Genomes and Genes
Affiliation: Boston University
- Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring StudyStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Stroke 41:600-6. 2010..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
- The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysisStephanie Debette
Clinical Neuroscience, St George s University of London, London
BMJ 341:c3666. 2010..To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death...
- Parental occurrence of stroke and risk of stroke in their children: the Framingham studySudha Seshadri
Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
Circulation 121:1304-12. 2010..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status...
- Visceral fat is associated with lower brain volume in healthy middle-aged adultsStephanie Debette
Department of Neurology, Boston University School of Medicine, MA, USA
Ann Neurol 68:136-44. 2010....
- Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
- Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring StudyZaldy S Tan
Veterans Administration Boston HealthcareSystem, Boston, MA, USA
Diabetes Care 34:1766-70. 2011..We aimed to comprehensively relate all of the components of metabolic dysregulation to cognitive function and brain magnetic resonance imaging (MRI) in middle-aged adults...
- Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring StudyAleksandra Pikula
Boston University Schools of Medicine and Public Health, MA, USA
Circulation 125:2100-7. 2012....
- Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE ConsortiumStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
Stroke 41:210-7. 2010..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
- Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levelsStephanie Debette
Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
Circ Res 109:554-63. 2011..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings...