Vladimir Botchkarev

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint p53 is essential for chemotherapy-induced hair loss
    V A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    Cancer Res 60:5002-6. 2000
  2. ncbi request reprint Neurotrophins in skin biology and pathology
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 126:1719-27. 2006
  3. ncbi request reprint Edar signaling in the control of hair follicle development
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Investig Dermatol Symp Proc 10:247-51. 2005
  4. ncbi request reprint BMP signaling in the control of skin development and hair follicle growth
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, 609 Albany Steeet, Boston, MA 02118, USA
    Differentiation 72:512-26. 2004
  5. ncbi request reprint Neurotrophins and their role in pathogenesis of alopecia areata
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02112, USA
    J Investig Dermatol Symp Proc 8:195-8. 2003
  6. ncbi request reprint Molecular biology of hair morphogenesis: development and cycling
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Exp Zool B Mol Dev Evol 298:164-80. 2003
  7. ncbi request reprint Molecular mechanisms of chemotherapy-induced hair loss
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    J Investig Dermatol Symp Proc 8:72-5. 2003
  8. ncbi request reprint Molecular control of epithelial-mesenchymal interactions during hair follicle cycling
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Investig Dermatol Symp Proc 8:46-55. 2003
  9. pmc Stress and the hair follicle: exploring the connections
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Pathol 162:709-12. 2003
  10. ncbi request reprint Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 118:3-10. 2002

