DOUGLAS COTANCHE

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Hair cell fate decisions in cochlear development and regeneration
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Boston University School of Medicine, Boston, MA 02118, USA
    Hear Res 266:18-25. 2010
  2. pmc Genetic and pharmacological intervention for treatment/prevention of hearing loss
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital Boston, Boston, MA, USA
    J Commun Disord 41:421-43. 2008
  3. pmc Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells
    Mark A Parker
    Department of Communication Sciences and Disorders, Emerson College, Boston, MA 02114, USA
    Hear Res 232:29-43. 2007
  4. ncbi request reprint REST mRNA expression in normal and regenerating avian auditory epithelium
    David W Roberson
    Department of Otolaryngology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02155, USA
    Hear Res 172:62-72. 2002
  5. ncbi request reprint Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium
    David W Roberson
    Department of Otolaryngology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci Res 78:461-71. 2004
  6. pmc 5-Ethynyl-2'-deoxyuridine labeling detects proliferating cells in the regenerating avian cochlea
    Christina L Kaiser
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Laryngoscope 119:1770-5. 2009
  7. pmc Comparison of activated caspase detection methods in the gentamicin-treated chick cochlea
    Christina L Kaiser
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Evans 637, Boston University Medical Center, 715 Albany Street, Boston, MA 02118, USA
    Hear Res 240:1-11. 2008
  8. pmc Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae
    NATHANIEL J SPENCER
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
    Biomaterials 29:1028-42. 2008
  9. ncbi request reprint Regeneration and replacement in the vertebrate inner ear
    Jonathan I Matsui
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
    Drug Discov Today 10:1307-12. 2005
  10. ncbi request reprint Expression profile of an operationally-defined neural stem cell clone
    Mark A Parker
    Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 194:320-32. 2005

Research Grants

Detail Information

Publications17

  1. pmc Hair cell fate decisions in cochlear development and regeneration
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Boston University School of Medicine, Boston, MA 02118, USA
    Hear Res 266:18-25. 2010
    ..We need to know not only what genes are involved, but understand how their gene products interact with one another in a structural and temporal framework to guide hair cell and supporting cell differentiation and maturation...
  2. pmc Genetic and pharmacological intervention for treatment/prevention of hearing loss
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital Boston, Boston, MA, USA
    J Commun Disord 41:421-43. 2008
    ....
  3. pmc Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells
    Mark A Parker
    Department of Communication Sciences and Disorders, Emerson College, Boston, MA 02114, USA
    Hear Res 232:29-43. 2007
    ..Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea...
  4. ncbi request reprint REST mRNA expression in normal and regenerating avian auditory epithelium
    David W Roberson
    Department of Otolaryngology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02155, USA
    Hear Res 172:62-72. 2002
    ..Our results indicate that REST inactivation is an important step in finalizing HC fate in the chick inner ear...
  5. ncbi request reprint Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium
    David W Roberson
    Department of Otolaryngology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci Res 78:461-71. 2004
    ..The identical morphology of regenerating HCs from both pathways suggests that once HC fate is established, all new HCs follow similar cellular processes during differentiation and reorganization into the regenerated epithelium...
  6. pmc 5-Ethynyl-2'-deoxyuridine labeling detects proliferating cells in the regenerating avian cochlea
    Christina L Kaiser
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Laryngoscope 119:1770-5. 2009
    ..We propose that EdU is as effective as BrdU, but without the requirement for harsh denaturation or the use of antibodies for detection...
  7. pmc Comparison of activated caspase detection methods in the gentamicin-treated chick cochlea
    Christina L Kaiser
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Evans 637, Boston University Medical Center, 715 Albany Street, Boston, MA 02118, USA
    Hear Res 240:1-11. 2008
    ..This makes CaspaTag ideal for showing an overall pattern or level of cell death over a period of time, while caspase antibodies provide a snapshot of cell death at a specific time point...
  8. pmc Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae
    NATHANIEL J SPENCER
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
    Biomaterials 29:1028-42. 2008
    ..With further optimization, this system will enable the performance of many novel biophysical and pharmacological studies involving hair cells and supporting cells...
  9. ncbi request reprint Regeneration and replacement in the vertebrate inner ear
    Jonathan I Matsui
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
    Drug Discov Today 10:1307-12. 2005
    ..Current research efforts are focusing on gene manipulation, gene therapy and stem cell transplantation for repairing or replacing damaged mammalian cochlear hair cells, which could lead to therapies for treating deafness in humans...
  10. ncbi request reprint Expression profile of an operationally-defined neural stem cell clone
    Mark A Parker
    Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 194:320-32. 2005
    ..Furthermore, when operational definitions are employed, a common set of stem-like genes does emerge across both embryonic and somatic stem cells of various organ systems, including the nervous system...
  11. ncbi request reprint The potential use of stem cells for cochlear repair
    Mark A Parker
    Department of Otology and Laryngology, Harvard Medical School, Boston, Mass, USA
    Audiol Neurootol 9:72-80. 2004
    ..The potential use of several types of stem cells, including embryonic, neural and hematopoietic stem cells, as agents for cochlear repair is examined...
  12. ncbi request reprint Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment
    Dominic A Mangiardi
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Comp Neurol 475:1-18. 2004
    ....
  13. pmc Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms
    Luke J Duncan
    Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 499:691-701. 2006
    ..These cells did not label for BrdU and differentiated far too early to be of mitotic origin, suggesting they arose by direct transdifferentiation of supporting cells into hair cells...
  14. ncbi request reprint 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes
    Hong Wang
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:2049-58. 2004
    ..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death...
  15. ncbi request reprint Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo
    Jonathan I Matsui
    Division of Biology and Biomedical Sciences, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 23:6111-22. 2003
    ..These findings suggest that inhibiting the activation of caspases promotes the survival of hair cells and protects against vestibular function deficits after aminoglycoside treatment...
  16. ncbi request reprint Hair cell regeneration in the avian auditory epithelium
    Jennifer S Stone
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, University of Washington Seattle, WA 98195 7923, USA
    Int J Dev Biol 51:633-47. 2007
    ..The continued study of mechanisms controlling regeneration in the avian auditory epithelium may lead to strategies for inducing significant and functional regeneration in mammals...
  17. ncbi request reprint Regeneration of the inner ear as a model of neural plasticity
    D Kent Morest
    Department of Neuroscience, The University of Connecticut Health Center, Farmington, CT 06030, USA
    J Neurosci Res 78:455-60. 2004
    ..The possibility is raised that transitional forms of hair cell and supporting cell precursors may reside in the inner ear in a quiescent state until stimulated by damage...

Research Grants17

  1. CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATION
    DOUGLAS COTANCHE; Fiscal Year: 2009
    ..abstract_text> ..
  2. CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATION
    DOUGLAS COTANCHE; Fiscal Year: 2007
    ....
  3. CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATION
    DOUGLAS COTANCHE; Fiscal Year: 2005
    ....
  4. CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATION
    DOUGLAS COTANCHE; Fiscal Year: 2000
    ....
  5. CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATION
    DOUGLAS COTANCHE; Fiscal Year: 1993
    ....