Emelia J Benjamin

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Addition of inflammatory biomarkers did not improve diabetes prediction in the community: the framingham heart study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA D D, M G L, J D F, E J B, C S F Division of General Internal Medicine, Boston University School of Medicine, Boston, MA D D
    J Am Heart Assoc 1:e000869. 2012
  2. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
  3. pmc Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study
    Abigail May Khan
    Division of Cardiology, University of Pennsylvania, Philadelphia, USA
    Circulation 127:33-8. 2013
  4. pmc Comparison of m-mode echocardiographic left ventricular mass measured using digital and strip chart readings: the Atherosclerosis Risk in Communities (ARIC) study
    Donna K Arnett
    Division of Epidemiology, University of Minnesota, School of Public Health, Minneapolis, MN, USA
    Cardiovasc Ultrasound 1:8. 2003
  5. pmc Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cardiovasc Ultrasound 4:43. 2006
  6. pmc The relation of C--reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study
    Ervin R Fox
    Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA
    BMC Nephrol 11:1. 2010
  7. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  8. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
  9. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
  10. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006

Detail Information

Publications127 found, 100 shown here

  1. pmc Addition of inflammatory biomarkers did not improve diabetes prediction in the community: the framingham heart study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA D D, M G L, J D F, E J B, C S F Division of General Internal Medicine, Boston University School of Medicine, Boston, MA D D
    J Am Heart Assoc 1:e000869. 2012
    ..Prior studies have reported conflicting findings with regard to the association of biomarkers in the prediction of incident type 2 diabetes. We evaluated 12 biomarkers as possible diabetes predictors in the Framingham Heart Study...
  2. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
    ..abstract:..
  3. pmc Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study
    Abigail May Khan
    Division of Cardiology, University of Pennsylvania, Philadelphia, USA
    Circulation 127:33-8. 2013
    ..Low serum magnesium has been linked to increased risk of atrial fibrillation (AF) after cardiac surgery. It is unknown whether hypomagnesemia predisposes to AF in the community...
  4. pmc Comparison of m-mode echocardiographic left ventricular mass measured using digital and strip chart readings: the Atherosclerosis Risk in Communities (ARIC) study
    Donna K Arnett
    Division of Epidemiology, University of Minnesota, School of Public Health, Minneapolis, MN, USA
    Cardiovasc Ultrasound 1:8. 2003
    ..We sought to determine if systematic differences in LV mass occur between the two methods by comparing LV mass measured from simultaneous M-mode strip chart recordings and digitized recordings...
  5. pmc Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cardiovasc Ultrasound 4:43. 2006
    ..However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans...
  6. pmc The relation of C--reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study
    Ervin R Fox
    Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA
    BMC Nephrol 11:1. 2010
    ..73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on the role of inflammation in renal dysfunction in African Americans in the community...
  7. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  8. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  9. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  10. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  11. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  12. pmc Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop
    Emelia J Benjamin
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 119:606-18. 2009
    ....
  13. ncbi Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study
    Emelia J Benjamin
    Evans Department of Medicine, Boston University School of Medicine, Framingham Study, Boston, Mass 01702 5827, USA
    Circulation 109:613-9. 2004
    ..Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in the community have not been described...
  14. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  15. ncbi Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  16. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  17. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  18. pmc Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study
    Carolyn S P Lam
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:884-90. 2010
    ..Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course...
  19. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  20. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  21. pmc Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 118:2252-8, 5p following 2258. 2008
    ..Several biological pathways are activated concomitantly during left ventricular (LV) remodeling. However, the relative contribution of circulating biomarkers representing these distinct pathways to LV geometry is unclear...
  22. pmc Multimarker approach for the prediction of heart failure incidence in the community
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 122:1700-6. 2010
    ..There are no data, however, on the incremental utility of a parsimonious set of biomarkers (reflecting pathways implicated in HF) for predicting HF risk in the community...
  23. ncbi Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  24. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  25. ncbi Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study)
    Avni H Thakore
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:1598-602. 2007
    ..In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers...
  26. ncbi Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  27. pmc Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
    Vasc Med 14:351-60. 2009
    ..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
  28. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
    ..In conclusion, circulating homocysteine, aldosterone, and BNP provide incremental information regarding risk for incident CKD and MA beyond traditional risk factors...
