Shalender Bhasin

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. doi Diagnosis and treatment of hypogonadism in men
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston, MA 02118, United States
    Best Pract Res Clin Endocrinol Metab 25:251-70. 2011
  2. ncbi Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:1049-57. 2007
  3. doi Anabolic applications of androgens for functional limitations associated with aging and chronic illness
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    Front Horm Res 37:163-82. 2009
  4. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
  5. pmc Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point
    Eric Bachman
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston Medical Center, Massachusetts
    J Gerontol A Biol Sci Med Sci 69:725-35. 2014
  6. pmc Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells
    Wen Guo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Claude D Pepper Older Americans Independence Center, Boston Medical Center, Boston, MA 02118, USA
    Aging Cell 12:280-91. 2013
  7. doi The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:87-95. 2013
  8. pmc Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation
    Thomas G Travison
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 66:1090-9. 2011
  9. pmc Adverse events associated with testosterone administration
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    N Engl J Med 363:109-22. 2010
  10. pmc The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men
    Kishore M Lakshman
    Division of Endocrinology, Diabetes and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:3955-64. 2010

Detail Information

Publications105 found, 100 shown here

  1. doi Diagnosis and treatment of hypogonadism in men
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston, MA 02118, United States
    Best Pract Res Clin Endocrinol Metab 25:251-70. 2011
    ....
  2. ncbi Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:1049-57. 2007
    ..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown...
  3. doi Anabolic applications of androgens for functional limitations associated with aging and chronic illness
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    Front Horm Res 37:163-82. 2009
    ..Concerns about the potential adverse effects of testosterone on the prostate have encouraged the development of selective androgen receptor modulators that increase muscle mass while sparing the prostate...
  4. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
    ....
  5. pmc Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point
    Eric Bachman
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston Medical Center, Massachusetts
    J Gerontol A Biol Sci Med Sci 69:725-35. 2014
    ..The mechanisms by which testosterone increases hemoglobin and hematocrit remain unclear...
  6. pmc Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells
    Wen Guo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Claude D Pepper Older Americans Independence Center, Boston Medical Center, Boston, MA 02118, USA
    Aging Cell 12:280-91. 2013
    ..In conclusion, testosterone inhibits hepcidin transcription through its interaction with BMP/Smad signaling. Testosterone administration is associated with increased iron incorporation into red blood cells...
  7. doi The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:87-95. 2013
    ..Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones...
  8. pmc Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation
    Thomas G Travison
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 66:1090-9. 2011
    ..The changes in muscle performance and physical function were evaluated in relation to participant's perception of change...
  9. pmc Adverse events associated with testosterone administration
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    N Engl J Med 363:109-22. 2010
    ..Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied...
  10. pmc The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men
    Kishore M Lakshman
    Division of Endocrinology, Diabetes and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:3955-64. 2010
    ..During testosterone (T) therapy, T is partly converted to 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown...
  11. pmc Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir
    Wen Guo
    Section of Endocrinology, Boston University School of Medicine, 670 Albany Street, Second Floor, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:2028-32. 2009
    ..The purpose of this study was to test the hypothesis that inhibition of adipose lipolysis will retard atherogenic lesion development induced by the antiviral protease inhibitors...
  12. pmc AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis
    Wen Guo
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    PLoS ONE 8:e71017. 2013
    ..Cultured aortic endothelial cells responded to myostatin with a reduction in eNOS phosphorylation and an increase in ICAM-1 and VCAM-1 expression...
  13. pmc Circulating estrone levels are associated prospectively with diabetes risk in men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Boston, Massachusetts, USA
    Diabetes Care 36:2591-6. 2013
    ..We determined the relationship between circulating estradiol and estrone levels and diabetes risk in community-dwelling men of the Framingham Heart Study (FHS)...
  14. doi Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, School of Medicine, Boston University, Boston, MA, USA
    Clin Endocrinol (Oxf) 78:629-34. 2013
    ..The impact of longitudinal trajectory patterns from serial sex steroid and gonadotrophin measurements on the observed associations is unknown to date...
  15. ncbi Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:2536-59. 2010
    ..Our objective was to update the guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006...
