Jiang Fan Chen


Affiliation: Boston University
Country: USA


  1. Chen J, Lee C, Chern Y. Adenosine receptor neurobiology: overview. Int Rev Neurobiol. 2014;119:1-49 pubmed publisher
    ..We concluded the review with the contention that these new developments extend and strengthen the support for A1 and A2ARs in brain as therapeutic targets for neurologic and psychiatric diseases. ..
  2. Chen J. Adenosine receptor control of cognition in normal and disease. Int Rev Neurobiol. 2014;119:257-307 pubmed publisher
  3. Hou X, Liang X, Chen J, Zheng J. Ecto-5'-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines. Neuroscience. 2015;297:118-26 pubmed publisher
    ..These findings suggest that CD73 plays a protective role in the development of CCH-induced WMLs and cognitive impairment via the regulation of glial cell activation and proinflammatory cytokine expression. ..
  4. Matos M, Shen H, Augusto E, Wang Y, Wei C, Wang Y, et al. Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol Psychiatry. 2015;78:763-74 pubmed publisher
  5. Li W, Silva H, Real J, Wang Y, Rial D, Li P, et al. Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiol Dis. 2015;79:70-80 pubmed publisher
  6. Chen J, Yu L, Shen H, He J, Wang X, Zheng R. What knock-out animals tell us about the effects of caffeine. J Alzheimers Dis. 2010;20 Suppl 1:S17-24 pubmed publisher
  7. Hoss A, Labadorf A, Latourelle J, Kartha V, Hadzi T, Gusella J, et al. miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics. 2015;8:10 pubmed publisher
  8. Xu K, Di Luca D, Orrú M, Xu Y, Chen J, Schwarzschild M. Neuroprotection by caffeine in the MPTP model of parkinson's disease and its dependence on adenosine A2A receptors. Neuroscience. 2016;322:129-37 pubmed publisher
    ..Taken together, these results indicate that neuroprotection by caffeine in the MPTP model of PD relies on the A2AR, although the specific cellular localization of these receptors remains to be determined. ..
  9. request reprint
    Chen J, Sonsalla P, Pedata F, Melani A, Domenici M, Popoli P, et al. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol. 2007;83:310-31 pubmed

More Information


  1. Bai G, Cheung I, Shulha H, Coelho J, Li P, Dong X, et al. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015;24:1441-56 pubmed publisher
    ..These findings, taken together, suggest that epigenetic dysregulation of HES4 could play a critical role in modifying HD disease pathogenesis and severity. ..
  2. Zhao Z, Ning Y, Li P, Yang N, Peng Y, Xiong R, et al. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behav Brain Res. 2017;323:146-153 pubmed publisher
    ..These findings provide experimental support for the role of p-tau in cognitive impairment in the early phase after TBI. ..