Jiang Fan Chen

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002
  2. pmc Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation
    Hai Ying Shen
    Molecular Neuropharmacology Lab, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 8:e80902. 2013
  3. ncbi request reprint Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease
    Jiang Fan Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02118, USA
    Neurology 61:S74-81. 2003
  4. doi request reprint What knock-out animals tell us about the effects of caffeine
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    J Alzheimers Dis 20:S17-24. 2010
  5. ncbi request reprint The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Drug News Perspect 16:597-604. 2003
  6. ncbi request reprint Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Handb Exp Pharmacol 200:267-310. 2011
  7. ncbi request reprint Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA
    Prog Neurobiol 83:310-31. 2007
  8. ncbi request reprint Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, E301, Boston, MA 02118, USA
    Curr Pharm Des 14:1490-9. 2008
  9. ncbi request reprint Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice
    Kui Xu
    Department of Neurology, Massachusetts General Hospital, 02129, Charlestown, MA, USA
    Neurosci Lett 322:13-6. 2002
  10. ncbi request reprint Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors
    Silva Fredduzzi
    Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 22:1054-62. 2002

Detail Information

Publications66

  1. ncbi request reprint 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002
    ..Together, these data indicate that CSC possesses dual actions of MAO-B inhibition and A(2A) receptor antagonism, a unique combination suggesting a new class of compounds with the potential for enhanced neuroprotective properties...
  2. pmc Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation
    Hai Ying Shen
    Molecular Neuropharmacology Lab, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 8:e80902. 2013
    ....
  3. ncbi request reprint Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease
    Jiang Fan Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02118, USA
    Neurology 61:S74-81. 2003
    ..Potential presynaptic, postsynaptic (cellular), and trans-synaptic (network) mechanisms are discussed...
  4. doi request reprint What knock-out animals tell us about the effects of caffeine
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    J Alzheimers Dis 20:S17-24. 2010
    ....
  5. ncbi request reprint The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Drug News Perspect 16:597-604. 2003
    ..This review summarizes multiple potential benefits of the A(2A) receptor blockade in treating the motor symptoms as well as the underlying dopaminergic neurodegeneration of Parkinson's disease...
  6. ncbi request reprint Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Handb Exp Pharmacol 200:267-310. 2011
    ....
  7. ncbi request reprint Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA
    Prog Neurobiol 83:310-31. 2007
    ....
  8. ncbi request reprint Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, E301, Boston, MA 02118, USA
    Curr Pharm Des 14:1490-9. 2008
    ....
  9. ncbi request reprint Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice
    Kui Xu
    Department of Neurology, Massachusetts General Hospital, 02129, Charlestown, MA, USA
    Neurosci Lett 322:13-6. 2002
    ..These data raise the possibility that caffeine may induce neuroprotection and locomotion by distinct mechanisms...
  10. ncbi request reprint Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors
    Silva Fredduzzi
    Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 22:1054-62. 2002
    ..Furthermore, they raise the possibility that the maladaptive dyskinetic responses to chronic l-DOPA treatment in Parkinson's disease may be attenuated by A(2A) receptor inactivation...
  11. doi request reprint A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs
    Hai Ying Shen
    Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:2970-5. 2008
    ..These results indicate that A(2A)Rs in striatal and extrastriatal neurons exert an opposing modulation of psychostimulant effects and provide the first direct demonstration of a predominant facilitatory role of extrastriatal A(2A)Rs...
  12. ncbi request reprint A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization
    Elena Bastia
    Molecular Neurobiology Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 30:891-900. 2005
    ..Thus activation of brain A(2A)Rs plays a critical role in developing augmented psychomotor responses to repeated psychostimulant exposure...
  13. ncbi request reprint Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation
    Qing Yuan Huang
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 26:11371-8. 2006
    ..exacerbation of 3-NP-induced striatal damage. Thus, cell-type-selective inactivation of A2ARs reveals that A2ARs in BMDCs but not in forebrain neurons are an important contributor to striatal damage induced by mitochondrial dysfunction...
  14. ncbi request reprint Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice
    Hai Ying Shen
    Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:39962-9. 2005
    ....
  15. ncbi request reprint Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum
    Liqun Yu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Physiol Genomics 23:89-102. 2005
    ..Taken together, these results strongly support the existence of an Egr-2-directed transcriptional regulatory network controlled by striatal A2ARs...
  16. ncbi request reprint Cross-sensitization between caffeine- and L-dopa-induced behaviors in hemiparkinsonian mice
    Liqun Yu
    Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, 02114, USA
    Neurosci Lett 393:31-5. 2006
    ....
  17. ncbi request reprint Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage
    J Stephen Fink
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    J Neurochem 88:538-44. 2004
    ....
