Alexandra Dumitriu

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
    Parkinsons Dis 2012:614212. 2012
  2. pmc Comparative multi-goal tradeoffs in systems engineering of microbial metabolism
    David Byrne
    Bioinformatics Program, Boston University, Boston, MA 02215, USA
    BMC Syst Biol 6:127. 2012
  3. pmc Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002794. 2012
  4. pmc Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, E 304, Boston, MA 02118, USA
    Hum Mol Genet 20:1478-87. 2011
  5. pmc Evaluation of Parkinson disease risk variants as expression-QTLs
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46199. 2012
  6. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
  7. doi MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
    Andrew G Hoss
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America Graduate Program in Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004188. 2014
  8. pmc Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease
    Amélie C Lanoue
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    Exp Neurol 226:207-17. 2010

Detail Information

Publications8

  1. pmc Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
    Parkinsons Dis 2012:614212. 2012
    ..For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples...
  2. pmc Comparative multi-goal tradeoffs in systems engineering of microbial metabolism
    David Byrne
    Bioinformatics Program, Boston University, Boston, MA 02215, USA
    BMC Syst Biol 6:127. 2012
    ..Persistent during these advances has been the desire to develop design strategies that address multiple simultaneous engineering goals, such as maximizing productivity, while minimizing raw material costs...
  3. pmc Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002794. 2012
    ..These results implicate FOXO1 as a PD-relevant gene and warrant further functional analyses of its transcriptional regulatory mechanisms...
  4. pmc Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, E 304, Boston, MA 02118, USA
    Hum Mol Genet 20:1478-87. 2011
    ..This, combined with GAK's observed relationship to the levels of α-synuclein expression and toxicity, suggests that the protein is an attractive therapeutic target for the treatment of PD...
  5. pmc Evaluation of Parkinson disease risk variants as expression-QTLs
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46199. 2012
    ..These findings provide additional context for the interpretation of PD associated SNPs identified in recent GWAS as well as potential insight into the mechanisms underlying the observed SNP associations...
  6. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
    ..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age...
  7. doi MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
    Andrew G Hoss
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America Graduate Program in Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004188. 2014
    ..Recently, miRNAs have shown promise as biomarkers for human diseases and given their relationship to disease expression, these miRNAs are biomarker candidates in HD. ..
  8. pmc Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease
    Amélie C Lanoue
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    Exp Neurol 226:207-17. 2010
    ..Altogether, the results support the possibility that GABAergic neurotransmission is impaired in the DLPFC in PD, an effect that may be involved in some of the behavioral deficits associated with the disease...