  16. pmc Effect of testosterone administration on liver fat in older men with mobility limitation: results from a randomized controlled trial
    Grace Huang
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA02118, USA
    J Gerontol A Biol Sci Med Sci 68:954-9. 2013
    ....
  17. doi Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial
    Matthew Spitzer
    Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    Ann Intern Med 157:681-91. 2012
    ..Erectile dysfunction and low testosterone levels frequently occur together...
  18. pmc Risk factors associated with cardiovascular events during testosterone administration in older men with mobility limitation
    Shehzad Basaria
    Department of Internal Medicine, Boston University School of Medicine, 670 Albany Street, Suite 205, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:153-60. 2013
    ..We evaluated changes in gonadal hormones and markers of inflammation and coagulation to elucidate risk factors associated with cardiovascular events...
  19. doi Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany St, Boston, MA 02118, USA
    JAMA 307:931-9. 2012
    ....
  20. pmc Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes
    Vandana Gupta
    Department of Medicine, Boston University, School of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Mol Cell Endocrinol 296:32-40. 2008
    ..DHT stimulated forskolin-stimulated lipolysis in subcutaneous and mesenteric preadipocytes and inhibited incorporation of fatty acid into triglyceride in adipocytes differentiated from preadipocytes from all fat depots...
  21. pmc Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
    Shalender Bhasin
    Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Endocrinol Metab 2:146-59. 2006
    ....
  22. pmc Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study
    Joanne B Krasnoff
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, 670 Albany Street, Second Floor, Boston, Massachusetts 02118 2393, USA
    J Clin Endocrinol Metab 95:2790-9. 2010
    ..Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood...
  23. pmc Testosterone improves the regeneration of old and young mouse skeletal muscle
    Carlo Serra
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:17-26. 2013
    ..These data suggest prospective application of androgens to improve the regenerating potential of the aged human skeletal muscle...
  24. pmc Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods
    Nathan K Lebrasseur
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, United States
    Contemp Clin Trials 30:133-40. 2009
    ..Clinicaltrials.gov identifier: NCT00240981...
  25. pmc Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men
    Thomas W Storer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:1991-9. 2008
    ..To examine the effect of graded doses of testosterone on physical function and muscle performance in healthy, older men...
  26. pmc Habitual physical activity levels are associated with performance in measures of physical function and mobility in older men
    Marina Morie
    Laboratory of Exercise Physiology and Physical Performance, Section of Endocrinology, Diabetes, and Nutrition, School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 58:1727-33. 2010
    ..To determine whether objectively measured physical activity levels are associated with physical function and mobility in older men...
  27. ncbi Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial
    Grace Huang
    From the 1Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 2Department of Biostatistics, Boston University School of Public Health, Boston, MA 3Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA and 4Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, University of California, Los Angeles, CA
    Menopause 21:612-23. 2014
    ..This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy...
  28. pmc Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice
    Wen Guo
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e51180. 2012
    ..Concurrently, mice receiving T/PT also displayed increased expression of markers for reduced tissue oxidative damage and improved muscle quality...
  29. pmc Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA
    Diabetes Care 34:2464-70. 2011
    ..We determined whether testosterone or sex hormone-binding globulin (SHBG) is independently associated with the risk of metabolic syndrome...
  30. pmc Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis
    Eric Bachman
    Department of Medicine, Boston University School of Medicine, 670 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:4743-7. 2010
    ..The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown...
  31. doi Novel strategies for improving physical function
    Shalender Bhasin
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Horm Res Paediatr 76:17-23. 2011
    ..However, clinical development has been slowed by vexing trial design issues...
  32. pmc Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4776-84. 2009
    ..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown...
  33. doi The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders
    Shalender Bhasin
    Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, MA 02118, United States
    Steroids 73:1311-7. 2008
    ..These steps will facilitate the development of rational criteria for the diagnosis of androgen disorders in men, women, and children...
  34. pmc Selective androgen receptor modulators as function promoting therapies
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 12:232-40. 2009
    ..This review describes the historical evolution, the rationale for SARM development, and the mechanisms of testosterone action and SARM selectivity...
  35. pmc The role of GH and IGF-I in mediating anabolic effects of testosterone on androgen-responsive muscle
    Carlo Serra
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Boston, Massachusetts 02118, USA
    Endocrinology 152:193-206. 2011
    ..However, IGF-IR signaling in skeletal muscle fibers does not appear to be obligatory for mediating the anabolic effects of T on the mass of androgen-responsive skeletal muscles in mice...
