Subimal Datta

Summary

Affiliation: Boston University
Country: USA

Publications

  1. request reprint
    Datta S. Activation of pedunculopontine tegmental PKA prevents GABAB receptor activation-mediated rapid eye movement sleep suppression in the freely moving rat. J Neurophysiol. 2007;97:3841-50 pubmed
    ..These findings suggest that the PPT GABA(B) receptor activation-mediated REM sleep regulating mechanism involves inactivation of cAMP-PKA signaling in the freely moving rat. ..
  2. request reprint
    Datta S, Spoley E, Patterson E. Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat. Am J Physiol Regul Integr Comp Physiol. 2001;280:R752-9 pubmed
    ..The knowledge of this optimal dose will be useful in future studies investigating the second messenger systems involved in the regulation of wakefulness and REM sleep...
  3. Datta S, Siwek D, Stack E. Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep. Neuroscience. 2009;163:397-414 pubmed publisher
    ..Moreover the results indicate that during REM sleep, PPT intracellular PKA activation and a transcriptional cascade involving pCREB occur exclusively in the cholinergic neurons. ..
  4. Datta S, Desarnaud F. Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. J Neurosci. 2010;30:12263-73 pubmed publisher
    ..945; n = 40 rats). Collectively, these results provide evidence that activation of intracellular PKA in the PPT contributes to REM sleep recovery following REM sleep deprivation. ..
  5. Datta S, O Malley M, Patterson E. Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness. J Neurosci. 2011;31:17007-16 pubmed publisher
    ..These findings are relevant for designing a drug that could treat excessive sleepiness by promoting alertness. ..

Locale

Detail Information

Publications5

  1. request reprint
    Datta S. Activation of pedunculopontine tegmental PKA prevents GABAB receptor activation-mediated rapid eye movement sleep suppression in the freely moving rat. J Neurophysiol. 2007;97:3841-50 pubmed
    ..These findings suggest that the PPT GABA(B) receptor activation-mediated REM sleep regulating mechanism involves inactivation of cAMP-PKA signaling in the freely moving rat. ..
  2. request reprint
    Datta S, Spoley E, Patterson E. Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat. Am J Physiol Regul Integr Comp Physiol. 2001;280:R752-9 pubmed
    ..The knowledge of this optimal dose will be useful in future studies investigating the second messenger systems involved in the regulation of wakefulness and REM sleep...
  3. Datta S, Siwek D, Stack E. Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep. Neuroscience. 2009;163:397-414 pubmed publisher
    ..Moreover the results indicate that during REM sleep, PPT intracellular PKA activation and a transcriptional cascade involving pCREB occur exclusively in the cholinergic neurons. ..
  4. Datta S, Desarnaud F. Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. J Neurosci. 2010;30:12263-73 pubmed publisher
    ..945; n = 40 rats). Collectively, these results provide evidence that activation of intracellular PKA in the PPT contributes to REM sleep recovery following REM sleep deprivation. ..
  5. Datta S, O Malley M, Patterson E. Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness. J Neurosci. 2011;31:17007-16 pubmed publisher
    ..These findings are relevant for designing a drug that could treat excessive sleepiness by promoting alertness. ..