  29. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  30. pmc Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA, USA
    Eur J Heart Fail 12:812-8. 2010
    ..To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure...
  31. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  32. pmc Circulating angiogenic cell populations, vascular function, and arterial stiffness
    Susan Cheng
    Framingham Heart Study, Framingham, MA 02118, United States
    Atherosclerosis 220:145-50. 2012
    ..We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness...
  33. ncbi Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  34. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  35. pmc Insulin resistance and atrial fibrillation (from the Framingham Heart Study)
    Joao D Fontes
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 109:87-90. 2012
    ..18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF...
  36. pmc Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 125:2836-43. 2012
    ..Although impaired vascular function is hypothesized to influence the BP response during exercise, limited data exist on the association of vascular function with exercise BP in the community...
  37. ncbi Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  38. pmc Association of visceral and subcutaneous adiposity with kidney function
    Jill A Young
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1786-91. 2008
    ..Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations...
  39. ncbi A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  40. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  41. ncbi Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  42. ncbi Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  43. pmc Galectin 3 and incident atrial fibrillation in the community
    Jennifer E Ho
    Boston University and the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA Electronic address
    Am Heart J 167:729-734.e1. 2014
    ..The same mechanisms that lead to cardiac fibrosis in heart failure may influence development of atrial fibrosis and atrial fibrillation (AF). We examined the association of Gal-3 and incident AF in the community...
  44. ncbi Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  45. ncbi Relations of inflammation and novel risk factors to valvular calcification
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 97:1502-5. 2006
    ..In conclusion, inflammatory markers were elevated in patients with valvular calcium. Our findings suggest that much of the observed association between systemic inflammatory markers and valvular calcium may be due to shared risk factors...
  46. pmc Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 58, USA
    Arterioscler Thromb Vasc Biol 30:2283-8. 2010
    ..To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community...
  47. ncbi Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study
    Joseph A Vita
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:3604-9. 2004
    ..The precise relations among risk factors, inflammation, and nitric oxide bioavailability remain uncertain...
  48. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  49. ncbi Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
    ..We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort...
  50. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  51. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  52. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  53. pmc Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)
    Angela L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 108:1346-51. 2011
    ..In conclusion, although these observational cross-sectional data cannot establish causality, they suggest a nonlinear association between LVEF and measures of accelerated cognitive aging...
  54. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
    ..Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood...
  55. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
    ..In conclusion, subjects with prolonged QRS durations, even without bundle branch block, are at increased risk for future pacemaker implantation. Such individuals may warrant monitoring for progressive conduction disease...
  56. pmc Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease
    Naomi M Hamburg
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:82-8. 2008
    ..In conclusion, our observations are consistent with the hypothesis that MS and insulin resistance impair vascular function predominantly through the influence of the component metabolic abnormalities that comprise MS...
  57. ncbi Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  58. ncbi Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  59. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  60. pmc Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 120:1195-202. 2009
    ..Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass...
  61. ncbi Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes
    Erik Ingelsson
    National Heart, Lung, and Blood Institute s Framingham Study, Framingham, Massachusetts 01702 5803, USA
    Diabetes 56:1718-26. 2007
    ..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...
  62. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  63. pmc Electrocardiographic PR interval and adverse outcomes in older adults: the Health, Aging, and Body Composition study
    Jared W Magnani
    Cardiology Section, Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Arrhythm Electrophysiol 6:84-90. 2013
    ..We sought to determine the associations between PR interval and heart failure, AF, and mortality in a biracial cohort of older adults...
  64. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    ..Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial...
  65. pmc Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 124:24-30. 2011
    ..We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF...
  66. pmc Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
    Ashish Upadhyay
    Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 26:920-6. 2011
    ..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood...
  67. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  68. pmc The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations
    Renate B Schnabel
    NHLBIs Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circ Cardiovasc Genet 2:229-37. 2009
    ..In the family-based Framingham Heart Study, we investigated heritability and candidate gene associations of systemic inflammatory biomarkers...
  69. ncbi Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 30:2529-35. 2007
    ..Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans...
  70. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  71. ncbi Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  72. pmc C-reactive protein, inflammatory conditions, and cardiovascular disease risk
    Ravi Dhingra
    National Heart Lung and Blood Institute s NHBLI Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am J Med 120:1054-62. 2007
    ..It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community...
