Research Topics
Genomes and Genes | Jiang Fan ChenSummaryAffiliation: Boston University Country: USA Publications
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Publications
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonismJiang Fan Chen
Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
J Biol Chem 277:36040-4. 2002..Together, these data indicate that CSC possesses dual actions of MAO-B inhibition and A(2A) receptor antagonism, a unique combination suggesting a new class of compounds with the potential for enhanced neuroprotective properties...- Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's diseaseJiang Fan Chen
Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02118, USA
Neurology 61:S74-81. 2003..Potential presynaptic, postsynaptic (cellular), and trans-synaptic (network) mechanisms are discussed... 
What knock-out animals tell us about the effects of caffeineJiang Fan Chen
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
J Alzheimers Dis 20:S17-24. 2010....- The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatmentJiang Fan Chen
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Drug News Perspect 16:597-604. 2003..This review summarizes multiple potential benefits of the A(2A) receptor blockade in treating the motor symptoms as well as the underlying dopaminergic neurodegeneration of Parkinson's disease... - Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studiesJiang Fan Chen
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Handb Exp Pharmacol 200:267-310. 2011.... - Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptorsJiang Fan Chen
Department of Neurology, Boston University School of Medicine, 715 Albany Street, E301, Boston, MA 02118, USA
Curr Pharm Des 14:1490-9. 2008.... - Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulationJiang Fan Chen
Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA
Prog Neurobiol 83:310-31. 2007.... - A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitizationElena Bastia
Molecular Neurobiology Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 30:891-900. 2005..Thus activation of brain A(2A)Rs plays a critical role in developing augmented psychomotor responses to repeated psychostimulant exposure... - Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivationQing Yuan Huang
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 26:11371-8. 2006..exacerbation of 3-NP-induced striatal damage. Thus, cell-type-selective inactivation of A2ARs reveals that A2ARs in BMDCs but not in forebrain neurons are an important contributor to striatal damage induced by mitochondrial dysfunction... - Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptorsSilva Fredduzzi
Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosci 22:1054-62. 2002..Furthermore, they raise the possibility that the maladaptive dyskinetic responses to chronic l-DOPA treatment in Parkinson's disease may be attenuated by A(2A) receptor inactivation... - A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outsHai Ying Shen
Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 28:2970-5. 2008..These results indicate that A(2A)Rs in striatal and extrastriatal neurons exert an opposing modulation of psychostimulant effects and provide the first direct demonstration of a predominant facilitatory role of extrastriatal A(2A)Rs... - Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatumLiqun Yu
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Physiol Genomics 23:89-102. 2005..Taken together, these results strongly support the existence of an Egr-2-directed transcriptional regulatory network controlled by striatal A2ARs... - Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damageJ Stephen Fink
Department of Neurology, Boston University School of Medicine, MA 02118, USA
J Neurochem 88:538-44. 2004.... - Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's diseaseMichael A Schwarzschild
Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA
Neurology 61:S55-61. 2003.... - Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian miceAnil Kachroo
MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosci 25:10414-9. 2005..These data also strengthen a rationale for pursuing a combinational drug strategy for enhancing the antiparkinsonian effects of A2A and mGlu5 antagonists... - Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian miceDanqing Xiao
Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 26:13548-55. 2006.... - Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitizationJiang Fan Chen
Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
Neuropsychopharmacology 28:1086-95. 2003.... 
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's diseaseDanqing Xiao
MassGeneral Institute for Neurolodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
Brain Res 1367:310-8. 2011..Our findings raise the possibility that A₁ or A(₂A) receptors blockade might also confer a disease-modifying benefit of reduced risk of disabling LID, whereas the effect of their combined inactivation is less clear...- Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanismsLiqun Yu
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Ann Neurol 63:338-46. 2008..To investigate whether the motor and neuroprotective effects of adenosine A(2A) receptor (A(2A)R) antagonists are mediated by distinct cell types in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease... - Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's diseaseKui Xu
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 26:535-41. 2006.... - Caffeinated clues and the promise of adenosine A(2A) antagonists in PDMichael A Schwarzschild
Department of Neurology, Massachusetts General Hospital, Boston, USA
Neurology 58:1154-60. 2002..Now, with the prospect of a neuroprotective bonus, the novel therapeutic potential of A(2A) antagonists appears all the more promising just as they are entering clinical trials for PD... - Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in miceKui Xu
Department of Neurology, Massachusetts General Hospital, 02129, Charlestown, MA, USA
