Jerome Brody

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Transcriptome alterations induced by cigarette smoke
    Jerome S Brody
    Boston University School of Medicine, Pulmonary Center R 3, Boston, MA
    Int J Cancer 131:2754-62. 2012
  2. ncbi Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
  3. ncbi Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
  4. ncbi Interaction of cigarette exposure and airway epithelial cell gene expression
    Jerome S Brody
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Physiol 73:437-56. 2011
  5. ncbi State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer
    Jerome S Brody
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Am Thorac Soc 3:535-7. 2006
  6. ncbi "What we've got here is a failure to communicate"
    Jerome S Brody
    Professor of Medicine, Director, Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Crit Care Med 168:415-6. 2003
  7. ncbi MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    Frank Schembri
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:2319-24. 2009
  8. ncbi Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5043. 2009
  9. ncbi Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
  10. ncbi Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling
    Avrum Spira
    Pulmonary Center, Boston University Medical Center, 715 Albany Street, Room 304, Boston, MA 02118, USA
    Biotechniques 36:484-7. 2004

Research Grants

  1. Airway Epithelial Gene Expression in COPD
    Jerome Brody; Fiscal Year: 2003

Collaborators

Detail Information

Publications21

  1. ncbi Transcriptome alterations induced by cigarette smoke
    Jerome S Brody
    Boston University School of Medicine, Pulmonary Center R 3, Boston, MA
    Int J Cancer 131:2754-62. 2012
    ....
  2. ncbi Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
    ..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
  3. ncbi Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
    ..In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers...
  4. ncbi Interaction of cigarette exposure and airway epithelial cell gene expression
    Jerome S Brody
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Physiol 73:437-56. 2011
    ....
  5. ncbi State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer
    Jerome S Brody
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Am Thorac Soc 3:535-7. 2006
    ....
  6. ncbi "What we've got here is a failure to communicate"
    Jerome S Brody
    Professor of Medicine, Director, Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Crit Care Med 168:415-6. 2003
  7. ncbi MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    Frank Schembri
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:2319-24. 2009
    ..These data indicate that mir-218 levels modulate the airway epithelial gene expression response to cigarette smoke and support a role for miRNAs in regulating host response to environmental toxins...
  8. ncbi Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5043. 2009
    ....
  9. ncbi Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
    ..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
  10. ncbi Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling
    Avrum Spira
    Pulmonary Center, Boston University Medical Center, 715 Albany Street, Room 304, Boston, MA 02118, USA
    Biotechniques 36:484-7. 2004
  11. ncbi SIEGE: Smoking Induced Epithelial Gene Expression Database
    Vishal Shah
    Bioinformatics Program, College of Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Nucleic Acids Res 33:D573-9. 2005
    ..Query results are embedded with graphical capabilities as well as with links to other databases containing valuable gene resources, including Entrez Gene, GO, Biocarta, GeneCards, dbSNP and the NCBI Map Viewer...
  12. ncbi Gene expression profiling of human lung tissue from smokers with severe emphysema
    Avrum Spira
    The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 31:601-10. 2004
    ....
  13. ncbi Effects of cigarette smoke on the human airway epithelial cell transcriptome
    Avrum Spira
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, MA 02118, USA
    Proc Natl Acad Sci U S A 101:10143-8. 2004
    ....
  14. ncbi Impact of cigarette smoke on the normal airway transcriptome
    Avrum Spira
    Pulmonary Center, Boston University School of Medicine, Boston, University, Boston, MA 02118-2526, USA
    Chest 125:115S. 2004
  15. ncbi The field of tissue injury in the lung and airway
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Prev Res (Phila) 1:396-403. 2008
    ....
  16. ncbi Airway PI3K pathway activation is an early and reversible event in lung cancer development
    Adam M Gustafson
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Sci Transl Med 2:26ra25. 2010
    ..Our work further suggests that additional lung cancer chemoprevention trials either targeting the PI3K pathway or measuring airway PI3K activation as an intermediate endpoint are warranted...
  17. ncbi Gene expression in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Cell Mol Biol 29:157-62. 2003
    ..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers...
  18. ncbi The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
    ..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage...
  19. ncbi Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressor
    Charles A Powell
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Chest 121:6S-7S. 2002
  20. ncbi Microsensor arrays for saliva diagnostics
    David R Walt
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
    Ann N Y Acad Sci 1098:389-400. 2007
    ..These results are reported in the second part of this article...
  21. ncbi Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
    Lung Cancer 39:23-9. 2003
    ..Our results suggest that the early steps of lung carcinogenesis differ in nonsmokers compared with smokers. In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers...

Research Grants2

  1. Airway Epithelial Gene Expression in COPD
    Jerome Brody; Fiscal Year: 2003
    ..We believe that these studies will lead to "class prediction" models that can subsequently be tested using custom-designed (rather than discovery arrays) in larger populations of smokers with and without COPD. ..