WILLIAM ELDRED

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy
    Thomas J Giove
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, MA 02215, USA
    Mol Vis 15:2249-58. 2009
  2. pmc Evidence for a functional adrenomedullin signaling pathway in the mouse retina
    Jan Blom
    Boston University, Laboratory of Visual Neurobiology, Department of Biology, Boston, MA 02215, USA
    Mol Vis 18:1339-53. 2012
  3. pmc Imaging of nitric oxide in the retina
    William D Eldred
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, MA 02215, USA
    Vision Res 45:3469-86. 2005
  4. doi Functional localization of the nitric oxide/cGMP pathway in the salamander retina
    Jan J Blom
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Vis Neurosci 26:275-86. 2009
  5. doi Interactions of the gaseous neuromodulators nitric oxide, carbon monoxide, and hydrogen sulfide in the salamander retina
    Winnie W Pong
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, MA 02215, USA
    J Neurosci Res 87:2356-64. 2009
  6. doi Role of acetylcholine in nitric oxide production in the salamander retina
    Beth A Cimini
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 507:1952-63. 2008
  7. pmc Gycine and GABA interact to regulate the nitric oxide/cGMP signaling pathway in the turtle retina
    Dou Yu
    Boston University, Program in Neuroscience, Massachusetts 02215, USA
    Vis Neurosci 22:825-38. 2005
  8. pmc Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina
    Dou Yu
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 483:278-91. 2005
  9. ncbi GABA(A) and GABA(C) receptor antagonists increase retinal cyclic GMP levels through nitric oxide synthase
    Dou Yu
    Department of Biology, Boston University, Boston, MA 02215, USA
    Vis Neurosci 20:627-37. 2003
  10. ncbi Activation of the cGMP/nitric oxide signal transduction system by nicotine in the retina
    Todd A Blute
    Department of Biology, Boston University, Boston, MA 02215, USA
    Vis Neurosci 20:165-76. 2003

Research Grants

  1. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2007
  2. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 1999
  3. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2000
  4. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2001
  5. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2003
  6. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2004
  7. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2005
  8. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2006
  9. TRAINING IN NEUROSCIENCE
    WILLIAM ELDRED; Fiscal Year: 2007

Collaborators

  • Thomas J Giove
  • Winnie W Pong
  • Dou Yu
  • Todd A Blute
  • Jan Blom
  • Jan J Blom
  • Monika M Deshpande
  • Beth A Cimini
  • Kent T Keyser
  • Luxiang Cao
  • Miguel Sena-Esteves
  • Christine S Gagen
  • Christianne E Strang
  • Virginia E Wotring
  • Jan P Kraus
  • Nina Frank
  • Renata Stouracova
  • Christianne Strang

Detail Information

Publications14

  1. pmc Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy
    Thomas J Giove
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, MA 02215, USA
    Mol Vis 15:2249-58. 2009
    ....
  2. pmc Evidence for a functional adrenomedullin signaling pathway in the mouse retina
    Jan Blom
    Boston University, Laboratory of Visual Neurobiology, Department of Biology, Boston, MA 02215, USA
    Mol Vis 18:1339-53. 2012
    ..However, ADM can also function as a neurotransmitter/neuromodulator, and studies suggest ADM is upregulated in the eye in several ocular diseases. However, no studies to date have described an ADM signaling pathway in the retina...
  3. pmc Imaging of nitric oxide in the retina
    William D Eldred
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, MA 02215, USA
    Vision Res 45:3469-86. 2005
    ..The use of NO imaging will continue to play a critical role in future studies of the function of NO in retina and other neural systems...
  4. doi Functional localization of the nitric oxide/cGMP pathway in the salamander retina
    Jan J Blom
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Vis Neurosci 26:275-86. 2009
    ..The results of this study showed that the NO/cGMP signaling pathway was functional and its components were widely distributed throughout specific cell types in the outer and inner salamander retina...
  5. doi Interactions of the gaseous neuromodulators nitric oxide, carbon monoxide, and hydrogen sulfide in the salamander retina
    Winnie W Pong
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, MA 02215, USA
    J Neurosci Res 87:2356-64. 2009
    ..We now show that H2S inhibits NO-induced cGMP-LI but not CO-induced cGMP-LI. In conclusion, all three gaseous neuromodulators have interactive roles in modulating retinal cGMP signaling...
  6. doi Role of acetylcholine in nitric oxide production in the salamander retina
    Beth A Cimini
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 507:1952-63. 2008
    ..As GABA and glycine are the primary inhibitory neurotransmitters in the retina, signaling pathways that modulate their levels or release will have major implications for the processing of complex stimuli by the retina...
  7. pmc Gycine and GABA interact to regulate the nitric oxide/cGMP signaling pathway in the turtle retina
    Dou Yu
    Boston University, Program in Neuroscience, Massachusetts 02215, USA
    Vis Neurosci 22:825-38. 2005
    ..Such interacting inhibitory pathways could shape the course of signal transduction of the NO/cGMP pathway under different physiological situations...
  8. pmc Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina
    Dou Yu
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 483:278-91. 2005
    ..Thus it appears that some of the previously described reciprocal interactions between GABA and glycine in the retina function through specific NO signaling pathways...
  9. ncbi GABA(A) and GABA(C) receptor antagonists increase retinal cyclic GMP levels through nitric oxide synthase
    Dou Yu
    Department of Biology, Boston University, Boston, MA 02215, USA
    Vis Neurosci 20:627-37. 2003
    ..These results suggest that inhibitory synaptic pathways involving both types of GABA receptors work through excitatory glutamatergic receptors to regulate the NO/cGMP signal-transduction pathway in retina...
  10. ncbi Activation of the cGMP/nitric oxide signal transduction system by nicotine in the retina
    Todd A Blute
    Department of Biology, Boston University, Boston, MA 02215, USA
    Vis Neurosci 20:165-76. 2003
    ..This indicates that both of the major excitatory retinal transmitters, glutamate and acetylcholine, can stimulate NO production that increases levels of cGMP-LI in overlapping populations of retinal cells...
  11. doi Identification of alternate transcripts of neuronal nitric oxide synthase in the mouse retina
    Thomas J Giove
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci Res 87:3134-42. 2009
    ..Our findings indicated that the primary source of NO in the mammalian retina is nNOS alpha and that nNOS gamma may contribute to NO production as well...
  12. ncbi Inhibitors of nitric oxide synthase block carbon monoxide-induced increases in cGMP in retina
    Luxiang Cao
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Brain Res 988:78-83. 2003
    ..We postulate that the increases of cGMP in response to CO might be mediated, at least partly, by CO displacing and releasing NO from its intracellular storage pool(s)...
  13. ncbi Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals
    Winnie W Pong
    Laboratory of Visual Neurobiology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Comp Neurol 505:158-65. 2007
    ....
  14. pmc Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection
    Thomas J Giove
    Laboratory of Visual Neurobiology, Boston University, Department of Biology, 5 Cummington St, Boston, MA 02215, USA
    Exp Eye Res 91:652-9. 2010
    ....

Research Grants9

  1. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2007
    ..Results indicate that NO modulates the neuronal levels of GABA, glycine, and serotonin, and that the selective blocking of GABAergic, glycinergic, and dopaminergic receptors modulates NO/cGMP in retina. ..
  2. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 1999
    ....
  3. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2000
    ....
  4. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2001
    ....
  5. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2003
    ..Results indicate that NO modulates the neuronal levels of GABA, glycine, and serotonin, and that the selective blocking of GABAergic, glycinergic, and dopaminergic receptors modulates NO/cGMP in retina. ..
  6. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2004
    ..Results indicate that NO modulates the neuronal levels of GABA, glycine, and serotonin, and that the selective blocking of GABAergic, glycinergic, and dopaminergic receptors modulates NO/cGMP in retina. ..
  7. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2005
    ..Results indicate that NO modulates the neuronal levels of GABA, glycine, and serotonin, and that the selective blocking of GABAergic, glycinergic, and dopaminergic receptors modulates NO/cGMP in retina. ..
  8. MODULATION OF CGMP IN RETINA
    WILLIAM ELDRED; Fiscal Year: 2006
    ..Results indicate that NO modulates the neuronal levels of GABA, glycine, and serotonin, and that the selective blocking of GABAergic, glycinergic, and dopaminergic receptors modulates NO/cGMP in retina. ..
  9. TRAINING IN NEUROSCIENCE
    WILLIAM ELDRED; Fiscal Year: 2007
    ....