GERALD DENIS

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
    Anna C Belkina
    1 72 East Concord St, Rm K520, Boston, MA 02118, USA Twitter http www twitter com GdenisBoston
    J Leukoc Biol 95:451-60. 2014
  2. pmc 'Metabolically healthy obesity': origins and implications
    Gerald V Denis
    Immunology Training Program, Cancer Research Center and Boston Nutrition Obesity Research Center, Boston University School of Medicine, 72 East Concord St Room K520, Boston, MA, USA
    Mol Aspects Med 34:59-70. 2013
  3. pmc Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation
    Gerald V Denis
    Cancer Research Center, Boston University School of Medicine, 72 East Concord Street, K520, Boston, Massachusetts 02118, USA
    Discov Med 10:489-99. 2010
  4. pmc An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis
    Gerald V Denis
    Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    FEBS Lett 584:3260-8. 2010
  5. pmc RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Massachusetts 02118, USA
    Cell Growth Differ 11:417-24. 2000
  6. pmc Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines
    Gerald V Denis
    Pharmacology and Medicine, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Proteome Res 5:502-11. 2006
  7. pmc Bromodomain motifs and "scaffolding"?
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA
    Front Biosci 6:D1065-8. 2001
  8. pmc Duality in bromodomain-containing protein complexes
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA
    Front Biosci 6:D849-52. 2001
  9. pmc Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A
    Anupama Sinha
    Cancer Research Center, Boston University School of Medicine, 80 East Concord Street, K521, Boston, MA 02118, USA
    Biochem J 387:257-69. 2005
  10. pmc Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes
    Jianxin You
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Virol 80:8909-19. 2006

Research Grants

  1. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 1999
  2. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 2000
  3. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 2001
  4. Biomarkers for lymphoma in a new transgenic mouse model
    GERALD DENIS; Fiscal Year: 2005
  5. Proteomic biomarkers for lymphoma
    GERALD DENIS; Fiscal Year: 2007
  6. BRD2-MULTIPROTEIN COMPLEXES IN MAMMALIAN CELL CYCLE TRANSCRIPTIONAL CONTROL
    GERALD DENIS; Fiscal Year: 2004

Collaborators

  • DOUGLAS FALLER
  • Gavin R Schnitzler
  • BARBARA SUSANNE NIKOLAJCZYK
  • Anna C Belkina
  • Anupama Sinha
  • Wanda P Blanton
  • Fangnian Wang
  • Marc E Lenburg
  • Jianxin You
  • Rebecca J Greenwald
  • Hongsheng Liu
  • Anna Belkina
  • Nathan K Lebrasseur
  • Mary E Ballestas
  • Kenneth M Kaye
  • Peter M Howley
  • William J Harrington
  • Viswanathan Srinivasan
  • Joseph R Tumang
  • Nicolas Currier
  • Robert D Cardiff
  • Thomas L Rothstein

Detail Information

Publications14

  1. pmc The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
    Anna C Belkina
    1 72 East Concord St, Rm K520, Boston, MA 02118, USA Twitter http www twitter com GdenisBoston
    J Leukoc Biol 95:451-60. 2014
    ..Brd2-specific knockdown experiments show that Brd2 is also required for hematopoiesis. We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes, particularly cyclin A, in B cells. ..
  2. pmc 'Metabolically healthy obesity': origins and implications
    Gerald V Denis
    Immunology Training Program, Cancer Research Center and Boston Nutrition Obesity Research Center, Boston University School of Medicine, 72 East Concord St Room K520, Boston, MA, USA
    Mol Aspects Med 34:59-70. 2013
    ....
  3. pmc Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation
    Gerald V Denis
    Cancer Research Center, Boston University School of Medicine, 72 East Concord Street, K520, Boston, Massachusetts 02118, USA
    Discov Med 10:489-99. 2010
    ....
  4. pmc An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis
    Gerald V Denis
    Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    FEBS Lett 584:3260-8. 2010
    ..The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity...
  5. pmc RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Massachusetts 02118, USA
    Cell Growth Differ 11:417-24. 2000
    ..These data suggest that RING3 is a potentially important regulator of E2F-dependent cell cycle genes...
  6. pmc Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines
    Gerald V Denis
    Pharmacology and Medicine, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Proteome Res 5:502-11. 2006
    ..This multiprotein complex is likely to contribute to cell cycle control and play a role in proliferation and cancer...
  7. pmc Bromodomain motifs and "scaffolding"?
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA
    Front Biosci 6:D1065-8. 2001
    ....
  8. pmc Duality in bromodomain-containing protein complexes
    G V Denis
    Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA
    Front Biosci 6:D849-52. 2001
    ..Their versatility and ubiquity ensures diverse, rapid and flexible transcriptional responses...
  9. pmc Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A
    Anupama Sinha
    Cancer Research Center, Boston University School of Medicine, 80 East Concord Street, K521, Boston, MA 02118, USA
    Biochem J 387:257-69. 2005
    ....
  10. pmc Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes
    Jianxin You
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Virol 80:8909-19. 2006
    ..Additionally, because Brd4 has recently been shown to have a role in transcription, we examined whether Brd4 can regulate the CDK2 promoter, which can be transactivated by LANA...
  11. pmc E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia
    Rebecca J Greenwald
    Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Harvard Medcial School, Boston, MA, USA
    Blood 103:1475-84. 2004
    ..This report is the first to describe a transgenic mouse model for constitutive expression of a protein with more than one bromodomain...
  12. pmc Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis
    Marc E Lenburg
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:4803-11. 2007
    ....
  13. pmc Brd2 disruption in mice causes severe obesity without Type 2 diabetes
    Fangnian Wang
    Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 425:71-83. 2010
    ..Thus hypomorphic Brd2 shifts energy balance toward storage without causing glucose intolerance and may provide a novel model for obese metabolically healthy humans...
  14. pmc Obesity genes and insulin resistance
    Anna C Belkina
    Boston Nutrition Obesity Research Center, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Endocrinol Diabetes Obes 17:472-7. 2010
    ..The molecular basis for this protection is not well understood but is likely to involve reduced inflammatory responses. The inflammatory cells and pathways that respond to overnutrition are the primary subject matter for this review...

Research Grants8

  1. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 1999
    ....
  2. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 2000
    ....
  3. NOVEL MITOGEN ACTIVATED NUCLEAR KINASE
    GERALD DENIS; Fiscal Year: 2001
    ....
  4. Biomarkers for lymphoma in a new transgenic mouse model
    GERALD DENIS; Fiscal Year: 2005
    ....
  5. Proteomic biomarkers for lymphoma
    GERALD DENIS; Fiscal Year: 2007
    ..This approach greatly simplifies proteomic biomarker discovery for lymphoid malignancy. The heuristic should be adaptable and extendable to a wide spectrum of human hematologic malignancies, including myeloid leukemias. ..
  6. BRD2-MULTIPROTEIN COMPLEXES IN MAMMALIAN CELL CYCLE TRANSCRIPTIONAL CONTROL
    GERALD DENIS; Fiscal Year: 2004
    ..Abstract Not Provided. ..