Tai C Chen

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Novel vitamin d analogs for prostate cancer therapy
    Tai C Chen
    Boston University School of Medicine, Room M 1022, 715 Albany Street, Boston, MA 02118, USA
    ISRN Urol 2011:301490. 2011
  2. ncbi Vitamin D and prostate cancer prevention and treatment
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Endocrinol Metab 14:423-30. 2003
  3. pmc Vitamin D for the prevention and treatment of pancreatic cancer
    Kun Chun Chiang
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
    World J Gastroenterol 15:3349-54. 2009
  4. ncbi Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase and its implication in prostate cancer
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    J Cell Biochem 88:315-22. 2003
  5. ncbi Evaluation of vitamin D analogs as therapeutic agents for prostate cancer
    Tai C Chen
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:273-88. 2003
  6. ncbi The roles of cytochrome P450 enzymes in prostate cancer development and treatment
    Tai C Chen
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Anticancer Res 32:291-8. 2012
  7. ncbi 25-Hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1) is a new class of tumor suppressor in the prostate
    Tai C Chen
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 28:2015-7. 2008
  8. ncbi Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer
    T C Chen
    Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 103:717-20. 2007
  9. ncbi The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer
    T C Chen
    Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Massachusetts 02118, USA
    Clin Cancer Res 6:901-8. 2000
  10. pmc Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
    Rachael M Biancuzzo
    Department of Medicine, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 91:1621-6. 2010

Detail Information

Publications73

  1. pmc Novel vitamin d analogs for prostate cancer therapy
    Tai C Chen
    Boston University School of Medicine, Room M 1022, 715 Albany Street, Boston, MA 02118, USA
    ISRN Urol 2011:301490. 2011
    ....
  2. ncbi Vitamin D and prostate cancer prevention and treatment
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Endocrinol Metab 14:423-30. 2003
    ....
  3. pmc Vitamin D for the prevention and treatment of pancreatic cancer
    Kun Chun Chiang
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
    World J Gastroenterol 15:3349-54. 2009
    ..Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway. 1alpha,25(OH)(2)D(3) and its analogs are potentially attractive novel therapies for pancreatic cancer...
  4. ncbi Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase and its implication in prostate cancer
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    J Cell Biochem 88:315-22. 2003
    ..Thus, the results suggest that the defect in enzyme activity may result from the decreased promoter activity in prostate cancer cells...
  5. ncbi Evaluation of vitamin D analogs as therapeutic agents for prostate cancer
    Tai C Chen
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:273-88. 2003
    ..These compounds may be good candidates for human clinical trials in prostate cancer...
  6. ncbi The roles of cytochrome P450 enzymes in prostate cancer development and treatment
    Tai C Chen
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Anticancer Res 32:291-8. 2012
    ....
  7. ncbi 25-Hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1) is a new class of tumor suppressor in the prostate
    Tai C Chen
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 28:2015-7. 2008
    ..Thus, the 1alpha-OHase gene is a tumor suppressor gene responsible for the normal regulation of prostate cell growth...
  8. ncbi Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer
    T C Chen
    Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 103:717-20. 2007
    ..Thus, these two analogs could be developed to be effective therapeutic agents for treating early and late stages of prostate cancer...
  9. ncbi The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer
    T C Chen
    Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Massachusetts 02118, USA
    Clin Cancer Res 6:901-8. 2000
    ..Both drugs are approved for human use and may be good candidates for human clinical trials in prostate cancer...
  10. pmc Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
    Rachael M Biancuzzo
    Department of Medicine, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 91:1621-6. 2010
    ..Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements...
  11. ncbi Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D
    John N Flanagan
    Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 26:2567-72. 2006
    ..Here, the questions of whether prostate cells express vitamin D-25-hydroxylase (25-OHase) and can convert vitamin D3 to 1alpha,25(OH)2D3 were investigated...
  12. ncbi Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells
    Narasimha Swamy
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Clin Cancer Res 10:8018-27. 2004
    ..Collectively, these results strongly suggested that 25-OH-D(3)-3-BE has a strong potential as a therapeutic agent for androgen-sensitive and androgen-refractory prostate cancer...
  13. doi MART-10, a less calcemic vitamin D analog, is more potent than 1α,25-dihydroxyvitamin D3 in inhibiting the metastatic potential of MCF-7 breast cancer cells in vitro
    Kun Chun Chiang
    General Surgery Department, Chang Gung Memorial Hospital, 222, Mai Chin Road, Keelung, Taiwan, ROC Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei Shan, Taoyuan, Taiwan, ROC
    J Steroid Biochem Mol Biol 139:54-60. 2014
    ..Further in vivo animal study comparing MART-10 with 1α,25(OH)2D3 and other potent and less calcemic analogs of vitamin D is warranted. ..
