RALPH B D'AGOSTINO

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint Invited commentary: Clinical usefulness of the Framingham cardiovascular risk profile beyond its statistical performance
    RALPH B D'AGOSTINO
    Department of Mathematics and Statistics, Boston University, Massachusetts 02215, USA
    Am J Epidemiol 176:187-9. 2012
  2. pmc Cardiovascular risk estimation in 2012: lessons learned and applicability to the HIV population
    RALPH B D'AGOSTINO
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    J Infect Dis 205:S362-7. 2012
  3. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
  4. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  5. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
  6. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
  7. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
  8. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
  9. ncbi request reprint Non-inferiority trials: design concepts and issues - the encounters of academic consultants in statistics
    RALPH B D'AGOSTINO
    Boston University Statistics and Consulting Unit, 111 Cummington Street, Boston, MA 02215, USA
    Stat Med 22:169-86. 2003
  10. ncbi request reprint New developments in medical clinical trials
    R B D'Agostino
    Boston University, Mathematics and Statistics Department, Statistics and Consulting Unit, 111 Cummington St, Boston, MA 02215, USA
    J Dent Res 83:C18-24. 2004

Research Grants

  1. Data Coordinating Center for IMMEDIATE Trial
    RALPH D AGOSTINO; Fiscal Year: 2006

Detail Information

Publications93

  1. doi request reprint Invited commentary: Clinical usefulness of the Framingham cardiovascular risk profile beyond its statistical performance
    RALPH B D'AGOSTINO
    Department of Mathematics and Statistics, Boston University, Massachusetts 02215, USA
    Am J Epidemiol 176:187-9. 2012
    ..There are both useful and negative aspects of this application, and caution is advised against a too enthusiastic acceptance of it to evaluate prediction rules for primary prevention of cardiovascular disease...
  2. pmc Cardiovascular risk estimation in 2012: lessons learned and applicability to the HIV population
    RALPH B D'AGOSTINO
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    J Infect Dis 205:S362-7. 2012
    ....
  3. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  4. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  5. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  6. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  7. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  8. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  9. ncbi request reprint Non-inferiority trials: design concepts and issues - the encounters of academic consultants in statistics
    RALPH B D'AGOSTINO
    Boston University Statistics and Consulting Unit, 111 Cummington Street, Boston, MA 02215, USA
    Stat Med 22:169-86. 2003
    ..Serious consideration to expansions of and alternatives to non-inferiority trials are needed...
  10. ncbi request reprint New developments in medical clinical trials
    R B D'Agostino
    Boston University, Mathematics and Statistics Department, Statistics and Consulting Unit, 111 Cummington St, Boston, MA 02215, USA
    J Dent Res 83:C18-24. 2004
    ..We close with a brief discussion of the unit of analysis, the role of newer statistical analysis methods, safety issues, subset analysis, and, most importantly, clinical significance...
  11. ncbi request reprint Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  12. pmc Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Heart Assoc 2:e005066. 2013
    ..Available data are inconsistent regarding factors influencing plasma cholesterol homeostasis marker concentrations and their value in predicting subsequent cardiovascular disease (CVD) events...
  13. ncbi request reprint Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    JAMA 307:1925-33. 2012
    ..Clinical trials have not consistently shown these benefits, possibly due to delayed administration...
  14. ncbi request reprint Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  15. pmc Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study
    Marion Dietrich
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Stroke Cerebrovasc Dis 20:155-61. 2011
    ..For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation...
  16. ncbi request reprint Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study
    Vallabh Janardhan
    Department of Neurology, Boston University, Boston, Mass, USA
    Stroke 35:736-41. 2004
    ..Prior cohort studies included only selected subjects, mostly men. We related serum concentrations of aCLs to incident first ischemic stroke/TIA among men and women in the Framingham Heart Study cohort and offspring...
  17. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  18. pmc Resistin, adiponectin, and risk of heart failure the Framingham offspring study
    David S Frankel
    Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    J Am Coll Cardiol 53:754-62. 2009
    ..We tested the association of the adipokines resistin and adiponectin with incident heart failure...