  73. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  74. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  75. pmc Resistin, adiponectin, and risk of heart failure the Framingham offspring study
    David S Frankel
    Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    J Am Coll Cardiol 53:754-62. 2009
    ..We tested the association of the adipokines resistin and adiponectin with incident heart failure...
  76. pmc Visceral and subcutaneous adiposity and brachial artery vasodilator function
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:2054-9. 2009
    ..265), above and beyond traditional risk factors. VAT, but not SAT was associated with FMD% after adjusting for clinical covariates. Nevertheless, the differential association with VAT as compared to SAT was minimal...
  77. ncbi Multiple biomarkers and the risk of incident hypertension
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Hypertension 49:432-8. 2007
    ..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension...
  78. ncbi Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample
    Anjali A Patwardhan
    Boston University School of Medicine, Boston, MA, USA
    Sleep 29:1301-6. 2006
    ..We examined the association of OSAH with natriuretic peptides in a community-based sample...
  79. pmc P wave duration and risk of longitudinal atrial fibrillation in persons ≥ 60 years old (from the Framingham Heart Study)
    Jared W Magnani
    Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 107:917-921.e1. 2011
    ..In conclusion, maximum P wave duration at the upper fifth percentile was associated with long-term AF risk in an elderly community-based cohort. P wave duration is an electrocardiographic endophenotype for AF...
  80. ncbi Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  81. pmc Relation of smoking status to a panel of inflammatory markers: the framingham offspring
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, United States
    Atherosclerosis 201:217-24. 2008
    ..We sought to investigate the hypothesis that smoking is accompanied by systemic inflammation...
  82. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  83. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    ..52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization...
  84. pmc The MYH9/APOL1 region and chronic kidney disease in European-Americans
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study and Center for Population Studies, Framingham, MA, USA
    Hum Mol Genet 20:2450-6. 2011
    ..These data suggest that the MYH9 polymorphism rs4821480 is associated with an increased risk of non-diabetic CKD in individuals of European ancestry...
  85. pmc Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    Benjamin F Voight
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Nat Genet 42:579-89. 2010
    ..We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits...
  86. pmc Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene
    David Reich
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000360. 2009
    ..We confirm that rs2814778 is predictive of WBC and neutrophil count in African Americans above beyond the previously described admixture association (P = 3.8 x 10(-5)), establishing a novel phenotype for this genetic variant...
  87. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
    ....
  88. pmc Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002264. 2011
    ..We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish...
  89. pmc The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
    ..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
  90. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
    ..Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18))...
  91. ncbi Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  92. ncbi Optimal threshold value for left ventricular hypertrophy in blacks: the Atherosclerosis Risk in Communities study
    Eduardo Nunez
    Division of Epidemiology, University of Minnesota, Minneapolis, Minn 55454, USA
    Hypertension 45:58-63. 2005
    ..Because these values are close to the 51 g/m(2.7) established from predominantly white populations, this cutpoint is appropriate for both groups...
  93. ncbi Left ventricular structure and systolic function in African Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Vuyisile T Nkomo
    University of Minnesota, School of Public Health, Division of Epidemiology, Minneapolis, Minnesota, 55454 1015, USA
    Ethn Dis 14:483-8. 2004
    ..To estimate prevalence of left ventricular (LV) hypertrophy and its relation to systolic function in a population-based sample of African Americans...
  94. ncbi Does job strain increase the risk for coronary heart disease or death in men and women? The Framingham Offspring Study
    Elaine D Eaker
    Eaker Epidemiology Enterprises, LLC, Chili, WI 54420, USA
    Am J Epidemiol 159:950-8. 2004
    ..For men, higher education, personal income, and occupational prestige were related to decreased risk of total mortality and CHD. These findings do not support high job strain as a significant risk factor for CHD or death in men or women...
  95. ncbi Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  96. ncbi Genome-wide scan for pulse pressure in the National Heart, Lung and Blood Institute's Framingham Heart Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, T418E, Boston, Mass 02118, USA
    Hypertension 44:152-5. 2004
    ..58). In conclusion, we have demonstrated a substantial genetic component to PP and have identified 4 chromosomal regions that may harbor genes influencing vascular stiffness...
  97. ncbi Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  98. ncbi Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
    ..Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women...
