L Adrienne Cupples

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Comparison of statistical approaches to rare variant analysis for quantitative traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Proc 5:S113. 2011
  2. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
  3. pmc Joint modeling of linkage and association using affected sib-pair data
    Ming Huei Chen
    Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, Massachusetts 02115, USA
    BMC Proc 1:S38. 2007
  4. pmc Two-stage approach for identifying single-nucleotide polymorphisms associated with rheumatoid arthritis using random forests and Bayesian networks
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, 715 Albany Street, Boston, Massachusetts 02118 USA
    BMC Proc 1:S56. 2007
  5. pmc Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
  6. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  7. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
  8. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
  9. pmc Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    Agustin G Yip
    Department of Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston MA 02118 2526, USA
    BMC Geriatr 5:2. 2005
  10. pmc Power and type I error rate of false discovery rate approaches in genome-wide association studies
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 6:S134. 2005

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. pmc Comparison of statistical approaches to rare variant analysis for quantitative traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Proc 5:S113. 2011
    ....
  2. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  3. pmc Joint modeling of linkage and association using affected sib-pair data
    Ming Huei Chen
    Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, Massachusetts 02115, USA
    BMC Proc 1:S38. 2007
    ..When testing linkage or association, the conditional logistic regression method was more powerful than FBAT...
  4. pmc Two-stage approach for identifying single-nucleotide polymorphisms associated with rheumatoid arthritis using random forests and Bayesian networks
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, 715 Albany Street, Boston, Massachusetts 02118 USA
    BMC Proc 1:S56. 2007
    ..We evaluated the performance of this method using independent test data sets for up to 100 replicates...
  5. pmc Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
    ..012)...
  6. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  7. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
    ....
  8. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  9. pmc Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    Agustin G Yip
    Department of Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston MA 02118 2526, USA
    BMC Geriatr 5:2. 2005
    ..We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-epsilon4 carrier status and ethnicity...
  10. pmc Power and type I error rate of false discovery rate approaches in genome-wide association studies
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 6:S134. 2005
    ..Further evaluation of the type I error rate and power of the FDR approaches for higher linkage disequilibrium and for haplotype analyses is warranted...
  11. pmc Impact of non-ignorable missingness on genetic tests of linkage and/or association using case-parent trios
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    BMC Genet 6:S90. 2005
    ..However, the power of these tests appears to be inflated over the complete information case due to an excess of heterozygous parents in dyads...
  12. pmc Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Genet 7:7. 2006
    ..We performed variance components linkage analysis on these intersection datasets and on their sex-specific subsets...
  13. pmc Performance of random forest when SNPs are in linkage disequilibrium
    Yan A Meng
    Department of Medicine, Boston University, MA, USA
    BMC Bioinformatics 10:78. 2009
    ....
  14. doi request reprint Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study
    L Adrienne Cupples
    Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Curr Opin Lipidol 19:144-50. 2008
    ..Are these approaches now passé? Here we discuss the role of family studies in modern genetics research, using results from the Framingham Heart Study as examples...
  15. ncbi request reprint Data mining
    L Adrienne Cupples
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Genet Epidemiol 29:S103-9. 2005
    ..Nevertheless, Group 14 found that these methods offered strategies to gain a better understanding of the complex pathways by which disease develops...
  16. pmc Description of the Framingham Heart Study data for Genetic Analysis Workshop 13
    L Adrienne Cupples
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S2. 2003
  17. pmc APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Arch Intern Med 169:1897-906. 2009
    ..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level...
  18. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  19. ncbi request reprint Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  20. ncbi request reprint Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
    ..Applying the i-TDT to the Framingham Heart Study data, we found that the apolipoprotein E (APOE) gene is significantly linked and associated with cross-sectional measures and longitudinal changes in total cholesterol...
  21. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
    ..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels...
  22. ncbi request reprint Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Circulation 113:2062-70. 2006
    ..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
  23. pmc Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits
    James B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2314-22. 2008
    ..Such interactions might also influence trait-locus associations and may be useful to consider in diabetes genome-wide association studies...
  24. doi request reprint Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
    ..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women...
  25. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  26. ncbi request reprint Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
  27. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  28. pmc Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study
    Elliot S Stolerman
    Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:1971-7. 2008
    ..We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or another variant in linkage disequilibrium with it...
  29. pmc Genetic susceptibility loci for subtypes of breast cancer in an African American population
    Julie R Palmer
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 22:127-34. 2013
    ..Few GWAS hits have replicated in African ancestry populations...
  30. pmc Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study
    Ching Lung Cheung
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 25:1564-71. 2010
    ..The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation...
  31. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  32. pmc Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 120:1195-202. 2009
    ..Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass...
  33. ncbi request reprint Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
    ..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...
  34. ncbi request reprint PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  35. pmc Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program and the Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture, HNRCA, Tufts University, Boston, MA 02111 1524, USA
    Am J Clin Nutr 89:416-24. 2009
    ..Few studies have examined the association between carotenoid intake (other than beta-carotene) and bone mineral density (BMD)...
  36. pmc Frailty and the degradation of complex balance dynamics during a dual-task protocol
    Hyun Gu Kang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 64:1304-11. 2009
    ....
  37. ncbi request reprint Metacarpal cortical area and risk of coronary heart disease: the Framingham Study
    Elizabeth J Samelson
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, 1200 Center Street, Boston, MA 02131, USA
    Am J Epidemiol 159:589-95. 2004
    ..53, 1.00; p(trend) = 0.03). In contrast, no association was present in men (highest vs. lowest quartile of metacarpal cortical area: hazard ratio = 1.14, 95% confidence interval: 0.84, 1.56; p(trend) = 0.55)...
  38. pmc Effects of beer, wine, and liquor intakes on bone mineral density in older men and women
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1188-96. 2009
    ..Moderate intake of alcohol has been reported to have beneficial effects on bone. However, different classes of alcoholic beverages have not been investigated...
  39. pmc Mapping quantitative traits in unselected families: algorithms and examples
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Genet Epidemiol 33:617-27. 2009
    ..We demonstrate our methods on simulated data and on fasting insulin, a quantitative trait measured in the Framingham Heart Study...
  40. pmc Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 58:750-6. 2009
    ..Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits...
  41. ncbi request reprint Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 45:2096-105. 2004
    ..In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs...
  42. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  43. ncbi request reprint Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study
    Serkalem Demissie
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
    Atherosclerosis 185:210-8. 2006
    ..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women...
  44. pmc Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    Diabetes 57:3353-9. 2008
    ..Using comprehensive linkage disequilibrium mapping, we genotyped single nucleotide polymorphisms (SNPs) in ADIPOQ to evaluate the association of common variants with adiponectin levels and risk of diabetes...
  45. pmc Genome-wide association with diabetes-related traits in the Framingham Heart Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S16. 2007
    ..Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants...
  46. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005
    ..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...
  47. ncbi request reprint Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  48. pmc Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study
    Masumi Ai
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 217:543-8. 2011
    ..Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk...
  49. pmc Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease
    Gina M Peloso
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    J Lipid Res 51:3524-32. 2010
    ....
  50. ncbi request reprint Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study
    Qiong Yang
    Department of Biostatistics, Boston University, Boston, MA 02118, USA
    J Lipid Res 46:1416-25. 2005
    ..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism...
  51. pmc Calcium intake is not associated with increased coronary artery calcification: the Framingham Study
    Elizabeth J Samelson
    Department of Medicine, Harvard Medical School and Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    Am J Clin Nutr 96:1274-80. 2012
    ..Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern...
  52. pmc Genetics of the Framingham Heart Study population
    Diddahally R Govindaraju
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Adv Genet 62:33-65. 2008
    ..Finally, the use of this unique sample to study genotype and environment interactions is described...
  53. pmc Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors
    Kenneth S Cohen
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 121:e50-6. 2013
    ..CD34(+) frequency is highly heritable. The results of the present study have implications for therapies that use CD34(+) cell populations and support efforts to better understand the genetic mechanisms that underlie CD34(+) frequency...
  54. pmc Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002705. 2012
    ..rs10198628 near TRIB2 is associated with pericardial fat but not measures of generalized or visceral adiposity, reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution...
  55. ncbi request reprint Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study
    Roberto Elosua
    The Department of Biostatistics, Boston University, Boston, MA, United States The USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA
    Atherosclerosis 189:222-8. 2006
    ..To determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness (IMT) and stenosis...
  56. pmc Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
    Caroline S Fox
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S18. 2007
    ..We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study...
  57. ncbi request reprint BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Obesity (Silver Spring) 14:1454-61. 2006
    ..Because white fat is a major source of IL-6 in resting individuals, we tested the hypothesis that BMI modifies the association among the IL-6 genotype, insulin resistance (IR) (measured using the homeostasis model), and risk of diabetes...
  58. ncbi request reprint Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene
    Inga Peter
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Hypertension 49:1000-6. 2007
    ..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure...
  59. ncbi request reprint Glycemic index, glycemic load, and cereal fiber intake and risk of type 2 diabetes in US black women
    Supriya Krishnan
    Slone Epidemiology Center, Boston, MA 02215, USA
    Arch Intern Med 167:2304-9. 2007
    ..Previous studies of carbohydrate quality and risk of type 2 diabetes mellitus have yielded inconsistent findings. Because diet is in part culturally determined, a study of dietary factors in US black women is of interest...
  60. ncbi request reprint Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    JAMA 310:1256-62. 2013
    ..Screening for osteoporosis with bone mineral density (BMD) is recommended for older adults. It is unclear whether repeating a BMD screening test improves fracture risk assessment...
  61. ncbi request reprint Sequence kernel association test for survival traits
    Han Chen
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    Genet Epidemiol 38:191-7. 2014
    ..We also present results in an application to time-to-obesity using genotypes from Framingham Heart Study SNP Health Association Resource. ..
  62. pmc Variants in the CNR1 and the FAAH genes and adiposity traits in the community
    Wolfgang Lieb
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:755-60. 2009
    ....
  63. pmc Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study
    Andrew D Johnson
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 127:799-810. 2013
    ..3 region followed by a comprehensive study of genetic associations with clinical and subclinical cardiovascular disease and its risk factors, as well as with copy number variation and gene expression, in the Framingham Heart Study (FHS)...
  64. ncbi request reprint Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  65. ncbi request reprint Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 67:70-4. 2005
    ..Microalbuminuria is a powerful risk factor for cardiovascular disease. It is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples...
  66. pmc Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach
    Qiong Yang
    Departments of Biostatistics, Boston University, Boston, Massachusetts, USA
    BMC Genet 4:S29. 2003
    ..A variance components model (SOLAR) was employed in the univariate approaches. A mixed regression model with polynomials was employed in the multivariate approach and implemented in SAS/IML...
  67. pmc Consistency of linkage results across exams and methods in the Framingham Heart Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, USA
    BMC Genet 4:S30. 2003
    ..We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data...
  68. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  69. pmc Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
    ..Results for the other MRI traits were unremarkable. This study highlights the potential value of neuroimaging endophenotypes as a tool for finding genes influencing AD pathogenesis...
  70. ncbi request reprint Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
    ..We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study...
  71. ncbi request reprint LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 188:59-67. 2006
    ..We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events...
  72. pmc Disclosure of APOE genotype for risk of Alzheimer's disease
    Robert C Green
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 361:245-54. 2009
    ..We examined the effect of genotype disclosure in a prospective, randomized, controlled trial...
  73. pmc Optimizing the tracking of falls in studies of older participants: comparison of quarterly telephone recall with monthly falls calendars in the MOBILIZE Boston Study
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131 1097, USA
    Am J Epidemiol 171:1031-6. 2010
    ..Retrospective 3-month recall of falls resulted in underreporting of falls by as much as 25% compared with daily calendars. Calendars should be considered the preferred method of ascertaining falls in longitudinal studies...
  74. ncbi request reprint Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
    ....
  75. pmc Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data
    Chunyu Liu
    Department of Neurology, Boston University School of Public Health, Boston, Massachusetts, USA
    BMC Genet 6:S103. 2005
    ..Moreover, information on disease severity appears to be useful to improve the ability to detect associations between markers and disease loci...
  76. pmc Assessment of cortical and striatal involvement in 523 Huntington disease brains
    Tiffany C Hadzi
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 79:1708-15. 2012
    ..To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors...
  77. ncbi request reprint APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Mol Med (Berl) 85:119-28. 2007
    ..In conclusion, the APOA5-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women...
  78. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
    ..Our results suggest that low serum paraoxonase activity is a risk factor for AD. Furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic...
  79. pmc Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies
    Joanne M Murabito
    Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01701, USA
    Circ Cardiovasc Genet 5:100-12. 2012
    ..To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts...
  80. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD...
  81. ncbi request reprint A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Thromb Res 110:57-64. 2003
    ..It remains unknown what role, if any, is played by other genetic variants in the inter-individual variability in levels of fibrinogen in the general population...
  82. pmc Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Breast Cancer Res Treat 123:525-30. 2010
    ..We successfully used the shorter range of LD in our AA sample to refine the localization of the putative causal variant...
  83. pmc Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    J Bone Miner Res 25:1555-63. 2010
    ..Most of the similarity between the quantitative bone phenotypes may be attributed to pleiotropic effects of genes. This knowledge may prove helpful in defining the best phenotypes to be used in genetic studies of osteoporosis...
  84. pmc Effect of Alzheimer disease genetic risk disclosure on dietary supplement use
    Jacqueline A Vernarelli
    Department of Neurology, Boston University School of Public Health, Boston, MA, USA
    Am J Clin Nutr 91:1402-7. 2010
    ..Little is known about whether APOE genotype disclosure would actually prompt changes in nutrition behaviors among at-risk individuals...
  85. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  86. pmc Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    Bone 46:1114-21. 2010
    ..Subsequent focus on the spectrum of genetic polymorphisms in these refined regions may contribute to finding variants predisposing to osteoporosis...
  87. pmc MHC region and risk of systemic lupus erythematosus in African American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Hum Genet 130:807-15. 2011
    ..In summary, we found four independent signals in the MHC region associated with risk of SLE in African American women...
  88. ncbi request reprint A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets
    Jose C Florez
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 56:3063-74. 2007
    ..To use genome-wide fixed marker arrays and improved analytical tools to detect genetic associations with type 2 diabetes in a carefully phenotyped human sample...
  89. ncbi request reprint Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:936-42. 2006
    ..In addition to displacing healthier beverages, colas contain caffeine and phosphoric acid (H3PO4), which may adversely affect bone...
  90. ncbi request reprint Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  91. ncbi request reprint Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial
    J Scott Roberts
    Departments of Neurology and Medicine Genetics Program, Boston University School of Medicine, 715 Albany Street B 7800, Boston, MA 02118, USA
    Genet Med 6:197-203. 2004
    ..This study's main purposes were to estimate interest in such testing and to examine demographic predictors of study participation...
  92. pmc High vitamin C intake is associated with lower 4-year bone loss in elderly men
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:1931-8. 2008
    ..Null associations were observed among women. These results suggest a possible protective role of vitamin C for bone health in older men...
  93. ncbi request reprint Intake of fruits, vegetables, and dairy products in early childhood and subsequent blood pressure change
    Lynn L Moore
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Epidemiology 16:4-11. 2005
    ..Diets characterized by high intakes of fruits and vegetables and low-fat dairy products (for example, the DASH diet) have been shown to reduce blood pressure in adults. The effects of similar diets on children's blood pressure are unknown...
  94. pmc Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:2206-12. 2008
    ..Elevated homocysteine is a strong risk factor for osteoporotic fractures among elders, yet it may be a marker for low B-vitamin status...
  95. ncbi request reprint Obesity modulates the association among APOE genotype, insulin, and glucose in men
    Roberto Elosua
    Nutrition and Genomics Laboratory and Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Obes Res 11:1502-8. 2003
    ..Obesity, insulin resistance, and apolipoprotein E (APOE) genotype have all been associated with coronary heart disease. We examined the interaction between obesity and APOE genotype in determining fasting insulin and glucose levels...
  96. pmc Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: results from the Framingham Offspring Study
    Seiko Otokozawa
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 213:251-5. 2010
    ..We evaluated direct low density lipoprotein (LDL) cholesterol (C) and high density lipoprotein (HDL) cholesterol (C) versus standard methods using fasting plasma samples from participants in cycle 6 of the Framingham Offspring Study...
  97. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
    ..Clinical trials are required to isolate any putative effects of vitamin K on rates of bone loss. The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study...
  98. pmc Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data
    Richard Sherva
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA, USA
    J Alzheimers Dis 23:349-59. 2011
    ..Several of these variants show modest evidence for association in other Caucasian populations...
  99. pmc A genome wide linkage scan of metacarpal size and geometry in the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA
    Am J Hum Biol 20:663-70. 2008
    ..Genes in these regions may regulate bone geometry via effects on body size. Identification and subsequent characterization of loci for bone geometry can further elucidate the genetic contributions to bone's resistance to stress...