  18. ncbi request reprint Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice
    Anil Kachroo
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 25:10414-9. 2005
    ..These data also strengthen a rationale for pursuing a combinational drug strategy for enhancing the antiparkinsonian effects of A2A and mGlu5 antagonists...
  19. ncbi request reprint Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease
    Michael A Schwarzschild
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA
    Neurology 61:S55-61. 2003
    ....
  20. pmc Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease
    Danqing Xiao
    MassGeneral Institute for Neurolodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Brain Res 1367:310-8. 2011
    ..Our findings raise the possibility that A₁ or A(₂A) receptors blockade might also confer a disease-modifying benefit of reduced risk of disabling LID, whereas the effect of their combined inactivation is less clear...
  21. ncbi request reprint Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice
    Danqing Xiao
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:13548-55. 2006
    ....
  22. doi request reprint Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms
    Liqun Yu
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Ann Neurol 63:338-46. 2008
    ..To investigate whether the motor and neuroprotective effects of adenosine A(2A) receptor (A(2A)R) antagonists are mediated by distinct cell types in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease...
  23. ncbi request reprint Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization
    Jiang Fan Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Neuropsychopharmacology 28:1086-95. 2003
    ....
  24. pmc Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes
    Marco Matos
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, CNC Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal, and FMUC Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 33:18492-502. 2013
    ....
  25. ncbi request reprint Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson's disease
    Anti Kalda
    Molecular Neuropharmacology Lab, Department of Neurology, Boston University Medical Center, Boston, MA 02118, USA
    J Neurol Sci 248:9-15. 2006
    ..Intensive investigations are under way to dissect out common cellular mechanisms (such as A(2A) receptor modulation of neuroinflammation) which may underlie the broad spectrum of neuroprotection by A(2A) receptor inactivation in brain...
  26. ncbi request reprint Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
    Liqun Yu
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, Massachusetts 02118, USA
    Nat Med 10:1081-7. 2004
    ..These results indicate that the A(2A)R-stimulated cascade in BMDCs is an important modulator of ischemic brain injury and that ischemic brain and liver injuries are regulated distinctly by A(2A)Rs on BMDCs...
  27. pmc Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain
    Catherine J Wei
    Molecular Neuropharmacology Laboratory, Department of Neurology, and Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts
    Biol Psychiatry 75:855-63. 2014
    ..e., hippocampus, cortex), integrating dopamine, glutamate, and brain-derived neurotrophic factor (BDNF) signaling, and are thus essential for striatal neuroplasticity and fear and anxiety behavior...
  28. ncbi request reprint Caffeinated clues and the promise of adenosine A(2A) antagonists in PD
    Michael A Schwarzschild
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 58:1154-60. 2002
    ..Now, with the prospect of a neuroprotective bonus, the novel therapeutic potential of A(2A) antagonists appears all the more promising just as they are entering clinical trials for PD...
  29. ncbi request reprint Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Kui Xu
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:535-41. 2006
    ....
  30. ncbi request reprint Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses
    Liqun Yu
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Brain Res 1000:156-73. 2004
    ..This raises the possibility of generating multiple tissue-specific A(2A)R mRNA species by alternative promoters with varying regulatory susceptibility...
  31. pmc Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions
    Elisabete Augusto
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    J Neurosci 33:11390-9. 2013
    ..This study points to CD73 as a new target that can fine-tune A2AR activity, and a novel therapeutic target to manipulate A2AR-mediated control of striatal function and neurodegeneration. ..
  32. pmc Detection of functional DNA motifs via statistical over-representation
    Martin C Frith
    Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Nucleic Acids Res 32:1372-81. 2004
    ..It also demonstrates superior performance over two contingency table based over-representation methods. In conclusion, Clover has the potential to greatly accelerate characterization of signals that regulate transcription...
  33. ncbi request reprint Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice
    Qing Yuan Huang
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, E301 Boston, MA, USA
    Neurosci Lett 418:175-80. 2007
    ..These results demonstrate that altered SOD1 activity (mSOD(G93A)) in BMDCs affects striatal damage probably through a mechanism involving a systemic factor...
  34. ncbi request reprint Targeting adenosine A2A receptors in Parkinson's disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
    Trends Neurosci 29:647-54. 2006
    ..Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics...
  35. pmc Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning
    Catherine J Wei
    Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA
    Learn Mem 18:459-74. 2011
    ..This study provides the first direct demonstration that targeting striatal A(2A)Rs may be an effective, novel strategy to facilitate cognitive flexibility under normal and pathologic conditions...
  36. pmc Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling
    Liqun Yu
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Physiol Genomics 37:199-210. 2009
    ....