  36. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  37. ncbi Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss
    Monty Montano
    Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:2793-802. 2007
    ..Although androgen treatment increases muscle mass, the cell-intrinsic mechanisms engaged remain poorly understood...
  38. doi Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss
    Philip E Knapp
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 294:E1135-43. 2008
    ..Improvements in mood, fatigue, and quality-of-life measures in the testosterone group, although clinically important, need further confirmation...
  39. pmc Testosterone dose-response relationships with cardiovascular risk markers in androgen-deficient women: a randomized, placebo-controlled trial
    Grace Huang
    Section of Men s Health Aging and Metabolism G H, M D, H S, T G T, S BH, S Ba, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 and Department of Radiology E T, A A, S A, H J, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118
    J Clin Endocrinol Metab 99:E1287-93. 2014
    ..Conclusion: Short-term T administration over a wide range of doses for 24 weeks in women with low T levels was not associated with worsening of cardiovascular risk markers. ..
  40. pmc Tests of muscle strength and physical function: reliability and discrimination of performance in younger and older men and older men with mobility limitations
    Nathan K Lebrasseur
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:2118-23. 2008
    ..To compare the reliability of muscle strength and physical function measures in younger and older men...
  41. pmc Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice
    Powen Tu
    Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 58:1739-48. 2009
    ..In this study, we determined whether Mstn disruption could prevent the development of insulin resistance, proatherogenic dyslipidemia, and atherogenesis...
  42. pmc Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    Shalender Bhasin
    Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 96:2430-9. 2011
    ..We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men...
  43. doi Dynamics of coregulator-induced conformational perturbations in androgen receptor ligand binding domain
    Mikhail N Zakharov
    Section of Endocrinology, Boston University School of Medicine, 670 Albany St, Boston, MA 02118, USA
    Mol Cell Endocrinol 341:1-8. 2011
    ..We posit that this coactivator-specific conformational gating may then dictate subsequent binding partners and interaction/affinity for the DNA-response elements...
  44. doi Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy
    Ravi Jasuja
    Research Program in Men s Health Aging and Metabolism, Boston Claude D Pepper Older Americans Independence Center for Function, Promoting Anabolic Therapies, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA
    Aging Cell 13:303-10. 2014
    ..Co-administration of testosterone and Odc1 inhibitor presents a novel therapeutic strategy for prostate-sparing anabolic therapy. ..
  45. doi Risks and benefits of testosterone therapy in older men
    Matthew Spitzer
    The Research Program in Men s Health Ageing and Metabolism, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Nat Rev Endocrinol 9:414-24. 2013
    ..Therefore, a general policy of testosterone replacement in all older men with age-related decline in testosterone levels is not justified...
  46. pmc Relation between sex hormone concentrations, peripheral arterial disease, and change in ankle-brachial index: findings from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:3724-32. 2011
    ..Our objective was to investigate cross-sectional and longitudinal associations of sex hormone concentrations with ankle-brachial index (ABI) and peripheral arterial disease (PAD)...
  47. pmc Effects of graded doses of testosterone on erythropoiesis in healthy young and older men
    Andrea D Coviello
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 670 Albany Street, 2nd Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:914-9. 2008
    ..Erythrocytosis is a dose-limiting adverse effect of testosterone therapy, especially in older men...
  48. doi Topical androgen antagonism promotes cutaneous wound healing without systemic androgen deprivation by blocking β-catenin nuclear translocation and cross-talk with TGF-β signaling in keratinocytes
    Gianluca Toraldo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Wound Repair Regen 20:61-73. 2012
    ..Together, these data show that blockade of β-catenin can, as a potential target for novel therapeutic interventions, accelerate cutaneous wound healing...
  49. pmc N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:4224-33. 2009
    ..We investigated P3NP as a biomarker of lean body mass (LBM) and muscle strength gains in response to testosterone and GH...
  50. pmc Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain
    Ravi Jasuja
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02199, USA
    Mol Endocrinol 23:1231-41. 2009
    ..DHT binding to AR-LBD involves biphasic receptor rearrangement including population of a molten globule-like intermediate state...
