Affiliation: Boston University School of Medicine
- Krüppel-like factor 4 is transactivated by butyrate in colon cancer cellsZhi Yi Chen
Section of Gastroenterology, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA 02118, USA
J Nutr 134:792-8. 2004..Moreover, transactivation of KLF4 by butyrate appears to be mediated through interaction with a Sp1-binding domain on the promoter and is also likely to involve histone acetylation...
- 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal traZhi Yi Chen
Section of Gastroenterology, Boston University School of medicine EBRC X 513, 650 Albany Street, Boston, MA 02118, USA
Mol Pharmacol 68:1203-13. 2005..This induction is unlikely to be mediated through the PPARgamma receptor but may involve the mitogen-activated protein kinase kinase/ERK pathway and is STAT1-dependent...
- Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathwayZhi Yi Chen
Section of Gastroenterology, VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts 02118, USA
Cancer Res 65:10394-400. 2005..Collectively, these results indicate that destabilization of KLF4 following serum stimulation is mediated, at least in part, through a ubiquitin-proteasome pathway...
- Fish oil slows S phase progression and may cause upstream shift of DHFR replication origin ori-beta in CHO cellsNawfal W Istfan
Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 88 E Newton Street, Evans 201, Boston, MA 02118, USA
Am J Physiol Cell Physiol 283:C1009-24. 2002..This study suggests novel mechanism(s) by which fats affect cell proliferation and DNA replication in mammalian cells...