Vincent Falanga

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers
    V Falanga
    Department of Dermatology, Boston University School of Medicine, MA, USA
    Wound Repair Regen 7:201-7. 1999
  2. doi request reprint Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    J Cutan Pathol 35:473-6. 2008
  3. pmc Stem cells in tissue repair and regeneration
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Invest Dermatol 132:1538-41. 2012
  4. ncbi request reprint The chronic wound: impaired healing and solutions in the context of wound bed preparation
    Vincent Falanga
    Department of Dermatology and Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Blood Cells Mol Dis 32:88-94. 2004
  5. ncbi request reprint Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Elmhurst Building, 50 Maude Street, Providence, RI 02908, USA
    Wound Repair Regen 12:320-6. 2004
  6. ncbi request reprint Wound healing and its impairment in the diabetic foot
    Vincent Falanga
    Department of Dermatology, Boston University, Boston, MA, USA
    Lancet 366:1736-43. 2005
  7. ncbi request reprint Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Tissue Eng 13:1299-312. 2007
  8. ncbi request reprint Wound bed score and its correlation with healing of chronic wounds
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Dermatol Ther 19:383-90. 2006
  9. ncbi request reprint Migration of the epidermal over the dermal component (epiboly) in a bilayered bioengineered skin construct
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, and Boston University School of Medicine, Boston, Massachusetts, USA
    Tissue Eng 13:21-8. 2007
  10. ncbi request reprint Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel
    Vincent Falanga
    Boston University, Department of Dermatology, Boston, MA, USA
    Ostomy Wound Manage . 2008

Research Grants

  1. The New Stem Cell Biology
    Vincent Falanga; Fiscal Year: 2007
  2. New Approaches to Tissue Repair
    Vincent Falanga; Fiscal Year: 2010
  3. New Approaches to Tissue Repair
    Vincent Falanga; Fiscal Year: 2009
  4. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
  5. The New Stem Cell Biology
    Vincent Falanga; Fiscal Year: 2006
  6. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2006
  7. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2005
  8. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
  9. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2004
  10. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003

