Research Topics
Species | Shalendar BhasinSummaryAffiliation: Boston University Country: USA Publications
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Publications
Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cellsJorge N Artaza
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Endocrinology 146:3547-57. 2005..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young menShehzad Basaria
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 68:87-95. 2013..Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones...- Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trialShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany St, Boston, MA 02118, USA
JAMA 307:931-9. 2012.... - Sexual dysfunction in men and women with endocrine disordersShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, MA 02199, USA
Lancet 369:597-611. 2007..We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women... - Approach to the infertile manShalender Bhasin
Boston University School of Medicine, Chief, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
J Clin Endocrinol Metab 92:1995-2004. 2007..Men considering ICSI should be offered karyotyping, Yq microdeletion testing, and genetic counseling by counselors experienced in reproductive disorders... 
Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and agingShalender Bhasin
Boston University School of Medicine, Boston, MA 02118, USA
Nat Clin Pract Endocrinol Metab 2:146-59. 2006....- The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disordersShalender Bhasin
Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, MA 02118, United States
Steroids 73:1311-7. 2008..These steps will facilitate the development of rational criteria for the diagnosis of androgen disorders in men, women, and children... - Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trialsOlga M Calof
Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 60:1451-7. 2005..We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men... - Selective androgen receptor modulators as function promoting therapiesShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston, Massachusetts, USA
Curr Opin Clin Nutr Metab Care 12:232-40. 2009..This review describes the historical evolution, the rationale for SARM development, and the mechanisms of testosterone action and SARM selectivity... - Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart studyShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA
Diabetes Care 34:2464-70. 2011..We determined whether testosterone or sex hormone-binding globulin (SHBG) is independently associated with the risk of metabolic syndrome... - Novel strategies for improving physical functionShalender Bhasin
Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
Horm Res Paediatr 76:17-23. 2011.... - Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohortsShalender Bhasin
Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
J Clin Endocrinol Metab 96:2430-9. 2011..We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men... - N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosteroneShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 94:4224-33. 2009..We investigated P3NP as a biomarker of lean body mass (LBM) and muscle strength gains in response to testosterone and GH... - Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitationThomas G Travison
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 66:1090-9. 2011..The changes in muscle performance and physical function were evaluated in relation to participant's perception of change... - Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older menIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 91:3024-33. 2006..Testosterone-induced skeletal muscle hypertrophy in older men is associated with increased satellite cell replication and activation... - Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled studyCarl Grunfeld
University of California San Francisco, and Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 41:304-14. 2006..To evaluate the efficacy and safety of oxandrolone in promoting body weight and body cell mass (BCM) gain in HIV-associated weight loss... - Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight lossKaren L Herbst
Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
Fertil Steril 85:1794-802. 2006.... - Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosteroneAndrea D Coviello
Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 91:4669-75. 2006..We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels... - Serum androgen levels in black, Hispanic, and white menHeather J Litman
New England Research Institutes, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 91:4326-34. 2006..Racial/ethnic differences in androgen levels could account for differences in prostate cancer risk, body composition, and bone loss... - The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging StudyBeth A Mohr
New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
Eur J Endocrinol 155:443-52. 2006..Since weight gain is highly prevalent in older men, over-reliance on TT levels in the diagnosis of androgen deficiency could result in substantial misclassification... - Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older menRanganath Muniyappa
Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 91:4445-52. 2006..The clinical significance of sex steroid modulation of DHEA secretion in older persons remains to be elucidated... - Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscleShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 90:678-88. 2005..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength... - Making a diagnosis of androgen deficiency in adult men: what to do until all the facts are in?Shalender Bhasin
Nat Clin Pract Endocrinol Metab 2:529. 2006 - Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight lossPhilip E Knapp
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 294:E1135-43. 2008..Improvements in mood, fatigue, and quality-of-life measures in the testosterone group, although clinically important, need further confirmation... - The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathwaysWen Guo
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
J Biol Chem 283:9136-45. 2008..These effects were mediated, in part, by activation of Smad3 and cross-communication of the TGFbeta/Smad signal to Wnt/beta-catenin/TCF4 pathway, leading to down-regulation of PPARgamma... - Effects of graded doses of testosterone on erythropoiesis in healthy young and older menAndrea D Coviello
