Shalendar Bhasin

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
  2. pmc Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice
    Powen Tu
    Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 58:1739-48. 2009
  3. pmc Premature expression of a muscle fibrosis axis in chronic HIV infection
    Rebecca L Kusko
    Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA
    Skelet Muscle 2:10. 2012
  4. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
  5. doi request reprint The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:87-95. 2013
  6. doi request reprint Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany St, Boston, MA 02118, USA
    JAMA 307:931-9. 2012
  7. pmc Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    Shalender Bhasin
    Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 96:2430-9. 2011
  8. pmc N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:4224-33. 2009
  9. pmc Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
    Shalender Bhasin
    Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Endocrinol Metab 2:146-59. 2006
  10. ncbi request reprint Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    Olga M Calof
    Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 60:1451-7. 2005

Research Grants

  1. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2010
  2. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
  3. TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIA
    Shalendar Bhasin; Fiscal Year: 2007
  4. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalender Bhasin; Fiscal Year: 2006
  5. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2006
  6. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
  7. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2006
  8. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
  9. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
  10. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004

Detail Information

Publications74

  1. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
    ..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
  2. pmc Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice
    Powen Tu
    Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 58:1739-48. 2009
    ..In this study, we determined whether Mstn disruption could prevent the development of insulin resistance, proatherogenic dyslipidemia, and atherogenesis...
  3. pmc Premature expression of a muscle fibrosis axis in chronic HIV infection
    Rebecca L Kusko
    Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA
    Skelet Muscle 2:10. 2012
    ..abstract:..
  4. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
    ....
  5. doi request reprint The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:87-95. 2013
    ..Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones...
  6. doi request reprint Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany St, Boston, MA 02118, USA
    JAMA 307:931-9. 2012
    ....
  7. pmc Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    Shalender Bhasin
    Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 96:2430-9. 2011
    ..We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men...
  8. pmc N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:4224-33. 2009
    ..We investigated P3NP as a biomarker of lean body mass (LBM) and muscle strength gains in response to testosterone and GH...
  9. pmc Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
    Shalender Bhasin
    Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Endocrinol Metab 2:146-59. 2006
    ....
  10. ncbi request reprint Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    Olga M Calof
    Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 60:1451-7. 2005
    ..We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men...
  11. doi request reprint The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders
    Shalender Bhasin
    Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, MA 02118, United States
    Steroids 73:1311-7. 2008
    ..These steps will facilitate the development of rational criteria for the diagnosis of androgen disorders in men, women, and children...
  12. pmc Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA
    Diabetes Care 34:2464-70. 2011
    ..We determined whether testosterone or sex hormone-binding globulin (SHBG) is independently associated with the risk of metabolic syndrome...
  13. doi request reprint Novel strategies for improving physical function
    Shalender Bhasin
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Horm Res Paediatr 76:17-23. 2011
    ..However, clinical development has been slowed by vexing trial design issues...
  14. pmc Selective androgen receptor modulators as function promoting therapies
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 12:232-40. 2009
    ..This review describes the historical evolution, the rationale for SARM development, and the mechanisms of testosterone action and SARM selectivity...
  15. ncbi request reprint Approach to the infertile man
    Shalender Bhasin
    Boston University School of Medicine, Chief, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    J Clin Endocrinol Metab 92:1995-2004. 2007
    ..Infertility is one of commonest disorders to afflict young men and women. The evaluation of infertility is initiated typically after 1 yr of failure to conceive...
  16. ncbi request reprint Sexual dysfunction in men and women with endocrine disorders
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, MA 02199, USA
    Lancet 369:597-611. 2007
    ..We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women...
  17. pmc Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation
    Thomas G Travison
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 66:1090-9. 2011
    ..The changes in muscle performance and physical function were evaluated in relation to participant's perception of change...
  18. ncbi request reprint Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone
    Andrea D Coviello
    Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:4669-75. 2006
    ..We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels...
  19. ncbi request reprint Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss
    Karen L Herbst
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    Fertil Steril 85:1794-802. 2006
    ....
  20. doi request reprint Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss
    Philip E Knapp
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 294:E1135-43. 2008
    ..Improvements in mood, fatigue, and quality-of-life measures in the testosterone group, although clinically important, need further confirmation...
  21. ncbi request reprint Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 91:3024-33. 2006
    ..In this study, we determined the effects of graded doses of testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number and replication in older men...
  22. ncbi request reprint Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study
    Carl Grunfeld
    University of California San Francisco, and Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 41:304-14. 2006
    ..To evaluate the efficacy and safety of oxandrolone in promoting body weight and body cell mass (BCM) gain in HIV-associated weight loss...
  23. ncbi request reprint The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study
    Beth A Mohr
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    Eur J Endocrinol 155:443-52. 2006
    ..We aimed to determine whether changes in adiposity predict follow-up levels and rates of change in TT, FT and sex hormone-binding globulin (SHBG) in men...
  24. ncbi request reprint Serum androgen levels in black, Hispanic, and white men
    Heather J Litman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:4326-34. 2006
    ..Racial/ethnic differences in androgen levels could account for differences in prostate cancer risk, body composition, and bone loss...
  25. ncbi request reprint Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  26. pmc Effects of graded doses of testosterone on erythropoiesis in healthy young and older men
    Andrea D Coviello
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 670 Albany Street, 2nd Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:914-9. 2008
    ..Erythrocytosis is a dose-limiting adverse effect of testosterone therapy, especially in older men...
  27. ncbi request reprint Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4445-52. 2006
    ....
  28. ncbi request reprint Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss
    Monty Montano
    Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:2793-802. 2007
    ..Although androgen treatment increases muscle mass, the cell-intrinsic mechanisms engaged remain poorly understood...
  29. ncbi request reprint Testosterone, sex hormone-binding globulin, and frailty in older men
    Beth A Mohr
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Am Geriatr Soc 55:548-55. 2007
    ..To determine whether testosterone (T) levels are associated with frailty or its components...
  30. ncbi request reprint Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:718-26. 2004
    ..Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh...