  14. ncbi A cross-sectional study of osteocalcin and body fat measures among obese adolescents
    Carine M Lenders
    Boston Medical Center, Boston University School of Medicine, USA
    Obesity (Silver Spring) 21:808-14. 2013
    ..Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures...
  15. ncbi The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D
    Michael V Young
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Carcinogenesis 25:967-71. 2004
    ..These findings support the hypothesis that vitamin D or 25(OH)D may be useful as chemopreventive agents for prostate cancer because their administration should cause an increased synthesis of 1 alpha,25(OH)(2)D within prostate cells...
  16. ncbi Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density
    Vin Tangpricha
    Vitamin D, Skin and Bone Research Laboratory and the Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 80:1645-9. 2004
    ..Subjects who use a tanning bed that emits ultraviolet B radiation (290-315 nm) are likely to have higher 25-hydroxyvitamin D [25(OH)D] concentrations than do subjects who do not regularly use a tanning bed...
  17. ncbi Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer
    John N Flanagan
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Anticancer Res 29:3547-53. 2009
    ..Thus, these data suggest that MART-10 may be a potential candidate as a therapeutic agent for prostate cancer, especially for patients who fail in conventional therapies...
  18. doi Vitamin D status among 4-month-old infants in New England: a prospective cohort study
    Anne Merewood
    Division of General Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Hum Lact 28:159-66. 2012
    ..Also, while many researchers label "breastfeeding" as a risk factor for vitamin D deficiency, few differentiate between any breastfeeding, exclusive breastfeeding, and supplemented or unsupplemented breastfeeders...
  19. ncbi 25-Hydroxyvitamin D-1alpha-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer
    Lyman W Whitlatch
    Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Boston University School of Medicine, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 81:135-40. 2002
    ....
  20. ncbi Widespread vitamin D deficiency in urban Massachusetts newborns and their mothers
    Anne Merewood
    Division of General Pediatrics, Boston Medical Center, 88 E Newton St, Vose 3, Boston, MA 02118, USA
    Pediatrics 125:640-7. 2010
    ..To determine vitamin D status and associated factors in a cohort of newly delivered infants and their mothers in Boston, Massachusetts...
  21. doi MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase
    Kun Chun Chiang
    General Surgery Department, Chang Gung Memorial Hospital, 222, Mai Chin Road, Keelung, Taiwan, ROC Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei Shan, Taoyuan, Taiwan, ROC
    J Steroid Biochem Mol Biol 138:427-34. 2013
    ....
  22. pmc Effects of sunlight and diet on vitamin D status of pulmonary tuberculosis patients in Tbilisi, Georgia
    Nirali S Desai
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Nutrition 28:362-6. 2012
    ..Vitamin D deficiency is common in tuberculosis (TB) and this may modulate immune responses. This study investigated vitamin D status in patients with TB and examined the sources of vitamin D in Tbilisi, Georgia...
  23. ncbi Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cells
    Lilin Wang
    Department of Medicine, Endocrine Division, Boston University Medical Center, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 89:127-30. 2004
    ..Because EGF has no effect on 1alpha-OHase promoter activity in LNCaP cells, we propose that the ability of EGF to stimulate 1alpha,25(OH)(2)D synthesis may be abolished or diminished in cancer cells...
  24. ncbi Sickle cell bone disease: response to vitamin D and calcium
    Adeboye H Adewoye
    The Center of Excellence in Sickle Cell Disease and the Vitamin D, Skin and Bone Research Laboratories, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Hematol 83:271-4. 2008
    ..Treatment of adult SCD with vitamin D and calcium can restore 25(OH)D levels to normal and improve BMD, but, markers of bone resorption remained unchanged. Screening for vitamin D deficiency and BMD in SCD patients seems warranted...
  25. ncbi Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice
    Vin Tangpricha
    Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 135:2350-4. 2005
    ..We conclude that vitamin D deficiency enhances the growth of colon cancer in mice. The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D...
  26. doi Hepatocellular carcinoma and vitamin D: a review
    Kun Chun Chiang
    General Surgery Department of Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan
    J Gastroenterol Hepatol 26:1597-603. 2011
    ....
  27. ncbi Vitamin D and skin physiology: a D-lightful story
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 22:V28-33. 2007
    ....
  28. ncbi Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health
    Vin Tangpricha
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Am J Clin Nutr 77:1478-83. 2003
    ..Additional foods need to be fortified with vitamin D...
  29. ncbi Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor
    Lilin Wang
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 28:2009-13. 2008
    ....
  30. doi 19-Nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells
    Kun Chun Chiang
    General Surgery Department of Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan
    Steroids 76:1513-9. 2011
    ..Overall, our findings suggest that MART-10 is a good candidate as a novel therapeutic regimen against liver cancer. Further pre-clinical studies using animal models and the subsequent human clinical trials are warranted...
  31. ncbi Vitamin D deficiency: a worldwide problem with health consequences
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Am J Clin Nutr 87:1080S-6S. 2008
    ..Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations...
  32. ncbi Vitamin D autocrine system and prostate cancer
    Lilin Wang
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:223-37. 2003
    ..Thus, our results suggest that differential phosphorylation of CREB through PKA and MAPK pathways may be involved in the regulation of 1alpha-OHase promoter activity...
  33. ncbi 1alpha,25-Dihydroxyvitamin D3-3beta-(2)-bromoacetate, an affinity labeling derivative of 1alpha,25-dihydroxyvitamin D3 displays strong antiproliferative and cytotoxic behavior in prostate cancer cells
    Narasimha Swamy
    Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    J Cell Biochem 89:909-16. 2003
    ..Therefore, these results raise the possibility that 1,25(OH)(2)D(3)-3-BE or similar VDR-cross linking analogs of 1,25(OH)(2)D(3) might be considered for further development as potential candidates for prostate cancer...
  34. ncbi Chemopreventive and chemotherapeutic effect of dietary supplementation of vitamin D on cholangiocarcinoma in a Chemical-Induced animal model
    Kun Chun Chiang
    General Surgery Department, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC
    Oncotarget 5:3849-61. 2014
    ..Further studies of application of vitamin D or its analog against ICC are warranted. ..
  35. ncbi Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial
    Michael F Holick
    Boston University School of Medicine, Boston, MA, USA
    J Bone Miner Metab 28:342-50. 2010
    ..01). Treatment with hop rho iso-alpha acids, berberine sulfate trihydrate, vitamin D(3) and vitamin K(1) produced a more favorable bone biomarker profile that supports a healthy bone metabolism...
  36. ncbi Regulation of the 25-hydroxyvitamin D-1alpha-hydroxylase gene and its splice variant
    John N Flanagan
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:157-67. 2003
    ....
  37. ncbi Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells
    Kun Chun Chiang
    Department of Surgery, Chang Gung Memorial Hospital Chang Gung University, Taiwan, R O C
    Anticancer Res 29:3591-6. 2009
    ....
  38. ncbi Vitamin D deficiency and osteoporosis in rehabilitation inpatients
    Leonid M Shinchuk
    Department of Physical Medicine and Rehabilitation, Boston University Medical Center, Boston, MA, USA
    Arch Phys Med Rehabil 87:904-8. 2006
    ..To determine vitamin D status and bone mineral density (BMD) in patients admitted to a subacute rehabilitation facility...
  39. pmc Factors that influence the cutaneous synthesis and dietary sources of vitamin D
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Biochem Biophys 460:213-7. 2007
    ....
  40. pmc Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy
    Andrew J Westwood
    From the Department of Neurology A J W, A B, A P, R A, P A W, S S and Sections of Preventative Medicine and Cardiology, Department of Medicine R S V, Boston University School of Medicine Department of Biostatistics A B, Boston University School of Public Health, Boston Framingham Heart Study A B, A P, R A, P A W, R S V, S S, Framingham, MA University of California at Davis C D, Sacramento, CA National Institute on Aging T B H, Bethesda, MD Boston University Medical Center T C C, X m H, L E B, Section of Endocrinology, Diabetes, and Nutrition, Boston Novartis Institutes for Biomedical Research R R, Cambridge, MA
    Neurology 82:1613-9. 2014
    ..To relate serum insulin-like growth factor-1 (IGF-1) to risk of Alzheimer disease (AD) dementia and to brain volumes in a dementia-free community sample spanning middle and older ages...
  41. pmc Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Clin Endocrinol Metab 93:40-6. 2008
    ..Although racial and ethnic differences in vitamin D status and bone mineral density (BMD) are recognized, less is known about how differences in vitamin D status impact BMD, especially among men...
  42. pmc Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:677-81. 2008
    ..Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status...
  43. pmc Association between vitamin D deficiency and primary cesarean section
    Anne Merewood
    Department of Pediatrics, Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, and Division of General Pediatrics, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:940-5. 2009
    ..The current U.S. cesarean birth rate is at an all-time high of 30.2%. We analyzed the relationship between maternal serum 25-hydroxyvitamin D [25(OH)D] status, and prevalence of primary cesarean section...