  37. pmc Caffeine consumption and risk of dyskinesia in CALM-PD
    Anne Marie A Wills
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Mov Disord 28:380-3. 2013
    ..Adenosine A2A receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia...
  38. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
    ..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation...
  39. ncbi request reprint Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages
    Arvand Haschemi
    Transplant and Immunobiology Research Centers, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Immunol 178:5921-9. 2007
    ..Taken together, these data suggest the existence of a positive feedback loop among adenosine, HO-1, CO, and the A2aR in the chronological resolution of the inflammatory response...
  40. pmc Adenosine receptors as drug targets--what are the challenges?
    Jiang Fan Chen
    Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Rev Drug Discov 12:265-86. 2013
    ..Here, we focus on the biology of adenosine signalling to identify hurdles in the development of additional pharmacological compounds targeting adenosine receptors and discuss strategies to overcome these challenges...
  41. ncbi request reprint Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis
    Shu Qin Yao
    Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    J Neurochem 123:100-12. 2012
    ..Collectively, these findings suggest that extracellular adenosine acting at A(2A)Rs triggers an important neuroprotective mechanism. Thus, the A(2A) receptor is a potential target for therapeutic approaches to multiple sclerosis...
  42. pmc Human-specific histone methylation signatures at transcription start sites in prefrontal neurons
    Hennady P Shulha
    Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 10:e1001427. 2012
    ....
  43. pmc Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin
    Samuel Joseph Leibovich
    Department of Cell Biology and Molecular Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Pathol 160:2231-44. 2002
    ....
  44. ncbi request reprint Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
    M Carmen Montesinos
    New York University School of Medicine, New York, New York 10016, USA
    Arthritis Rheum 48:240-7. 2003
    ....
  45. ncbi request reprint A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Regul Integr Comp Physiol 291:R959-69. 2006
    ..We conclude that endogenous or exogenous A3AR activation confers significant protection from murine septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis...
  46. doi request reprint Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia
    Greg Miekisiak
    Department of Neurosurgery, Mount Sinai Medical School, New York, New York 10029, USA
    J Cereb Blood Flow Metab 28:1656-64. 2008
    ..05) in WT mice, but was without effect in KO mice. We conclude that adenosine via A2aR is responsible for a significant proportion of the hyperemia during hypoxia...
  47. ncbi request reprint Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  48. pmc Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors
    M Carmen Montesinos
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Am J Pathol 160:2009-18. 2002
    ..Thus, targeting the adenosine A(2A) receptor is a novel approach to promoting wound healing and angiogenesis in normal individuals and those suffering from chronic wounds...
  49. ncbi request reprint Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart
    Eugene I Tikh
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:83-90. 2008
    ..These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility...
  50. ncbi request reprint Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Annu Rev Pharmacol Toxicol 45:385-412. 2005
    ..The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted...
  51. ncbi request reprint Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice
    Ainhoa Bilbao
    Departamento de Psicobiologia, Instituto Universitario de Drogodependencias, Universidad Complutense, Madrid 28223, Spain
    Psychopharmacology (Berl) 185:160-8. 2006
    ..When combined with the opioid antagonist naloxone, methylxanthines produce a characteristic quasi-morphine withdrawal syndrome (QMWS) in opiate-naive animals...
  52. pmc Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 148:1144-55. 2006
    ..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis...
  53. pmc A2A adenosine receptor protects tumors from antitumor T cells
    Akio Ohta
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:13132-7. 2006
    ..Thus, although using the hypoxia-->adenosine-->A2AR pathway inhibitors may improve antitumor immunity, the recruitment of this pathway by selective drugs is expected to attenuate the autoimmune tissue damage...
  54. ncbi request reprint Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia
    Josep Saura
    Department of Pharmacology and Toxicology, IIBB, CSIC, IDIBAPS, Barcelona, Spain
    J Neurochem 95:919-29. 2005
    ....
  55. ncbi request reprint Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo
    Dmitriy Lukashev
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 11N 256, Bethesda, MD 20892, USA
    J Immunol 173:21-4. 2004
    ....
  56. pmc Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice
    Anti Kalda
    Department of Pharmacology, Centre of Excellence of Molecular and Clinical Medicine, University of Tartu, Ravila 19, 51014 Tartu, Estonia
    Behav Brain Res 181:76-84. 2007
    ..Together, these results suggest that dynamic changes in chromatin modification may be an important mechanism underlying amphetamine-induced neuronal plasticity and associative learning...
  57. ncbi request reprint Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    ..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors...
  58. pmc Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells
    Yuan Ji Day
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 112:883-91. 2003
    ..We conclude that protection from renal IRI by A2AR agonists or endogenous adenosine requires activation of receptors expressed on BM-derived cells...