  51. ncbi Determinants of serum total and free testosterone levels in women over the age of 65 years
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Endocrinol Metab 92:509-16. 2007
    ..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age...
  52. doi Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration
    Kishore M Lakshman
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States
    Mol Cell Endocrinol 302:26-32. 2009
    ..Myostatin levels were not significantly associated with lean body mass in either young or older men...
  53. ncbi Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine S B, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:1995-2010. 2006
    ..The objective was to provide guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men...
  54. ncbi Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone
    Andrea D Coviello
    Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:4669-75. 2006
    ..We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels...
  55. pmc Durability of the effects of testosterone and growth hormone supplementation in older community-dwelling men: the HORMA Trial
    Fred R Sattler
    Department of Medicine, University of Southern CaliforniaDivision of Biokinesiology, University of Southern California, Los Angeles, CASection of Endocrinology, Diabetes, and Nutrition, Boston University, Boston, MADepartment of Preventive Medicine, University of Southern California, Los Angeles, CADepartment of Medicine, Washington University, St Louis, MOJean Mayer USDA Human Nutrition Research Center on Aging of Tufts University, Boston, MADepartment of Urology, University of Southern California, Los Angeles, CA, USA
    Clin Endocrinol (Oxf) 75:103-11. 2011
    ..To determine the durability of anabolic effects and adverse events (AEs) after stopping testosterone and growth hormone supplementation in older men...
  56. pmc Premature expression of a muscle fibrosis axis in chronic HIV infection
    Rebecca L Kusko
    Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA
    Skelet Muscle 2:10. 2012
    ..abstract:..
  57. pmc The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways
    Wen Guo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Biol Chem 283:9136-45. 2008
    ..These effects were mediated, in part, by activation of Smad3 and cross-communication of the TGFbeta/Smad signal to Wnt/beta-catenin/TCF4 pathway, leading to down-regulation of PPARgamma...
  58. pmc DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination
    Wen Guo
    Department of Internal Medicine, Boston University School of Medicine, Section of Endocrinology, Boston, MA 02118, USA
    Mitochondrion 9:261-5. 2009
    ..We conclude genomic DNA sample preparation can meaningfully influence mtDNA copy number determination by qPCR...
  59. ncbi Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    Olga M Calof
    Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 60:1451-7. 2005
    ..We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men...
  60. doi The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports
    Karen Choong
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    Asian J Androl 10:351-63. 2008
    ..In spite of effective methods for detecting androgen doping, the policies for screening of athletes are highly variable in different countries and organizations and even existing policies are not uniformly enforced...
  61. pmc A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation
    Andrea D Coviello
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002805. 2012
    ..The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance...
  62. ncbi Targeting the skeletal muscle-metabolism axis in prostate-cancer therapy
    Shehzad Basaria
    From the Department of Medicine, Division of Endocrinology and Metabolism, Boston University School of Medicine, Boston
    N Engl J Med 367:965-7. 2012
    ..How the loss of anabolic signals leads to sarcopenia and metabolic abnormalities may be informative...
  63. pmc Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA
    J Am Med Dir Assoc 12:249-56. 2011
    ..23 kg/m(2) in men and ≤ 5.67 kg/m(2) in women). Sarcopenia is a highly prevalent condition in older persons that leads to disability, hospitalization, and death...
  64. ncbi Sexual dysfunction in men and women with endocrine disorders
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, MA 02199, USA
    Lancet 369:597-611. 2007
    ..We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women...
  65. ncbi Development of models to predict anabolic response to testosterone administration in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 284:E1009-17. 2003
    ..Hence, the anabolic response of healthy, young men to exogenous testosterone administration can largely be predicted by the testosterone dose...
  66. ncbi Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:718-26. 2004
    ..Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh...
  67. ncbi Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine Science, University of California Los Angeles School of Medicine, 90059, USA
    Clin Infect Dis 37:S142-9. 2003
    ..However, the long-term risks and benefits of testosterone administration in human immunodeficiency virus-infected men with fat redistribution syndrome have not been studied in randomized clinical trials...
  68. ncbi Testosterone supplementation for aging-associated sarcopenia
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:1002-8. 2003
    ..The long-term risks and benefits of testosterone supplementation in older men are not known...