Collaborators

Detail Information

Publications59

  1. ncbi request reprint A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers
    V Falanga
    Department of Dermatology, Boston University School of Medicine, MA, USA
    Wound Repair Regen 7:201-7. 1999
    ..005), and over 60% more effective in achieving wound closure than active control (p < 0.01). These data indicate that Graftskin is an effective treatment for venous ulcers of greater than 1 year's duration...
  2. doi request reprint Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    J Cutan Pathol 35:473-6. 2008
    ..To our knowledge, this is the first report of the collision of a squamous cell carcinoma and desmoplastic-neurotropic melanoma...
  3. pmc Stem cells in tissue repair and regeneration
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Invest Dermatol 132:1538-41. 2012
    ..We have gone from recombinant growth factors, to living tissue engineering constructs, to stem cells. The task now is to pursue true regeneration, thus achieving complete restoration of structure and function...
  4. ncbi request reprint The chronic wound: impaired healing and solutions in the context of wound bed preparation
    Vincent Falanga
    Department of Dermatology and Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Blood Cells Mol Dis 32:88-94. 2004
    ..We have established in animal models and in humans that stem cells have the potential to bring about fundamental changes in the repair process and, ultimately, a "quantum" jump in our therapeutic success...
  5. ncbi request reprint Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Elmhurst Building, 50 Maude Street, Providence, RI 02908, USA
    Wound Repair Regen 12:320-6. 2004
    ..We conclude that this novel tail-wounding model may be useful for studying delayed wound closure...
  6. ncbi request reprint Wound healing and its impairment in the diabetic foot
    Vincent Falanga
    Department of Dermatology, Boston University, Boston, MA, USA
    Lancet 366:1736-43. 2005
    ..Enhanced understanding and correction of pathogenic factors, combined with stricter adherence to standards of care and with technological breakthroughs in biological agents, is giving new hope to the problem of impaired healing...
  7. ncbi request reprint Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Tissue Eng 13:1299-312. 2007
    ..These findings indicate that autologous bone marrow-derived MSC can be safely and effectively delivered to wounds using a fibrin spray system...
  8. ncbi request reprint Wound bed score and its correlation with healing of chronic wounds
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Dermatol Ther 19:383-90. 2006
    ..If confirmed and widely adopted in this and other types of wounds, it could be a useful tool in both the clinical and research setting...
  9. ncbi request reprint Migration of the epidermal over the dermal component (epiboly) in a bilayered bioengineered skin construct
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, and Boston University School of Medicine, Boston, Massachusetts, USA
    Tissue Eng 13:21-8. 2007
    ..This process of epiboly provides novel mechanisms of action for bioengineered skin constructs...
  10. ncbi request reprint Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel
    Vincent Falanga
    Boston University, Department of Dermatology, Boston, MA, USA
    Ostomy Wound Manage . 2008
    ..A panel of experts convened to address the rationale and method of maintenance debridement...
  11. ncbi request reprint Wound bed preparation: future approaches
    Vincent Falanga
    Dermatology and Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Ostomy Wound Manage 49:30-3. 2003
  12. ncbi request reprint Wounding of bioengineered skin: cellular and molecular aspects after injury
    Vincent Falanga
    Department of Dermatology, Boston University School of Medicine, Roger Williams Medical Center, Providence, RI 02908, USA
    J Invest Dermatol 119:653-60. 2002
    ....
  13. ncbi request reprint Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island 02908, USA
    J Cell Physiol 191:42-50. 2002
    ..Since hypoxia is a critical feature of the early phases of wound repair, we conclude that it may act as a potent physiologic stimulus for collagen synthesis. TGF-beta1 appears to be a critical component of this response...
  14. ncbi request reprint Fibroblasts from non-healing human chronic wounds show decreased expression of beta ig-h3, a TGF-beta inducible protein
    Jisun Cha
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    J Dermatol Sci 50:15-23. 2008
    ....
  15. pmc Unusual causes of cutaneous ulceration
    Jaymie Panuncialman
    Department of Dermatology, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908, USA
    Surg Clin North Am 90:1161-80. 2010
    ..In this article, the authors discuss several examples of inflammatory ulcers and the approach to the diagnosis and treatment of these ulcers...
  16. pmc Differential keratin expression during epiboly in a wound model of bioengineered skin and in human chronic wounds
    Su Luo
    Roger Williams Medical Center, Providence, RI 02908, USA
    Int J Low Extrem Wounds 10:122-9. 2011
    ..Therefore, these findings provide further and important validity for the study of epithelialization and the hope of developing prognostic markers for venous ulcer healing...
  17. ncbi request reprint The longevity of a bilayered skin substitute after application to venous ulcers
    Tania J Phillips
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Arch Dermatol 138:1079-81. 2002
    ..Its mechanism of action has not been fully determined...
  18. ncbi request reprint Safety and efficacy of a bilayered skin construct in full-thickness surgical wounds
    Kevin G Donohue
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02906, USA
    J Dermatol 32:626-31. 2005
