Martin L Duennwald

Summary

Affiliation: Boston Biomedical Research Institute
Country: USA

Publications

  1. pmc Countering amyloid polymorphism and drug resistance with minimal drug cocktails
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, MA, USA
    Prion 4:244-51. 2010
  2. pmc Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin
    Sidhartha M Chafekar
    Regenerative Biology Program, Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS ONE 7:e37929. 2012
  3. ncbi request reprint Polyglutamine misfolding in yeast: toxic and protective aggregation
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, MA, USA
    Prion 5:285-90. 2011
  4. doi request reprint Monitoring polyglutamine toxicity in yeast
    Martin L Duennwald
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Methods 53:232-7. 2011
  5. pmc Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation
    Sidhartha M Chafekar
    Boston Biomedical Research Institute, Watertown, MA 04272 2829, USA
    ACS Chem Biol 7:1556-64. 2012
  6. pmc Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS Biol 10:e1001346. 2012

Collaborators

  • James Shorter
  • Sidhartha M Chafekar
  • Christopher G Evans
  • Analisa Echeverria
  • Leah N Makley
  • Gladis M Walter
  • Susanne Wisén
  • Andrea D Thompson
  • Jason E Gestwicki

Detail Information

Publications6

  1. pmc Countering amyloid polymorphism and drug resistance with minimal drug cocktails
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, MA, USA
    Prion 4:244-51. 2010
    ..We suggest that minimal drug cocktails, small collections of drugs that collectively antagonize all amyloid polymorphs, should be identified to besiege various neurodegenerative disorders...
  2. pmc Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin
    Sidhartha M Chafekar
    Regenerative Biology Program, Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS ONE 7:e37929. 2012
    ....
  3. ncbi request reprint Polyglutamine misfolding in yeast: toxic and protective aggregation
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, MA, USA
    Prion 5:285-90. 2011
    ..Future studies like the ones discussed here have the potential to transform basic concepts of protein misfolding in human diseases and may thus help to identify new therapeutic strategies for their treatment...
  4. doi request reprint Monitoring polyglutamine toxicity in yeast
    Martin L Duennwald
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Methods 53:232-7. 2011
    ..Here, we describe different expression systems for polyQ-expansion proteins in yeast and we outline experimental protocols to reliably and quantitatively monitor polyQ toxicity in yeast...
  5. pmc Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation
    Sidhartha M Chafekar
    Boston Biomedical Research Institute, Watertown, MA 04272 2829, USA
    ACS Chem Biol 7:1556-64. 2012
    ..Our results thus support an emerging concept in which certain kinds of polyQ aggregates may be protective, while more soluble polyQ species are toxic...
  6. pmc Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
    Martin L Duennwald
    Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS Biol 10:e1001346. 2012
    ..Thus, we elucidate a heretofore-unrecognized human amyloid-depolymerase system that could have applications in various neurodegenerative disorders...