Boston, MA, USA
    BMC Genet 6:S146. 2005
  7. pmc Genome-wide screen for heavy alcohol consumption
    Diego F Wyszynski
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    BMC Genet 4:S106. 2003
  8. pmc Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays
    Qianli Ma
    Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    BMC Genet 6:S8. 2005
  9. pmc Whole-genome variance components linkage analysis using single-nucleotide polymorphisms versus microsatellites on quantitative traits of derived phenotypes from factor analysis of electroencephalogram waves
    Yi Yu
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    BMC Genet 6:S15. 2005
  10. pmc Search for genetic factors predisposing to atherogenic dyslipidemia
    Agustin G Yip
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    BMC Genet 4:S100. 2003

Research Grants

Detail Information

Publications59

  1. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
    ..Here, we reevaluated tau pathologies in the same TgCRND8 mouse model as the previous studies...
  2. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
    ..Our results suggest that low serum paraoxonase activity is a risk factor for AD. Furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic...
  3. pmc Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study
    Richard Sherva
    Department of Medicine, Genetics Program, Boston University School of Medicine, Boston 02118, USA
    BMC Med Genet 11:51. 2010
    ..To identify genetic modifiers influencing disease severity, we conducted a two-stage genome scan in groups of 207 mild and 305 severe unrelated patients from Thailand with Hb E/beta0 thalassemia and normal alpha-globin genes...
  4. pmc Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    Agustin G Yip
    Department of Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston MA 02118 2526, USA
    BMC Geriatr 5:2. 2005
    ..We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-epsilon4 carrier status and ethnicity...
  5. pmc Empirically derived phenotypic subgroups - qualitative and quantitative trait analyses
    Marsha A Wilcox
    Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Genet 4:S15. 2003
    ....
  6. pmc Multifactor-dimensionality reduction versus family-based association tests in detecting susceptibility loci in discordant sib-pair studies
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, Boston, MA, USA
    BMC Genet 6:S146. 2005
    ..Using MDR, the best result we obtained identified two interactions. However, neither of these reached a level of statistical significance. This is mainly due to the heterogeneity of the disease trait and noise in the data...
  7. pmc Genome-wide screen for heavy alcohol consumption
    Diego F Wyszynski
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    BMC Genet 4:S106. 2003
    ....
  8. pmc Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays
    Qianli Ma
    Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    BMC Genet 6:S8. 2005
    ..We conclude that genome-wide linkage analysis by using approximately 5,000 SNP markers evenly distributed across the human genome is sufficient and might be more powerful than current 10-cM microsatellite marker assays...
  9. pmc Whole-genome variance components linkage analysis using single-nucleotide polymorphisms versus microsatellites on quantitative traits of derived phenotypes from factor analysis of electroencephalogram waves
    Yi Yu
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    BMC Genet 6:S15. 2005
    ..73) and Illumina SNP data (LOD = 3.30). We also demonstrated that, in a sample like the COGA data, a dense single-nucleotide polymorphism map provides better linkage signals than low-resolution microsatellite map with quantitative traits...
  10. pmc Search for genetic factors predisposing to atherogenic dyslipidemia
    Agustin G Yip
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    BMC Genet 4:S100. 2003
    ..Here we report the results of a whole-genome screen for AD using the Framingham Heart Study population...
  11. pmc Performance of random forest when SNPs are in linkage disequilibrium
    Yan A Meng
    Department of Medicine, Boston University, MA, USA
    BMC Bioinformatics 10:78. 2009
    ....
  12. ncbi Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community
    Lindsay A Farrer
    Department of Medicine, Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 12:415-22. 2003
    ..The unique characteristics of this community together with the emergent human genome data should allow for the rapid identification of DAT genes in these candidate regions...
  13. pmc Association of variants in MANEA with cocaine-related behaviors
    Lindsay A Farrer
    Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Arch Gen Psychiatry 66:267-74. 2009
    ....
  14. ncbi Genetic and environmental epidemiology of Alzheimer's disease in arabs residing in Israel
    Lindsay A Farrer
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Neurosci 20:207-12. 2003
    ....
