Research Topics
| Howard B EichenbaumSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Hippocampus: remembering the choicesHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Neuron 77:999-1001. 2013..In this issue of Neuron, Singer et al. (2013) provide evidence that the hippocampus retrieves spatial sequences in support of memory, strengthening a convergence between the two perspectives on hippocampal function...
Memory on timeHoward Eichenbaum
Center for Memory and Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA
Trends Cogn Sci 17:81-8. 2013....- What H.M. taught usHoward Eichenbaum
Center for Memory and Brain, Boston University, Room 109, 2 Cummington Street, Boston, MA 02215, USA
J Cogn Neurosci 25:14-21. 2013..M. and improve our understanding of the memory functions of the hippocampal system... - Towards a functional organization of episodic memory in the medial temporal lobeHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215 USA
Neurosci Biobehav Rev 36:1597-608. 2012.... 
Hippocampus: cognitive processes and neural representations that underlie declarative memoryHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Neuron 44:109-20. 2004....- The neurobiology of memory based predictionsHoward Eichenbaum
Center for Memory and Brain, Boston University2 Cummington Street, Boston, MA 02215, USA
Philos Trans R Soc Lond B Biol Sci 364:1183-91. 2009..Our data show that animals have the capacity for transitive inference and that the hippocampus plays a central role in the ability to predict outcomes of events that have not yet occurred... - Using olfaction to study memoryH Eichenbaum
Department of Psychology, Boston University, Massachusetts 02215, USA
Ann N Y Acad Sci 855:657-69. 1998..These studies that exploit the exceptional qualities of olfactory learning are helping to clarify the nature of higher order memory processes in all mammals, and extending to declarative memory in humans... - Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areasHoward Eichenbaum
Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Hippocampus 18:1314-24. 2008.... - Bridging the gap between brain and behavior: cognitive and neural mechanisms of episodic memoryHoward Eichenbaum
Center for Memory and Brain, Boston University, Massachusetts 02215, USA
J Exp Anal Behav 84:619-29. 2005..We also discuss electrophysiological evidence, from our laboratory and that of others, pointing to associative and sequential coding in hippocampal cells as potential neural mechanisms underlying episodic memory... - Remembering: functional organization of the declarative memory systemHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Curr Biol 16:R643-5. 2006.... - To sleep, perchance to integrateHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:7317-8. 2007 - The medial temporal lobe and recognition memoryH Eichenbaum
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
Annu Rev Neurosci 30:123-52. 2007.... - Olfactory memory: a bridge between humans and animals in models of cognitive agingHoward Eichenbaum
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 1170:658-63. 2009.... - A cortical-hippocampal system for declarative memoryH Eichenbaum
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, 64 Cummington Street, Boston, Massachusetts 02215, USA
Nat Rev Neurosci 1:41-50. 2000..Here I describe how these mechanisms work together to create and re-create fully networked representations of previous experiences and knowledge about the world... - The hippocampus and mechanisms of declarative memoryH Eichenbaum
Department of Psychology, Laboratory of Cognitive Neurobiology, Boston University, MA 02215, USA
Behav Brain Res 103:123-33. 1999..It is suggested that these episodic codings are linked by common elements to construct an organized representation of acquired knowledge... - The hippocampus and declarative memory: cognitive mechanisms and neural codesH Eichenbaum
Department of Psychology, Boston University, Boston, MA 02215, USA
Behav Brain Res 127:199-207. 2001..This combination of coding properties suggests that the hippocampus contributes to declarative memory by mediating the construction of a "memory space" composed of a network of linked episodic representations... - Hippocampus: mapping or memory?H Eichenbaum
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Curr Biol 10:R785-7. 2000..New findings on place cells point the way towards a reconciliation of the mapping and memory views... - An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memoryH Eichenbaum
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Neuropsychologia 48:2281-9. 2010.... - The hippocampus: The shock of the newH Eichenbaum
Laboratory of Cognitive Neurobiology, Boston University, 64 Cummington Street, Boston, Massachusetts 02215, USA
Curr Biol 9:R482-4. 1999.... - Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, MA 02215, USA
