Micah Dembo

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Stresses at the cell-to-substrate interface during locomotion of fibroblasts
    M Dembo
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 2407, USA
    Biophys J 76:2307-16. 1999
  2. ncbi request reprint Mechanics of neutrophil phagocytosis: experiments and quantitative models
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 119:1903-13. 2006
  3. pmc Baseline mechanical characterization of J774 macrophages
    Jonathan Lam
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Biophys J 96:248-54. 2009
  4. pmc Form and function in cell motility: from fibroblasts to keratocytes
    Marc Herant
    Biomedical Engineering Department, Boston University, Boston, Massachusetts, USA
    Biophys J 98:1408-17. 2010
  5. pmc Influence of type I collagen surface density on fibroblast spreading, motility, and contractility
    Christianne Gaudet
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Biophys J 85:3329-35. 2003
  6. pmc Cytopede: a three-dimensional tool for modeling cell motility on a flat surface
    Marc Herant
    Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, USA
    J Comput Biol 17:1639-77. 2010
  7. pmc Protrusive push versus enveloping embrace: computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors
    Marc Herant
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001068. 2011
  8. ncbi request reprint Mechanics of neutrophil phagocytosis: behavior of the cortical tension
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 118:1789-97. 2005
  9. pmc Analysis of actin FLAP dynamics in the leading lamella
    Igor R Kuznetsov
    Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e10082. 2010
  10. pmc Cell-cell mechanical communication through compliant substrates
    Cynthia A Reinhart-King
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Biophys J 95:6044-51. 2008

Research Grants

Collaborators

  • Marc Herant
  • Volkmar Heinrich
  • Cynthia A Reinhart-King
  • Joyce Wong
  • S Chien
  • Amit Gefen
  • Song Li
  • Ira Mellman
  • Daniel Coombs
  • Martin Schwartz
  • Karen A Beningo
  • William A Marganski
  • Yu li Wang
  • Igor R Kuznetsov
  • Jonathan Lam
  • Maria L Lombardi
  • Lee A Smith
  • Sangwon V Kim
  • Daniel A Hammer
  • Matthew J Paszek
  • Yan Ting Shiu
  • Christianne Gaudet
  • Juliet Lee
  • Jered B Haun
  • Helim Aranda-Espinoza
  • David A Knecht
  • Kozue Hamao
  • Wajahat Z Mehal
  • Hiroshi Hosoya
  • Mark S Mooseker
  • Marc Pypaert
  • Richard A Flavell
  • Dianqing Wu
  • Xuemei Dong
  • Kandice R Johnson
  • Nastaran Zahir
  • David Boettiger
  • Susan S Margulies
  • Johnathon N Lakins
  • Valerie M Weaver
  • Gabriela I Rozenberg
  • Shunichi Usami
  • Sooyoung Kim
  • Maria L Burgess
  • Vanessa M De Biase
  • Christopher T Brown
  • Vaibhavi Gunderia

