Subrata Chakrabarti

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint CD40 ligand influences platelet release of reactive oxygen intermediates
    Subrata Chakrabarti
    The Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 25:2428-34. 2005
  2. ncbi request reprint Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Cardiovasc Pharmacol 50:449-57. 2007
  3. doi request reprint The role of CD40L and VEGF in the modulation of angiogenesis and inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Vascul Pharmacol 53:130-7. 2010
  4. pmc M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Thrombolysis 28:394-400. 2009
  5. doi request reprint Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Immunol Lett 122:170-84. 2009
  6. ncbi request reprint CD40-40L signaling in vascular inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:18307-17. 2007
  7. doi request reprint Review: Nutriceuticals as antithrombotic agents
    Subrata Chakrabarti
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Ther 28:227-35. 2010
  8. ncbi request reprint The effect of dipyridamole on vascular cell-derived reactive oxygen species
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Pharmacol Exp Ther 315:494-500. 2005
  9. doi request reprint Neutrophil CD40 enhances platelet-mediated inflammation
    Pantila Vanichakarn
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Thromb Res 122:346-58. 2008
  10. ncbi request reprint Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates
    Olga Vitseva
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cardiovasc Pharmacol 46:445-51. 2005

Collaborators

  • Dermot Cox
  • John D Folts
  • Jane Freedman
  • Price Blair
  • Mark D Iafrati
  • Lea M Beaulieu
  • David Iyu
  • Peter J Mason
  • Chie Hayashi
  • C A Genco
  • P P W Luke
  • PATTY LEE
  • Renu Kowluru
  • Anjaneyulu Kowluru
  • Zia A Khan
  • Shali Chen
  • Hana Farhangkhoee
  • Xiping Xin
  • Jane Chiu
  • Yousef P Barbin
  • Mark Cukiernik
  • Morris Karmazyn
  • Biao Feng
  • Asad Zeidan
  • Harkiran Kaur
  • Zia Ali Khan
  • Chandan Chakraborty
  • Muhammad Rizvi
  • Bingying Xu
  • Pantila Vanichakarn
  • Sabzali Javadov
  • Iram Siddiqui
  • Bosco M Chan
  • Shashi Uniyal
  • John R Gonder
  • Olga Vitseva
  • Gen Fukuda
  • Jeffrey R Scott
  • Paul C Adams
  • Suranjana Mukherjee
  • Biju George
  • Didi Pathak
  • Cindy Wu
  • Bing Ying Xu
  • Karly J Steinhoff
  • Venkatesh Rajapurohitam
  • Ben Paylor
  • Lynda Bere
  • Jeffery L Mahon
  • Bertha Garcia
  • Jifu Jiang
  • Dameng Lian
  • Robert Zhong
  • Daryl K Gray
  • Aurelia Bihari
  • Amit Badhwar
  • Sonia Varghese
  • Shin ichi Akiyama
  • Kenneth A Harris
  • Peiying Shan
  • Yoko Notoya
  • Masato Odawara
  • Noriko Yoshitake
  • Richard F Potter
  • Xiao Fang Che
  • Wolfgang Scholz
  • Masao Kanazawa
  • Akio Tomoda
  • Xuchen Zhang
  • Norbert Beier
  • Donal Downey
  • Denise Hileeto
  • Terry Evans
  • Yousef Barbin
  • Peeyush K Lala
  • S Jeffrey Dixon
  • Peter Chidiac

Detail Information

Publications48

  1. ncbi request reprint CD40 ligand influences platelet release of reactive oxygen intermediates
    Subrata Chakrabarti
    The Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 25:2428-34. 2005
    ..In this study, we examined the effect of sCD40L on platelet function and reactive oxygen and nitrogen species (RONS) generation...
  2. ncbi request reprint Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Cardiovasc Pharmacol 50:449-57. 2007
    ....
  3. doi request reprint The role of CD40L and VEGF in the modulation of angiogenesis and inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Vascul Pharmacol 53:130-7. 2010
    ..Together, these studies reveal a new pathway by which VEGF-CD40L interactions can regulate the angiogenic and inflammatory process depending on the specific environment...