    ..The data also suggest that BSC may facilitate management by decreasing post-operative pain. It is unclear whether or not BSC decreases healing time of acute wounds or results in a better cosmetic outcome...
  19. ncbi request reprint Human beta-defensin-2 expression is increased in chronic wounds
    Janet Butmarc
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Elmhurst, 50 Maude Street, Providence, RI 02908, USA
    Wound Repair Regen 12:439-43. 2004
    ..We conclude that the expression of hbetaD-2 is up-regulated after injury. Chronic wounds uniformly show a constitutively high baseline expression of hbetaD-2, possibly due to ongoing tissue injury and bacterial colonization...
  20. pmc Wound edge biopsy sites in chronic wounds heal rapidly and do not result in delayed overall healing of the wounds
    Jaymie Panuncialman
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Wound Repair Regen 18:21-5. 2010
    ..Therefore, we conclude that chronic wounds do not worsen after being biopsied and that wound biopsies are a safe procedure that does not delay overall healing of the chronic wound...
  21. ncbi request reprint Treatment of chronic wounds with bone marrow-derived cells
    Evangelos V Badiavas
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Arch Dermatol 139:510-6. 2003
    ..These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin...
  22. ncbi request reprint Human chronic wounds treated with bioengineered skin: histologic evidence of host-graft interactions
    Evangelos V Badiavas
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Boston University School of Medicine, Boston, MA, USA
    J Am Acad Dermatol 46:524-30. 2002
    ..The consistently found deposition of mucin may point to a fetal pattern of wound repair associated with the neonatal cells in BSC...
  23. ncbi request reprint Participation of bone marrow derived cells in cutaneous wound healing
    Evangelos V Badiavas
    Department of Dermatology, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island, USA
    J Cell Physiol 196:245-50. 2003
    ..Wounding could be a stimulus for bone marrow derived stem cells to travel to organs and aid in the regeneration of damaged tissue...
  24. doi request reprint The science of wound bed preparation
    Jaymie Panuncialman
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI, USA
    Surg Clin North Am 89:611-26. 2009
    ..In WBP we can optimize our therapeutic agents to accelerate endogenous healing or to increase the effectiveness of advanced therapies...
  25. ncbi request reprint Evaluation of Apligraf persistence and basement membrane restoration in donor site wounds: a pilot study
    Shasa Hu
    Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Wound Repair Regen 14:427-33. 2006
    ..Apligraf's success in speeding healing of acute wounds appears to be related to factors other than the persistence of donor DNA or effect on basement membrane restoration...
  26. pmc The utility of the DNA microarray scanner to simplify the immunofluorescence evaluation of autoimmune bullous diseases
    Satori Iwamoto
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Am J Dermatopathol 31:218-22. 2009
    ....
  27. ncbi request reprint Clinical classification of bioengineered skin use and its correlation with healing of diabetic and venous ulcers
    Liliana J Saap
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Dermatol Surg 30:1095-100. 2004
    ..The classification system evaluates the early clinical effect of bioengineered skin and early construct appearance giving a total score named the skin substitute score...
  28. ncbi request reprint Innovative therapies in wound healing
    John T Shen
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Cutan Med Surg 7:217-24. 2003
    ..Apligraf is a bioengineered skin product composed of neonatal fibroblasts and keratinocytes. The FDA has approved Apligraf for the treatment of chronic venous ulcers and diabetic ulcers...
  29. ncbi request reprint The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds
    Ganary Dabiri
    Roger Williams Medical Center, Department of Dermatology and Skin Cancer, 50 Maude Street, Providence, RI 02908, USA
    Expert Opin Emerg Drugs 18:405-19. 2013
    ..There is emerging evidence that the use of bone marrow-derived mesenchymal stem cells (BM-MSCs) can offset this situation of impaired healing...
  30. doi request reprint Bone marrow cell mobilization by the systemic use of granulocyte colony-stimulating factor (GCSF) improves wound bed preparation
    Satori Iwamoto
    1Boston University School of Medicine, Boston, MA, USA
    Int J Low Extrem Wounds 12:256-64. 2013
    ..These findings are associated with an increased accumulation of collagen and promising results in terms of wound bed preparation and healing. ..
  31. pmc Diagnostic utility of cytokeratin 17 immunostaining in morpheaform basal cell carcinoma and for facilitating the detection of tumor cells at the surgical margins
    Heidi Anderson-Dockter
    Department of Dermatology and Skin Cancer, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Dermatol Surg 38:1357-66. 2012
    ..This tumor may also be difficult to distinguish from other adnexal neoplasms having a benign clinical course. Previous work has shown that cytokeratin 17 (CK17 or K17) expression is high in BCC...
  32. ncbi request reprint Leg ulcers
    Dana Paquette
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Clin Geriatr Med 18:77-88, vi. 2002
    ..Characteristic clinical findings and appropriate treatment options are discussed. Finally, the latest advances in the treatment of venous ulcers and their implications for clinical practice are emphasized...
  33. ncbi request reprint The science of wound bed preparation
    Jaymie Panuncialman
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Clin Plast Surg 34:621-32. 2007
