Emiliano Biasini

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint The hydrophobic core region governs mutant prion protein aggregation and intracellular retention
    Emiliano Biasini
    Dulbecco Telethon Institute, Milan, Italy
    Biochem J 430:477-86. 2010
  2. pmc A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 33:2408-18. 2013
  3. pmc The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33472. 2012
  4. pmc Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway
    Tania Massignan
    Dulbecco Telethon Institute DTI c o Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Mol Cell Proteomics 9:611-22. 2010
  5. pmc The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc)
    Jessie A Turnbaugh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 32:8817-30. 2012
  6. pmc An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
    Brian R Fluharty
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:7857-66. 2013
  7. pmc An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity
    Isaac H Solomon
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:14724-36. 2011
  8. ncbi request reprint Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse
    Tania Massignan
    Dulbecco Telethon Institute, Milan, Italy
    Biochem Biophys Res Commun 353:719-25. 2007
  9. pmc Immunopurification of pathological prion protein aggregates
    Emiliano Biasini
    Dulbecco Telethon Institute, Milan, Italy
    PLoS ONE 4:e7816. 2009
  10. pmc Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities
    Roberto Chiesa
    Department of Neuroscience, Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Neurosci 28:13258-67. 2008

Collaborators

Detail Information

Publications16

  1. doi request reprint The hydrophobic core region governs mutant prion protein aggregation and intracellular retention
    Emiliano Biasini
    Dulbecco Telethon Institute, Milan, Italy
    Biochem J 430:477-86. 2010
    ..The discovery that Delta114-121 counteracts misfolding and improves the cellular trafficking of mutant PrP provides an unprecedented model for assessing the role of intracellular aggregation in the pathogenesis of prion diseases...
  2. pmc A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 33:2408-18. 2013
    ..A similar mechanism may operate in other neurodegenerative disorders attributable to toxic, β-rich oligomers that bind to PrP(C)...
  3. pmc The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33472. 2012
    ..These results provide important insights into how ΔCR PrP subverts a normal physiological function of PrP(C), and the cellular mechanisms underlying the rescuing process...
  4. pmc Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway
    Tania Massignan
    Dulbecco Telethon Institute DTI c o Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Mol Cell Proteomics 9:611-22. 2010
    ..Our data are consistent with a model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway...
  5. pmc The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc)
    Jessie A Turnbaugh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 32:8817-30. 2012
    ..It may be possible to specifically target this region for treatment of prion diseases as well as other neurodegenerative disorders due to β-sheet-rich oligomers that bind to PrP(C)...
  6. pmc An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
    Brian R Fluharty
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:7857-66. 2013
    ..These data suggest that N1, or small peptides derived from it, could be potent inhibitors of Aβ oligomer toxicity and represent an entirely new class of therapeutic agents for AD...
  7. pmc An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity
    Isaac H Solomon
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:14724-36. 2011
    ..The sequence domains identified in our study are also critical for PrP(Sc) formation, suggesting that common structural features may govern both the functional activity of PrP(C) and its conversion to PrP(Sc)...
  8. ncbi request reprint Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse
    Tania Massignan
    Dulbecco Telethon Institute, Milan, Italy
    Biochem Biophys Res Commun 353:719-25. 2007
    ..Moreover, we found a variation in the isoform pattern of cyclophilin A, a molecular chaperone that protects cells from the oxidative stress...
  9. pmc Immunopurification of pathological prion protein aggregates
    Emiliano Biasini
    Dulbecco Telethon Institute, Milan, Italy
    PLoS ONE 4:e7816. 2009
    ..However, protease treatment cannot be used to isolate abnormal forms of PrP lacking conventional protease resistance, such as those found in several genetic and atypical sporadic cases...
  10. pmc Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities
    Roberto Chiesa
    Department of Neuroscience, Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Neurosci 28:13258-67. 2008
    ....
  11. pmc The N-terminal, polybasic region is critical for prion protein neuroprotective activity
    Jessie A Turnbaugh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25675. 2011
    ..Small molecule ligands targeting this region may also represent useful therapeutic agents for treatment of prion diseases...
  12. ncbi request reprint Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity
    Emiliano Biasini
    Prion Unit, Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, Milano, Italy
    Proteomics 6:2823-34. 2006
    ....
  13. pmc Prion protein at the crossroads of physiology and disease
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Neurosci 35:92-103. 2012
    ..These data suggest surprising new connections between the physiological function of PrP(C) and its role in neurodegenerative diseases beyond those caused by prions...
  14. pmc Ion channels induced by the prion protein: mediators of neurotoxicity
    Isaac H Solomon
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Prion 6:40-5. 2012
    ..Therapeutic regimens designed to inhibit prion-induced toxicity, as well as formation of PrP(Sc) , may prove to be the most clinically beneficial...
  15. pmc A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide
    Tania Massignan
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Methods 53:214-9. 2011
    ..This assay provides a unique tool for studying PrP cytotoxic and cytoprotective activities in cell culture...
  16. ncbi request reprint Redox regulation of cyclophilin A by glutathionylation
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Proteomics 6:817-25. 2006
    ..Finally, we suggest that glutathionylation of CypA may have biological implications and that CypA may play a key role in redox regulation of immunity...