  69. ncbi Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 283:E154-64. 2002
    ..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy...
  70. ncbi A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
    ....
  71. ncbi Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 284:E120-8. 2003
    ..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men...
  72. ncbi Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss
    Karen L Herbst
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    Fertil Steril 85:1794-802. 2006
    ....
  73. ncbi Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4445-52. 2006
    ....
  74. ncbi Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study
    Carl Grunfeld
    University of California San Francisco, and Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 41:304-14. 2006
    ..To evaluate the efficacy and safety of oxandrolone in promoting body weight and body cell mass (BCM) gain in HIV-associated weight loss...
  75. ncbi Testosterone and atherosclerosis progression in men
    Shalender Bhasin
    Diabetes Care 26:1929-31. 2003
  76. ncbi Androgen effects on body composition
    Shalender Bhasin
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Growth Horm IGF Res 13:S63-71. 2003
    ....
  77. ncbi Testosterone, sex hormone-binding globulin, and frailty in older men
    Beth A Mohr
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Am Geriatr Soc 55:548-55. 2007
    ..To determine whether testosterone (T) levels are associated with frailty or its components...
  78. ncbi Pharmacokinetics of a testosterone gel in healthy postmenopausal women
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Drew University of California Los Angeles Reproductive Science Research Center, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 91:136-44. 2006
    ..The paucity of pharmacokinetic data on androgen formulations in women has hindered clinical trials of testosterone supplementation in women...
  79. ncbi Secular decline in male reproductive function: Is manliness threatened?
    Shalender Bhasin
    J Clin Endocrinol Metab 92:44-5. 2007
  80. ncbi The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 87:136-43. 2002
    ..Long-term studies are needed to determine whether T supplementation of older men with low T levels affects atherosclerosis progression...
  81. ncbi Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, UCLA Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Androl 24:299-311. 2003
  82. ncbi Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression
    Kun Ma
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E363-71. 2003
    ..We propose that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression through a glucocorticoid receptor-mediated pathway...
  83. ncbi Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men
    Peter B Gray
    Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:3838-46. 2005
    ..The relationships between testosterone dose and its effects on sexual function, mood, and visuospatial cognition are poorly understood...
  84. ncbi Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 285:E197-205. 2003
    ..We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure...
  85. ncbi Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 293:E769-75. 2007
    ..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men...
  86. ncbi Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol (1985) 103:1299-310. 2007
    ..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients...
  87. ncbi Androgen supplementation in older women: too much hype, not enough data
    Maria Clara M Padero
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    J Am Geriatr Soc 50:1131-40. 2002
    ..This article reviews testosterone's effects on sexual function, cognitive function, muscle mass, body composition, and immune function in postmenopausal women...
  88. ncbi Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  89. ncbi The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study
    Beth A Mohr
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    Eur J Endocrinol 155:443-52. 2006
    ..We aimed to determine whether changes in adiposity predict follow-up levels and rates of change in TT, FT and sex hormone-binding globulin (SHBG) in men...
  90. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  91. ncbi Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  92. ncbi Female androgen deficiency syndrome--an unproven hypothesis
    Shalender Bhasin
    J Clin Endocrinol Metab 90:4970-2. 2005
  93. ncbi Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 91:3024-33. 2006
    ..In this study, we determined the effects of graded doses of testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number and replication in older men...
  94. ncbi Making a diagnosis of androgen deficiency in adult men: what to do until all the facts are in?
    Shalender Bhasin
    Nat Clin Pract Endocrinol Metab 2:529. 2006
  95. ncbi Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005
    ..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength...
  96. ncbi Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men
    Ravi Jasuja
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:855-63. 2005
    ....
  97. ncbi Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:5245-55. 2004
    ..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle...
  98. ncbi Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, CA 90509, USA
    Curr Opin Obstet Gynecol 16:405-9. 2004
    ....
  99. ncbi Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  100. ncbi Testosterone action on skeletal muscle
    Karen L Herbst
    UCLA School of Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    Curr Opin Clin Nutr Metab Care 7:271-7. 2004
    ..To highlight recent data demonstrating direct anabolic effects of androgens on the mammalian skeletal muscle and review the mechanisms by which testosterone regulates body composition...
  101. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...