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint p53 is essential for chemotherapy-induced hair loss
    V A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    Cancer Res 60:5002-6. 2000
    ..These observations indicate that local pharmacological inhibition of p53 may be useful to prevent chemotherapy-associated hair loss...
  2. ncbi request reprint Neurotrophins in skin biology and pathology
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 126:1719-27. 2006
    ....
  3. ncbi request reprint Edar signaling in the control of hair follicle development
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Investig Dermatol Symp Proc 10:247-51. 2005
    ..We also review data on the cross-talk between Edar and Wnt, transforming growth factor-beta/bone morphogenic protein/activin, and Shh signaling pathways in the control of HF development and cycling...
  4. ncbi request reprint BMP signaling in the control of skin development and hair follicle growth
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, 609 Albany Steeet, Boston, MA 02118, USA
    Differentiation 72:512-26. 2004
    ..Progress in this area of research will hopefully lead to the development of new therapeutic approaches for using BMPs and BMP antagonists in the treatment of skin and hair growth disorders...
  5. ncbi request reprint Neurotrophins and their role in pathogenesis of alopecia areata
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02112, USA
    J Investig Dermatol Symp Proc 8:195-8. 2003
    ..Progress in this area of research will hopefully lead to the development of multiple applications for neurotrophins and their agonists/antagonists in alopecia areata and other hair growth disorders...
  6. ncbi request reprint Molecular biology of hair morphogenesis: development and cycling
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Exp Zool B Mol Dev Evol 298:164-80. 2003
    ....
  7. ncbi request reprint Molecular mechanisms of chemotherapy-induced hair loss
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    J Investig Dermatol Symp Proc 8:72-5. 2003
    ..Sufficient pharmacological inhibition of chemotherapy-induced hair loss may require a combination of inhibitors to block complementary or redundant pathways of apoptosis in hair follicles...
  8. ncbi request reprint Molecular control of epithelial-mesenchymal interactions during hair follicle cycling
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    J Investig Dermatol Symp Proc 8:46-55. 2003
    ..Further progress in this area of research will hopefully lead to the development of new drugs for the treatment of hair growth disorders...
  9. pmc Stress and the hair follicle: exploring the connections
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Pathol 162:709-12. 2003
  10. ncbi request reprint Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 118:3-10. 2002
    ..This suggests that regulation of BMP2/4 signaling by noggin is essential for the induction of secondary hair follicles, as well as for advanced stages of development in primary hair follicles...
  11. pmc p53 Involvement in the control of murine hair follicle regression
    V A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Pathol 158:1913-9. 2001
    ....
  12. ncbi request reprint Noggin is required for induction of the hair follicle growth phase in postnatal skin
    V A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    FASEB J 15:2205-14. 2001
    ..This suggests that modulation of BMP4 signaling by noggin is essential for hair growth phase induction in postnatal skin and that the hair growth-inducing effect of noggin is mediated, at least in part, by Shh...
  13. ncbi request reprint Bone morphogenetic proteins and their antagonists in skin and hair follicle biology
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    J Invest Dermatol 120:36-47. 2003
    ..Therefore, BMPs represent new important players in the molecular network regulating homeostasis in normal and diseased skin. Pharmacologic modulation of BMP signaling may be used as a new approach for managing skin and hair disorders...
  14. pmc Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
    Anna Lyubimova
    Gastrointestinal Unit and Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 120:446-56. 2010
    ..We therefore propose that N-WASP acts as a positive regulator of beta-catenin-dependent transcription, modulating differentiation of HF progenitor cells...
  15. pmc Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation
    Andrei A Sharov
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    EMBO J 22:2992-3003. 2003
    ..These data suggest that the BMP signaling pathway plays an important role in regulation of genetic programs of eyelid opening and skin remodeling during the final steps of eye morphogenesis...
  16. ncbi request reprint Epithelial growth control by neurotrophins: leads and lessons from the hair follicle
    Vladimir A Botchkarev
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Prog Brain Res 146:493-513. 2004
    ....
  17. ncbi request reprint Modulations of nerve growth factor and Bcl-2 in ultraviolet-irradiated human epidermis
    Catherine M Stefanato
    Section of Dermatopathology, Boston University School of Medicine, Boston, MA, USA
    J Cutan Pathol 30:351-7. 2003
    ..The purpose of this study was to determine NGF and Bcl-2 modulations in UV-irradiated human skin...
  18. ncbi request reprint Fate of melanocytes during development of the hair follicle pigmentary unit
    Natalia V Botchkareva
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    J Investig Dermatol Symp Proc 8:76-9. 2003
    ....
  19. pmc Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway
    Andrey A Sharov
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:93-8. 2005
    ....
  20. pmc Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes
    Andrey A Sharov
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 103:18166-71. 2006
    ..These data suggest that BMP signaling plays an important role in regulating cell proliferation and controls the size of anagen HFs by modulating the expression of cell-cycle-associated genes in hair matrix KC...
  21. ncbi request reprint Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss
    Andrei A Sharov
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 120:27-35. 2003
    ..Pharmacologic manipulation of Fas and c-kit signaling pathways might be useful for the correction of skin hyperpigmentation as a side-effect of chemotherapy...
  22. ncbi request reprint Fas signaling is involved in the control of hair follicle response to chemotherapy
    Andrei A Sharov
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cancer Res 64:6266-70. 2004
    ..These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy...
  23. pmc Involvement of the Edar signaling in the control of hair follicle involution (catagen)
    Michael Y Fessing
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Am J Pathol 169:2075-84. 2006
    ..Thus, our data demonstrate that in addition to its well-established role in HF morphogenesis, Edar signaling is also involved in hair cycle control and regulates apoptosis in HF keratinocytes during catagen...
  24. ncbi request reprint Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata)
    Frank Siebenhaar
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 127:1489-97. 2007
    ..These data suggest that SP, NEP, and NK-1R serve as important regulators in the molecular signaling network modulating inflammatory response in autoimmune hair loss...
  25. ncbi request reprint Neurotrophins in autoimmune diseases: possible implications for alopecia areata
    T N Palkina
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Investig Dermatol Symp Proc 10:282. 2005
  26. ncbi request reprint Changes in different melanocyte populations during hair follicle involution (catagen)
    Andreya Sharov
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Invest Dermatol 125:1259-67. 2005
    ....
  27. ncbi request reprint Oligonucleotide treatment increases eumelanogenesis, hair pigmentation and melanocortin-1 receptor expression in the hair follicle
    Ruzanna Y Atoyan
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    Exp Dermatol 16:671-7. 2007
    ..These data demonstrate that pTT treatment increases eumelanogenesis in HFs, associated with increased tyrosinase, TRP-1 and MC-1R expression. These data also raise the possibility of using T-oligos to modulate hair pigmentation...
  28. ncbi request reprint Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
    Cristina Mammucari
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Dev Cell 8:665-76. 2005
    ..Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control...
  29. ncbi request reprint Neurotrophin-3 regulates mast cell functions in neonatal mouse skin
    Martin Metz
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    Exp Dermatol 13:273-81. 2004
    ..Our data suggest a role for NT-3 in the maturation of MCs, such as a TrkC-mediated stimulation of the differentiation of pre-existing, less mature MCs and/or by enhancing the migration of circulating MC precursors into the skin...
  30. pmc The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling
    Desmond J Tobin
    Department of Biomedical Sciences, University of Bradford, Bradford, England
    Am J Pathol 160:1807-21. 2002
    ..Principal target tissues that may contain protein substrate(s) for this cysteine protease include the developing hair cone, inner root sheath, anchoring apparatus of the telogen club, and organelles of lysosomal origin (eg, melanosomes)...
  31. ncbi request reprint Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52. 2002
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  32. ncbi request reprint p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen)
    Vladimir A Botchkarev
    J Invest Dermatol 120:168-9. 2003
  33. ncbi request reprint Kit is expressed by epithelial cells in vivo
    Eva M J Peters
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 121:976-84. 2003
    ..The expression of Kit in the most rapidly proliferating compartment of the hair follicle epithelium suggests intriguing, as yet unexplored new functions of Kit signaling in epithelial cell biology...

Research Grants11

  1. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..abstract_text> ..
  2. FUNCTIONS OF NOGGIN AND SMAD1/5 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2007
    ..Successful realization of this project will help in further understanding the pathobiology of different hair-loss conditions and may provide new strategies for their therapy using BMP agonists or antagonists. ..
  3. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    ....
  4. MOLECULAR MECHANISMS OF CHEMOTHERAPY-INDUCED HAIR LOSS
    Vladimir Botchkarev; Fiscal Year: 2005
    ..Patients with many forms of p53-negative cancers treated by chemotherapy may ultimately benefit from this study. ..
  5. Bone Morphogentic Protein signaling in the control of skin development, hair grow
    Vladimir A Botchkarev; Fiscal Year: 2010
    ..This work will provide new insights into stem cell biology and will help in establishing new therapeutic approaches for modulating the activity of stem cells during skin regeneration and carcinogenesis. ..