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 670 Albany Street, 2nd Floor, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 93:914-9. 2008..Erythrocytosis is a dose-limiting adverse effect of testosterone therapy, especially in older men... - Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trialE Todd Schroeder
Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
Clin Trials 4:560-71. 2007..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging... - Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight lossMonty Montano
Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, School of Public Health, Boston University, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 92:2793-802. 2007..Although androgen treatment increases muscle mass, the cell-intrinsic mechanisms engaged remain poorly understood... - Testosterone, sex hormone-binding globulin, and frailty in older menBeth A Mohr
New England Research Institutes, Watertown, Massachusetts 02472, USA
J Am Geriatr Soc 55:548-55. 2007..To determine whether testosterone (T) levels are associated with frailty or its components... - Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesityShalender Bhasin
Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 92:1049-57. 2007..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown... - Determinants of serum total and free testosterone levels in women over the age of 65 yearsAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Clin Endocrinol Metab 92:509-16. 2007..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age... - Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factorsRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
Endocrinology 147:141-54. 2006..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens... - Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adultsJulio Licinio
Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:4531-6. 2004..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior... - Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatinSuzanne Reisz-Porszasz
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 285:E876-88. 2003..The mechanism of gender specificity remains to be clarified... - Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young menIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
Am J Physiol Endocrinol Metab 285:E197-205. 2003..We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure... - Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young menLinda J Woodhouse
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 89:718-26. 2004..Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh... - Development of models to predict anabolic response to testosterone administration in healthy young menLinda J Woodhouse
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 284:E1009-17. 2003..Hence, the anabolic response of healthy, young men to exogenous testosterone administration can largely be predicted by the testosterone dose... - Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathwayRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
Endocrinology 144:5081-8. 2003..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men... - Testosterone action on skeletal muscleKaren L Herbst
UCLA School of Medicine, Charles R. Drew University, Los Angeles, California 90059, USA
Curr Opin Clin Nutr Metab Care 7:271-7. 2004.... - Effects of an oral androgen on muscle and metabolism in older, community-dwelling menE Todd Schroeder
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Am J Physiol Endocrinol Metab 284:E120-8. 2003..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men... - Androgen effects on body compositionShalender Bhasin
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
Growth Horm IGF Res 13:S63-71. 2003.... - Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tractMat H Ho
Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, CA 90509, USA
Curr Opin Obstet Gynecol 16:405-9. 2004.... - A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatmentThomas W Storer
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 90:4474-82. 2005.... - The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen actionShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass... - Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cellsJorge N Artaza
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Cell Physiol 190:170-9. 2002..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation... - Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal menRavi Jasuja
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 90:855-63. 2005.... - Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophyIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
Am J Physiol Endocrinol Metab 283:E154-64. 2002..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy... - Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatmentIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 89:5245-55. 2004..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle... - Testosterone supplementation for aging-associated sarcopeniaShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
J Gerontol A Biol Sci Med Sci 58:1002-8. 2003..The long-term risks and benefits of testosterone supplementation in older men are not known... - Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring planShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, UCLA-Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Androl 24:299-311. 2003 - Functional outcomes for clinical trials in frail older persons: time to be movingShalender Bhasin
J Gerontol A Biol Sci Med Sci 63:160-4. 2008 - Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tensionThomas W Storer
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 88:1478-85. 2003.... - Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expressionKun Ma
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 285:E363-71. 2003..We propose that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression through a glucocorticoid receptor-mediated pathway... - Female androgen deficiency syndrome--an unproven hypothesisShalender Bhasin
J Clin Endocrinol Metab 90:4970-2. 2005 - Androgen supplementation in older women: too much hype, not enough dataMaria Clara M Padero
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