Psychopharmacology (Berl) 161:278-87. 2002..This region of the DST was investigated because it selectively regulates stimulus-response learning that is disrupted by 10 microg of bilaterally infused lidocaine... - Hippocampal memory system function and the regulation of cocaine self-administration behavior in ratsYolanda D Black
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
Behav Brain Res 151:225-38. 2004.... - Influence of cocaine self-administration on learning related to prefrontal cortex or hippocampus functioning in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, MA 02215, USA
Psychopharmacology (Berl) 181:227-36. 2005..A preclinical means to investigate this issue is to use a yoked-triad procedure in which sets of three animals either contingently self-administer cocaine or receive passive administration of cocaine or saline in a noncontingent manner... - Complementary tasks to measure working memory in distinct prefrontal cortex subregions in ratsNina C Di Pietro
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
Behav Neurosci 118:1042-51. 2004..The described methods provide a complementary means to study working memory in PFC subregions using a radial-arm maze... - Critical role of the hippocampus in memory for sequences of eventsNorbert J Fortin
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Nat Neurosci 5:458-62. 2002..These findings support the hypothesis that hippocampal networks mediate associations between sequential events that constitute elements of an episodic memory... - The hippocampus and memory for "what," "where," and "when"Ceren Ergorul
Center for Memory and Brain, Program in Neuroscience, Boston University, Boston, Massachusetts 02215, USA
Learn Mem 11:397-405. 2004..These findings indicate that rats integrate "what," "where," and "when" information in memory for single experiences, and that the hippocampus is critical to this capacity... - Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in ratsTomoko Udo
Laboratory of Behavioral Neuroscience1, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
Psychopharmacology (Berl) 174:237-45. 2004.... - Gradual changes in hippocampal activity support remembering the order of eventsJoseph R Manns
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Neuron 56:530-40. 2007..The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors... - Oscillatory entrainment of striatal neurons in freely moving ratsJoshua D Berke
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, MA 02215, USA
Neuron 43:883-96. 2004..The orchestration of oscillatory activity by networks of striatal interneurons may be an important mechanism in the pathophysiology of neurological disorders such as Parkinson's disease... - The secret life of memoriesHoward Eichenbaum
Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA
Neuron 50:350-2. 2006..The current findings of Morris et al. in this issue of Neuron suggest that reconsolidation may involve a complex interaction between synaptic and system processing of recent as well as remote experiences... - Hippocampal CA1 spiking during encoding and retrieval: relation to theta phaseJoseph R Manns
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Neurobiol Learn Mem 87:9-20. 2007..The modeling results obtained here demonstrated that the experimentally observed phase differences are consistent with different levels of CA3 synaptic input to CA1 during recognition of repeated items... - Cognitive aging: a common decline of episodic recollection and spatial memory in ratsR Jonathan Robitsek
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 28:8945-54. 2008.... - Robust conjunctive item-place coding by hippocampal neurons parallels learning what happens whereRobert W Komorowski
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 29:9918-29. 2009..These findings support the view that conjunctive representations in the hippocampus underlie the acquisition of context-specific memories... - Recognition memory: opposite effects of hippocampal damage on recollection and familiarityMagdalena M Sauvage
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Nat Neurosci 11:16-8. 2008..These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity... - Striatal versus hippocampal representations during win-stay maze performanceJoshua D Berke
University of Michigan, Department of Psychology, Ann Arbor, MI 48109 1109, USA
J Neurophysiol 101:1575-87. 2009.... - The amygdala modulates neuronal activation in the hippocampus in response to spatial noveltyArchana Sheth
Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Hippocampus 18:169-81. 2008..These findings also raise the possibility that amygdala abnormalities may contribute to impairments in cognitive information processing in subjects with major psychoses... - Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory taskAmy L Griffin
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 27:2416-23. 2007..Our results suggest that trial-phase-selective coding is common in tasks that require rapid alternation between encoding and retrieval processes... - Hippocampal mechanisms for the context-dependent retrieval of episodesMichael E Hasselmo