Detail Information

Publications21

  1. pmc Stresses at the cell-to-substrate interface during locomotion of fibroblasts
    M Dembo
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 2407, USA
    Biophys J 76:2307-16. 1999
    ..These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action...
  2. ncbi request reprint Mechanics of neutrophil phagocytosis: experiments and quantitative models
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 119:1903-13. 2006
    ..5 microm), and that the flattening force can plausibly be generated by the known concentrations of unconventional myosins at the leading edge...
  3. pmc Baseline mechanical characterization of J774 macrophages
    Jonathan Lam
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Biophys J 96:248-54. 2009
    ..Scanning electron micrographs show how microscopic membrane wrinkles are smoothed out and recruited into the apparent surface area during phagocytosis of large targets...
  4. pmc Form and function in cell motility: from fibroblasts to keratocytes
    Marc Herant
    Biomedical Engineering Department, Boston University, Boston, Massachusetts, USA
    Biophys J 98:1408-17. 2010
    ..These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components...
  5. pmc Influence of type I collagen surface density on fibroblast spreading, motility, and contractility
    Christianne Gaudet
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Biophys J 85:3329-35. 2003
    ....
  6. pmc Cytopede: a three-dimensional tool for modeling cell motility on a flat surface
    Marc Herant
    Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, USA
    J Comput Biol 17:1639-77. 2010
    ....
  7. pmc Protrusive push versus enveloping embrace: computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors
    Marc Herant
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001068. 2011
    ..These linkages are presumably actin-binding protein complexes associating with the cytoplasmic domains of cell-surface receptors that are engaged in adhesion to zymosan and Fc-domains...
  8. ncbi request reprint Mechanics of neutrophil phagocytosis: behavior of the cortical tension
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 118:1789-97. 2005
    ..We propose that this is the result of phagocytosis-triggered enzymatic activity that releases spare plasma membrane normally sequestered by velcro-like bonds in a reservoir of surface folds and villi...
  9. pmc Analysis of actin FLAP dynamics in the leading lamella
    Igor R Kuznetsov
    Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e10082. 2010
    ..Science, v. 300, pp. 142-145 [1])...
  10. pmc Cell-cell mechanical communication through compliant substrates
    Cynthia A Reinhart-King
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Biophys J 95:6044-51. 2008
    ..These findings are critical for the understanding of cell-cell adhesion during tissue formation and disease progression, and for the design of biomaterials intended to support both cell-matrix and cell-cell adhesion...
  11. ncbi request reprint Demonstration of altered fibroblast contractile activity in hypertensive heart disease
    William A Marganski
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Cardiovasc Res 60:547-56. 2003
    ..The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD)...
  12. pmc The mechanics of neutrophils: synthetic modeling of three experiments
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Biophys J 84:3389-413. 2003
    ....
  13. ncbi request reprint Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
    ..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
  14. pmc Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors
    Karen A Beningo
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:18024-9. 2004
    ..Changes in cell shape may in turn affect diverse cellular activities, including gene expression, growth, and differentiation, as shown in numerous previous studies...
  15. pmc The dynamics and mechanics of endothelial cell spreading
    Cynthia A Reinhart-King
    Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 89:676-89. 2005
    ..This study is the first to monitor the dynamic changes in the cell shape, spreading rate, and forces exerted during the early stages (first several hours) of endothelial cell adhesion...
  16. pmc Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs
    Daniel Coombs
    Department of Mathematics, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada
    Biophys J 86:1408-23. 2004
    ..We demonstrate our model by application to the T cell/antigen-presenting-cell system and outline applications to natural killer cell adhesion...
  17. pmc Rho mediates the shear-enhancement of endothelial cell migration and traction force generation
    Yan Ting Shiu
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, California 92093 0427, USA
    Biophys J 86:2558-65. 2004
    ..Our results indicate that shear stress enhances the migration speed of endothelial cells by modulating the biophysical force of tractions through the biochemical pathway of Rho-p160ROCK...
  18. ncbi request reprint Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement
    Maria L Lombardi
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
    J Cell Sci 120:1624-34. 2007
    ..We propose that myosin II motor activity increases the rate and frequency at which traction stress asymmetry develops, whereas actin crosslinking activity is important for stabilizing it...
  19. pmc Neutrophil traction stresses are concentrated in the uropod during migration
    Lee A Smith
    Biophys J 92:L58-60. 2007
    ..Our findings suggest an entirely new model of neutrophil locomotion...
  20. pmc Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase
    Karen A Beningo
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Arch Biochem Biophys 456:224-31. 2006
    ....
  21. ncbi request reprint Modulation of cell adhesion and motility in the immune system by Myo1f
    Sangwon V Kim
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 314:136-9. 2006
    ..In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection...

Research Grants8

  1. THE BIOPHYSICS OF CELL-SUBSTRATUM TRACTION STRESS
    Micah Dembo; Fiscal Year: 2003
    ..AIM number 4 to test the functional linkage between the transmission to traction forces to the substratum, the presence of various integrin isotypes and the presence of Zxyin containing adhesion sites. ..
  2. Quantitative Models of Cell Shape and Motion
    Micah Dembo; Fiscal Year: 2007
    ..3. To use this shallow-water computational tool to model whole cell migration on a surface. Emphasis will be put on the analysis of popular experimental systems of motility such as fish keratocytes or 3T3 fibroblasts. ..