    ..In WBP we can optimize our therapeutic agents to accelerate endogenous healing or to increase the effectiveness of advanced therapies...
  34. pmc Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
    Lauren A Licata
    1 825 Chalkstone Ave, Providence, RI 02908, USA
    J Leukoc Biol 94:813-23. 2013
    ..PD-1 blockade represents an attractive strategy for reversing intrahepatic immunosuppression while limiting inflammatory liver damage. ..
  35. ncbi request reprint Debridement performance index and its correlation with complete closure of diabetic foot ulcers
    Liliana J Saap
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Wound Repair Regen 10:354-9. 2002
    ..0-5.6). In conclusion, this novel scoring system for debridement performance appears to be very promising as a predictive tool for determining outcome in clinical trials and, most likely, in clinical practice...
  36. ncbi request reprint Calciphylaxis with peau d'orange induration and absence of classical features of purpura, livedo reticularis and ulcers
    Walter K Nahm
    Boston University School of Medicine, Roger Williams Medical Center, USA
    J Dermatol 29:209-13. 2002
    ....
  37. pmc Evaluation of dermal pericapillary fibrin cuffs in venous ulceration using confocal microscopy
    Kendra L Kobrin
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island, USA
    Wound Repair Regen 16:503-6. 2008
    ....
  38. doi request reprint Bioengineered skin constructs and their use in wound healing
    Tamara Lazic
    Department of Dermatology and the National Institutes of Health Center of Biomedical Research Excellence, Roger Williams Medical Center, Rovidence, RI, USA
    Plast Reconstr Surg 127:75S-90S. 2011
    ..In large part because of these advances, clinicians are now able to offer and deliver more sophisticated and effective treatments to patients with acute wounds, chronic wounds, burns, and other types of injuries...
  39. ncbi request reprint Stem cells in cutaneous wound healing
    Jisun Cha
    Department of Dermatology, Roger Williams Medical Center Providence, RI 02908, USA
    Clin Dermatol 25:73-8. 2007
    ..Still, proper wound care and adherence to basic principles cannot be bypassed, even by the most sophisticated approaches...
  40. ncbi request reprint Diabetic foot ulcer calluses show histological similarities to HPV infection without evidence of HPV involvement by nested PCR
    Lucy Li
    Roger Williams Medical Center, Providence, RI 02908, USA
    Int J Low Extrem Wounds 9:84-9. 2010
    ..The authors therefore conclude that HPV infection is unlikely to play a significant role in diabetic foot callus pathogenesis, in spite of histological findings similar to those seen with verruca vulgaris...
  41. ncbi request reprint Sustained ability for fibroblast outgrowth from stored neonatal foreskin: a model for studying mechanisms of fibroblast outgrowth
    Walter K Nahm
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Boston University School of Medicine, 50 Maude Street, Providence, RI 02908, USA
    J Dermatol Sci 28:152-8. 2002
    ..Moreover, these findings may be useful in understanding the lack of fibroblast growth in such conditions as found in delayed wound healing and aging...
  42. ncbi request reprint Histologic progression of B16 F10 metastatic melanoma in C57BL/6 mice over a six week time period: distant metastases before local growth
    Cheryl Lee D Eberting
    Department of Dermatology, Roger Williams Medical Center, Providence, RI 02908, USA
    J Dermatol 31:299-304. 2004
    ..This may prove to be a good model for investigation of local growth of tumor cells and their interaction with metastatic lesions...
  43. ncbi request reprint Basic approach to inflammatory ulcers
    Jaymie Panuncialman
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Dermatol Ther 19:365-76. 2006
    ..The present authors will emphasize that the approach needs to be all-encompassing, and not focused on the ulceration alone. Certain clues are critical to diagnosis. The management, whereas often difficult, can be very rewarding...
  44. ncbi request reprint Preliminary study of fine changes in the duration of dynamic cooling during 755-nm laser hair removal on pain and epidermal damage in patients with skin types III-V
    Walter K Nahm
    Department of Dermatology and Skin Surgery, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Lasers Surg Med 31:247-51. 2002
    ..This study was designed to determine what effect, changes in the duration of dynamic cooling would have on pain and epidermal damage with laser hair removal (755 nm alexandrite) in patients with darker skin types...
  45. doi request reprint Healing of ulcers due to cryofibrinogenemia with colchicine and high-dose pentoxifylline
    Molly Chartier
    Department of Dermatology, Roger Williams Medical Center Boston University School of Medicine, Providence, Rhode Island 02908, USA
    Am J Clin Dermatol 10:39-42. 2009
    ..To our knowledge, this is the first report documenting use of the combination of colchicine and high-dose pentoxifylline to successfully treat ulcers due to cryofibrinogenemia...
  46. pmc Connective tissue ulcers
    Ganary Dabiri
    Department of Dermatology and Skin Cancer, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908, USA
    J Tissue Viability 22:92-102. 2013
    ..Indeed, these less common but intractable ulcers represent a major medical and economic problem for patients, physicians and nurses, and even well organized multidisciplinary wound healing centers. ..
  47. pmc The effects of sorafenib on liver regeneration in a model of partial hepatectomy
    Peter C Kurniali
    Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Surg Res 178:242-7. 2012
    ..The effects of sorafenib on liver regeneration have not been clearly defined. Our objective was to identify the effects of sorafenib on liver regeneration in a murine partial hepatectomy (PH) model...
