Research Topics
| Micah DemboSummaryAffiliation: Boston University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Stresses at the cell-to-substrate interface during locomotion of fibroblastsM Dembo
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 2407, USA
Biophys J 76:2307-16. 1999..These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action...
Mechanics of neutrophil phagocytosis: experiments and quantitative modelsMarc Herant
Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
J Cell Sci 119:1903-13. 2006..5 microm), and that the flattening force can plausibly be generated by the known concentrations of unconventional myosins at the leading edge...- Baseline mechanical characterization of J774 macrophagesJonathan Lam
Department of Biomedical Engineering, University of California, Davis, California 95616, USA
Biophys J 96:248-54. 2009..Scanning electron micrographs show how microscopic membrane wrinkles are smoothed out and recruited into the apparent surface area during phagocytosis of large targets... - Form and function in cell motility: from fibroblasts to keratocytesMarc Herant
Biomedical Engineering Department, Boston University, Boston, Massachusetts, USA
Biophys J 98:1408-17. 2010..These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components... - Influence of type I collagen surface density on fibroblast spreading, motility, and contractilityChristianne Gaudet
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
Biophys J 85:3329-35. 2003.... - Cytopede: a three-dimensional tool for modeling cell motility on a flat surfaceMarc Herant
Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, USA
J Comput Biol 17:1639-77. 2010.... - Protrusive push versus enveloping embrace: computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchorsMarc Herant
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
PLoS Comput Biol 7:e1001068. 2011..These linkages are presumably actin-binding protein complexes associating with the cytoplasmic domains of cell-surface receptors that are engaged in adhesion to zymosan and Fc-domains... - Mechanics of neutrophil phagocytosis: behavior of the cortical tensionMarc Herant
Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
J Cell Sci 118:1789-97. 2005..We propose that this is the result of phagocytosis-triggered enzymatic activity that releases spare plasma membrane normally sequestered by velcro-like bonds in a reservoir of surface folds and villi... - Analysis of actin FLAP dynamics in the leading lamellaIgor R Kuznetsov
Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
PLoS ONE 5:e10082. 2010..Science, v. 300, pp. 142-145 [1])... - Cell-cell mechanical communication through compliant substratesCynthia A Reinhart-King
Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
Biophys J 95:6044-51. 2008..These findings are critical for the understanding of cell-cell adhesion during tissue formation and disease progression, and for the design of biomaterials intended to support both cell-matrix and cell-cell adhesion... - Demonstration of altered fibroblast contractile activity in hypertensive heart diseaseWilliam A Marganski
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Cardiovasc Res 60:547-56. 2003..CONCLUSION: These in vitro data suggest that among the many factors producing hypertensive heart disease in SHR's are excessive contraction of their cardiac fibroblasts and defective control of fibroblast contraction by Ang II... - The mechanics of neutrophils: synthetic modeling of three experimentsMarc Herant
Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Biophys J 84:3389-413. 2003.... - Tensional homeostasis and the malignant phenotypeMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 8:241-54. 2005..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype... - Responses of fibroblasts to anchorage of dorsal extracellular matrix receptorsKaren A Beningo
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 101:18024-9. 2004..Changes in cell shape may in turn affect diverse cellular activities, including gene expression, growth, and differentiation, as shown in numerous previous studies... - The dynamics and mechanics of endothelial cell spreadingCynthia A Reinhart-King
Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biophys J 89:676-89. 2005..This study is the first to monitor the dynamic changes in the cell shape, spreading rate, and forces exerted during the early stages (first several hours) of endothelial cell adhesion... - Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairsDaniel Coombs
Department of Mathematics, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada
Biophys J 86:1408-23. 2004..We demonstrate our model by application to the T cell/antigen-presenting-cell system and outline applications to natural killer cell adhesion... - Rho mediates the shear-enhancement of endothelial cell migration and traction force generationYan-Ting Shiu
Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, California 92093-0427, USA
Biophys J 86:2558-65. 2004..Our results indicate that shear stress enhances the migration speed of endothelial cells by modulating the biophysical force of tractions through the biochemical pathway of Rho-p160ROCK... - Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movementMaria L Lombardi
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
J Cell Sci 120:1624-34. 2007..We propose that myosin II motor activity increases the rate and frequency at which traction stress asymmetry develops, whereas actin crosslinking activity is important for stabilizing it... - Neutrophil traction stresses are concentrated in the uropod during migrationLee A Smith
Biophys J 92:L58-60. 2007..Our findings suggest an entirely new model of neutrophil locomotion... - Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinaseKaren A Beningo
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Arch Biochem Biophys 456:224-31. 2006.... - Modulation of cell adhesion and motility in the immune system by Myo1fSangwon V Kim
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 314:136-9. 2006..In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection...
Research Grants
- THE BIOPHYSICS OF CELL-SUBSTRATUM TRACTION STRESSMicah Dembo; Fiscal Year: 2003..AIM number 4 to test the functional linkage between the transmission to traction forces to the substratum, the presence of various integrin isotypes and the presence of Zxyin containing adhesion sites. ..
- Quantitative Models of Cell Shape and MotionMicah Dembo; Fiscal Year: 2007..3. To use this shallow-water computational tool to model whole cell migration on a surface. Emphasis will be put on the analysis of popular experimental systems of motility such as fish keratocytes or 3T3 fibroblasts. ..