  44. pmc Relation of body fat indexes to vitamin D status and deficiency among obese adolescents
    Carine M Lenders
    Boston Medical Center, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 90:459-67. 2009
    ..Data on the relation between vitamin D status and body fat indexes in adolescence are lacking...
  45. ncbi A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study
    Kerry E Broe
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 55:234-9. 2007
    ..To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents...
  46. ncbi The anti-cancer actions of vitamin D
    Kun Chun Chiang
    Department of General Surgery, Chang Gung Memorial Hospital, 222, Mai Chin Road, Keelung, Taiwan, 204, R O C
    Anticancer Agents Med Chem 13:126-39. 2013
    ..In this review, we describe the anticancer actions of vitamin D, with special emphasis on different pathways underlying the VDR-mediated genomic as well as less-defined non-genomic actions of vitamin D...
  47. pmc MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1α,25-Dihydroxyvitamin D(3) in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells
    Kun Chun Chiang
    General Surgery Department, Chang Gung Memorial Hospital, 222 Mai Chin Road, Keelung 204, Taiwan Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei Shan, Taoyuan 333, Taiwan
    Evid Based Complement Alternat Med 2012:310872. 2012
    ..Thus, further in vivo animal study is warranted...
  48. pmc Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts2The Framingham Heart Study, Boston, Massachusetts
    JAMA Neurol 71:55-61. 2014
    ..Some prior studies showed lower circulating BDNF in persons with Alzheimer disease (AD) compared with control participants; however, it remains uncertain whether reduced levels precede dementia onset...
  49. pmc Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes
    Yasuo Ido
    Section of Endocrinology and Diabetes Research Unit, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35092. 2012
    ..They also suggest that this action of AMPK may be cell or context-specific...
  50. pmc Vitamin D insufficiency among free-living healthy young adults
    Vin Tangpricha
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Med 112:659-62. 2002
  51. ncbi Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration
    Joshua D Safer
    Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 13:159-65. 2003
    ..Insight into the interplay among the competing factors will be important in understanding thyroid hormone regulation of skin physiology...
  52. pmc Testosterone increases bone mineral density in female-to-male transsexuals: a case series of 15 subjects
    Adrian Turner
    Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston, Massachusetts, USA
    Clin Endocrinol (Oxf) 61:560-6. 2004
    ..The aim of this study is to examine the effects of testosterone treatment on the genetic female skeleton...
  53. pmc Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults
    Andrew S Whiteman
    Department of Psychology and Center for Memory and Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA
    Behav Brain Res 259:302-12. 2014
    ..In addition, IGF-1 was positively associated with aerobic fitness, but not with recognition memory. Our results may suggest an exercise adaptation-related change in the BDNF dose-response curve that relates to hippocampal memory. ..
  54. ncbi 1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells
    N W Istfan
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 103:726-30. 2007
    ..Based on these results, we hypothesize that dietary components, such as omega3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state...
  55. ncbi Enhancing 1 alpha-hydroxylase activity with the 25-hydroxyvitamin D-1 alpha-hydroxylase gene in cultured human keratinocytes and mouse skin
    J N Flanagan
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    J Invest Dermatol 116:910-4. 2001
    ....
  56. ncbi Expression of 25-hydroxyvitamin D3-24-hydroxylase mRNA in cultured human keratinocytes
    M L Chen
    Department of Medicine, Boston University Medical Center, Massachusetts
    Proc Soc Exp Biol Med 207:57-61. 1994
    ..These results demonstrate that 1 alpha,25(OH)2D3 up-regulates the expression of 24-OHase mRNA, and this may be an important first step in the initiation of catabolism of 1 alpha,25(OH)2D3 in human keratinocytes...
  57. ncbi Do panther chameleons bask to regulate endogenous vitamin D3 production?
    Gary W Ferguson
    Department of Biology, Texas Christian University, Fort Worth, TX 76129, USA
    Physiol Biochem Zool 76:52-9. 2003
    ..Vitamin D(3) photoregulation seems to be an important additional component of the function of basking...
  58. ncbi High-throughput system for analyzing ligand-induced cofactor recruitment by vitamin D receptor
    Midori A Arai
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Bioconjug Chem 18:614-20. 2007
    ....
  59. ncbi Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 25:1015-26. 2004
    ....
  60. ncbi Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1
    Naoko Urushino
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Oiwake cho, Sakyo ku, Kyoto, Japan
    Drug Metab Dispos 35:1482-8. 2007
    ..Thus, the results suggest that 25(OH)-19-nor-D(3) has potential as an attractive agent for prostate cancer therapy...