  59. ncbi request reprint The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration
    Olga Björklund
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Toxicology 241:119-33. 2007
    ..Thus, the consequences of MeHg toxicity during gestation and lactation can be reduced by adenosine A(1) and A(2A) receptor inactivation, either via their genetic deletion or by treatment with their antagonist caffeine...
  60. ncbi request reprint Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists
    Neal Castagnoli
    Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0212, USA
    Neurology 61:S62-8. 2003
    ..The results raise the possibility that a single structure may offer the combined benefits of two pharmacologic strategies, each with symptomatic and potential neuroprotective benefits, for the management of PD...
  61. ncbi request reprint Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs
    Benjamin K Yee
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
    Eur J Neurosci 26:3237-52. 2007
    ..The present findings are of relevance to current pathophysiological hypotheses of schizophrenia and its pharmacotherapy...
  62. pmc Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders
    Rodrigo A Cunha
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
    Curr Pharm Des 14:1512-24. 2008
    ..However, the introduction of A(2A) receptors antagonists in clinics as anti-parkinsonian agents is hoped to bolster our knowledge on the role of A(2A) receptors in mood disorders in the near future...
  63. ncbi request reprint Psychosis pathways converge via D2high dopamine receptors
    Philip Seeman
    Department of Pharmacology, University of Toronto, and Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5S 1A8
    Synapse 60:319-46. 2006
    ..Dopamine supersensitivity, in turn, correlates with D2High states. The finding that all antipsychotics, traditional and recent ones, act on D2High dopamine receptors further supports the proposition...
  64. ncbi request reprint Adenosine and brain function
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet Stockholm, Sweden
    Int Rev Neurobiol 63:191-270. 2005
  65. pmc Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis
    Gabriela E Garcia
    Department of Medicine, Nephrology Section, Alkek N520, One Baylor Plaza, Houston TX, 77030, USA
    FASEB J 22:445-54. 2008
    ..Accordingly, pharmacological activation of A(2A)R could be developed into a novel treatment for glomerulonephritis and other macrophage-related inflammatory diseases...
  66. ncbi request reprint Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice
    Amir Mohsenin
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, University of Texas, Houston, Texas 77030, USA
    Am J Physiol Lung Cell Mol Physiol 293:L753-61. 2007
    ..There were no compensatory changes in the other adenosine receptors in the lungs of ADA/A(2A)R double knockout mice. These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation...

Research Grants20

  1. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2001
    ....
  2. CRCNS-Bioinformatics & ident.:cis-elements: DA receptors
    Jiang Fan Chen; Fiscal Year: 2006
    ....
  3. A1/A2A Receptors and Caffeine Psychostimulation
    Jiang Fan Chen; Fiscal Year: 2006
    ..abstract_text> ..
  4. Bioinformatics & identification of cis elements for dopamine gene expression
    Jiang Fan Chen; Fiscal Year: 2007
    ....
  5. A1/A2A Receptors and Caffeine Psychostimulation
    Jiang Fan Chen; Fiscal Year: 2007
    ..abstract_text> ..
  6. Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece
    Jiang Fan Chen; Fiscal Year: 2009
    ..g. striatopallidal, cerebral cortical neurons, microglial). These results will provide a cellular basis for improved clinical use of A2AR antagonists in Parkinson's disease patients. ..
  7. A1/A2A Receptors and Caffeine Psychostimulation
    Jiang Fan Chen; Fiscal Year: 2009
    ..abstract_text> ..
  8. A1/A2A Receptors and Caffeine Psychostimulation
    Jiang Fan Chen; Fiscal Year: 2005
    ..abstract_text> ..
  9. CRCNS-Bioinformatics & ident.:cis-elements: DA receptors
    Jiang Fan Chen; Fiscal Year: 2005
    ....
  10. ADENOSINE /DOPAMINE INTERACTIONS IN A2A RECEPTOR KO MICE
    Jiang Fan Chen; Fiscal Year: 2002
    ..abstract_text> ..
  11. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2001
    ....
  12. ADENOSINE /DOPAMINE INTERACTIONS IN A2A RECEPTOR KO MICE
    Jiang Fan Chen; Fiscal Year: 2001
    ..abstract_text> ..
  13. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2002
    ....
  14. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2003
    ....
  15. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2004
    ....
  16. NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELS
    Jiang Fan Chen; Fiscal Year: 2005
    ....
  17. Bioinformatics /molecular ident. /cis elements /dopamine
    Jiang Fan Chen; Fiscal Year: 2004
    ....
  18. Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece
    Jiang Fan Chen; Fiscal Year: 2010
    ..g. striatopallidal, cerebral cortical neurons, microglial). These results will provide a cellular basis for improved clinical use of A2AR antagonists in Parkinson's disease patients. ..