  99. ncbi Long-term trends in the incidence of and survival with heart failure
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    N Engl J Med 347:1397-402. 2002
    ..Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized...
  100. ncbi Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  101. ncbi Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...

Research Grants20

  1. Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
    Emelia J Benjamin; Fiscal Year: 2010
    ..The proposed study will fundamentally contribute insight about the relations of inflammation and aging. ..
  2. Identification of common genetic variants for atrial fibrillation and PR interval
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ....
  3. Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
    Emelia Benjamin; Fiscal Year: 2009
    ..The proposed study will fundamentally contribute insight about the relations of inflammation and aging. ..
  4. Identification of common genetic variants for atrial fibrillation and PR interval
    Emelia Benjamin; Fiscal Year: 2009
    ....
  5. Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
    Emelia Benjamin; Fiscal Year: 2007
    ..The proposed study will fundamentally contribute insight about the relations of inflammation and aging. ..
  6. Framingham: Inflammation, Genes & Cardiovascular Disease
    Emelia Benjamin; Fiscal Year: 2007
    ..These insights will fundamentally contribute to knowledge about the pathophysiology of CVD and may lead to improved prevention, risk stratification and management of CVD. ..
  7. Framingham: Inflammation, Genes & Cardiovascular Disease
    Emelia Benjamin; Fiscal Year: 2006
    ..These insights will fundamentally contribute to knowledge about the pathophysiology of CVD and may lead to improved prevention, risk stratification and management of CVD. ..
  8. Vascular Function in the Framingham Third Generation
    Emelia Benjamin; Fiscal Year: 2005
    ..The combination of investigator expertise and a well-characterized multi-generational sample will provide a unique vascular function data set, and will increase the understanding of the pathophysiology of HTN and CVD. ..
  9. INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
    Emelia Benjamin; Fiscal Year: 2003
    ..The proposed study provides a unique opportunity to assess the prognostic importance of inflammatory markers and is likely to yield new information that will directly improve the prevention and management of CVD. ..
  10. Framingham: Inflammation, Genes & Cardiovascular Disease
    Emelia Benjamin; Fiscal Year: 2004
    ..These insights will fundamentally contribute to knowledge about the pathophysiology of CVD and may lead to improved prevention, risk stratification and management of CVD. ..
  11. INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
    Emelia Benjamin; Fiscal Year: 2001
    ..The proposed study provides a unique opportunity to assess the prognostic importance of inflammatory markers and is likely to yield new information that will directly improve the prevention and management of CVD. ..
  12. Vascular Function in the Framingham Third Generation
    Emelia Benjamin; Fiscal Year: 2004
    ..The combination of investigator expertise and a well-characterized multi-generational sample will provide a unique vascular function data set, and will increase the understanding of the pathophysiology of HTN and CVD. ..
  13. Vascular Function in the Framingham Third Generation
    Emelia Benjamin; Fiscal Year: 2003
    ..The combination of investigator expertise and a well-characterized multi-generational sample will provide a unique vascular function data set, and will increase the understanding of the pathophysiology of HTN and CVD. ..
  14. INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
    Emelia Benjamin; Fiscal Year: 2002
    ..The proposed study provides a unique opportunity to assess the prognostic importance of inflammatory markers and is likely to yield new information that will directly improve the prevention and management of CVD. ..
  15. Vascular Function in the Framingham Third Generation
    Emelia Benjamin; Fiscal Year: 2002
    ..The combination of investigator expertise and a well-characterized multi-generational sample will provide a unique vascular function data set, and will increase the understanding of the pathophysiology of HTN and CVD. ..
  16. Framingham: Inflammation, Genes & Cardiovascular Disease
    Emelia Benjamin; Fiscal Year: 2005
    ..These insights will fundamentally contribute to knowledge about the pathophysiology of CVD and may lead to improved prevention, risk stratification and management of CVD. ..
  17. Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
    Emelia Benjamin; Fiscal Year: 2006
    ..The proposed study will fundamentally contribute insight about the relations of inflammation and aging. ..
  18. INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
    Emelia Benjamin; Fiscal Year: 2000
    ..The proposed study provides a unique opportunity to assess the prognostic importance of inflammatory markers and is likely to yield new information that will directly improve the prevention and management of CVD. ..