George L Barnes
Affiliation: Boston University
- Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblastsGeorge L Barnes
Orthopaedic Research Laboratory of the Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Cell Biochem 87:458-69. 2002..As such this is the first demonstration of a common regulatory mechanism utilized by both chondrocytes and osteoblasts for the tissue-restricted expression of the BSP gene...
- Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cellsGeorge L Barnes
Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
Cancer Res 63:2631-7. 2003....
- Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic diseaseGeorge L Barnes
Department of Orthopaedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
Cancer Res 64:4506-13. 2004..These results demonstrate that Runx2 expression in breast cancer cells provides a molecular phenotype that enables the interactions between tumor cells and the bone microenvironment that lead to osteolytic disease...
- Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatmentGeorge L Barnes
Department of Orthopaedic Surgery, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118, USA
J Bone Joint Surg Am 90:120-7. 2008....
- Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cellsLouis C Gerstenfeld
Department of Orthopedic Surgery, Orthopedic Research, Boston University Medical Center, Massachusetts 02118, USA
J Bone Miner Res 17:221-30. 2002..These results show that chondrocytes express soluble morphogenetic factors that selectively promote osteogenesis, and this selective effect is not mimicked by an exogenously added BMP...
- Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulationLouis C Gerstenfeld
Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
J Cell Biochem 88:873-84. 2003....
- Enhanced chondrogenesis and Wnt signaling in PTH-treated fracturesSanjeev Kakar
Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts, USA
J Bone Miner Res 22:1903-12. 2007....
- Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical functionElise F Morgan
Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
Bone 44:335-44. 2009..These findings form the basis for developing non-invasive assessments of fracture healing and for identifying biological and biomechanical mechanisms that lead to impaired or enhanced healing...
- Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfacesKetul C Popat
Department of Physiology and Division of Bioengineering, University of California at San Francisco, San Francisco, California, USA
J Biomed Mater Res A 80:955-64. 2007....
- Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivoAmjad Javed
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Proc Natl Acad Sci U S A 102:1454-9. 2005..Our findings suggest that fidelity of Runx2 intranuclear organization is necessary for expression of target genes that mediate the osteolytic activity of metastatic breast cancer cells...
- CORE--CELLULAR AND MOLECULAR BIOLOGYGeorge Barnes; Fiscal Year: 2007..All projects will use the surgical support and cell and molecular components of the core equally. ..