George L Barnes

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblasts
    George L Barnes
    Orthopaedic Research Laboratory of the Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 87:458-69. 2002
  2. ncbi Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Res 63:2631-7. 2003
  3. ncbi Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
    Cancer Res 64:4506-13. 2004
  4. ncbi Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118, USA
    J Bone Joint Surg Am 90:120-7. 2008
  5. ncbi Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells
    Louis C Gerstenfeld
    Department of Orthopedic Surgery, Orthopedic Research, Boston University Medical Center, Massachusetts 02118, USA
    J Bone Miner Res 17:221-30. 2002
  6. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
  7. ncbi Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures
    Sanjeev Kakar
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 22:1903-12. 2007
  8. ncbi Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
  9. ncbi Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfaces
    Ketul C Popat
    Department of Physiology and Division of Bioengineering, University of California at San Francisco, San Francisco, California, USA
    J Biomed Mater Res A 80:955-64. 2007
  10. ncbi Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    Amjad Javed
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 102:1454-9. 2005

Research Grants

  1. CORE--CELLULAR AND MOLECULAR BIOLOGY
    George Barnes; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. ncbi Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblasts
    George L Barnes
    Orthopaedic Research Laboratory of the Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 87:458-69. 2002
    ..As such this is the first demonstration of a common regulatory mechanism utilized by both chondrocytes and osteoblasts for the tissue-restricted expression of the BSP gene...
  2. ncbi Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Res 63:2631-7. 2003
    ....
  3. ncbi Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
    Cancer Res 64:4506-13. 2004
    ..These results demonstrate that Runx2 expression in breast cancer cells provides a molecular phenotype that enables the interactions between tumor cells and the bone microenvironment that lead to osteolytic disease...
  4. ncbi Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118, USA
    J Bone Joint Surg Am 90:120-7. 2008
    ....
  5. ncbi Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells
    Louis C Gerstenfeld
    Department of Orthopedic Surgery, Orthopedic Research, Boston University Medical Center, Massachusetts 02118, USA
    J Bone Miner Res 17:221-30. 2002
    ..These results show that chondrocytes express soluble morphogenetic factors that selectively promote osteogenesis, and this selective effect is not mimicked by an exogenously added BMP...
  6. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
    ....
  7. ncbi Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures
    Sanjeev Kakar
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 22:1903-12. 2007
    ....
  8. ncbi Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
    ..These findings form the basis for developing non-invasive assessments of fracture healing and for identifying biological and biomechanical mechanisms that lead to impaired or enhanced healing...
  9. ncbi Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfaces
    Ketul C Popat
    Department of Physiology and Division of Bioengineering, University of California at San Francisco, San Francisco, California, USA
    J Biomed Mater Res A 80:955-64. 2007
    ....
  10. ncbi Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    Amjad Javed
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 102:1454-9. 2005
    ..Our findings suggest that fidelity of Runx2 intranuclear organization is necessary for expression of target genes that mediate the osteolytic activity of metastatic breast cancer cells...

Research Grants2

  1. CORE--CELLULAR AND MOLECULAR BIOLOGY
    George Barnes; Fiscal Year: 2007
    ..All projects will use the surgical support and cell and molecular components of the core equally. ..