Daniel J Dwyer

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Role of reactive oxygen species in antibiotic action and resistance
    Daniel J Dwyer
    Howard Hughes Medical Institute, Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Curr Opin Microbiol 12:482-9. 2009
  2. pmc Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death
    Michael A Kohanski
    Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 135:679-90. 2008
  3. pmc Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis
    Daniel J Dwyer
    Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA
    Mol Cell 46:561-72. 2012
  4. ncbi request reprint A common mechanism of cellular death induced by bactericidal antibiotics
    Michael A Kohanski
    Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 130:797-810. 2007
  5. doi request reprint Identification and characterization of programmed cell death markers in bacterial models
    Daniel J Dwyer
    Department of Biomedical Engineering and Center for BioDynamics, Howard Hughes Medical Institute, Boston University, Boston, MA, USA
    Methods Mol Biol 1004:145-59. 2013
  6. pmc Antibiotics induce redox-related physiological alterations as part of their lethality
    Daniel J Dwyer
    Howard Hughes Medical Institute, Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215
    Proc Natl Acad Sci U S A 111:E2100-9. 2014
  7. pmc Antibiotic efficacy is linked to bacterial cellular respiration
    Michael A Lobritz
    Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115 Institute for Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139 Broad Institute of MIT and Harvard, Cambridge, MA 02139 Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114 Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:8173-80. 2015
  8. pmc How antibiotics kill bacteria: from targets to networks
    Michael A Kohanski
    Howard Hughes Medical Institute and the Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Rev Microbiol 8:423-35. 2010
  9. pmc Networking opportunities for bacteria
    Daniel J Dwyer
    Howard Hughes Medical Institute, Center for BioDynamics, Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 135:1153-6. 2008
  10. pmc Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli
    Daniel J Dwyer
    Program in Molecular Biology, Cell Biology and Biochemistry, Boston University, Boston, MA 02215, USA
    Mol Syst Biol 3:91. 2007

Collaborators

  • Noriko Takahashi
  • Farren J Isaacs
  • Guillaume Cottarel
  • Michael A Kohanski
  • James J Collins
  • Michael A Lobritz
  • Jarred M Callura
  • Caroline B M Porter
  • Peter Belenky
  • Arnaud Gutierrez
  • Jason H Yang
  • Ahmad S Khalil
  • Eric G Schwarz
  • Charles R Cantor
  • Jamey Wierzbowski
  • Carolyn A Lawrence
  • Boris Hayete

Detail Information

Publications11

  1. pmc Role of reactive oxygen species in antibiotic action and resistance
    Daniel J Dwyer
    Howard Hughes Medical Institute, Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Curr Opin Microbiol 12:482-9. 2009
    ..Additionally, we describe ways in which these responses are being taken advantage to combat bacterial infections and arrest the rise of resistant strains...
  2. pmc Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death
    Michael A Kohanski
    Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 135:679-90. 2008
    ....
  3. pmc Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis
    Daniel J Dwyer
    Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA
    Mol Cell 46:561-72. 2012
    ....
  4. ncbi request reprint A common mechanism of cellular death induced by bactericidal antibiotics
    Michael A Kohanski
    Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 130:797-810. 2007
    ..g., reca...
  5. doi request reprint Identification and characterization of programmed cell death markers in bacterial models
    Daniel J Dwyer
    Department of Biomedical Engineering and Center for BioDynamics, Howard Hughes Medical Institute, Boston University, Boston, MA, USA
    Methods Mol Biol 1004:145-59. 2013
    ....
  6. pmc Antibiotics induce redox-related physiological alterations as part of their lethality
    Daniel J Dwyer
    Howard Hughes Medical Institute, Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215
    Proc Natl Acad Sci U S A 111:E2100-9. 2014
    ....
  7. pmc Antibiotic efficacy is linked to bacterial cellular respiration
    Michael A Lobritz
    Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115 Institute for Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139 Broad Institute of MIT and Harvard, Cambridge, MA 02139 Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114 Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:8173-80. 2015
    ..Our data collectively show that antibiotics perturb the metabolic state of bacteria and that the metabolic state of bacteria impacts antibiotic efficacy...
  8. pmc How antibiotics kill bacteria: from targets to networks
    Michael A Kohanski
    Howard Hughes Medical Institute and the Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Rev Microbiol 8:423-35. 2010
    ....
  9. pmc Networking opportunities for bacteria
    Daniel J Dwyer
    Howard Hughes Medical Institute, Center for BioDynamics, Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 135:1153-6. 2008
    ..Here, we highlight recent systems biology studies in prokaryotes, consider the challenges ahead, and suggest opportunities for future studies in bacterial models...
  10. pmc Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli
    Daniel J Dwyer
    Program in Molecular Biology, Cell Biology and Biochemistry, Boston University, Boston, MA 02215, USA
    Mol Syst Biol 3:91. 2007
    ..Together, this series of biochemical reactions appears to compose a maladaptive response, that serves to amplify the primary effect of gyrase inhibition by oxidatively damaging DNA, proteins and lipids...
  11. pmc Tracking, tuning, and terminating microbial physiology using synthetic riboregulators
    Jarred M Callura
    Howard Hughes Medical Institute, Boston University, MA 02215, USA
    Proc Natl Acad Sci U S A 107:15898-903. 2010
    ..This work establishes a broad, easy-to-use synthetic biology platform for microbiology experiments and biotechnology applications...