  15. pmc Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community
    Yan Meng
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Hum Genet 78:871-7. 2006
    ..1 x 10(-12)), but the only consistently associated alleles were in rs4343 and rs4351. These results suggest that a variant in close proximity to rs4343 and rs4351 modulates susceptibility to AD in this community...
  16. ncbi Polymorphisms in the promoter region of catalase gene and essential hypertension
    Xiao Feng Zhou
    Center for Human Genetics, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Dis Markers 21:3-7. 2005
    ..In addition, the genetic factors that contribute to hypertension maybe different between ethnic groups...
  17. pmc Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes
    Richard Sherva
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 35:1921-31. 2010
    ..These data reinforce the importance of variation in the chromosome 15 nicotinic receptor subunit gene cluster for risk of dependence on multiple substances, although the direction of the effects may vary across substances...
  18. ncbi Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study
    L Adrienne Cupples
    Departments of Biostatistics and Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Med 6:192-6. 2004
    ..The protocol presents risk information as cumulative incidence curves. This article describes how these curves were estimated...
  19. pmc Confirmation and generalization of an alcohol-dependence locus on chromosome 10q
    Carolien I Panhuysen
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 35:1325-32. 2010
    ..Results of our study confirm a chromosome 10 risk locus for AD in two genetically distinct populations and suggest that this locus may correspond more precisely to a specific component of the disorder...
  20. pmc Substance dependence low-density whole genome association study in two distinct American populations
    Yi Yu
    Department of Medicine Genetics Program, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Hum Genet 123:495-506. 2008
    ..Our study provides an initial substance dependence trait-specific blueprint of associated regions for future candidate gene studies...
  21. ncbi Genetic variants of WNK4 in whites and African Americans with hypertension
    Porat M Erlich
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 41:1191-5. 2003
    ..However, because the associated SNP does not appear to be a functional variant and the limitations of case/control association studies, confirmation of these results in additional cohorts is warranted...
  22. ncbi Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial
    J Scott Roberts
    Departments of Neurology and Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street B 7800, Boston, MA 02118, USA
    Genet Med 6:197-203. 2004
    ..This study's main purposes were to estimate interest in such testing and to examine demographic predictors of study participation...
  23. doi Collection of clinical and epidemiological data for genetic linkage and association studies
    Lindsay Farrer
    Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Protoc Hum Genet . 2012
    ....
  24. ncbi Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 21:85-91. 2007
    ..In the Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study of AD-discordant siblings, MRI traits are heritable and are potential endophenotypes for genetic association studies...
  25. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  26. ncbi Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans
    Yi Yu
    Department of Medicine, Genetics Program, Boston University School of Medicine, MA, USA
    Hum Mol Genet 15:2192-9. 2006
    ..These findings confirm a previous report of association of DDC with ND, localize the causative variants to the 3' end of the coding region and extend the association to multiple population groups...
  27. pmc Disclosure of APOE genotype for risk of Alzheimer's disease
    Robert C Green
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 361:245-54. 2009
    ..We examined the effect of genotype disclosure in a prospective, randomized, controlled trial...
  28. pmc Magnetic resonance imaging traits in siblings discordant for Alzheimer disease
    Karen T Cuenco
    Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    J Neuroimaging 18:268-75. 2008
    ..We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their association with AD in families from the Multi-Institutional Research in Alzheimer Genetic Epidemiology (MIRAGE) Study...
  29. ncbi Polymorphisms in the PON gene cluster are associated with Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 15:77-85. 2006
    ..The most significantly associated haplotype comprised SNPs in the region spanning the -161[C/T] SNP (P=0.00009). Our results demonstrate association between AD and variants in the PON gene cluster in Caucasians and African Americans...
  30. ncbi Association between apolipoprotein E genotype and Alzheimer disease in African American subjects
    Neill R Graff-Radford
    Genetics Program L 320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 59:594-600. 2002
    ..The association between Alzheimer disease (AD) and genotypes at the apolipoprotein E (APOE) locus has been confirmed in numerous populations worldwide, but appears to be inconsistent in African American subjects...
  31. ncbi Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease
    J Scott Roberts
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Alzheimer Dis Assoc Disord 17:86-93. 2003
    ..3, p < 0.01). Findings suggest that genetic susceptibility testing is of interest to individuals at risk for AD for a variety of reasons, even in the relative absence of available treatments...
  32. ncbi Risk of dementia among white and African American relatives of patients with Alzheimer disease
    Robert C Green
    Genetics Program and Alzheimer s Disease Center, Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    JAMA 287:329-36. 2002
    ..Family studies of probands with AD offer an opportunity to evaluate lifetime risk of dementia among relatives of these probands...
  33. pmc Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    Karen T Cuenco
    Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 65:1640-8. 2008
    ....
  34. ncbi Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
    Abimbola Akomolafe
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Arch Neurol 63:1551-5. 2006
    ..Diabetes mellitus (DM) could increase the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between DM and the development of AD remains uncertain...
  35. ncbi Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Br J Haematol 128:266-72. 2005
    ..These findings may have broader implications in sickle cell disease, as KL encodes a membrane protein that regulates many vascular functions, including vascular endothelial growth factor expression and endothelial nitric oxide release...
  36. pmc Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis
    Clinton Baldwin
    Center for Human Genetics, Department of Pediatrics, Boston University School of Medicine, 715 Albany St, W408, Boston, MA 02118, USA
    Blood 106:372-5. 2005
    ..Our results may provide insight into the pathogenesis of osteonecrosis in sickle cell disease, help identify individuals who are at high risk for osteonecrosis, and thus allow earlier and more effective therapeutic intervention...
  37. ncbi Depression as a risk factor for Alzheimer disease: the MIRAGE Study
    Robert C Green
    Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 60:753-9. 2003
    ..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
  38. ncbi Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Hematol 82:179-84. 2007
    ..Our results suggest that, as with other subphenotypes of sickle cell disease, renal function may be genetically modulated...
  39. doi BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies
    Amanda E Sedgewick
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Blood Cells Mol Dis 41:255-8. 2008
    ..Taken together, the data suggest that the functional motifs responsible for modulating F-cells and HbF levels reside within a 3 kb region in the second intron of BCL11A...
  40. doi Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong
    Geoffrey T Gibney
    Division of Hematology Oncology, Department of Medicine, Boston University, Boston, Massachusetts02118, USA
    Am J Hematol 83:458-64. 2008
    ....
  41. pmc Association between SORL1 and Alzheimer's disease in a genome-wide study
    Yan Meng
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Neuroreport 18:1761-4. 2007
    ..These results provide an independent replication of the association between AD and SORL1...
  42. ncbi Association of asthma with a functional promoter polymorphism in the IL16 gene
    Kristin M Burkart
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 117:86-91. 2006
    ..A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described...
  43. ncbi Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer's disease
    David H Tsai
    Boston University School of Medicine, 715 Albany St, L 320, Boston, MA 02118, USA
    J Neuropsychiatry Clin Neurosci 18:384-8. 2006
    ..Clinicians counseling family members of Alzheimer's disease patients who express subjective memory complaint should first evaluate cognition. If cognition is intact, depression should be considered...
  44. pmc Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Br J Haematol 133:570-8. 2006
    ..Haemolysis-driven phenotypes, such as leg ulcers, could be improved by agents that reduce sickle erythrocyte density or increase NO bioavailability...
  45. ncbi Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia
    Yi Yu
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 46:2202-13. 2005
    ..These data also indicate that a large proportion of the variance of TG levels in the Turkish population is explained by the interaction of multiple genetic loci...
  46. doi Collection of clinical and epidemiological data for linkage studies
    Lindsay Farrer
    Boston University School of Medicine and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Hum Genet . 2004
    ..The commentary discusses methods for evaluating evidence of genetic versus environmental influences in a disease and for assessing individual pedigrees...
  47. pmc Serum heat shock protein 70 level as a biomarker of exceptional longevity
    Dellara F Terry
    Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA
    Mech Ageing Dev 127:862-8. 2006
    ..05, 1.13, 3.07, 6.93, respectively, suggesting that a low serum Hsp70 level is associated with longevity; however, no genetic associations were found with two SNPs within two hsp70 genes...