  19. ncbi request reprint Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
  20. pmc Diet quality, physical activity, smoking status, and weight fluctuation are associated with weight change in women and men
    Ruth W Kimokoti
    Department of Family Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 140:1287-93. 2010
    ..Women who stopped smoking over follow-up and had poor diet quality gained the most weight. Preventive interventions need to be sex-specific and consider lifestyle factors...
  21. ncbi request reprint Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  22. doi request reprint Patterns of weight change and progression to overweight and obesity differ in men and women: implications for research and interventions
    Ruth W Kimokoti
    Department of Nutrition, Simmons College, 300 The Fenway, Park Science Building, Boston, MA 02115, USA
    Public Health Nutr 16:1463-75. 2013
    ..To evaluate long-term patterns of weight change and progression to overweight and obesity during adulthood...
  23. ncbi request reprint Social networks and inflammatory markers in the Framingham Heart Study
    Eric B Loucks
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA, USA
    J Biosoc Sci 38:835-42. 2006
    ..The possibility that inflammatory markers may be potential mediators between social integration and coronary heart disease merits further investigation...
  24. ncbi request reprint Dietary patterns predict the development of overweight in women: The Framingham Nutrition Studies
    Paula A Quatromoni
    Framingham Nutrition Studies, Department of Social and Behavioral Sciences, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    J Am Diet Assoc 102:1239-46. 2002
    ..To investigate relationships between dietary patterns and the development of overweight...
  25. ncbi request reprint Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Diabetes 55:530-7. 2006
    ..09-1.77). We conclude that in this community-based sample, plasma markers of endothelial dysfunction increased risk of incident diabetes independent of other diabetes risk factors including obesity, insulin resistance, and inflammation...
  26. ncbi request reprint Obesity, diabetes and cognitive deficit: The Framingham Heart Study
    Merrill F Elias
    Boston University, Department of Mathematics and Statistics, Statistics and Consulting Unit, 111 Cummington Street, Boston, MA 02215, USA
    Neurobiol Aging 26:11-6. 2005
    ..To determine the independent effects of obesity on cognitive performance and to examine interactions between obesity and non-insulin dependent diabetes mellitus (NIDDM)...
  27. ncbi request reprint Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study
    Barbara E Millen
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 84:434-41. 2006
    ..Diet is recognized as a key factor in the cause and management of the metabolic syndrome (MetS). However, policies to guide preventive clinical nutrition interventions of the condition are limited...
  28. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  29. pmc The association of tumor necrosis factor alpha receptor 2 and tumor necrosis factor alpha with insulin resistance and the influence of adipose tissue biomarkers in humans
    Marie France Hivert
    Harvard Medical School, Boston, MA 02115, USA
    Metabolism 59:540-6. 2010
    ..We conclude that, in a representative community sample, measures of TNFalpha activity are associated with insulin resistance, even after accounting for central adiposity and other adipose tissue biomarkers...
  30. pmc Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease
    Wolfram Goessling
    Division of Genetics and Gastroenterology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:1935-44, 1944.e1. 2008
    ..We studied the relationship between ALT levels and these disorders in a long-term follow-up study...
  31. pmc Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    J Am Diet Assoc 108:1453-60. 2008
    ..Essential in this task is the evaluation of methods to accurately identify these unique dietary patterns...
  32. pmc Cross-sectional association of dietary patterns with insulin-resistant phenotypes among adults without diabetes in the Framingham Offspring Study
    Enju Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 102:576-83. 2009
    ....
  33. ncbi request reprint Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, Framingham, Massachusetts Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Am Coll Cardiol 45:685-9. 2005
    ..The goal of this study was to assess the relations of electrocardiographic QRS duration to left ventricular (LV) measurements in individuals without heart failure (HF) or prior myocardial infarction (MI)...
  34. pmc Dietary patterns of women are associated with incident abdominal obesity but not metabolic syndrome
    Ruth W Kimokoti
    Department of Nutrition, Simmons College, Boston, MA, USA
    J Nutr 142:1720-7. 2012
    ..The Higher Fat and Wine and Moderate Eating patterns showed an inverse association with abdominal obesity; certain foods might be targeted in these habitual patterns to achieve optimal dietary patterns for MetS prevention...
