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Genomes and GenesSpecies | Subimal DattaSummaryAffiliation: Boston University Country: USA Publications
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Publications
Fear extinction memory consolidation requires potentiation of pontine-wave activity during REM sleepSubimal Datta
Laboratory of Sleep and Cognitive Neuroscience, and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 33:4561-9. 2013....- Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulnessSubimal Datta
Laboratory of Sleep and Cognitive Neuroscience, and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 31:17007-16. 2011..These findings are relevant for designing a drug that could treat excessive sleepiness by promoting alertness... 
Prenatal protein malnourished rats show changes in sleep/wake behavior as adultsS Datta
Sleep Research Laboratory, Department of Psychiatry and Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Sleep Res 9:71-9. 2000..Prenatally malnourished rats are an excellent animal model to study the role of endogenous serotonin in the regulation of the normal sleep/wake cycle...- Improvement of two-way active avoidance memory requires protein kinase a activation and brain-derived neurotrophic factor expression in the dorsal hippocampusSubimal Datta
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, Suite M 902, Boston, MA, 02118, USA
J Mol Neurosci 38:257-64. 2009..Together, these findings suggest that the PKA activation and BDNF expression in the DH-CA3 is essential for the improvement of TWAA memory... - Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep-wake cycle in the freely moving ratsSubimal Datta
Sleep Research Laboratory, Program in Behavioral Neuroscience and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci Res 70:611-21. 2002..Additionally, these neurons may be an integral part of the brainstem wakefulness and REM sleep-generating mechanisms in the rat... - Activation of phasic pontine-wave generator in the rat: a mechanism for expression of plasticity-related genes and proteins in the dorsal hippocampus and amygdalaSubimal Datta
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Eur J Neurosci 27:1876-92. 2008..These findings are discussed in relation to the role of P-wave generator activation for the REM sleep-dependent development and cognitive functions of the brain... - Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidenceSubimal Datta
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry and Behavioral Neuroscience, Boston University School of Medicine, Boston, MA 02118, USA
Neurosci Biobehav Rev 31:775-824. 2007.... - Regulation of rapid eye movement sleep in the freely moving rat: local microinjection of serotonin, norepinephrine, and adenosine into the brainstemSubimal Datta
Sleep Research Laboratory, Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
Sleep 26:513-20. 2003..This study also tests an alternate hypothesis that serotonin may inhibit REM sleep signs by direct action on the individual REM sleep sign generators... - Activation of pedunculopontine tegmental PKA prevents GABAB receptor activation-mediated rapid eye movement sleep suppression in the freely moving ratSubimal Datta
Sleep and Cognitive Neuroscience Lab, Dept of Psychiatry, Boston Univ School of Medicine, M 902, 715 Albany St, Boston, MA 02118, USA
J Neurophysiol 97:3841-50. 2007..These findings suggest that the PPT GABA(B) receptor activation-mediated REM sleep regulating mechanism involves inactivation of cAMP-PKA signaling in the freely moving rat... - Activation of phasic pontine-wave generator prevents rapid eye movement sleep deprivation-induced learning impairment in the rat: a mechanism for sleep-dependent plasticitySubimal Datta
Sleep Research Laboratory, Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 24:1416-27. 2004..This evidence supports our hypothesis that the activation of the P-wave generator during REM sleep deprivation enhances a physiological process of memory, which occurs naturally during post-training REM sleep... - Novel role of brain stem pedunculopontine tegmental adenylyl cyclase in the regulation of spontaneous REM sleep in the freely moving ratSubimal Datta
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, M 902, 715 Albany St, Boston, Massachusetts 02118, USA
J Neurophysiol 94:1928-37. 2005..These findings suggest that activation of the cAMP-signaling pathway within the cholinergic cell compartment of the PPT is an intracellular biochemical/molecular step for generating REM sleep in the freely moving rat... - Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleepS Datta
Laboratory of Sleep and Cognitive Neuroscience, Boston University School of Medicine, 85 East Newton Street, Suite M 902, Boston, MA 02118, USA
Neuroscience 163:397-414. 2009..Moreover the results indicate that during REM sleep, PPT intracellular PKA activation and a transcriptional cascade involving pCREB occur exclusively in the cholinergic neurons... - A novel role of pedunculopontine tegmental kainate receptors: a mechanism of rapid eye movement sleep generation in the ratS Datta
Sleep Research Laboratory, Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, M 913, 715 Albany Street, Boston, MA 02118, USA
Neuroscience 114:157-64. 2002..The results also suggest that the different types of glutamate receptors within a small part of the brainstem may be involved in different types of physiological functions... - Evidence that REM sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptorSubimal Datta
Sleep Research Laboratory, Program in Behavioral Neuroscience and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurophysiol 87:1790-8. 2002.... - Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleepS Datta
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
Synapse 27:69-78. 1997..The present results demonstrate that endogenous NO synthesized within the PPT cholinergic cells functions as a paracrine signal in the control of waking and sleep by modulating local cholinergic cells... - Localization of pontine PGO wave generation sites and their anatomical projections in the ratS Datta