  48. ncbi Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)
    Diego F Wyszynski
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:194-8. 2005
    ..In subjects aged <35 years, atherogenic dyslipidemia frequently occurs in the absence of other metabolic syndrome risk factors...
  49. ncbi Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia
    Adeboye H Adewoye
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 43:593-8. 2006
    ..We suggest that both IGF1R and the TGF-beta /BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype...
  50. pmc Hemolysis-associated priapism in sickle cell disease
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, MA, USA
    Blood 106:3264-7. 2005
    ..These findings suggest an association of priapism with increased hemolysis. Hemolysis decreases the availability of circulating nitric oxide, which plays an important role in erectile function...
  51. pmc Education effects on cognitive function in a healthy aged Arab population
    Rivka Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Int Psychogeriatr 19:593-603. 2007
    ..We investigated the influence of gender, education and occupation in a cognitively normal community sample which was assessed using an Arabic translation of the MMSE and the BCST...
  52. ncbi Complement factor H polymorphism and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 308:421-4. 2005
    ..Possession of at least one histidine at amino acid position 402 increased the risk of AMD 2.7-fold and may account for 50% of the attributable risk of AMD...
  53. pmc Association studies between the plasmin genes and late-onset Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Neurobiol Aging 28:1041-3. 2007
    ..Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD...
  54. ncbi Differences between African Americans and Whites in their attitudes toward genetic testing for Alzheimer's disease
    Yvonne G Hipps
    Department of Pharmacology, Morehouse School of Medicine, Altanta, Georgia, USA
    Genet Test 7:39-44. 2003
    ..Future research in real-life testing situations with more representative samples will be necessary to confirm these racial and cultural differences in perceptions of genetic testing...
  55. ncbi The genetics of adult-onset neuropsychiatric disease: complexities and conundra?
    James L Kennedy
    Departments of Psychiatry and Medicine, Centre for Addiction and Mental Health, Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H9, Canada
    Science 302:822-6. 2003
    ..Several strategies have recently been applied to address this complexity, leading to the identification of a number of candidate susceptibility loci/genes...
  56. ncbi Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
    Maya Saleh
    Department of Biochemistry, Molecular Biology and Pharmacology, Merck Frosst Centre for Therapeutic Research, Montreal, Quebec H9H 3L1, Canada
    Nature 429:75-9. 2004
    ..Thus, Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis...
  57. ncbi Analysis of the glucocerebrosidase gene in Parkinson's disease
    Christine Sato
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:367-70. 2005
    ..Our results demonstrate a marginally significant association of GBA mutations with PD and suggest that variations in the GBA gene may constitute a rare susceptibility factor for PD (P = 0.048)...
  58. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...
  59. ncbi Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future
    Warachal E Faison
    Alzheimer s Research and Clinical Programs, Neurosciences Department, Medical University of South Carolina, Charleston, South Carolina 29406, USA
    Int Psychogeriatr 19:539-58. 2007
    ..for AD to answer two questions: (1) what are the challenges to diagnose and treat AD across different ethnic groups, and (2) are there differences in response to pharmacologic interventions for AD across these different ethnic groups?..

Research Grants28

  1. Genetic Epidemiological Studies of Alzheimer Disease
    Lindsay Farrer; Fiscal Year: 2006
    ..Our registry will provide DNA resources and baseline data for studies beyond the next funding period. The ultimate goal of this study is to find new targets, genetic and non-genetic, for therapy. ..
  2. Multi-ethnic genome-wide Alzheimer's association study
    Lindsay Farrer; Fiscal Year: 2007
    ....
  3. GENETIC EPIDEMIOLOGICAL STUDIES OF ALZHEIMERS DISEASE
    Lindsay Farrer; Fiscal Year: 1993
    ..Progress in these areas will hopefully lead to better methods for identifying genes involved in expression of AD and for assessing risk of AD in individuals according to family history and other risk factors...
  4. GENETIC EPIDEMIOLOGICAL STUDIES OF ALZHEIMERS DISEASE
    Lindsay Farrer; Fiscal Year: 2001
    ....
  5. Multi-ethnic Genome-wide Alzheimer association study
    Lindsay A Farrer; Fiscal Year: 2010
    ....