Department of Psychology Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
Neural Netw 18:1172-90. 2005..The model links data at the cellular level to behavior at the systems level, describing a physiologically plausible mechanism for the brain to recall a given episode which occurred at a specific place and time... - Gradual translocation of spatial correlates of neuronal firing in the hippocampus toward prospective reward locationsInah Lee
Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA
Neuron 51:639-50. 2006..The within-session shifts in preferred firing locations in the absence of any changes in the environment suggest that certain cognitive factors can significantly alter the location-bound coding scheme of hippocampal neurons... - Evolution of declarative memoryJoseph R Manns
Department of Psychology, Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
Hippocampus 16:795-808. 2006.... - The hippocampus and disambiguation of overlapping sequencesKara L Agster
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 22:5760-8. 2002.... - Hippocampal formation lesions impair performance in an odor-odor association task independently of spatial contextPablo Alvarez
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Massachusetts 02215, USA
Neurobiol Learn Mem 78:470-6. 2002..These results support the view that the hippocampal system is necessary for the flexible expression of nonspatial memories even when the spatial context in which the memory is acquired is not critical to retrieval... - The episodic memory system: neurocircuitry and disordersBradford C Dickerson
Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 35:86-104. 2010..A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals... - A cognitive map for object memory in the hippocampusJoseph R Manns
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Learn Mem 16:616-24. 2009..The results suggested that objects were represented as points of interest on the hippocampal cognitive map and that this map was useful in remembering encounters with particular objects in specific locations... - Representations of odors in the rat orbitofrontal cortex change during and after learningPablo Alvarez
Department of Psychology, Boston University, Massachusetts 02215, USA
Behav Neurosci 116:421-33. 2002..Thus, only some of the changes in firing reflected acquisition of the task. The results suggest that learning triggers a continuing reorganization of OF neural ensembles representing odors and their rewards... - Recollection-like memory retrieval in rats is dependent on the hippocampusNorbert J Fortin
Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA
Nature 431:188-91. 2004..Furthermore, following selective damage to the hippocampus the ROC curve became entirely symmetrical and remained curvilinear, supporting the view that the hippocampus specifically mediates the capacity for recollection... - Time and treason to the trisynaptic teachings: theoretical comment on Kesner et Al. (2005)Joseph R Manns
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Behav Neurosci 119:1140-3. 2005.... - Disambiguation of overlapping experiences by neurons in the medial entorhinal cortexPaul A Lipton
Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 27:5787-95. 2007..Furthermore, the results suggest that neuronal populations in the dcMEC and CA1 differentially emphasize complementary aspects of spatial memory representations... - Dynamics of hippocampal and cortical activation during consolidation of a nonspatial memoryRobert S Ross
Center for Memory and Brain, Psychology Department, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 26:4852-9. 2006..These findings support the view that different cortical networks support long-term memory for different types of information... - Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience and Cognitive Neurobiology Laboratory, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 22:1126-36. 2002..The basis for this dissociation might be related to neuroanatomical connections of the rBLA and cBLA with segregated, but parallel, corticostriatalpallidothalamic circuits... - Recognition memory: adding a response deadline eliminates recollection but spares familiarityMagdalena M Sauvage
Center for Memory and Brain, Boston University, Boston 02215, Massachusetts, USA
Learn Mem 17:104-8. 2010..This dissociation, combined with the earlier findings, demonstrates that familiarity and recollection are differentially sensitive to specific memory demands, strongly supporting the dual process view... - Medial prefrontal cortex supports recollection, but not familiarity, in the ratAnja Farovik
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 28:13428-34. 2008..This pattern of findings is similar to that observed in humans with dorsolateral prefrontal damage and is complementary to the selective deficit in hit rate observed after hippocampal damage... - Essential role of the hippocampal formation in rapid learning of higher-order sequential associationsCeren Ergorul