Neurosci Lett 322:13-6. 2002..These data raise the possibility that caffeine may induce neuroprotection and locomotion by distinct mechanisms... - Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in miceQing Yuan Huang
Department of Neurology, Boston University School of Medicine, 715 Albany Street, E301 Boston, MA, USA
Neurosci Lett 418:175-80. 2007..These results demonstrate that altered SOD1 activity (mSOD(G93A)) in BMDCs affects striatal damage probably through a mechanism involving a systemic factor... - Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analysesLiqun Yu
Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Brain Res 1000:156-73. 2004..This raises the possibility of generating multiple tissue-specific A(2A)R mRNA species by alternative promoters with varying regulatory susceptibility... - Cross-sensitization between caffeine- and L-dopa-induced behaviors in hemiparkinsonian miceLiqun Yu
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, 02114, USA
Neurosci Lett 393:31-5. 2006.... - Targeting adenosine A2A receptors in Parkinson's diseaseMichael A Schwarzschild
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
Trends Neurosci 29:647-54. 2006..Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics... - Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson's diseaseAnti Kalda
Molecular Neuropharmacology Lab, Department of Neurology, Boston University Medical Center, Boston, MA 02118, USA
J Neurol Sci 248:9-15. 2006..Intensive investigations are under way to dissect out common cellular mechanisms (such as A(2A) receptor modulation of neuroinflammation) which may underlie the broad spectrum of neuroprotection by A(2A) receptor inactivation in brain... - Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profilingLiqun Yu
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Physiol Genomics 37:199-210. 2009.... - Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in miceHai-ying Shen
Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 280:39962-9. 2005.... - Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophagesArvand Haschemi
Transplant and Immunobiology Research Centers, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
J Immunol 178:5921-9. 2007..Taken together, these data suggest the existence of a positive feedback loop among adenosine, HO-1, CO, and the A2aR in the chronological resolution of the inflammatory response... - Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionSilvia Deaglio
Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Exp Med 204:1257-65. 2007..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation... - Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learningCatherine J Wei
Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA
Learn Mem 18:459-74. 2011..This study provides the first direct demonstration that targeting striatal A(2A)Rs may be an effective, novel strategy to facilitate cognitive flexibility under normal and pathologic conditions... - Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitisShu Qin Yao
Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
J Neurochem 123:100-12. 2012..Collectively, these findings suggest that extracellular adenosine acting at A(2A)Rs triggers an important neuroprotective mechanism. Thus, the A(2A) receptor is a potential target for therapeutic approaches to multiple sclerosis... - Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injuryLiqun Yu
Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, Massachusetts 02118, USA
Nat Med 10:1081-7. 2004..These results indicate that the A(2A)R-stimulated cascade in BMDCs is an important modulator of ischemic brain injury and that ischemic brain and liver injuries are regulated distinctly by A(2A)Rs on BMDCs... - Detection of functional DNA motifs via statistical over-representationMartin C Frith
Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Nucleic Acids Res 32:1372-81. 2004..It also demonstrates superior performance over two contingency table based over-representation methods. In conclusion, Clover has the potential to greatly accelerate characterization of signals that regulate transcription... - Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heartEugene I Tikh
Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Physiol 216:83-90. 2008..These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility... - Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in miceAnti Kalda
Department of Pharmacology, Centre of Excellence of Molecular and Clinical Medicine, University of Tartu, Ravila 19, 51014 Tartu, Estonia
Behav Brain Res 181:76-84. 2007..Together, these results suggest that dynamic changes in chromatin modification may be an important mechanism underlying amphetamine-induced neuronal plasticity and associative learning... - The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administrationOlga Björklund
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Toxicology 241:119-33. 2007..Thus, the consequences of MeHg toxicity during gestation and lactation can be reduced by adenosine A(1) and A(2A) receptor inactivation, either via their genetic deletion or by treatment with their antagonist caffeine... - Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxiaGreg Miekisiak
Department of Neurosurgery, Mount Sinai Medical School, New York, New York 10029, USA
J Cereb Blood Flow Metab 28:1656-64. 2008..05) in WT mice, but was without effect in KO mice. We conclude that adenosine via A2aR is responsible for a significant proportion of the hyperemia during hypoxia... - Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeineZhi Li Huang
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
Nat Neurosci 8:858-9. 2005..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors... - Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptorsM Carmen Montesinos
Department of Medicine, New York University School of Medicine, New York, New York, USA
Am J Pathol 160:2009-18. 2002..Thus, targeting the adenosine A(2A) receptor is a novel approach to promoting wound healing and angiogenesis in normal individuals and those suffering from chronic wounds... - Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxinSamuel Joseph Leibovich
Department of Cell Biology and Molecular Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Am J Pathol 160:2231-44. 2002.... - Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68M Carmen Montesinos
New York University School of Medicine, New York, New York 10016, USA
Arthritis Rheum 48:240-7. 2003..Moreover, these results provide strong evidence that adenosine, acting at either or both of these receptors, mediates the antiinflammatory effects of methotrexate and its analog MX-68... - Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cellsYuan Ji Day
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 112:883-91. 2003..We conclude that protection from renal IRI by A2AR agonists or endogenous adenosine requires activation of receptors expressed on BM-derived cells... - Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonistsNeal Castagnoli
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0212, USA
Neurology 61:S62-8. 2003..The results raise the possibility that a single structure may offer the combined benefits of two pharmacologic strategies, each with symptomatic and potential neuroprotective benefits, for the management of PD... - Sleep regulation in adenosine A2A receptor-deficient miceYoshihiro Urade
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
Neurology 61:S94-6. 2003 - Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivoDmitriy Lukashev
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 11N 256, Bethesda, MD 20892, USA
J Immunol 173:21-4. 2004.... - Actions of adenosine at its receptors in the CNS: insights from knockouts and drugsBertil B Fredholm
Department of Physiology and Pharmacology, Karolinska Institutet, S-17177 Stockholm, Sweden
Annu Rev Pharmacol Toxicol 45:385-412. 2005..The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted... - Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microgliaJosep Saura
Department of Pharmacology and Toxicology, IIBB, CSIC, IDIBAPS, Barcelona, Spain
J Neurochem 95:919-29. 2005.... - Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout miceAinhoa Bilbao
Departamento de Psicobiologia, Instituto Universitario de Drogodependencias, Universidad Complutense, Madrid 28223, Spain
Psychopharmacology (Berl) 185:160-8. 2006..When combined with the opioid antagonist naloxone, methylxanthines produce a characteristic quasi-morphine withdrawal syndrome (QMWS) in opiate-naive animals... - A2A adenosine receptor protects tumors from antitumor T cellsAkio Ohta
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:13132-7. 2006..Thus, although using the hypoxia-->adenosine-->A2AR pathway inhibitors may improve antitumor immunity, the recruitment of this pathway by selective drugs is expected to attenuate the autoimmune tissue damage... - A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitisH Thomas Lee
Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
Am J Physiol Regul Integr Comp Physiol 291:R959-69. 2006..We conclude that endogenous or exogenous A3AR activation confers significant protection from murine septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis... - Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosisEdwin S L Chan
Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Br J Pharmacol 148:1144-55. 2006..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis... - Psychosis pathways converge via D2high dopamine receptorsPhilip Seeman
Department of Pharmacology, University of Toronto, and Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5S 1A8
Synapse 60:319-46. 2006..Dopamine supersensitivity, in turn, correlates with D2High states. The finding that all antipsychotics, traditional and recent ones, act on D2High dopamine receptors further supports the proposition... - Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient miceAmir Mohsenin
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, University of Texas, Houston, Texas 77030, USA
Am J Physiol Lung Cell Mol Physiol 293:L753-61. 2007..There were no compensatory changes in the other adenosine receptors in the lungs of ADA/A(2A)R double knockout mice. These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation... - Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritisGabriela E Garcia
Department of Medicine, Nephrology Section, Alkek N520, One Baylor Plaza, Houston TX, 77030, USA
FASEB J 22:445-54. 2008..Accordingly, pharmacological activation of A(2A)R could be developed into a novel treatment for glomerulonephritis and other macrophage-related inflammatory diseases... - Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugsBenjamin K Yee
Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
Eur J Neurosci 26:3237-52. 2007..The present findings are of relevance to current pathophysiological hypotheses of schizophrenia and its pharmacotherapy... - Adenosine and brain functionBertil B Fredholm
Department of Physiology and Pharmacology, Karolinska Institutet Stockholm, Sweden
Int Rev Neurobiol 63:191-270. 2005 - Potential therapeutic interest of adenosine A2A receptors in psychiatric disordersRodrigo A Cunha
Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
Curr Pharm Des 14:1512-24. 2008..However, the introduction of A(2A) receptors antagonists in clinics as anti-parkinsonian agents is hoped to bolster our knowledge on the role of A(2A) receptors in mood disorders in the near future...
Research Grants
- Bioinformatics & identification of cis elements for dopamine gene expressionJiang Fan Chen; Fiscal Year: 2007....
- A1/A2A Receptors and Caffeine PsychostimulationJiang Fan Chen; Fiscal Year: 2007..abstract_text> ..
- A1/A2A Receptors and Caffeine PsychostimulationJiang Fan Chen; Fiscal Year: 2009..abstract_text> ..
- ADENOSINE /DOPAMINE INTERACTIONS IN A2A RECEPTOR KO MICEJiang Fan Chen; Fiscal Year: 2002..abstract_text> ..
- NOVEL BENEFIT OF A2A RECEPTOR INACTIVATION IN PD MODELSJiang Fan Chen; Fiscal Year: 2005....
- Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A receJiang Fan Chen; Fiscal Year: 2010..g. striatopallidal, cerebral cortical neurons, microglial). These results will provide a cellular basis for improved clinical use of A2AR antagonists in Parkinson's disease patients. ..