  35. pmc Genetics of the Framingham Heart Study population
    Diddahally R Govindaraju
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Adv Genet 62:33-65. 2008
    ..Finally, the use of this unique sample to study genotype and environment interactions is described...
  36. ncbi request reprint Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  37. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  38. doi request reprint General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  39. pmc Diet quality and obesity in women: the Framingham Nutrition Studies
    Dolores M Wolongevicz
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Br J Nutr 103:1223-9. 2010
    ..This finding suggests that overall diet quality be considered a key component in planning and implementing programmes for obesity risk reduction and treatment recommendations...
  40. pmc Carotid-wall intima-media thickness and cardiovascular events
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    N Engl J Med 365:213-21. 2011
    ..Intima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events...
  41. ncbi request reprint Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
    Hypertension 49:439-45. 2007
    ....
  42. ncbi request reprint Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  43. pmc Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  44. pmc Relationship of lycopene intake and consumption of tomato products to incident CVD
    Paul F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 110:545-51. 2013
    ....
  45. ncbi request reprint Serum cholesterol and cognitive performance in the Framingham Heart Study
    Penelope K Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, Massachusetts 02215, USA
    Psychosom Med 67:24-30. 2005
    ....
  46. ncbi request reprint Framingham stroke risk profile and lowered cognitive performance
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Stroke 35:404-9. 2004
    ....
  47. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  48. ncbi request reprint Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
    ..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age...
  49. ncbi request reprint Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants
    Dellara F Terry
    Department of Geriatrics, Boston Medical Center, School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 53:1944-50. 2005
    ..To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85...
  50. pmc Predicting the 30-year risk of cardiovascular disease: the framingham heart study
    Michael J Pencina
    Department of Biostatistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    Circulation 119:3078-84. 2009
    ..Clustering of risk factors at younger ages and increasing life expectancy suggest the need for longer-term risk prediction tools...
  51. ncbi request reprint Dietary quality predicts adult weight gain: findings from the Framingham Offspring Study
    Paula A Quatromoni
    Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA
    Obesity (Silver Spring) 14:1383-91. 2006
    ..We tested the hypothesis that dietary quality, measured by adherence to the Dietary Guidelines, was related to weight change in adults...
  52. pmc Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004
    LYDIE N PANI
    Department of Medicine, Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:1991-6. 2008
    ..We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts...
  53. ncbi request reprint Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arch Neurol 63:246-50. 2006
    ..To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample...
  54. pmc Interpreting incremental value of markers added to risk prediction models
    Michael J Pencina
    Department of Biostatistics, Boston University, Massachusetts, USA
    Am J Epidemiol 176:473-81. 2012
    ....
  55. pmc Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    Jose M de Miguel-Yanes
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 34:121-5. 2011
    ..To test if knowledge of type 2 diabetes genetic variants improves disease prediction...
  56. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  57. pmc Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance
    Marie France Hivert
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3165-72. 2008
    ..Adipose tissue-derived adipokines may contribute to insulin resistance...
  58. ncbi request reprint Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome
    James B Meigs
    Harvard Medical School and the General Medicine Division, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 30:1219-25. 2007
    ..Metabolic syndrome increases the risk for type 2 diabetes and cardiovascular disease (CVD) and may be associated with insulin resistance...
  59. ncbi request reprint Unique dietary patterns and chronic disease risk profiles of adult men: the Framingham nutrition studies
    Barbara E Millen
    Graduate Programs in Medical Nutrition Sciences, Boston University School of Medicine, Boston, MA, USA
    J Am Diet Assoc 105:1723-34. 2005
    ..To identify the dietary patterns of adult men and examine their relationships with nutrient intake and chronic disease risk over long-term follow-up...