Center for Behavioral Development and Mental Retardation, Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA
Synapse 30:409-23. 1998..Since PGO-generating cells project to the entorhinal cortex, piriform cortex, amygdala, and hippocampus, these PGO-generating cells could also be involved in the modulation of cognitive functions... - Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleepSubimal Datta
Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 30:12263-73. 2010..945; n = 40 rats). Collectively, these results provide evidence that activation of intracellular PKA in the PPT contributes to REM sleep recovery following REM sleep deprivation... - Avoidance task training potentiates phasic pontine-wave density in the rat: A mechanism for sleep-dependent plasticityS Datta
Sleep Research Laboratory, Program in Behavioral Neuroscience, and Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 20:8607-13. 2000..These findings show that the increase in P-wave density during the post-training REM sleep episodes is correlated with the effective consolidation and retention of avoidance task learning... - The rat as an experimental model for sleep neurophysiologyS Datta
Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA
Behav Neurosci 114:1239-44. 2000..The results suggest that for many neurophysiological studies, the rat is a suitable alternative to the cat... - Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the ratS Datta
Sleep Research Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Physiol Regul Integr Comp Physiol 280:R752-9. 2001..The knowledge of this optimal dose will be useful in future studies investigating the second messenger systems involved in the regulation of wakefulness and REM sleep... - Brainstem afferents of the cholinoceptive pontine wave generation sites in the ratS Datta
Sleep Research Laboratory, Department of Psychiatry, University School of Medicine, Boston, Massachusetts 02118, USA
Sleep Res Online 2:79-82. 1999.... - Cellular and chemical neuroscience of mammalian sleepSubimal Datta
Laboratory of Sleep and Cognitive Neuroscience, Departments of Psychiatry, Neurology, and Neuroscience, Boston University School of Medicine, 85 East Newton Street, Suite M 902, Boston, MA 02118, USA
Sleep Med 11:431-40. 2010..I conclude this review by suggesting some potential future directions to further our understanding of the neurobiology of sleep... - Pontine-wave generator activation-dependent memory processing of avoidance learning involves the dorsal hippocampus in the ratSubimal Datta
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, Boston, MA 02118, USA
J Neurosci Res 80:727-37. 2005..The results also provide evidence that under mnemonic pressure, the dorsal hippocampus may not be involved directly in regulating the sleep-wake cycle... - Activation of pedunculopontine tegmental protein kinase A: a mechanism for rapid eye movement sleep generation in the freely moving ratRam S Bandyopadhya
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 26:8931-42. 2006..Together, these results provide the first evidence that the activation of the PPT intracellular PKA system is involved in the generation of REM sleep... - Spatio-temporal activation of cyclic AMP response element-binding protein, activity-regulated cytoskeletal-associated protein and brain-derived nerve growth factor: a mechanism for pontine-wave generator activation-dependent two-way active-avoidance memorJagadish Ulloor
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurochem 95:418-28. 2005..These dynamic changes in cellular and molecular features provide considerable insight into the mechanisms of the P-wave generator activation-dependent memory consolidation process... - Neurotoxic lesions of phasic pontine-wave generator cells impair retention of 2-way active avoidance memoryVijayakumar Mavanji
Department of Psychiatry, Boston University School of Medicine, Mass 02118, USA
Sleep 27:1282-92. 2004..This evidence supports our hypothesis that the P-wave generator in the brainstem may act as an on switch to provide activating input to forebrain structures for sleep-dependent memory processing... - Spontaneous REM sleep is modulated by the activation of the pedunculopontine tegmental GABAB receptors in the freely moving ratJagadish Ulloor
Sleep Research Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurophysiol 91:1822-31. 2004..Findings of the present study provide direct evidence that the PPT GABAB receptors and REM-on cells are involved in the regulation of REM sleep... - The relationship between anxiety and sleep-wake behavior after stressor exposure in the ratRobert Ross Maclean
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, 85 E Newton St M 902, Boston, MA 02118, USA
Brain Res 1164:72-80. 2007..Rather, individual anxiety may be exacerbated by disrupted sleep. To fully understand the relationship between anxiety and sleep-wake behavior, a more objective analysis of anxiety after stressor exposure is mandated... - Sharing stressful experiences attenuates anxiety-related cognitive and sleep impairmentsBrian W Macone
Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, M 902, Boston, MA 02118, USA
Behav Brain Res 222:351-6. 2011..While these results indicate the benefits and importance of companionship, the underlying mechanism of this phenomenon is yet to be elucidated... - Two-way active avoidance training-specific increases in phosphorylated cAMP response element-binding protein in the dorsal hippocampus, amygdala, and hypothalamusSubhash Saha
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, and Program in Behavioural Neuroscience, Boston University School of Medicine, Building M-902, 715 Albany Street, Boston, MA 02118, USA
Eur J Neurosci 21:3403-14. 2005.... - Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in ratsMax P Huang
Laboratory of Sleep and Cognitive Neurosciences, Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, M 902, Boston, MA 02118, USA
