Stephanie Debette

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
  2. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
  3. doi request reprint Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts Institut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux Department of Neurology, University Hospital of Bordeaux, Bordeaux, France Electronic address
    Biol Psychiatry 77:749-63. 2015
  4. doi request reprint Vascular risk factors and cognitive disorders
    S Debette
    Department of Neurology, Hopital Lariboisiere, 2, rue Ambroise Pare, 75475 Paris Cedex 10, France Inserm unit U740, Universite Paris Diderot Paris 7, UFR de médecine Paris Diderot Paris 7 site Villemin, 10, avenue de Verdun, 75010 Paris, France Paris 7 University, DHU neurovasc Sorbonne Paris Cité, 190, avenue de France, 75013 Paris, France Department of Neurology, Framingham Heart Study, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA Electronic address
    Rev Neurol (Paris) 169:757-64. 2013
  5. doi request reprint Abdominal obesity and lower gray matter volume: a Mendelian randomization study
    Stephanie Debette
    INSERM, Neuroepidemiology U708, Paris and Bordeaux, France Department of Epidemiology, University of Versailles Saint Quentin en Yvelines, Garches, France Department of Neurology, Boston University School of Medicine, Boston, MA, USA Department of Neurology, Lariboisiere Hospital, Paris 7 University, Paris, France Electronic address
    Neurobiol Aging 35:378-86. 2014
  6. pmc The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
    Stephanie Debette
    Clinical Neuroscience, St George s University of London, London
    BMJ 341:c3666. 2010
  7. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
  8. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
  9. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
  10. pmc Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study
    Zaldy S Tan
    Veterans Administration Boston HealthcareSystem, Boston, MA, USA
    Diabetes Care 34:1766-70. 2011

Detail Information

Publications15

  1. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
    ..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
  2. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  3. doi request reprint Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts Institut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux Department of Neurology, University Hospital of Bordeaux, Bordeaux, France Electronic address
    Biol Psychiatry 77:749-63. 2015
    ..Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting...
  4. doi request reprint Vascular risk factors and cognitive disorders
    S Debette
    Department of Neurology, Hopital Lariboisiere, 2, rue Ambroise Pare, 75475 Paris Cedex 10, France Inserm unit U740, Universite Paris Diderot Paris 7, UFR de médecine Paris Diderot Paris 7 site Villemin, 10, avenue de Verdun, 75010 Paris, France Paris 7 University, DHU neurovasc Sorbonne Paris Cité, 190, avenue de France, 75013 Paris, France Department of Neurology, Framingham Heart Study, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA Electronic address
    Rev Neurol (Paris) 169:757-64. 2013
    ..Future areas of investigation could include differential class effects of antihypertensive drugs on cognitive outcomes and identification of high risk individuals as target population for clinical trials initiated in midlife. ..
  5. doi request reprint Abdominal obesity and lower gray matter volume: a Mendelian randomization study
    Stephanie Debette
    INSERM, Neuroepidemiology U708, Paris and Bordeaux, France Department of Epidemiology, University of Versailles Saint Quentin en Yvelines, Garches, France Department of Neurology, Boston University School of Medicine, Boston, MA, USA Department of Neurology, Lariboisiere Hospital, Paris 7 University, Paris, France Electronic address
    Neurobiol Aging 35:378-86. 2014
    ..015). Age and BMI-adjusted effect estimates from the MR analysis confirmed the inverse association between GMV and WHR and are in favor of a causal association...
  6. pmc The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
    Stephanie Debette
    Clinical Neuroscience, St George s University of London, London
    BMJ 341:c3666. 2010
    ..To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death...
  7. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  8. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
    ....
  9. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
    ..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status...
  10. pmc Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study
    Zaldy S Tan
    Veterans Administration Boston HealthcareSystem, Boston, MA, USA
    Diabetes Care 34:1766-70. 2011
    ..We aimed to comprehensively relate all of the components of metabolic dysregulation to cognitive function and brain magnetic resonance imaging (MRI) in middle-aged adults...
  11. doi request reprint Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study
    Sara Kaffashian
    From INSERM U897 S K, C T, A s, C D, Y Z, S D, University of Bordeaux, France Peking Union Medical College Hospital Y Z, Beijing, China CNRS CEA UMR 5296 F C, B M, University of Bordeaux, France University of California Davis P M CHRU de Lille S S M, L B, Lille, France INSERM U837 S S M, L B, Lille, France Department of Neurology S D, Bordeaux University Hospital, France Department of Neurology S D, Boston University School of Medicine, Framingham Heart Study, Boston, MA
    Neurology 83:2038-45. 2014
    ..We investigated the relation of circulating plasma β-amyloid (Aβ) with MRI markers of small vessel disease (SVD) in dementia-free community persons...
  12. doi request reprint Plasma lipids and cerebral small vessel disease
    Sabrina Schilling
    From the University of Bordeaux Ségalen S S, C T, C D, Y Z, A A, S D, INSERM U897 Neuroepidemiology, Bordeaux, France Pekin Union Medical College Hospital Y Z, China Inserm U1061 C B, Montpellier University Montpellier I C B University Pierre et Marie Curie Paris 6 A A CNRS CEA UMR5296 F C, B M, Université Bordeaux Segalen, Bordeaux University of Versailles Saint Quentin en Yvelines S D Department of Neurology S D, Lariboisiere Hospital, Paris INSERM UMR S 1161 S D, Paris 7 University, France Department of Neurology S D, Bordeaux University Hospital, Bordeaux and Department of Neurology S D, Boston University School of Medicine, Framingham Heart Study, Boston, MA
    Neurology 83:1844-52. 2014
    ..We examined the cross-sectional association between lipid fractions and 2 MRI markers of cerebral small vessel disease, white matter hyperintensity volume (WMHV) and lacunes, representing powerful predictors of stroke and dementia...
  13. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  14. doi request reprint Pathophysiology and risk factors of cervical artery dissection: what have we learnt from large hospital-based cohorts?
    Stephanie Debette
    aDepartment of Neurology, Lariboisière Hospital bInserm Unit U740 cParis 7 University, DHU neurovasc Sorbonne Paris Cité, Paris, France dDepartment of Neurology, Framingham Heart Study, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Neurol 27:20-8. 2014
    ..Recent large collaborative projects have provided new insights into mechanisms and risk factors of CeAD...
  15. pmc Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
    Circ Res 109:554-63. 2011
    ..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings...