Isabel Dominguez

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi A role for CK2alpha/beta in Xenopus early embryonic development
    Isabel Dominguez
    Hematology Oncology Section, Department of Medicine, Boston University Medical School, Boston, MA, USA
    Mol Cell Biochem 274:125-31. 2005
  2. ncbi Gene targeting of CK2 catalytic subunits
    David C Seldin
    Department of Medicine, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Mol Cell Biochem 316:141-7. 2008
  3. ncbi CK2 as a positive regulator of Wnt signalling and tumourigenesis
    David C Seldin
    Section of Hematology Oncology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Mol Cell Biochem 274:63-7. 2005
  4. ncbi Threonine 393 of beta-catenin regulates interaction with Axin
    Hao Wu
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 108:52-63. 2009
  5. ncbi CK2α is essential for embryonic morphogenesis
    Isabel Dominguez
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Cell Biochem 356:209-16. 2011
  6. ncbi Self-organization of vertebrate mesoderm based on simple boundary conditions
    Jeremy B A Green
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Dyn 231:576-81. 2004
  7. ncbi Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer
    Nicolas Currier
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Genesis 48:183-94. 2010
  8. ncbi The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development
    David Y Lou
    Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Mol Cell Biol 28:131-9. 2008
  9. ncbi Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors
    Nicolas Currier
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Toxicol Pathol 33:726-37. 2005
  10. ncbi CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling
    Diane H Song
    Department of Medicine, Boston University Medical Center, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 278:24018-25. 2003

Collaborators

Detail Information

Publications14

  1. ncbi A role for CK2alpha/beta in Xenopus early embryonic development
    Isabel Dominguez
    Hematology Oncology Section, Department of Medicine, Boston University Medical School, Boston, MA, USA
    Mol Cell Biochem 274:125-31. 2005
    ..Our results demonstrate that CK2 is required for dorsal axis formation and is for normal upregulation of Wnt signaling genes and targets. Thus, CK2 is a regulator of endogenous axis formation in vertebrates...
  2. ncbi Gene targeting of CK2 catalytic subunits
    David C Seldin
    Department of Medicine, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Mol Cell Biochem 316:141-7. 2008
    ....
  3. ncbi CK2 as a positive regulator of Wnt signalling and tumourigenesis
    David C Seldin
    Section of Hematology Oncology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Mol Cell Biochem 274:63-7. 2005
    ..Inhibitors of GSK3 under development for treatment of diabetes could promote tumours, while CK2 inhibitors should be useful agents for treatment of cancer...
  4. ncbi Threonine 393 of beta-catenin regulates interaction with Axin
    Hao Wu
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 108:52-63. 2009
    ..In addition, the increased recruitment of GSK3beta to the destruction complex in the presence of activated beta-catenin mutants could be a feedback mechanism to suppress overactive Wnt signaling...
  5. ncbi CK2α is essential for embryonic morphogenesis
    Isabel Dominguez
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Cell Biochem 356:209-16. 2011
    ..Here, we summarize the overall phenotype found in CK2α (-/- ) mice and describe our initial analysis aimed to identify the cellular processes affected in CK2α mutants...
  6. ncbi Self-organization of vertebrate mesoderm based on simple boundary conditions
    Jeremy B A Green
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Dyn 231:576-81. 2004
    ..This process provides a remarkably simple organizing principle that contributes to the reliability of embryonic development as a whole...
  7. ncbi Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer
    Nicolas Currier
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Genesis 48:183-94. 2010
    ..Thus, this transgenic line is useful for ex vivo and in vitro studies of Wnt signaling in development and cancer...
  8. ncbi The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development
    David Y Lou
    Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Mol Cell Biol 28:131-9. 2008
    ..Defects in the formation of the heart lead to hydrops fetalis and are likely the cause of embryonic lethality. Thus, CK2alpha appears to play an essential and uncompensated role in mammalian development...
  9. ncbi Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors
    Nicolas Currier
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Toxicol Pathol 33:726-37. 2005
    ..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis...
  10. ncbi CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling
    Diane H Song
    Department of Medicine, Boston University Medical Center, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 278:24018-25. 2003
    ..Thus, CK2 is a positive regulator of Wnt signaling through phosphorylation of beta-catenin at Thr393, leading to proteasome resistance and increased protein and co-transcriptional activity...
  11. ncbi Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis
    Marganit Farago
    Molecular Medicine Program, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    Cancer Res 65:5792-801. 2005
    ..Thus, antagonism of GSK3beta activity is oncogenic in the mammary epithelium; mutation or pharmacologic down-regulation of GSK3beta could promote mammary tumors...
  12. ncbi Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos
    Isabel Dominguez
    Section of Hematology Oncology Department of Medicine, Boston University School of Medicine, Boston MA 02118, USA
    Dev Biol 274:110-24. 2004
    ..Taken together, these studies demonstrate that CK2 is a bona fide member of the Wnt pathway and has a critical role in the establishment of the dorsal embryonic axis...
  13. ncbi Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL
    Vipul C Chitalia
    Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Cell Biol 10:1208-16. 2008
    ..The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1...
  14. ncbi Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart
    Kyriakos N Papanicolaou
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circ Res 111:1012-26. 2012
    ..Mitofusins (Mfn-1 and Mfn-2) are known regulators of mitochondrial networks, but their role during perinatal maturation of the heart has yet to be examined...