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 26:4111-7. 2006..Extrahippocampal systems can also acquire complex sequential representations, albeit via a gradual learning mechanism... - The caudal medial entorhinal cortex: a selective role in recollection-based recognition memoryMagdalena M Sauvage
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 30:15695-9. 2010..The results indicate that cMEC plays a critical and selective role in recollection-based performance, supporting the view that cMEC supports memory for the spatial and temporal context in which events occur... - Prefrontal cortex: role in acquisition of overlapping associations and transitive inferenceLoren M DeVito
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
Learn Mem 17:161-7. 2010..These results suggest that the prefrontal cortex is part of an integral hippocampal-cortical network essential for relational memory organization... - The hippocampus contributes to memory expression during transitive inference in miceLoren M DeVito
Center for Memory and Brain, Boston University, Boston, MA 02215, USA
Hippocampus 20:208-17. 2010..Furthermore, this study extends to mice a role for the hippocampus in transitive inference, as previously observed in other species... - Distinct roles for dorsal CA3 and CA1 in memory for sequential nonspatial eventsAnja Farovik
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
Learn Mem 17:12-17. 2010..Thus, CA3 and CA1 are both involved in memory for sequential nonspatial events that compose unique experiences, and these areas play different roles that are distinguished by the duration of time that must be bridged between key events... - Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample taskJill McGaughy
Department of Psychology Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 25:10273-81. 2005..This indicates an important role for cholinergic innervation of the entorhinal cortex in working memory for novel stimuli... - It's time to pay attention to attention in agingJill McGaughy
Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Learn Mem 9:151-2. 2002 - Vasopressin 1b receptor knock-out impairs memory for temporal orderLoren M DeVito
Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 29:2676-83. 2009..Because schizophrenia and bipolar disorder are associated with a unique pathology in CA2 and impairments in both social behavior and episodic memory, this animal model could provide insights into the etiology of these disorders... - Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preferenceRobert S Ross
Center for Memory and Brain, Psychology Department, Boston University, Boston, Massachusetts, 02215, USA
Learn Mem 12:302-6. 2005..Cholinergic depletion in the OFC impaired expression of the socially transmitted odor association measured 2 d after training, indicating that cholinergic function in the OFC is essential for this form of associative learning...
Research Grants
- COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTIONHoward Eichenbaum; Fiscal Year: 2007..The combined studies will contribute to the development of animal models that are useful in the assessment of treatments for memory disorder. ..
- COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTIONHoward Eichenbaum; Fiscal Year: 2006..The combined studies will contribute to the development of animal models that are useful in the assessment of treatments for memory disorder. ..
- Core 3: Computer CoreHoward Eichenbaum; Fiscal Year: 2007..Thus, the computer core will enhance the synergistic interaction of the four projects within the center, and the interaction with the scientific community. ..
- HIPPOCAMPAL AND CORTICAL CODING IN MEMORYHoward B Eichenbaum; Fiscal Year: 2010..These characterizations of individual and combined network processing in the hippocampus and surrounding cortex will improve our understanding of the normal functions of this system as well as its breakdown in memory disorders. ..
- COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTIONHoward B Eichenbaum; Fiscal Year: 2010..The combined studies will contribute to the development of animal models that are useful in the assessment of treatments for memory disorder. ..
- HIPPOCAMPAL AND CORTICAL CODING IN MEMORYHoward Eichenbaum; Fiscal Year: 2004..The findings from this work will improve our understanding of 'what the hippocampus does' and what it does within the system of cortical structures with which it interacts in the service of declarative memory. ..
- COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTIONHoward Eichenbaum; Fiscal Year: 2003..abstract_text> ..
- SYNAPTIC PLASTICITY AND MEMORY CODINGHoward Eichenbaum; Fiscal Year: 2003....
- HIPPOCAMPAL AND CORTICAL CODING IN MEMORYHoward Eichenbaum; Fiscal Year: 1999....
- HIPPOCAMPAL AND CORTICAL CODING IN MEMORYHoward B Eichenbaum; Fiscal Year: 2011..These characterizations of individual and combined network processing in the hippocampus and surrounding cortex will improve our understanding of the normal functions of this system as well as its breakdown in memory disorders. ..