Affiliation: Boston University
- Transcriptome alterations induced by cigarette smokeJerome S Brody
Boston University School of Medicine, Pulmonary Center R 3, Boston, MA 02118, USA
Int J Cancer 131:2754-62. 2012....
- Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expressionJennifer Beane
Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
Genome Biol 8:R201. 2007..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
- Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epitheliumSriram Sridhar
Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
BMC Genomics 9:259. 2008..In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers...
- Interaction of cigarette exposure and airway epithelial cell gene expressionJerome S Brody
Pulmonary Center, Boston University School of Medicine, Massachusetts 02218, USA
Annu Rev Physiol 73:437-56. 2011....
- State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancerJerome S Brody
Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Proc Am Thorac Soc 3:535-7. 2006....
- "What we've got here is a failure to communicate"Jerome S Brody
Professor of Medicine, Director, Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Am J Respir Crit Care Med 168:415-6. 2003
- MicroRNAs as modulators of smoking-induced gene expression changes in human airway epitheliumFrank Schembri
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 106:2319-24. 2009..These data indicate that mir-218 levels modulate the airway epithelial gene expression response to cigarette smoke and support a role for miRNAs in regulating host response to environmental toxins...
- Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokersKatrina Steiling
The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 4:e5043. 2009....
- Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancerAvrum Spira
The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Med 13:361-6. 2007..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
- Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profilingAvrum Spira
Pulmonary Center, Boston University Medical Center, 715 Albany Street, Room 304, Boston, MA 02118, USA
Biotechniques 36:484-7. 2004
- SIEGE: Smoking Induced Epithelial Gene Expression DatabaseVishal Shah
Bioinformatics Program, College of Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Nucleic Acids Res 33:D573-9. 2005..Query results are embedded with graphical capabilities as well as with links to other databases containing valuable gene resources, including Entrez Gene, GO, Biocarta, GeneCards, dbSNP and the NCBI Map Viewer...
- Gene expression profiling of human lung tissue from smokers with severe emphysemaAvrum Spira
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
Am J Respir Cell Mol Biol 31:601-10. 2004....
- Effects of cigarette smoke on the human airway epithelial cell transcriptomeAvrum Spira
Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, MA 02118, USA
Proc Natl Acad Sci U S A 101:10143-8. 2004....
- Impact of cigarette smoke on the normal airway transcriptomeAvrum Spira
Pulmonary Center, Boston University School of Medicine, Boston, University, Boston, MA 02118 2526, USA
Chest 125:115S. 2004
- The field of tissue injury in the lung and airwayKatrina Steiling
The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
Cancer Prev Res (Phila) 1:396-403. 2008....
- Airway PI3K pathway activation is an early and reversible event in lung cancer developmentAdam M Gustafson
Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
Sci Transl Med 2:26ra25. 2010..Our work further suggests that additional lung cancer chemoprevention trials either targeting the PI3K pathway or measuring airway PI3K activation as an intermediate endpoint are warranted...
- Gene expression in lung adenocarcinomas of smokers and nonsmokersCharles A Powell
Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
Am J Respir Cell Mol Biol 29:157-62. 2003..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers...
- The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressorHan Kim
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
Am J Respir Cell Mol Biol 29:694-701. 2003..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage...
- Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressorCharles A Powell
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Chest 121:6S-7S. 2002
- Microsensor arrays for saliva diagnosticsDavid R Walt
Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA
Ann N Y Acad Sci 1098:389-400. 2007..These results are reported in the second part of this article...
- Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokersCharles A Powell
Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
Lung Cancer 39:23-9. 2003..Our results suggest that the early steps of lung carcinogenesis differ in nonsmokers compared with smokers. In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers...
- Airway Epithelial Gene Expression in COPDJerome Brody; Fiscal Year: 2003..We believe that these studies will lead to "class prediction" models that can subsequently be tested using custom-designed (rather than discovery arrays) in larger populations of smokers with and without COPD. ..