Research Topics
Genomes and Genes | Subrata ChakrabartiSummaryAffiliation: Boston University Country: USA Publications
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Publications
CD40 ligand influences platelet release of reactive oxygen intermediatesSubrata Chakrabarti
The Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Arterioscler Thromb Vasc Biol 25:2428-34. 2005..In this study, we examined the effect of sCD40L on platelet function and reactive oxygen and nitrogen species (RONS) generation...- Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effectsSubrata Chakrabarti
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
J Cardiovasc Pharmacol 50:449-57. 2007.... 
The role of CD40L and VEGF in the modulation of angiogenesis and inflammationSubrata Chakrabarti
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Vascul Pharmacol 53:130-7. 2010..Together, these studies reveal a new pathway by which VEGF-CD40L interactions can regulate the angiogenic and inflammatory process depending on the specific environment...
M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout miceSubrata Chakrabarti
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
J Thromb Thrombolysis 28:394-400. 2009..In an animal model of vascular plaque, M118 is a potent inhibitor of arterial thrombosis and, despite lower in vivo anti-Xa and anti-IIa activity levels, M118 was superior to UFH in the prevention of arterial thrombosis...- Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cellsSubrata Chakrabarti
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Immunol Lett 122:170-84. 2009..In summary, we show that hypoxia can alter CD40-CD40L mediated endothelial-monocyte interaction, playing a significant role in vascular inflammation and cellular adhesion processes... - CD40-40L signaling in vascular inflammationSubrata Chakrabarti
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 282:18307-17. 2007..Increased CD40L and MCP1 may contribute to the adherence of CD40-positive cells, such as platelets and monocytes, to the vessel wall modulating atherothrombosis... - Review: Nutriceuticals as antithrombotic agentsSubrata Chakrabarti
Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Cardiovasc Ther 28:227-35. 2010..In addition, therapeutic opportunities in the area of nutragenomics and nutraceuticals in vascular and nonvascular diseases are also discussed... - The effect of dipyridamole on vascular cell-derived reactive oxygen speciesSubrata Chakrabarti
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
J Pharmacol Exp Ther 315:494-500. 2005..These data suggest that the redox-dependent properties of dipyridamole have a direct effect on vascular cells... - Neutrophil CD40 enhances platelet-mediated inflammationPantila Vanichakarn
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Thromb Res 122:346-58. 2008..While CD40 was recently reported to be present on neutrophils, the detailed mechanism of its interaction with platelets via CD40-CD40L has not been examined... - Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediatesOlga Vitseva
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cardiovasc Pharmacol 46:445-51. 2005..These findings suggest potentially beneficial platelet-dependent antithrombotic and anti-inflammatory properties of purple grape-derived flavonoids... - Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinasePrice Blair
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston, MA 02118 2526, USA
Circ Res 104:346-54. 2009..This work substantiates the role of platelets in the immune and inflammatory response and suggests a mechanism by which bacteria could directly activate platelets... - Compensatory mechanisms influence hemostasis in setting of eNOS deficiencyMark D Iafrati
Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
Am J Physiol Heart Circ Physiol 288:H1627-32. 2005..Such compensatory mechanisms may partially explain the lack of spontaneous thrombosis, minimally elevated baseline blood pressure, and normal life span that are seen in animals deficient in a pivotal regulator of vascular patency... - CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular diseaseMuhammad Rizvi
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Trends Mol Med 14:530-8. 2008..Understanding the roles and regulation of CD40-CD40L-mediated oxidative signaling in immune and non-immune cells could facilitate the development of therapeutics targeting diverse inflammatory diseases... - Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular diseasePeter J Mason
Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Cardiol 96:1365-9. 2005..In conclusion, our data demonstrate the complex nature of CD40L and highlight the distinct processes of expression, shedding, and clearance of this ligand in patient populations... - Dipyridamole, cerebrovascular disease, and the vasculatureSubrata Chakrabarti
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA
Vascul Pharmacol 48:143-9. 2008.... - Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide releaseSubrata Chakrabarti
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02481, USA
Thromb Res 113:225-33. 2004..CONCLUSION: These observations suggest that the pharmacological effects of GPIIb/IIIa antagonists on platelet function, apart from inhibition of aggregation, may contribute to their efficacy... - Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunctionZia A Khan
Department of Pathology, University of Western Ontario, London, Canada
Free Radic Res 39:1203-10. 2005..In conclusion, our study suggests that glucose-induced alteration of iron transporters may arbitrate iron accumulation and oxidative stress in endothelial cells... - High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1Shali Chen
Department of Pathology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Am J Physiol Cell Physiol 284:C263-72. 2003..ET receptor blockade also prevented these HG- and ET-mediated changes. The results of this study indicate that glucose-induced increased FN production in diabetes may be mediated via ET-dependent NF-kappaB and AP-1 activation... - Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damageShali Chen
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Free Radic Res 38:1301-10. 2004..These data suggest that HO by itself and via elaboration of other vasoactive factors may cause endothelial injury and functional alteration. These findings are of importance in the context of chronic diabetic complications... - Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300Harkiran Kaur
Department of Pathology, 4011 Dental Sciences Building, University of Western Ontario, London, Ontario, Canada
Diabetes 55:3104-11. 2006..These results indicate that transcriptional coactivator p300 may regulate fibronectin expression via PARP and NF-kappaB activation in diabetes... - Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidantsRenu A Kowluru
Kresge Eye Institute, Wayne State University, 4717 St Antoine, Detroit, MI 48201, USA
Free Radic Res 37:1169-80. 2003..Beneficial effects of antioxidants on the development of diabetic retinopathy might involve inhibition of NF-kappaB activation and its downstream pathways in the retina... - Cellular signaling and potential new treatment targets in diabetic retinopathyZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Exp Diabetes Res 2007:31867. 2007..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy... - Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complicationsJane Chiu
Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
Can J Physiol Pharmacol 86:365-72. 2008..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications... - Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional levelBiao Feng
Department of Pathology, University of Western Ontario, London, ON, Canada
Am J Physiol Endocrinol Metab 294:E1119-26. 2008..We concluded that data from these studies demonstrate a novel glucose-induced epigenetic mechanism regulating gene expression and cardiomyocyte hypertrophy in diabetes... - PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetesBingying Xu
Department of Forensic Science, Kunming Medical College, Kunming, Yunnan, PR China
Diabetes Metab Res Rev 24:404-12. 2008..We investigated the role of PARP in the development of diabetic retinopathy and nephropathy... - Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nucleiAsad Zeidan
Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada
Cardiovasc Res 77:64-72. 2008..The present study investigated the role of lipid raft/caveolae in these responses and assessed the nature of p38 MAPK activation in mediating leptin-induced hypertrophy... - Akt activation and augmented fibronectin production in hyperhexosemiaXiping Xin
Dept of Pathology, 4011 Dental Sciences Bldg, Univ of Western Ontario, London, ON, Canada N6A 5C1
Am J Physiol Endocrinol Metab 293:E1036-44. 2007.... - Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathwaysAsad Zeidan
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
J Pharmacol Exp Ther 322:1110-6. 2007..Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics... - Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targetsHana Farhangkhoee
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Pharmacol Ther 111:384-99. 2006..In this review, we will highlight some of the important vascular changes leading to diabetic cardiomyopathy and discuss the emerging potential therapeutic interventions... - Therapeutic targeting of endothelial dysfunction in chronic diabetic complicationsZia A Khan
Department of Pathology, University of Western Ontario, London, Canada
Recent Patents Cardiovasc Drug Discov 1:167-75. 2006..We present the hypothesis that preservation and restoration of the endothelial cell function may potentially be the most efficient means of targeting the adverse effects of hyperglycemia... - Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophyShali Chen
Department of Pathology, University of Western Ontario, Ontario, Canada
Diabetes Metab Res Rev 23:356-67. 2007.... - Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complicationsShali Chen
Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
Am J Physiol Endocrinol Metab 284:E1089-97. 2003..These data indicate that, although ETs are important in increased FN production due to diabetes, the mechanisms with respect to transcription factor activation may vary depending on the microenvironment of the organ... - Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell lineChandan Chakraborty
Department of Anatomy and Cell Biology, The University of Western Ontario, London, Canada N6A 5C1
Mol Cell Endocrinol 201:63-73. 2003..Thus, ET-1 may represent an autocrine/paracrine mediator of invasive trophoblast function... - Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cellsPatrick P W Luke
Department of Surgery, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
Transplantation 76:400-9. 2003.... - Heme oxygenase in diabetes-induced oxidative stress in the heartHana Farhangkhoee
Department of Pathology, Dental Sciences Building, University of Western Ontario, London, Ont, Canada N6A 5C1
J Mol Cell Cardiol 35:1439-48. 2003..These results provide evidence of pro-oxidant activity of HO in the heart in diabetes, which could be mediated by increased redox-active iron... - The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retinaMark Cukiernik
University of Western Ontario, Department of Pathology, Canada
Diabetes Metab Res Rev 20:61-71. 2004..Our investigation attempts to determine the role of NHE-1 in the pathogenesis of early retinal microangiopathy due to diabetes... - Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic ratsRenu A Kowluru
Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
Diabetes 53:775-83. 2004..Thus, the results suggest that functional activation of H-Ras might be one of the signaling steps involved in glucose-induced capillary cell apoptosis and supports the role of H-Ras in the development of retinopathy in diabetes... - Heme-oxygenase-mediated iron accumulation in the liverZia A Khan
Department of Pathology, University of Western Ontario, London, Canada
Can J Physiol Pharmacol 82:448-56. 2004..Our data provides evidence of increased HO activity as an important pro-oxidant mechanism leading to iron accumulation in the liver... - Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesisXiping Xin
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Lab Invest 84:1451-9. 2004..These results suggested that glucose-induced, ET- and PKC-dependent, upregulation of FN is, in part, mediated via MAPK/ERK activation... - Glucose-induced serum- and glucocorticoid-regulated kinase activation in oncofetal fibronectin expressionZia A Khan
Department of Pathology, University of Western Ontario, London, Ont, Canada
Biochem Biophys Res Commun 329:275-80. 2005..These findings provide first evidence of glucose-induced SGK-1 activation in altered EDB(+) FN expression and provide novel avenues for therapeutic modalities... - 2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cellsGen Fukuda
Third Department of Internal Medicine, Tokyo Medical University, Tokyo 160-0023, Japan
Biol Pharm Bull 28:797-801. 2005.... - Heme oxygenase modulates small intestine leukocyte adhesion following hindlimb ischemia/reperfusion by regulating the expression of intercellular adhesion molecule-1Jeffrey R Scott
Medical Biophysics, University of Western Ontario, London, ON, USA
Crit Care Med 33:2563-70. 2005.... - EDB fibronectin and angiogenesis -- a novel mechanistic pathwayZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Angiogenesis 8:183-96. 2005..In conclusion, these results indicate that EDB(+) FN is involved in endothelial cell proliferation and vascular morphogenesis, findings which may provide novel avenues for the development of anti-angiogenic therapies... - Oncofetal fibronectin in diabetic retinopathyZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Invest Ophthalmol Vis Sci 45:287-95. 2004..Furthermore, the data suggest that oncofetal fibronectin is involved in endothelial cell proliferation... - Towards newer molecular targets for chronic diabetic complicationsZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Curr Vasc Pharmacol 4:45-57. 2006..This review will discuss the current mechanistic understanding of chronic diabetic complications and will explore the potential novel therapeutic interventions... - Endothelins: regulators of extracellular matrix protein production in diabetesZia A Khan
Department of Pathology, 4011 Dental Sciences Building, University of Western Ontario, London, Ontario, Canada NCA 5C1
Exp Biol Med (Maywood) 231:1022-9. 2006..These studies show that glucose-induced and ET-mediated FN and ED-B FN expressions involve complex interplays between signaling pathways and that ET may represent an ideal target for therapy in chronic diabetic complications... - Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathyIram Siddiqui
Department of Pathology, University of Western Ontario, London, Canada
Transplantation 82:406-14. 2006..In the present study, we investigated ED-B FN expression in chronic allograft nephropathy and its relationship with endothelins (ET)... - Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complicationsSubrata Chakrabarti
Department of Pathology, The University of Western Ontario, London, Ontario, Canada
Int J Exp Diabetes Res 3:217-31. 2002..This review discusses the contribution of ETs in the pathogenesis and the potential role of ET antagonism in the treatment of chronic diabetic complications...