Jose M Borreguero

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Thermodynamics and folding kinetics analysis of the SH3 domain form discrete molecular dynamics
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    J Mol Biol 318:863-76. 2002
  2. pmc Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:6015-20. 2005
  3. pmc Multiple folding pathways of the SH3 domain
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts, USA
    Biophys J 87:521-33. 2004
  4. ncbi request reprint Ab initio discrete molecular dynamics approach to protein folding and aggregation
    Brigita Urbanc
    Department of Physics, Center for Polymer Studies, Boston University, Massachusetts 02215, USA
    Methods Enzymol 412:314-38. 2006
  5. pmc Solvent and mutation effects on the nucleation of amyloid beta-protein folding
    Luis Cruz
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:18258-63. 2005
  6. ncbi request reprint Mechanism for the alpha-helix to beta-hairpin transition
    Feng Ding
    Center for Polymer Studies, Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Proteins 53:220-8. 2003
  7. ncbi request reprint Possible mechanism for cold denaturation of proteins at high pressure
    Manuel I Marqués
    Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev Lett 91:138103. 2003
  8. ncbi request reprint Identifying importance of amino acids for protein folding from crystal structures
    Nikolay V Dokholyan
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Methods Enzymol 374:616-38. 2003
  9. ncbi request reprint Benchmarking of TASSER in the ab initio limit
    Jose M Borreguero
    Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA
    Proteins 68:48-56. 2007

Detail Information

Publications9

  1. ncbi request reprint Thermodynamics and folding kinetics analysis of the SH3 domain form discrete molecular dynamics
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    J Mol Biol 318:863-76. 2002
    ..We predict that a set of amino acid contacts between the RT-loop and the distal hairpin are the critical folding nucleus of the SH3 fold and propose a hypothesis that explains this result...
  2. pmc Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:6015-20. 2005
    ..Substitutions may alter the frequency of Glu-22 or Asp-23 involvement in contact formation and affect the stability of the folding nucleus formed in the Abeta(21-30) region...
  3. pmc Multiple folding pathways of the SH3 domain
    Jose M Borreguero
    Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts, USA
    Biophys J 87:521-33. 2004
    ....
  4. ncbi request reprint Ab initio discrete molecular dynamics approach to protein folding and aggregation
    Brigita Urbanc
    Department of Physics, Center for Polymer Studies, Boston University, Massachusetts 02215, USA
    Methods Enzymol 412:314-38. 2006
    ..The in silico findings also provide further insights into the structure and dynamics of Abeta folding and oligomer formation that are amenable to in vitro testing...
  5. pmc Solvent and mutation effects on the nucleation of amyloid beta-protein folding
    Luis Cruz
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:18258-63. 2005
    ....
  6. ncbi request reprint Mechanism for the alpha-helix to beta-hairpin transition
    Feng Ding
    Center for Polymer Studies, Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Proteins 53:220-8. 2003
    ..For a certain range of side-chain interaction strengths, we find that the intermediate beta-hairpin state is destabilized and even disappears, suggesting an important role of the environment in the aggregation propensity of a peptide...
  7. ncbi request reprint Possible mechanism for cold denaturation of proteins at high pressure
    Manuel I Marqués
    Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev Lett 91:138103. 2003
    ..We find our results in agreement with data of bovine pancreatic ribonuclease A...
  8. ncbi request reprint Identifying importance of amino acids for protein folding from crystal structures
    Nikolay V Dokholyan
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Methods Enzymol 374:616-38. 2003
  9. ncbi request reprint Benchmarking of TASSER in the ab initio limit
    Jose M Borreguero
    Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA
    Proteins 68:48-56. 2007
    ..Thus, it is the effective configurational entropy of the protein that dictates the average likelihood of correctly arranging the secondary structure elements...