  4. pmc M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Thrombolysis 28:394-400. 2009
    ..In an animal model of vascular plaque, M118 is a potent inhibitor of arterial thrombosis and, despite lower in vivo anti-Xa and anti-IIa activity levels, M118 was superior to UFH in the prevention of arterial thrombosis...
  5. doi request reprint Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Immunol Lett 122:170-84. 2009
    ..In summary, we show that hypoxia can alter CD40-CD40L mediated endothelial-monocyte interaction, playing a significant role in vascular inflammation and cellular adhesion processes...
  6. ncbi request reprint CD40-40L signaling in vascular inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:18307-17. 2007
    ..Increased CD40L and MCP1 may contribute to the adherence of CD40-positive cells, such as platelets and monocytes, to the vessel wall modulating atherothrombosis...
  7. doi request reprint Review: Nutriceuticals as antithrombotic agents
    Subrata Chakrabarti
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Ther 28:227-35. 2010
    ..In addition, therapeutic opportunities in the area of nutragenomics and nutraceuticals in vascular and nonvascular diseases are also discussed...
  8. ncbi request reprint The effect of dipyridamole on vascular cell-derived reactive oxygen species
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Pharmacol Exp Ther 315:494-500. 2005
    ..These data suggest that the redox-dependent properties of dipyridamole have a direct effect on vascular cells...
  9. doi request reprint Neutrophil CD40 enhances platelet-mediated inflammation
    Pantila Vanichakarn
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Thromb Res 122:346-58. 2008
    ..While CD40 was recently reported to be present on neutrophils, the detailed mechanism of its interaction with platelets via CD40-CD40L has not been examined...
  10. ncbi request reprint Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates
    Olga Vitseva
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cardiovasc Pharmacol 46:445-51. 2005
    ..These findings suggest potentially beneficial platelet-dependent antithrombotic and anti-inflammatory properties of purple grape-derived flavonoids...
  11. pmc Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase
    Price Blair
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston, MA 02118 2526, USA
    Circ Res 104:346-54. 2009
    ..This work substantiates the role of platelets in the immune and inflammatory response and suggests a mechanism by which bacteria could directly activate platelets...
  12. ncbi request reprint Compensatory mechanisms influence hemostasis in setting of eNOS deficiency
    Mark D Iafrati
    Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 288:H1627-32. 2005
    ..Such compensatory mechanisms may partially explain the lack of spontaneous thrombosis, minimally elevated baseline blood pressure, and normal life span that are seen in animals deficient in a pivotal regulator of vascular patency...
  13. doi request reprint CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease
    Muhammad Rizvi
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Mol Med 14:530-8. 2008
    ..Understanding the roles and regulation of CD40-CD40L-mediated oxidative signaling in immune and non-immune cells could facilitate the development of therapeutics targeting diverse inflammatory diseases...
  14. ncbi request reprint Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease
    Peter J Mason
    Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 96:1365-9. 2005
    ..In conclusion, our data demonstrate the complex nature of CD40L and highlight the distinct processes of expression, shedding, and clearance of this ligand in patient populations...
  15. doi request reprint Dipyridamole, cerebrovascular disease, and the vasculature
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA
    Vascul Pharmacol 48:143-9. 2008
    ....
  16. ncbi request reprint Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02481, USA
    Thromb Res 113:225-33. 2004
    ..Blocking the GPIIb/IIIa receptor prevents platelet aggregation but not activation and the subsequent effect on other platelet pathways is largely unknown...
  17. ncbi request reprint Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunction
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Canada
    Free Radic Res 39:1203-10. 2005
    ..In conclusion, our study suggests that glucose-induced alteration of iron transporters may arbitrate iron accumulation and oxidative stress in endothelial cells...
  18. ncbi request reprint High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1
    Shali Chen
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Cell Physiol 284:C263-72. 2003
    ..ET receptor blockade also prevented these HG- and ET-mediated changes. The results of this study indicate that glucose-induced increased FN production in diabetes may be mediated via ET-dependent NF-kappaB and AP-1 activation...
  19. ncbi request reprint Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damage
    Shali Chen
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Free Radic Res 38:1301-10. 2004
    ..These data suggest that HO by itself and via elaboration of other vasoactive factors may cause endothelial injury and functional alteration. These findings are of importance in the context of chronic diabetic complications...
  20. ncbi request reprint Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300
    Harkiran Kaur
    Department of Pathology, 4011 Dental Sciences Building, University of Western Ontario, London, Ontario, Canada
    Diabetes 55:3104-11. 2006
    ..These results indicate that transcriptional coactivator p300 may regulate fibronectin expression via PARP and NF-kappaB activation in diabetes...
  21. ncbi request reprint Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, 4717 St Antoine, Detroit, MI 48201, USA
    Free Radic Res 37:1169-80. 2003
    ..Beneficial effects of antioxidants on the development of diabetic retinopathy might involve inhibition of NF-kappaB activation and its downstream pathways in the retina...
  22. pmc Cellular signaling and potential new treatment targets in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Exp Diabetes Res 2007:31867. 2007
    ..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
  23. doi request reprint Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications
    Jane Chiu
    Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
    Can J Physiol Pharmacol 86:365-72. 2008
    ..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications...
  24. doi request reprint Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level
    Biao Feng
    Department of Pathology, University of Western Ontario, London, ON, Canada
    Am J Physiol Endocrinol Metab 294:E1119-26. 2008
    ..We concluded that data from these studies demonstrate a novel glucose-induced epigenetic mechanism regulating gene expression and cardiomyocyte hypertrophy in diabetes...
  25. doi request reprint PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes
    Bingying Xu
    Department of Forensic Science, Kunming Medical College, Kunming, Yunnan, PR China
    Diabetes Metab Res Rev 24:404-12. 2008
    ..We investigated the role of PARP in the development of diabetic retinopathy and nephropathy...
  26. ncbi request reprint Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei
    Asad Zeidan
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada
    Cardiovasc Res 77:64-72. 2008
    ..The present study investigated the role of lipid raft/caveolae in these responses and assessed the nature of p38 MAPK activation in mediating leptin-induced hypertrophy...
  27. ncbi request reprint Akt activation and augmented fibronectin production in hyperhexosemia
    Xiping Xin
    Dept of Pathology, 4011 Dental Sciences Bldg, Univ of Western Ontario, London, ON, Canada N6A 5C1
    Am J Physiol Endocrinol Metab 293:E1036-44. 2007
    ....
  28. ncbi request reprint Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways
    Asad Zeidan
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    J Pharmacol Exp Ther 322:1110-6. 2007
    ..Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics...
  29. ncbi request reprint Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets
    Hana Farhangkhoee
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Pharmacol Ther 111:384-99. 2006
    ..In this review, we will highlight some of the important vascular changes leading to diabetic cardiomyopathy and discuss the emerging potential therapeutic interventions...
  30. ncbi request reprint Therapeutic targeting of endothelial dysfunction in chronic diabetic complications
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Canada
    Recent Pat Cardiovasc Drug Discov 1:167-75. 2006
    ..We present the hypothesis that preservation and restoration of the endothelial cell function may potentially be the most efficient means of targeting the adverse effects of hyperglycemia...
  31. ncbi request reprint Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy
    Shali Chen
    Department of Pathology, University of Western Ontario, Ontario, Canada
    Diabetes Metab Res Rev 23:356-67. 2007
    ....
  32. ncbi request reprint Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications
    Shali Chen
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Am J Physiol Endocrinol Metab 284:E1089-97. 2003
    ..These data indicate that, although ETs are important in increased FN production due to diabetes, the mechanisms with respect to transcription factor activation may vary depending on the microenvironment of the organ...
  33. ncbi request reprint Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line
    Chandan Chakraborty
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Canada N6A 5C1
    Mol Cell Endocrinol 201:63-73. 2003
    ..Thus, ET-1 may represent an autocrine/paracrine mediator of invasive trophoblast function...
  34. ncbi request reprint Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells
    Patrick P W Luke
    Department of Surgery, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Transplantation 76:400-9. 2003
    ....
  35. ncbi request reprint Heme oxygenase in diabetes-induced oxidative stress in the heart
    Hana Farhangkhoee
    Department of Pathology, Dental Sciences Building, University of Western Ontario, London, Ont, Canada N6A 5C1
    J Mol Cell Cardiol 35:1439-48. 2003
    ..These results provide evidence of pro-oxidant activity of HO in the heart in diabetes, which could be mediated by increased redox-active iron...
  36. ncbi request reprint The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina
    Mark Cukiernik
    University of Western Ontario, Department of Pathology, Canada
    Diabetes Metab Res Rev 20:61-71. 2004
    ..Our investigation attempts to determine the role of NHE-1 in the pathogenesis of early retinal microangiopathy due to diabetes...
  37. ncbi request reprint Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
    Diabetes 53:775-83. 2004
    ..Thus, the results suggest that functional activation of H-Ras might be one of the signaling steps involved in glucose-induced capillary cell apoptosis and supports the role of H-Ras in the development of retinopathy in diabetes...
  38. ncbi request reprint Heme-oxygenase-mediated iron accumulation in the liver
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Canada
    Can J Physiol Pharmacol 82:448-56. 2004
    ..Our data provides evidence of increased HO activity as an important pro-oxidant mechanism leading to iron accumulation in the liver...
  39. ncbi request reprint Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis
    Xiping Xin
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Lab Invest 84:1451-9. 2004
    ..These results suggested that glucose-induced, ET- and PKC-dependent, upregulation of FN is, in part, mediated via MAPK/ERK activation...
  40. ncbi request reprint Glucose-induced serum- and glucocorticoid-regulated kinase activation in oncofetal fibronectin expression
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ont, Canada
    Biochem Biophys Res Commun 329:275-80. 2005
    ..These findings provide first evidence of glucose-induced SGK-1 activation in altered EDB(+) FN expression and provide novel avenues for therapeutic modalities...
  41. ncbi request reprint 2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells
    Gen Fukuda
    Third Department of Internal Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Biol Pharm Bull 28:797-801. 2005
    ....
  42. ncbi request reprint Heme oxygenase modulates small intestine leukocyte adhesion following hindlimb ischemia/reperfusion by regulating the expression of intercellular adhesion molecule-1
    Jeffrey R Scott
    Medical Biophysics, University of Western Ontario, London, ON, USA
    Crit Care Med 33:2563-70. 2005
    ....
  43. ncbi request reprint EDB fibronectin and angiogenesis -- a novel mechanistic pathway
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Angiogenesis 8:183-96. 2005
    ..In conclusion, these results indicate that EDB(+) FN is involved in endothelial cell proliferation and vascular morphogenesis, findings which may provide novel avenues for the development of anti-angiogenic therapies...
  44. ncbi request reprint Oncofetal fibronectin in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Invest Ophthalmol Vis Sci 45:287-95. 2004
    ..Two such isoforms, oncofetal fibronectin variants that are characterized by the inclusion of the oncofetal domains A and B, were the focus of the present study...
  45. ncbi request reprint Towards newer molecular targets for chronic diabetic complications
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Curr Vasc Pharmacol 4:45-57. 2006
    ..This review will discuss the current mechanistic understanding of chronic diabetic complications and will explore the potential novel therapeutic interventions...
  46. ncbi request reprint Endothelins: regulators of extracellular matrix protein production in diabetes
    Zia A Khan
    Department of Pathology, 4011 Dental Sciences Building, University of Western Ontario, London, Ontario, Canada NCA 5C1
    Exp Biol Med (Maywood) 231:1022-9. 2006
    ..These studies show that glucose-induced and ET-mediated FN and ED-B FN expressions involve complex interplays between signaling pathways and that ET may represent an ideal target for therapy in chronic diabetic complications...
  47. ncbi request reprint Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathy
    Iram Siddiqui
    Department of Pathology, University of Western Ontario, London, Canada
    Transplantation 82:406-14. 2006
    ..In the present study, we investigated ED-B FN expression in chronic allograft nephropathy and its relationship with endothelins (ET)...
  48. pmc Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complications
    Subrata Chakrabarti
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada
    Int J Exp Diabetes Res 3:217-31. 2002
    ..This review discusses the contribution of ETs in the pathogenesis and the potential role of ET antagonism in the treatment of chronic diabetic complications...