Research Topics
Species | DOUGLAS COTANCHESummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Hair cell fate decisions in cochlear development and regenerationDouglas A Cotanche
Laboratory of Cellular and Molecular Hearing Research, Boston University School of Medicine, Boston, MA 02118, USA
Hear Res 266:18-25. 2010..We need to know not only what genes are involved, but understand how their gene products interact with one another in a structural and temporal framework to guide hair cell and supporting cell differentiation and maturation...- Genetic and pharmacological intervention for treatment/prevention of hearing lossDouglas A Cotanche
Laboratory of Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital Boston, Boston, MA, USA
J Commun Disord 41:421-43. 2008.... - Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cellsMark A Parker
Department of Communication Sciences and Disorders, Emerson College, Boston, MA 02114, USA
Hear Res 232:29-43. 2007..Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea... 
REST mRNA expression in normal and regenerating avian auditory epitheliumDavid W Roberson
Department of Otolaryngology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02155, USA
Hear Res 172:62-72. 2002..Our results indicate that REST inactivation is an important step in finalizing HC fate in the chick inner ear...- Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epitheliumDavid W Roberson
Department of Otolaryngology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neurosci Res 78:461-71. 2004..The identical morphology of regenerating HCs from both pathways suggests that once HC fate is established, all new HCs follow similar cellular processes during differentiation and reorganization into the regenerated epithelium... - 5-Ethynyl-2'-deoxyuridine labeling detects proliferating cells in the regenerating avian cochleaChristina L Kaiser
Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Laryngoscope 119:1770-5. 2009..We propose that EdU is as effective as BrdU, but without the requirement for harsh denaturation or the use of antibodies for detection... - Comparison of activated caspase detection methods in the gentamicin-treated chick cochleaChristina L Kaiser
Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Evans 637, Boston University Medical Center, 715 Albany Street, Boston, MA 02118, USA
Hear Res 240:1-11. 2008..This makes CaspaTag ideal for showing an overall pattern or level of cell death over a period of time, while caspase antibodies provide a snapshot of cell death at a specific time point... - Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleaeNATHANIEL J SPENCER
Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
Biomaterials 29:1028-42. 2008..With further optimization, this system will enable the performance of many novel biophysical and pharmacological studies involving hair cells and supporting cells... - Regeneration and replacement in the vertebrate inner earJonathan I Matsui
Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children's Hospital, Boston, MA 02115, USA
Drug Discov Today 10:1307-12. 2005..Current research efforts are focusing on gene manipulation, gene therapy and stem cell transplantation for repairing or replacing damaged mammalian cochlear hair cells, which could lead to therapies for treating deafness in humans... - Expression profile of an operationally-defined neural stem cell cloneMark A Parker
Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Exp Neurol 194:320-32. 2005..Furthermore, when operational definitions are employed, a common set of stem-like genes does emerge across both embryonic and somatic stem cells of various organ systems, including the nervous system... - The potential use of stem cells for cochlear repairMark A Parker
Department of Otology and Laryngology, Harvard Medical School, Boston, Mass, USA
Audiol Neurootol 9:72-80. 2004..The potential use of several types of stem cells, including embryonic, neural and hematopoietic stem cells, as agents for cochlear repair is examined... - Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatmentDominic A Mangiardi
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
J Comp Neurol 475:1-18. 2004.... - Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanismsLuke J Duncan
Laboratory for Cellular and Molecular Hearing Research, Department of Otolaryngology, Children's Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 499:691-701. 2006..These cells did not label for BrdU and differentiated far too early to be of mitotic origin, suggesting they arose by direct transdifferentiation of supporting cells into hair cells... - 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytesHong Wang
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Eur J Neurosci 20:2049-58. 2004..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death... - Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivoJonathan I Matsui
Washington U, St Louis, MO
J Neurosci 23:6111-22. 2003..These findings suggest that inhibiting the activation of caspases promotes the survival of hair cells and protects against vestibular function deficits after aminoglycoside treatment... - Hair cell regeneration in the avian auditory epitheliumJennifer S Stone
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, University of Washington Seattle, WA 98195 7923, USA
Int J Dev Biol 51:633-47. 2007..The continued study of mechanisms controlling regeneration in the avian auditory epithelium may lead to strategies for inducing significant and functional regeneration in mammals... - Regeneration of the inner ear as a model of neural plasticityD Kent Morest
Department of Neuroscience, The University of Connecticut Health Center, Farmington, CT 06030, USA
J Neurosci Res 78:455-60. 2004..The possibility is raised that transitional forms of hair cell and supporting cell precursors may reside in the inner ear in a quiescent state until stimulated by damage...
Research Grants
- CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 2009..abstract_text> ..
- CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 2007....
- CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 2005....
- CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 2000....
- CELL FORM AND GENE EXPRESSION IN HAIR CELL REGENERATIONDOUGLAS COTANCHE; Fiscal Year: 1993....