HERBERT TOD COHEN

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL
    Vipul C Chitalia
    Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Cell Biol 10:1208-16. 2008
  2. pmc Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
    Marc E Lenburg
    Department of Genetics and Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA
    BMC Cancer 3:31. 2003
  3. ncbi request reprint Advances in the molecular basis of renal neoplasia
    H T Cohen
    Department of Medicine, Boston University Medical Center, MA 02118, USA
    Curr Opin Nephrol Hypertens 8:325-31. 1999
  4. ncbi request reprint An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
    H T Cohen
    Renal and Hematology Oncology Sections, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 266:43-50. 1999
  5. ncbi request reprint Renal-cell carcinoma
    Herbert T Cohen
    Renal and Hematology Oncology Sections, Department of Medicine, Boston University School of Medicine, Evans Biomedical Research Center, Boston, MA 02118, USA
    N Engl J Med 353:2477-90. 2005
  6. ncbi request reprint Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent
    Mina I Zhou
    Renal and Hematology Oncology Sections, Departments of Medicine and Pathology, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Cancer Res 64:1278-86. 2004
  7. pmc Jade-1, a candidate renal tumor suppressor that promotes apoptosis
    Mina I Zhou
    Renal and Hematology Oncology Sections, Departments of Medicine and Pathology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:11035-40. 2005

Research Grants

  1. Jade-1 in cystic renal disease
    Herbert Cohen; Fiscal Year: 2008

Collaborators

Detail Information

Publications7

  1. pmc Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL
    Vipul C Chitalia
    Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Cell Biol 10:1208-16. 2008
    ..The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1...
  2. pmc Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
    Marc E Lenburg
    Department of Genetics and Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA
    BMC Cancer 3:31. 2003
    ..To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies...
  3. ncbi request reprint Advances in the molecular basis of renal neoplasia
    H T Cohen
    Department of Medicine, Boston University Medical Center, MA 02118, USA
    Curr Opin Nephrol Hypertens 8:325-31. 1999
    ..This review will highlight these and other new molecular advances in the renal cancer field...
  4. ncbi request reprint An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
    H T Cohen
    Renal and Hematology Oncology Sections, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 266:43-50. 1999
    ..VHL also directly interacts with the Sp1 zinc fingers and self-associates via the 96-122 domain, which furthermore suggest the domain may bind other metalloproteins and contribute to VHL dominant-negative effects...
  5. ncbi request reprint Renal-cell carcinoma
    Herbert T Cohen
    Renal and Hematology Oncology Sections, Department of Medicine, Boston University School of Medicine, Evans Biomedical Research Center, Boston, MA 02118, USA
    N Engl J Med 353:2477-90. 2005
  6. ncbi request reprint Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent
    Mina I Zhou
    Renal and Hematology Oncology Sections, Departments of Medicine and Pathology, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Cancer Res 64:1278-86. 2004
    ..Dysregulation of the VHL protein stabilization pathway or of Jade-1 itself may therefore contribute to VHL renal disease and renal cancer pathogenesis...
  7. pmc Jade-1, a candidate renal tumor suppressor that promotes apoptosis
    Mina I Zhou
    Renal and Hematology Oncology Sections, Departments of Medicine and Pathology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:11035-40. 2005
    ..Therefore, Jade-1 may be a renal tumor suppressor...

Research Grants1

  1. Jade-1 in cystic renal disease
    Herbert Cohen; Fiscal Year: 2008
    ..abstract_text> ..