  31. ncbi request reprint Making a diagnosis of androgen deficiency in adult men: what to do until all the facts are in?
    Shalender Bhasin
    Nat Clin Pract Endocrinol Metab 2:529. 2006
  32. ncbi request reprint Determinants of serum total and free testosterone levels in women over the age of 65 years
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Endocrinol Metab 92:509-16. 2007
    ..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age...
  33. pmc The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways
    Wen Guo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Biol Chem 283:9136-45. 2008
    ..These effects were mediated, in part, by activation of Smad3 and cross-communication of the TGFbeta/Smad signal to Wnt/beta-catenin/TCF4 pathway, leading to down-regulation of PPARgamma...
  34. ncbi request reprint Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  35. ncbi request reprint A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
    ....
  36. ncbi request reprint Testosterone supplementation for aging-associated sarcopenia
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:1002-8. 2003
    ..The long-term risks and benefits of testosterone supplementation in older men are not known...
  37. ncbi request reprint Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  38. ncbi request reprint Androgen effects on body composition
    Shalender Bhasin
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Growth Horm IGF Res 13:S63-71. 2003
    ....
  39. ncbi request reprint Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin
    Suzanne Reisz-Porszasz
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E876-88. 2003
    ..The mechanism of gender specificity remains to be clarified...
  40. ncbi request reprint Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 285:E197-205. 2003
    ..We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure...
  41. ncbi request reprint Development of models to predict anabolic response to testosterone administration in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 284:E1009-17. 2003
    ..Hence, the anabolic response of healthy, young men to exogenous testosterone administration can largely be predicted by the testosterone dose...
  42. ncbi request reprint Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 284:E120-8. 2003
    ..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men...
  43. ncbi request reprint Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 283:E154-64. 2002
    ..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy...
  44. ncbi request reprint The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
    ..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass...
  45. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  46. ncbi request reprint Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:1049-57. 2007
    ..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown...
  47. ncbi request reprint Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005
    ..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength...
  48. ncbi request reprint Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men
    Ravi Jasuja
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:855-63. 2005
    ....
  49. ncbi request reprint Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:5245-55. 2004
    ..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle...
  50. ncbi request reprint Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, CA 90509, USA
    Curr Opin Obstet Gynecol 16:405-9. 2004
    ....
  51. ncbi request reprint Testosterone action on skeletal muscle
    Karen L Herbst
    UCLA School of Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    Curr Opin Clin Nutr Metab Care 7:271-7. 2004
    ..To highlight recent data demonstrating direct anabolic effects of androgens on the mammalian skeletal muscle and review the mechanisms by which testosterone regulates body composition...
  52. ncbi request reprint Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Cell Physiol 190:170-9. 2002
    ..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation...
  53. ncbi request reprint Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, UCLA Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Androl 24:299-311. 2003
  54. ncbi request reprint Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol (1985) 103:1299-310. 2007
    ..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients...
  55. ncbi request reprint Experiments of nature--a glimpse into the mysteries of the pubertal clock
    Shalender Bhasin
    N Engl J Med 357:929-32. 2007
  56. ncbi request reprint Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol 194:63-76. 2007
    ..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation...
  57. ncbi request reprint Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 88:1478-85. 2003
    ....
  58. ncbi request reprint Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression
    Kun Ma
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E363-71. 2003
    ..We propose that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression through a glucocorticoid receptor-mediated pathway...
  59. ncbi request reprint Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine Science, University of California Los Angeles School of Medicine, 90059, USA
    Clin Infect Dis 37:S142-9. 2003
    ..However, the long-term risks and benefits of testosterone administration in human immunodeficiency virus-infected men with fat redistribution syndrome have not been studied in randomized clinical trials...
  60. ncbi request reprint Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight
    Wayne E Taylor
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    J Gravit Physiol 9:61-70. 2002
    ..These data indicate that following exposure to microgravity, there is downregulation of genes involved in regulation of muscle satellite cell replication...
  61. ncbi request reprint Time for (more research on) testosterone
    Elizabeth Barrett-Connor
    J Clin Endocrinol Metab 89:501-2. 2004
  62. ncbi request reprint The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 87:136-43. 2002
    ..Long-term studies are needed to determine whether T supplementation of older men with low T levels affects atherosclerosis progression...
  63. ncbi request reprint Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women
    Elliot Hirshman
    Department of Psychology, George Washington University, Washington, DC 20052, USA
    Horm Behav 45:144-55. 2004
    ....
  64. ncbi request reprint Role of myostatin in metabolism
    Nestor F Gonzalez-Cadavid
    Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
    Curr Opin Clin Nutr Metab Care 7:451-7. 2004
    ..Myostatin also controls muscle mass in other animals, and appears to affect adipose tissue mass...
  65. ncbi request reprint Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  66. ncbi request reprint Female androgen deficiency syndrome--an unproven hypothesis
    Shalender Bhasin
    J Clin Endocrinol Metab 90:4970-2. 2005
  67. ncbi request reprint Pharmacokinetics of a testosterone gel in healthy postmenopausal women
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Drew University of California Los Angeles Reproductive Science Research Center, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 91:136-44. 2006
    ..The paucity of pharmacokinetic data on androgen formulations in women has hindered clinical trials of testosterone supplementation in women...
  68. ncbi request reprint Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine S B, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:1995-2010. 2006
    ..The objective was to provide guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men...
  69. ncbi request reprint Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men
    Peter B Gray
    Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:3838-46. 2005
    ..The relationships between testosterone dose and its effects on sexual function, mood, and visuospatial cognition are poorly understood...
  70. ncbi request reprint Secular decline in male reproductive function: Is manliness threatened?
    Shalender Bhasin
    J Clin Endocrinol Metab 92:44-5. 2007
  71. ncbi request reprint An investigation of the relationship between sex-steroid levels and urological symptoms: results from the Boston Area Community Health survey
    Heather J Litman
    New England Research Institutes, Watertown, MA 02472, USA
    BJU Int 100:321-6. 2007
    ..To investigate whether circulating levels of sex hormones are associated with urological symptoms, using data from the Boston Area Community Health (BACH) Survey...
  72. ncbi request reprint Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 293:E769-75. 2007
    ..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men...
  73. ncbi request reprint Androgen supplementation in older women: too much hype, not enough data
    Maria Clara M Padero
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    J Am Geriatr Soc 50:1131-40. 2002
    ..This article reviews testosterone's effects on sexual function, cognitive function, muscle mass, body composition, and immune function in postmenopausal women...