Behav Brain Res 210:54-66. 2010..Contextual memory after administration of zolpidem, at all three doses, was severely disrupted. The results of this study suggest that eszopiclone at a low dose could be used effectively to control anxiety and anxiety-induced insomnia... - Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depressionVijayakumar Mavanji
Sleep Research Laboratory, Department of Psychiatry and Behavioral Neuroscience, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Neuroreport 13:1603-6. 2002.... - Activation of the phasic pontine-wave generator enhances improvement of learning performance: a mechanism for sleep-dependent plasticityVijayakumar Mavanji
Sleep Research Laboratory, Department of Psychiatry and Program in Behavioural Neuroscience, Boston University School of Medicine, Building M-913, 715 Albany Street, Boston, Massachusetts 02118, USA
Eur J Neurosci 17:359-70. 2003..In addition, these findings provide experimental evidence, for the first time, that activation of the P-wave generator may enhance consolidation and integration of memories, resulting in improved performance on a recently learned task... - Effects of passive-avoidance training on sleep-wake state-specific activity in the basolateral and central nuclei of the amygdalaVijayakumar Mavanji
Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA
Behav Neurosci 117:751-9. 2003..However, the PAL-specific changes in the local EEG suggest that some form of memory processing may occur within the amygdala during REM sleep... - Activation of extracellular signal-regulated kinase signaling in the pedunculopontine tegmental cells is involved in the maintenance of sleep in ratsFrank Desarnaud
Department of Laboratory of Sleep and Cognitive Neuroscience, Boston University School of Medicine, Boston, Massachusetts, USA
J Neurochem 116:577-87. 2011..Collectively, these results, for the first time, suggest that the increased ERK1/2 signaling in the PPT is associated with maintenance of sleep via suppression of wakefulness... - A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleepEdward C Stack
Laboratory of Sleep and Cognitive Neurosciences, Boston University School of Medicine, Boston, Massachusetts, USA
J Neurochem 112:271-81. 2010.... - Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed ratVijayakumar Mavanji
Sleep Research Laboratory, Department of Psychiatry and Behavioral Neuroscience, Boston University School of Medicine, M-913, 715 Albany Street, Boston, MA 02118, USA
Eur J Pharmacol 455:35-41. 2002..These results demonstrate for the first time that the central administration of mCPP and mianserin could act as an antidepressant in the clomipramine-induced rat model of depression... - Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: changes in the sleep-wake stages and electroencephalographic power spectraJ L Shea
Sleep and Cognitive Neuroscience Laboratory, Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Brain Res 1213:48-56. 2008..These findings suggest that the REM sleep homeostatic process involves increased delta- and decreased theta-frequency wave activities in the cortical EEG... - Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthoodVijayakumar Mavanji
Sleep Research Laboratory, Department of Psychiatry and Behavioral Neuroscience, Boston University School of Medicine, M 913, 715 Albany Street, Boston, MA 02118, USA
Neurosci Lett 330:119-21. 2002..These results suggest for the first time that the altered cholinergic activity in the specific areas of the brain may be involved in the behavioral depression observed in the rat model of human endogenous depression... - Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleepS Datta
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115
Sleep 16:8-14. 1993..These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL... - Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the ratS Datta
Sleep Research Laboratory, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci Res 66:109-16. 2001..Pretreatment with AP5 decreased the power of gamma-wave activity below its control level. These results support the hypothesis that the glutamate-induced-wakefulness and cortical activation effects are mediated via the NMDA receptors... - Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neuronsChangqing Xu
Department of Psychiatry, CMHC 335 A, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Eur J Neurosci 19:2299-309. 2004..Thus, the H-current in septohippocampal GABAergic neurons modulates the hippocampal theta rhythm... 
Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in ratsMatthew W O'Malley
Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry, Boston University School of Medicine Boston, MA, USA
Front Neurol 4:15. 2013....- The influence of the obstetrician in the relationship between epidural analgesia and cesarean section for dystociaS Segal
Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts, USA
Anesthesiology 91:90-6. 1999.... - Placental tissue enhances uterine relaxation by nitroglycerinS Segal
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115 6110, USA
Anesth Analg 86:304-9. 1998..This study shows that nitroglycerin can relax uterine contractions in the rat, provided that the placenta is adjacent to the uterus. The mechanism seems to be via the release of nitric oxide... - Electrotonic coupling in the nucleus SubCoeruleus. Focus on "evidence for electrical coupling in the SubCoeruleus (SubC) nucleus"Matthew Ennis
J Neurophysiol 97:2579. 2007
Research Grants
- CELLULAR AND NEUROCHEMICAL MECHANISMS OF REM SLEEPSubimal Datta; Fiscal Year: 2007..These studies are relevant not only to questions about the basic neurobiology of sleep but also to questions of sleep disorders and mental illness. ..
- CELLULAR AND NEUROCHEMICAL MECHANISMS OF REM SLEEPSubimal Datta; Fiscal Year: 2009....
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2009....
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2004..abstract_text> ..
- CELLULAR AND NEUROCHEMICAL MECHANISMS OF REM SLEEPSubimal Datta; Fiscal Year: 2002..abstract_text> ..
- CELLULAR AND NEUROCHEMICAL MECHANISMS OF REM SLEEPSubimal Datta; Fiscal Year: 2010....