  48. ncbi request reprint Contact sensitivity in patients with leg ulcerations: a North American study
    Liliana Saap
    Department of Dermatology and Skin Surgery, Boston University Roger Williams Medical Center, Providence, RI 02908, USA
    Arch Dermatol 140:1241-6. 2004
    ....
  49. doi request reprint Use of topical povidone-iodine resulting in an iododerma-like eruption
    Maureen Massé
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Dermatol 35:744-7. 2008
    ..Although it remains possible that the reaction was an unusual contact hypersensitivity response, the ulceration, pseudoepitheliomatous hyperplasia and abscess formation do support an iododerma-like eruption...
  50. ncbi request reprint Durometry for the assessment of skin disease in systemic sclerosis
    Eugene Y Kissin
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 55:603-9. 2006
    ..To examine the validity of a durometer to objectively measure skin hardness in systemic sclerosis (SSc), and to compare digital durometry with the modified Rodnan skin score (MRSS) and ultrasonography...
  51. ncbi request reprint Growth factors, signal transduction, and cellular responses
    John T Shen
    Department of Dermatology, Roger Williams Medical Center, Providence, RI 02908, USA
    J Dermatol 30:5-16. 2003
    ..We intend to explain the difficult nomenclatures associated with growth factors and their mechanisms of action...
  52. ncbi request reprint TIME heals all wounds
    Elizabeth A Ayello
    John A Hartford Institute of Geriatric Nursing, Division of Nursing, New York University, New York, N Y, USA
    Nursing 34:36-41; quiz, 41-2. 2004
  53. ncbi request reprint Protocol for the successful treatment of venous ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 188:1-8. 2004
    ..These treatment modalities, in combination with early recognition and regular monitoring using digital photography and planimetry measurements, will ensure rapid healing and minimize complications and cost...
  54. ncbi request reprint Best-practice algorithms for the use of a bilayered living cell therapy (Apligraf) in the treatment of lower-extremity ulcers
    Joseph Cavorsi
    Center for Advanced Wound Care, St Joseph s Medical Center, Reading, Pennsylvania, USA
    Wound Repair Regen 14:102-9. 2006
    ....
  55. ncbi request reprint Significance of N-methyl-D-aspartate (NMDA) receptor-mediated signaling in human keratinocytes
    Walter K Nahm
    University of California, San Diego, School of Medicine and Veteran Affairs Medical Center, San Diego, California USA
    J Cell Physiol 200:309-17. 2004
    ..This receptor may serve as a pharmacological target for modulating keratinocyte behavior and treating cutaneous disorders...
  56. doi request reprint Measurements in wound healing
    Vincent Falanga
    Int J Low Extrem Wounds 7:9-11. 2008
  57. ncbi request reprint Wound bed preparation: a systematic approach to wound management
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 11:S1-28. 2003
    ....
  58. ncbi request reprint Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta Type II receptor expression
    Byung Chul Kim
    National Institutes of Health, National Cancer Institute, Laboratory of Cell Regulation and Carcinogenesis, Bethesda, Maryland 20892, USA
    J Cell Physiol 195:331-6. 2003
    ..These findings suggest ways to address and treat the abnormal cellular phenotype of cells in chronic wounds...
  59. ncbi request reprint Compression therapy in the treatment of venous leg ulcers
    Michael Stacey
    University of Western Australia, Fremantle
    Nurs Times 98:39-43. 2002

Research Grants19

  1. The New Stem Cell Biology
    Vincent Falanga; Fiscal Year: 2007
    ..This grant also has real promise in expanding our understanding of stem cell plasticity and stem cell transcriptional regulation and developing pre-clinical models for wound healing and muscular dystrophy. ..
  2. New Approaches to Tissue Repair
    Vincent Falanga; Fiscal Year: 2010
    ..The PI, Dr. Vincent Falanga, is internationally known for his work in tissue repair and impaired healing and has a long and successful ..
  3. New Approaches to Tissue Repair
    Vincent Falanga; Fiscal Year: 2009
    ..The PI, Dr. Vincent Falanga, is internationally known for his work in tissue repair and impaired healing and has a long and successful ..
  4. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  5. The New Stem Cell Biology
    Vincent Falanga; Fiscal Year: 2006
    ..This grant also has real promise in expanding our understanding of stem cell plasticity and stem cell transcriptional regulation and developing pre-clinical models for wound healing and muscular dystrophy. ..
  6. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2006
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  7. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2005
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  8. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  9. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2004
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  10. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  11. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  12. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2002
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  13. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2002
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  14. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2001
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  15. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2001
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  16. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2000
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  17. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2000
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..