Research Grants60

  1. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2010
    ....
  2. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  3. TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIA
    Shalendar Bhasin; Fiscal Year: 2007
    ..The study will provide unique information about the effectiveness of a rational, but hitherto unproven therapeutic strategy, for older men with sarcopenia who are at increased risk of disability. ..
  4. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalender Bhasin; Fiscal Year: 2006
    ....
  5. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2006
    ..abstract_text> ..
  6. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  7. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2006
    ..abstract_text> ..
  8. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  9. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  10. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  11. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  12. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2007
    ....
  13. Optimizing Protein Intake in Older Americans with Mobility Limitations
    SHALENDAR contact BHASIN; Fiscal Year: 2010
    ..This issue has enormous public health and policy implications for older Americans. ..
  14. Population-Based Reference Ranges for Testosterone
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  15. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2010
    ....
  16. Mechanisms of Testosterone Action
    Shalendar Bhasin; Fiscal Year: 2010
    ..The proposed project also provides an outstanding opportunity to further our understanding of hormonal regulation of stem cell differentiation and cell fate. ..
  17. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  18. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  19. Population-Based Reference Ranges for Testosterone
    Shalendar Bhasin; Fiscal Year: 2009
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  20. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2005
    ..abstract_text> ..
  21. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2001
    ....
  22. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2001
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  23. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2000
    ....
  24. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 1999
    ....
  25. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2002
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  26. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2002
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  27. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  28. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalender Bhasin; Fiscal Year: 2005
    ....
  29. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  30. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2005
    ..abstract_text> ..
  31. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  32. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2004
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  33. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  34. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..abstract_text> ..
  35. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2003
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  36. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
  37. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2002
    ....
  38. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2003
    ..abstract_text> ..