  60. pmc Association of smoking cessation and weight change with cardiovascular disease among adults with and without diabetes
    Carole Clair
    Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    JAMA 309:1014-21. 2013
    ..Smoking cessation reduces the risks of cardiovascular disease (CVD), but weight gain that follows quitting smoking may weaken the CVD benefit of quitting...
  61. ncbi request reprint A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls
    Donald C Goff
    Massachusetts General Hospital, Harvard Medical School, Department of Psychiatry 25 Staniford Street, Boston, MA 02114, USA
    Schizophr Res 80:45-53. 2005
    ..The incidence of coronary heart disease (CHD) and the relative contribution of CHD to increased mortality in schizophrenia patients are not clear, despite recent concerns about metabolic complications of certain atypical antipsychotics...
  62. ncbi request reprint Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Alcohol Clin Exp Res 29:1906-12. 2005
    ..Alcohol intake has been associated with lower platelet activity; however, few large-scale studies have included women, and to our knowledge, the relationship of alcohol intake with measures of platelet activation has not been studied...
  63. pmc Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 163:315-22. 2012
    ..A trial of GIK used in the very first hours of ischemia has been needed, consistent with the timing of benefit seen in experimental studies...
  64. pmc Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 153:636-9. 2007
    ..Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease...
  65. pmc Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    J Ultrasound Med 29:1759-68. 2010
    ..The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD)...
  66. ncbi request reprint Association of educational level with inflammatory markers in the Framingham Offspring Study
    Eric B Loucks
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 163:622-8. 2006
    ..The association provides evidence suggestive of a biologic pathway by which socioeconomic position may predispose to coronary heart disease...
  67. pmc Misuse of DeLong test to compare AUCs for nested models
    Olga V Demler
    Department of Biostatistics, Boston University School of Public Health Crosstown, Boston, MA 02118, USA
    Stat Med 31:2577-87. 2012
    ....
  68. pmc Quantifying discrimination of Framingham risk functions with different survival C statistics
    Michael J Pencina
    Department of Biostatistics, Boston University, Boston, MA, USA
    Stat Med 31:1543-53. 2012
    ..We suggest researchers report which C statistic they are using, provide a rationale for their selection, and be aware that comparing different indices across studies may not be meaningful...
  69. pmc Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:3017-21. 2011
    ..Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke...
  70. ncbi request reprint Using metabolic syndrome traits for efficient detection of impaired glucose tolerance
    James B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 27:1417-26. 2004
    ..Efficient detection of impaired glucose tolerance (IGT) is needed to implement type 2 diabetes prevention interventions...
  71. ncbi request reprint Estimating lifetime risk of developing high serum total cholesterol: adjustment for baseline prevalence and single-occasion measurements
    Michael J Pencina
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 165:464-72. 2007
    ....
  72. ncbi request reprint New norms for a new generation: cognitive performance in the framingham offspring cohort
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Exp Aging Res 30:333-58. 2004
    ..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data...
  73. pmc Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study
    Joanne B Krasnoff
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, 670 Albany Street, Second Floor, Boston, Massachusetts 02118 2393, USA
    J Clin Endocrinol Metab 95:2790-9. 2010
    ..Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood...
  74. pmc Variations in common carotid artery intima-media thickness during the cardiac cycle: implications for cardiovascular risk assessment
    Joseph F Polak
    Tufts Medical Center, Department of Radiology, 800 Washington Street, Box 299, Boston, MA 02111, USA
    J Am Soc Echocardiogr 25:1023-8. 2012
    ..Common carotid artery intima-media thickness (IMT), a measure of atherosclerosis, varies between peak systole and end-diastole. This difference might affect cardiovascular risk assessment...
  75. ncbi request reprint Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Cardiol 93:710-3. 2004
    ..In conclusion, our data indicate little association between long-term moderate alcohol consumption and the risk of AF, but a significantly increased risk of AF among subjects consuming >36 g/day (approximatively >3 drinks/day)...
  76. ncbi request reprint Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies
    James B Meigs
    Department of Medicine, General Medicine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 52:2160-7. 2003
    ..S. By any criteria, subjects with the metabolic syndrome are more insulin resistant and at increased predicted risk for CHD versus those without the metabolic syndrome...