  61. ncbi Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue
    Michael Friedrich
    Department of Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Anticancer Res 26:2615-20. 2006
    ..The aim of this study was to analyze whether normal breast tissue or breast cancer cells expressed 1alpha-OHase and to evaluate whether breast tissue possessed the capacity to produce 1alpha,25(OH)2D3 from 25(OH)D3...
  62. ncbi Adolescent girls in Maine are at risk for vitamin D insufficiency
    Susan S Sullivan
    Department of Food Science and Human Nutrition, University of Maine, Orono 04469, USA
    J Am Diet Assoc 105:971-4. 2005
    ..Mean parathyroid hormone levels increased 4 pg/mL (15%) from September to March. Vitamin D intakes need to be increased in winter at northern latitudes...
  63. ncbi Ultraviolet exposure and vitamin D synthesis in a sun-dwelling and a shade-dwelling species of Anolis: are there adaptations for lower ultraviolet B and dietary vitamin D3 availability in the shade?
    Gary W Ferguson
    Department of Biology, Texas Christian University, Fort Worth, 76129, USA g ferguson tcu edu
    Physiol Biochem Zool 78:193-200. 2005
    ..Also, the ability to behaviorally regulate UV-B exposure, as shown for the panther chameleon, would benefit both species of Anolis and should be investigated...
  64. ncbi Creative synthesis of novel vitamin D analogs for health and disease
    Atsushi Kittaka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Sagamihara, Kanagawa 199 0195, Japan
    J Steroid Biochem Mol Biol 103:269-76. 2007
    ..Its IC(50) value is 7.4pM to inhibit differentiation of HL-60 cells induced by 10nM of 1...
  65. ncbi Synthesis of vitamin D in skin after burns
    Gordon L Klein
    Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555 0352, USA
    Lancet 363:291-2. 2004
    ..Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury...
  66. ncbi Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 77:204-10. 2003
    ..The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin...
  67. pmc Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series
    Prakash Chandra
    Graduate Program in Nutrition and Health Sciences and Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA
    Photodermatol Photoimmunol Photomed 23:179-85. 2007
    ..We evaluated whether a commercial portable ultraviolet (UV) indoor tanning lamp that has a spectral output that mimics natural sunlight could raise circulating 25-hydroxyvitamin D [25(OH)D] levels in subjects with CF and SBS...
  68. ncbi Vitamin D deficiency in a healthy group of mothers and newborn infants
    Joyce M Lee
    Division of Pediatric Endocrinology, Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, Michigan 48109 0456, USA
    Clin Pediatr (Phila) 46:42-4. 2007
    ..Maternal vitamin D deficiency may represent an important risk factor for the development of rickets in children...
  69. ncbi Diet composition and blood values of captive cheetahs (Acinonyx jubatus) fed either supplemented meat or commercial food preparations
    Ursula Bechert
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA
    J Zoo Wildl Med 33:16-28. 2002
    ..The high protein levels found in SMD may be linked to chronic renal disease, which was detected in some of these cheetahs...
  70. doi 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation
    Laura D Carbone
    Department of Veterans Affairs Medical Center, Memphis, TN 38104, USA
    Metabolism 57:741-8. 2008
    ..Overall, though, twice weekly exposure to UV radiation resulting in an increase in serum 25(OH)D had no significant impact on lipoprotein composition...
  71. ncbi Vitamin D status of wild Ricord's iguanas (Cyclura ricordii) and captive and wild rhinoceros iguanas (Cyclura cornuta cornuta) in the Dominican Republic
    Jan C Ramer
    Indianapolis Zoo, 1200 West Washington Street, Indianapolis, Indiana 46222, USA
    J Zoo Wildl Med 36:188-91. 2005
    ..On the basis of these results, serum concentrations of at least 325 nmol/L (130 ng/ml) for 25-hydroxyvitamin D should be considered normal for healthy Ricord's and rhinoceros iguanas...
  72. ncbi Fat soluble vitamins in blood and tissues of free-ranging and captive rhinoceros
    Marcus Clauss
    Institute of Animal Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximillians University, Veterinaerstr 13, 80539 Munich, Germany
    J Wildl Dis 38:402-13. 2002
    ..001) and higher vitamin A concentrations in liver tissue samples (P < 0.001) than other rhinoceros species. Equine requirements are not recommended as a model for rhinoceros vitamin requirements...
  73. pmc Prevalence of vitamin D deficiency in patients attending an outpatient cancer care clinic in Boston
    Vin Tangpricha
    Endocr Pract 10:292-3. 2004