J Am Geriatr Soc 50:1131-40. 2002..This article reviews testosterone's effects on sexual function, cognitive function, muscle mass, body composition, and immune function in postmenopausal women... - Experiments of nature--a glimpse into the mysteries of the pubertal clockShalender Bhasin
N Engl J Med 357:929-32. 2007 - Skeletal muscle adaptations to testosterone and resistance training in men with COPDMichael I Lewis
Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Appl Physiol 103:1299-310. 2007..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients... - Pharmacokinetics of a testosterone gel in healthy postmenopausal womenAtam B Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Drew-University of California-Los Angeles Reproductive Science Research Center, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 91:136-44. 2006..A 4.4-mg dose raised testosterone levels into the mid- to high-normal range. Previous estrogen therapy had no significant effect on testosterone pharmacokinetics over this short duration... - Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older menPeter B Gray
Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 90:3838-46. 2005..When considered together with previous data from young men, these data indicate that testosterone dose-response relationships for sexual function and visuospatial cognition differ in older and young men... - Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guidelineShalender Bhasin
Boston University School of Medicine (S.B, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 91:1995-2010. 2006..Men receiving testosterone therapy should be monitored using a standardized plan... - Effects of testosterone and resistance training in men with chronic obstructive pulmonary diseaseRichard Casaburi
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
Am J Respir Crit Care Med 170:870-8. 2004..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels... - Role of myostatin in metabolismNestor F Gonzalez-Cadavid
Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
Curr Opin Clin Nutr Metab Care 7:451-7. 2004..Myostatin also controls muscle mass in other animals, and appears to affect adipose tissue mass... - Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal womenElliot Hirshman
Department of Psychology, George Washington University, Washington, DC 20052, USA
Horm Behav 45:144-55. 2004.... - Time for (more research on) testosteroneElizabeth Barrett-Connor
J Clin Endocrinol Metab 89:501-2. 2004 - Secular decline in male reproductive function: Is manliness threatened?Shalender Bhasin
J Clin Endocrinol Metab 92:44-5. 2007 - The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young menAtam B Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 87:136-43. 2002..Long-term studies are needed to determine whether T supplementation of older men with low T levels affects atherosclerosis progression... - Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflightWayne E Taylor
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
J Gravit Physiol 9:61-70. 2002..These data indicate that following exposure to microgravity, there is downregulation of genes involved in regulation of muscle satellite cell replication... - An investigation of the relationship between sex-steroid levels and urological symptoms: results from the Boston Area Community Health surveyHeather J Litman
New England Research Institutes, Watertown, MA 02472, USA
BJU Int 100:321-6. 2007..To investigate whether circulating levels of sex hormones are associated with urological symptoms, using data from the Boston Area Community Health (BACH) Survey... - Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older menRanganath Muniyappa
Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Endocrinol Metab 293:E769-75. 2007..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men... - Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progressionShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine Science, University of California Los Angeles School of Medicine, 90059, USA
Clin Infect Dis 37:S142-9. 2003..However, the long-term risks and benefits of testosterone administration in human immunodeficiency virus-infected men with fat redistribution syndrome have not been studied in randomized clinical trials... - Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouseJorge N Artaza
Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
J Endocrinol 194:63-76. 2007..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation...
Research Grants
- Mechanism of Myostatin ActionShalendar Bhasin; Fiscal Year: 2010....
- Role of 5-alpha Reductase in Testosterone ActionsShalendar Bhasin; Fiscal Year: 2007..abstract_text> ..
- TESTOSTERONE SUPPLEMENTATION FOR MEN WITH SARCOPENIAShalendar Bhasin; Fiscal Year: 2007..The study will provide unique information about the effectiveness of a rational, but hitherto unproven therapeutic strategy, for older men with sarcopenia who are at increased risk of disability. ..
- TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MENShalender Bhasin; Fiscal Year: 2005..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
- Testosterone:Physical Function in Men on HemodialysisShalender Bhasin; Fiscal Year: 2004..Therefore, if successful, this study should help identify a therapeutic intervention that might improve physical function and reduce disability in men with end stage renal disease. ..
- Mechanisms of Testosterone Effects on Body CompositionShalendar Bhasin; Fiscal Year: 2007..abstract_text> ..
- Optimizing Protein Intake in Older Americans with Mobility LimitationsSHALENDAR contact BHASIN; Fiscal Year: 2010..This issue has enormous public health and policy implications for older Americans. ..
- Population-Based Reference Ranges for TestosteroneVASAN S RAMACHANDRAN; Fiscal Year: 2010..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
- Mechanism of Myostatin ActionShalendar Bhasin; Fiscal Year: 2010....
- Mechanisms of Testosterone ActionShalendar Bhasin; Fiscal Year: 2010..The proposed project also provides an outstanding opportunity to further our understanding of hormonal regulation of stem cell differentiation and cell fate. ..
- Testosterone Modulation of Response to Phosphodiesterase InhibitorsShalendar Bhasin; Fiscal Year: 2009....
- Population-Based Reference Ranges for TestosteroneShalendar Bhasin; Fiscal Year: 2009..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
- SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MENShalender Bhasin; Fiscal Year: 2002....