  77. pmc Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models
    Michael J Pencina
    Department of Biostatistics, Boston University, Cross Town, Boston, MA, USA
    Stat Med 31:101-13. 2012
    ..Our theoretical developments are illustrated with an example based on the Framingham Heart Study risk assessment model for high-risk men in primary prevention of cardiovascular disease...
  78. ncbi request reprint Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
    ..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
  79. ncbi request reprint Alcohol consumption and the risk of bladder cancer in the Framingham Heart Study
    Luc Djousse
    Preventive Medicine and Epidemiology Section, Evans Department of Medicine, Boston University School of Medicine, Rm B 612, 715 Albany St, Boston, MA 02118, USA
    J Natl Cancer Inst 96:1397-400. 2004
    ..03), whereas wine (P(trend) =.7) and spirit (P(trend) =.2) consumption were not. Our data suggest that total and beverage-specific alcohol consumption are not associated with an increased risk of bladder cancer...
  80. ncbi request reprint Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study
    Qiong Yang
    Department of Biostatistics, Boston University, Boston, MA 02118, USA
    J Lipid Res 46:1416-25. 2005
    ..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism...
  81. ncbi request reprint Choice of time scale and its effect on significance of predictors in longitudinal studies
    Michael J Pencina
    Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Stat Med 26:1343-59. 2007
    ..These findings are supported by four practical examples from the Framingham Heart Study...
  82. pmc Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
    Stat Med 30:11-21. 2011
    ..We recommend that researchers clearly define and justify the choices they make when choosing NRI for their application...
  83. pmc Statistical methods for assessment of added usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, Boston, MA 02115, USA
    Clin Chem Lab Med 48:1703-11. 2010
    ..Reporting of standard metrics, including measures of relative risk and the c statistic, is still recommended. These concepts are illustrated with a risk prediction example using data from the Framingham Heart Study...
  84. ncbi request reprint Genetic variation in white matter hyperintensity volume in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
    Stroke 35:1609-13. 2004
    ..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
  85. ncbi request reprint Presentation of multivariate data for clinical use: The Framingham Study risk score functions
    Lisa M Sullivan
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02115, USA
    Stat Med 23:1631-60. 2004
    ..The system is also readily available to patients who can easily estimate their own coronary heart disease risk and monitor this risk over time...
  86. doi request reprint Equivalence of improvement in area under ROC curve and linear discriminant analysis coefficient under assumption of normality
    Olga V Demler
    Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Stat Med 30:1410-8. 2011
    ..However, our practical example from the Framingham Heart Study data suggests that the finding might be sensitive to the assumption of normality...
  87. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
    ..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])...
  88. pmc On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 30:1105-17. 2011
    ..We provide a large sample approximation to the distribution of this estimator for making inferences about the concordance measure. Results from numerical studies suggest that the new procedure performs well in finite sample...
  89. ncbi request reprint Compliance with expert population-based dietary guidelines and lower odds of carotid atherosclerosis in women: the Framingham Nutrition Studies
    Barbara E Millen
    Department of Social and Behavioral Sciences, School of Public Health, Boston University, Boston, MA 02118, USA
    Am J Clin Nutr 82:174-80. 2005
    ..The relation between diet and stenosis is relatively unexplored, particularly in women...
  90. ncbi request reprint Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trial
    Harry P Selker
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Prehosp Emerg Care 15:139-48. 2011
    ....
  91. pmc Genetic and non-genetic correlates of vitamins K and D
    M K Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Clin Nutr 63:458-64. 2009
    ..To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women...
  92. ncbi request reprint Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohort
    K J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 104:1367-73. 2001
    ..Moderate alcohol consumers have lower rates of cardiovascular disease than abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but previous studies have provided conflicting results...
  93. pmc Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: the Framingham Heart Study
    T Irlbeck
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Obes (Lond) 34:781-7. 2010
    ....

Research Grants1

  1. Data Coordinating Center for IMMEDIATE Trial
    RALPH D AGOSTINO; Fiscal Year: 2006
    ..abstract_text> ..